ライフサイエンスコーパス: effector protein

1 oviding a three-dimensional model of an Avr4 effector protein.

2 eans of introducing DNA or mRNA encoding the effector protein.

3 , and ARGONAUTE4 (AGO4) is a major het-siRNA effector protein.

4 ation, as the most abundant type II secreted effector protein.

5 elevated response is independent of the CagA effector protein.

6 sed by the type III secretion system and its effector proteins.

7 al proteins and that compete with downstream effector proteins.

8 a variety of IFN-I signaling and downstream effector proteins.

9 istone tail modifications and binding of the effector proteins.

10 ffector delivery through binding to VgrG and effector proteins.

11 protein required for secretion of virulence effector proteins.

12 entiation through interactions with multiple effector proteins.

13 scovered an expansive reservoir of potential effector proteins.

14 t, controlling recruitment and activation of effector proteins.

15 nce in plants through the combined action of effector proteins.

16 transport not only DNA, but also toxins and effector proteins.

17 member of the SidE family of L. pneumophila effector proteins.

18 niche through the secretion of more than 300 effector proteins.

19 oxR and TcpP, function together with cognate effector proteins.

20 act host cell membranes and deliver type III effector proteins.

21 result in transcriptional down-regulation of effector proteins.

22 nt immunity that works by directly disarming effector proteins.

23 (a vesicle priming protein) as the relevant effector proteins.

24 members, which then recruit distinct sets of effector proteins.

25 at this pentameric assembly binds Legionella effector proteins.

26 Rab-GTPase binding effector protein 2 (RABEP2) was identified as a novel GS

27 Cdc42 effector protein-4 (CEP4) was recently identified by our

28 To identify these vacuolar effector proteins, a list of predicted C. burnetii T4BSS

29 mbination of Class 1 adaptation modules with effector proteins acquired from distinct mobile elements

30 ed contractile nanomachines that translocate effector proteins across bacterial membranes.

31 Salmonella enterica translocates virulence (effector) proteins across its vacuolar membrane via the

32 egatively and has demonstrated regulation of effector protein activities by cognate metaeffectors as

33 The effector proteins, alkyl hydroperoxide reductase and ace

34 These effector proteins all engage the same face of Cdc42, the

35 the crystal structure of the LpiR1 (Lpg0634) effector protein and investigate the effects of its over

36 We conclude that COH1 is a RAB6 effector protein and that reduced brain size in Cohen sy

37 , efficient "primed" adaptation requires Cas effector proteins and a CRISPR RNA (crRNA) whose spacer

38 ExoU is the most cytotoxic of the known effector proteins and has been associated with more seve

39 rface significantly reduced the secretion of effector proteins and HeLa cell cytotoxicity.

40 how higher oligomeric complexes assemble on effector proteins and if intermediates in assembly pathw

41 ptors (NLRs), to recognize specific pathogen effector proteins and induce immune responses.

42 Pathogens secrete effector proteins and many operate inside plant cells to

43 f-Avr4 to further define the biology of core effector proteins and outline a conceptual framework for

44 structures, and quaternary conformations of effector proteins and TPT were studied.

45 hroughput, modification or overexpression of effector proteins, and low temporal resolution.

46 clase activation, tuned binding constants of effector proteins, and physical interaction between cycl

47 tors of G proteins and randomly selected non-effector proteins, and tested their sensitivity and spec

48 engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit d

49 In this study, we identified the calcium-effector protein annexin A2 as a novel binding partner f

50 r the underlying polarization mechanisms and effector proteins are conserved.

51 Second, effector proteins are injected.

52 The majority of these effector proteins are known suppressors of immunity, but

53 While the Cas effector proteins are remarkably diverse, they commonly

54 Some effector proteins are secreted and are destined to be tr

55 Yet, how a large number of effector proteins are selectively recruited and processe

56 Nematode effector proteins are synthesized in the oesophageal gla

57 V expansion and prevent lysosomal targeting, effector proteins are translocated into the host cell wh

58 es to effect different functions, binding to effector proteins as monomers, intercalated dimers or, u

59 ausal agent of tomato wilt disease, produces effector protein Avr2.

60 ved protective protein serodominant secreted effector protein B (SseB-MB) was evaluated in a mouse in

61 eath commitment and then activates the nodal effector protein BAK to initiate the apoptotic cascade.

62 tumor suppressor p53 activates the apoptotic effector protein BAX to trigger apoptosis.

63 tein "destruction complex" to target the key effector protein beta-catenin for ubiquitin-mediated pro

64 signed to compete with endogenous IQGAPs for effector protein binding.

65 BipC was postulated as one of the TTSS-3 effector proteins, but its role in the pathogenesis of B

66 enicity relies on secretion of more than 300 effector proteins by a type IVb secretion system.

67 aling from GPCRs is relayed to intracellular effector proteins by trimeric G proteins, composed of al

68 incorporation of numerous type III secreted effector proteins, called inclusion membrane proteins (I

69 tion system consisting of an injectisome and effector proteins, called Yersinia outer proteins (Yops)

70 Secreted effector proteins can either display their activity in t

71 k Cas1 and Cas2 and encompass a single large effector protein, Cas13b, along with one of two previous

72 in the cell division cycle 42 (CDC42)-CDC42 effector protein (CDC42EP) signaling pathway, a key orga

73 Transformer 2beta1 (Tra2beta1) is a splicing effector protein composed of a core RNA recognition moti

74 CR repertoire, and accumulated intracellular effector proteins, consistent with a cytotoxic lymphocyt

75 gion of RAS interacts with a large number of effector proteins containing a common RAS-binding domain

76 Here we examine the role of the NGF-TrkA effector protein, Coronin-1, on postganglionic sympathet

77 addition, we have shown that the chlamydial effector protein, CPAF, which is secreted into the host

78 assemblage and accumulation of ZitP and its effector protein CpaM are orchestrated in time and space

79 m vulgare) powdery mildew candidate secreted effector proteins, CSEP0105 and CSEP0162, which contribu

80 Recently, the PV-localized effector protein CvpA was found to promote C. burnetii i

81 proteins recognize the presence of pathogen effector proteins delivered into host cells.

82 he YopD central region to facilitate optimal effector protein delivery into phagocytes, and therefore

83 secretion system (T3SS) to inject virulence effector proteins directly into eukaryotic cells to subv

84 The T6SS delivers multiple, diverse effector proteins directly into target cells using a dyn

85 eruginosa type III secretion system delivers effector proteins directly into target cells, allowing t

86 Although such effector proteins disrupt critical cellular signaling pa

87 Ca(2+) sensor, as the first neuroprotective effector protein downstream of the TF NPAS4.

88 i secretes many functionally uncharacterized effector proteins during infection.

89 l established, and it is known that pathogen effector proteins encoding acetyltransferases can direct

90 en species burst using two type III secreted effector proteins, ExoS and ExoT.

91 ed that the type III secretion system (T3SS) effector protein ExoT plays a pivotal role in facilitati

92 d cells resulted in monoubiquitination of FA effector proteins FANCI and FANCD2 (FANCI-D2) and requir

93 ly of T3Es is a widely distributed family of effector proteins found in both animal and plant pathoge

94 racellular signaling, Wnt pathways share the effector proteins frizzled, dishevelled, and beta-arrest

95 chitin-binding lectins, such as the Cf-Avr4 effector protein from the tomato pathogen Cladosporium f

96 Elegant work has demonstrated that effector proteins from ECM and arbuscular mycorrhizal (A

97 the export element (PEXEL) found in malaria effector proteins from Plasmodium falciparum These findi

98 A screen for type III effector proteins from Pst for their ability to interfer

99 est the ability of 200 type III and type IV effector proteins from six Gram-negative bacterial speci

100 inferring the toxic mechanism of individual effector proteins from the host's phenotype are often im

101 folds or as decoys that recruit or sequester effector proteins from their DNA, RNA, or protein target

102 biochemical activity of the host-interacting effector proteins from these prototypic strains has led

103 which is required to translocate at least 28 effector proteins from vacuolar-resident bacteria into h

104 structural protein sigmaNS with the major SG effector protein G3BP1 and subsequent localization of G3

105 cleavage and activation of the pore-forming effector protein gasdermin D by inflammatory caspases.

106 Here we report that the effector protein HaRxL106 from the oomycete pathogen Hya

107 The characterisation of some Ca(2+) effector proteins has begun to provide insights into the

108 adaptive immune systems in prokaryotes whose effector proteins have become powerful tools for basic r

109 al shutoff environment.IMPORTANCE SGs and SG effector proteins have emerged as important, yet poorly

110 onfers resistance to calprotectin, an immune effector protein highly produced in neutrophils that has

111 isolated Response to the bacterial type III effector protein HopBA1 (RBA1), a gene that encodes a TI

112 SP) and Ena-VASP-like (EVL) are cytoskeletal effector proteins implicated in regulating cell morpholo

113 ovide docking sites for distinct adapter and effector proteins important for regulating discrete SUMO

114 NK-lysin is an antimicrobial peptide and effector protein in the host innate immune system.

115 we report a new role of Armet, namely as an effector protein in the pea aphid, Acyrthosiphon pisum.

116 HI-base 4 are the direct targets of pathogen effector proteins in experimental and natural host organ

117 S by IglA/IglB and secretion of its putative effector proteins in response to environmental stimuli.

118 mechanisms by which H3 tails are read out by effector proteins in the cell.

119 ed the role of the complement system and its effector proteins in the progression of liver regenerati

120 The mode of action of effector proteins in these events is varied and complex.

121 r the small GTPase RAB25, as well as related effector proteins, in enacting both pro-oncogenic and an

122 e show that expression of the C. trachomatis effector protein IncD mediates the recruitment of the li

123 vealed decreased levels of several virulence effector proteins, including IpaA, -B, and -C and IcsA.

124 Many parasite effector proteins, including perforins, adhesins, and pr

125 terica serovar Typhimurium) secrete numerous effector proteins, including SifA, through a specialized

126 NLR proteins often detect pathogen effector proteins indirectly by detecting modification o

127 he molecular weight and isoelectric point of effector proteins, induce their methylation or demethyla

128 However, the neuroprotective effector proteins induced by RBM3 and the mechanisms by

129 lla, Pseudomonas, and Salmonella, to deliver effector proteins into eukaryotic cells.

130 nctions as a nanomachine to inject bacterial effector proteins into eukaryotic cells.

131 have evolved to deliver bacterially encoded effector proteins into eukaryotic cells.

132 type III secretion system (T3SS) to deliver effector proteins into eukaryotic host cells.

133 ype III secretion injectisome to translocate effector proteins into eukaryotic host cells.

134 and the injectisome that delivers pathogenic effector proteins into eukaryotic host cells.

135 x many Gram-negative pathogens use to inject effector proteins into host cells and cause disease.

136 I secretion systems (T3SSs) inject bacterial effector proteins into host cells and underlie the virul

137 ilament dynamics.Microbial pathogens secrete effector proteins into host cells to affect cellular fun

138 pathogens, plant-parasitic nematodes secrete effector proteins into host cells to facilitate infectio

139 secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular

140 III secretion system (T3SS) translocates Yop effector proteins into host cells to manipulate immune d

141 n is achieved via the injection of bacterial effector proteins into host cells using a Type III secre

142 ella enterica serovar Typhimurium can inject effector proteins into host cells via type III secretion

143 ia, the type III secretion system transports effector proteins into host cells, converting resources

144 x type III secretion system (T3SS) to inject effector proteins into host cells, take over host functi

145 To cause disease, diverse pathogens deliver effector proteins into host cells.

146 a type III secretion system (T3SS) to inject effector proteins into host cells.

147 IV secretion system to translocate over 300 effector proteins into host cells.

148 t/Icm T4SS injects approximately 300 protein effector proteins into host cells.

149 secretion system (T3SS)-mediated delivery of effector proteins into host cells.

150 III secretion systems that deliver bacterial effector proteins into host cells.

151 Dot type IVB secretion system to translocate effector proteins into host cells.

152 type III secretion system (T3SS) to deliver effector proteins into host cells.

153 eploys a type III secretion system to inject effector proteins into host epithelial cells and macroph

154 host immune systems, these yersiniae inject effector proteins into host macrophages.

155 nematodes synthesize and secrete a suite of effector proteins into infected host cells and tissues.

156 on systems (T3SS), Ysa and Ysc, which inject effector proteins into macrophages to prevent phagocytos

157 tracellular Salmonella enterica translocates effector proteins into mammalian cells.

158 -negative bacterial species to deliver toxic effector proteins into nearby bacteria prey cells to kil

159 perature promotes translocation of bacterial effector proteins into plant cells and causes a loss of

160 tiprotein needle-like apparatus that injects effector proteins into prokaryotic and/or eukaryotic tar

161 lycines, the soybean cyst nematode, delivers effector proteins into soybean roots to initiate and mai

162 rial pathogens and used to deliver virulence effector proteins into target cells.

163 exert their function by delivering bacterial effector proteins into target eukaryotic cells.

164 L. pneumophila delivers almost 300 effector proteins into the besieged host cell that alter

165 -like structure in order to inject bacterial effector proteins into the cytoplasm of a host cell.

166 ane of a eukaryotic cell to deliver multiple effector proteins into the cytosol of the target cell.

167 Secretion of effector proteins into the eukaryotic host cell is requi

168 etion system (T4BSS) that delivers bacterial effector proteins into the host cell cytosol.

169 Coxiella burnetii, requires translocation of effector proteins into the host cytosol by a Dot/Icm typ

170 E-mediated transport and secretion of fungal effector proteins into the host to modulate rice immunit

171 system (T4SS), which delivers more than 300 effector proteins into the host, where they rewire cellu

172 retion system to translocate a repertoire of effector proteins into the hosts for their survival and

173 e fungus Fusarium oxysporum secretes several effector proteins into the xylem tissue to promote virul

174 retion system (T3SS) to inject virulence or "effector" proteins into the cytoplasm of host intestinal

175 oding exophilin-5 (also known as Slac2-b, an effector protein involved in intracellular vesicle traff

176 Here, we found that the Shigella effector protein IpaJ potently inhibits STING signaling

177 Enhanced secretion of tumorigenic effector proteins is a feature of malignant cells.

178 In Yersinia, the switch to secretion of effector proteins is induced first after intimate contac

179 An arsenal of effector proteins is injected by bacterial pathogens int

180 tosis, GSDMD (gasdermin D), the pore-forming effector protein, is cleaved, forms oligomers, and inser

181 nk between the conserved Rho1 GTPase and its effector protein kinase C (Pkc1) with septin ring stabil

182 B2 downregulates Perp by activating an ErbB2 effector protein kinase Mek that blocks detachment-induc

183 stigate auto-regulation of the innate immune effector protein kinase R, which phosphorylates the euka

184 Checkpoint kinase 1 (Chk1) is a key effector protein kinase that regulates the DNA damage re

185 neurotransmitters via activation of its main effector, protein kinase A (PKA).

186 tes the activity of its essential downstream effector, protein kinase Ypk1.

187 ins are critical upstream modulators of many effector protein kinases.

188 inhibition of protease LapG by the c-di-GMP effector protein LapD, and resulting in proteolysis of t

189 multimolecular complex including downstream effector proteins linked to AR (AR-axis) responsible for

190 introduce LOCALIZER for predicting plant and effector protein localization to chloroplasts, mitochond

191 sufficiently high concentrations to modulate effector proteins located in the intimate vicinity of th

192 ng analogous resistance proteins, the fungus effector proteins may trigger resistance, rather than pr

193 ic Escherichia coli through the action of an effector protein, McpM.

194 The data suggest that Armet is an effector protein mediating aphid-plant interactions.

195 oth RIPK1 and RIPK3, but not the necroptosis effector protein, MLKL.

196 These effector proteins modulate a variety of cellular functio

197 These effector proteins modulate a variety of host transcripti

198 The type III secretion system effector protein NleE from enteropathogenic Escherichia

199 The bona fide F-box AnkB effector protein of L. pneumophila strain AA100/130b is

200 HopAF1 is a type III effector protein of unknown function encoded in the geno

201 The newly identified effector proteins of Brucella may represent targets for

202 This highlights how target effector proteins of small-molecule ligands can promote

203 Recognition of pathogen-secreted effector proteins often triggers the hypersensitive resp

204 The T4SS translocates effector proteins, or substrates, into the host cytosol,

205 While many R protein and effector protein pairs are known to trigger HR, other co

206 The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical pro

207 fat body including the presence of the piRNA effector protein Piwi and canonical 23-29 nt long TE-map

208 activity assists a dsRNA-dependent antiviral effector protein, PKR, and allows RIG-I to promote MDA5

209 The conserved membrane-associated effector protein PspA has four alpha-helical domains (HD

210 ing endosomes through recruitment of a Rab11 effector protein, Rab11-FIP3.

211 iation of phosphorylated HRAS(G12V) with its effector protein RAF proto-oncogene serine/threonine pro

212 ation and occurred via association of the SG effector protein, Ras-GAP SH3-binding protein 1 (G3BP1),

213 The effector proteins RavY and Lpg2505 were important for ef

214 a interferes with autophagy by delivering an effector protein, RavZ, into the host cytosol.

215 ctivation-competent complexes with the Notch effector protein RBP-Jk and promoter DNA.

216 By extending guide RNAs to include effector protein recruitment sites, we construct modular

217 how dynamic networks of sibling cyclases and effector proteins result in sensible outputs that govern

218 Loss-of-function mutations in genes encoding effector proteins resulted in host-specific or broad vir

219 ssociate with non-orthologous regulatory and effector proteins retaining functions similar to those i

220 ial pathogen Pseudomonas syringae depends on effector proteins secreted by its type III secretion sys

221 ) microchambers for codetection of 42 immune effector proteins secreted from single cells, representi

222 unteracts host cytotoxicity displayed by the effector protein SidI.

223 Mice lacking the TGF-beta effector protein SMAD3 are protected against diet-induce

224 report that L. pneumophila translocates the effector protein sphingosine-1 phosphate lyase (LpSpl) t

225 t shell protein (PduA), a type III secretion effector protein (SteA), and a metabolic enzyme (malate

226 antos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquiti

227 verified that Rac1, RhoA, and some of their effector proteins such as PAK and ROCK, are likely anti-

228 s class 2 effectors rely on single-component effector proteins such as the well-characterized Cas9.

229 ave developed a strategy to tightly regulate effector proteins such that HR is chemically inducible a

230 Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have

231 we found that MST1 associates with the Rab27 effector protein synaptotagmin-like protein 1 (JFC1, enc

232 ins (ZFP), four transcription activator-like effector proteins (TALE), CRISPR associated protein 9 (S

233 Transcription activator-like effector proteins (TALEs) contain large numbers of repea

234 The two Tribolium piRNA pathway effector proteins, Tc-Piwi/Aub and Tc-Ago3, are also exp

235 The Brucella effector protein TcpB suppresses Toll-like receptor 2 (T

236 one of the interacting partners of Brucella effector protein TcpB that negatively regulates TLR2 and

237 Pathogenic Yersinia bacteria inject effector proteins termed Yops, as well as pore-forming p

238 1 genes and secretes lesser amounts of SPI-1 effector proteins than S. Typhimurium, especially under

239 s the first to thoroughly characterize a Rab effector protein that contains two separate Rab binding

240 Complexin-1 is a SNARE effector protein that decreases spontaneous neurotransmi

241 Our data reveal IcaA as a novel C. burnetii effector protein that is secreted by the Dot/Icm type IV

242 invasion protein A (SipA) is a dual-function effector protein that plays roles in both actin polymeri

243 SpvD is a Salmonella enterica effector protein that we previously demonstrated to nega

244 Plant pathogens deliver effector proteins that alter host processes to create an

245 sponsible for the secretion of a plethora of effector proteins that alter the biology of the host cel

246 ght pathogen Phytophthora infestans secretes effector proteins that are delivered inside (cytoplasmic

247 a encodes a repertoire of over 300 different effector proteins that are delivered into host cells by

248 asitic cyst nematodes synthesize and secrete effector proteins that are essential for parasitism.

249 ray screen, we identify a cluster of mitotic effector proteins that are polyubiquitinated in a Gsk3-d

250 f these 3'-UTR functions are accomplished by effector proteins that are recruited by RNA-binding prot

251 to modulate autophagy through the action of effector proteins that are translocated into the host ce

252 pe IV secretion system (T4SS) to translocate effector proteins that direct the formation of a parasit

253 II secretion system (T3SS) to translocate 50 effector proteins that hijack and manipulate host cell s

254 ic bacterium Legionella pneumophila secretes effector proteins that induce the conversion of the plas

255 c and activated BCR signaling and identifies effector proteins that may be relevant for BL cell survi

256 s encode proteins that appear to function as effector proteins that may regulate symbiotic associatio

257 of bacterial pathogens translocate bacterial effector proteins that mediate disease into the eukaryot

258 he identification and mode of action of T6SS effector proteins that mediate this protective effect re

259 Effector proteins that mimic plant CLAVATA3/ENDOSPERM SU

260 The activity of the effector proteins that perform and coordinate these biol

261 e some of these processes, pathogens secrete effector proteins that promote colonization.

262 pe IV secretion system (T4SS) to translocate effector proteins that promote its survival and replicat

263 Unlike other effector proteins that subvert Rho GTPases to modulate u

264 e data indicate C. burnetii encodes multiple effector proteins that target the PV membrane and benefi

265 ain binds, directly or indirectly, different effector proteins that transmit signals.

266 Many bacterial pathogens secrete virulence (effector) proteins that interfere with immune signaling

267 g activation by its cognate pathogen-derived effector protein, the coat protein of potato virus X.

268 P21-activated kinase 4 (PAK4) is a Cdc42 effector protein thought to regulate cell adhesion disas

269 le or stabilisable orthologous dCas9 or Cpf1 effector proteins, thus opening options for multidimensi

270 induced by the virulence promoting secreted effector protein Tin2.

271 s a restricted host range and uses different effector proteins to alter host signaling.

272 associated proteins and functions to recruit effector proteins to chromatin through its ability to bi

273 l G proteins, Cdc42 binds to many downstream effector proteins to elicit its cellular effects.

274 their hosts, they employ a large arsenal of effector proteins to establish a successful infection.

275 Pathogens secrete effector proteins to establish a successful interaction

276 Filamentous plant pathogens deliver effector proteins to host cells to promote infection.

277 thora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to

278 Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways,

279 U. maydis deploys many effector proteins to manipulate its host.

280 Plant pathogens employ effector proteins to manipulate their hosts.

281 ella pneumophila, secretes approximately 300 effector proteins to modulate the host environment.

282 portant class of lipid that recruit specific effector proteins to organelle membranes.

283 topathogenic bacteria deploy a repertoire of effector proteins to perturb immune signaling.

284 orm of T-DNA (T-strands) and Virulence (Vir) effector proteins to plant cells.

285 Pathogens secrete effector proteins to suppress host immunity, mediate nut

286 mes from the identification of the Wolbachia effector protein TomO, which maintains host germline ste

287 nd the intracellular replication of Coxiella Effector proteins, translocated into the host cell throu

288 le pore protein EspD, which is essential for effector protein translocation into host cells.

289 ss by injecting the type IV secretion system effector protein VceC into host cells, is TRAF2, NOD1/2

290 Rab GTPases recruit effector proteins, via their GTP-dependent switch region

291 ere we show that the Vibrio parahaemolyticus effector protein VopQ is a potent inhibitor of membrane

292 nnii mutants lacking expression of virulence effector proteins, we demonstrated that bacterial driver

293 ting partners of WIPIs, WD-repeat PtdIns(3)P effector proteins, we found that Atg16L1 directly binds

294 CR signaling shared a considerable number of effector proteins, we identified distinct phosphorylatio

295 e secondary metabolite clusters and secreted effector proteins were identified with distinct infectio

296 CDI(+) bacteria deploy large CdiA effector proteins, which carry variable C-terminal toxin

297 CDI+ bacteria export filamentous CdiA effector proteins, which extend from the inhibitor-cell

298 in eukaryotes, reportedly serve as bacterial effector proteins with deSUMOylase, deubiquitinase, or,

299 n immune response triggered by the bacterial effector proteins XopQ and HopQ1, respectively.

300 ng et al. (2016) show that the Yersinia T3SS effector protein YopM counteracts this recognition pathw