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1 At the same dose levels, PIV5/G was less efficacious.
2 s, whereas the (S)-enantiomers are much more efficacious.
3 er therapies promoting Treg fragility may be efficacious.
4 zylmethylamine (dibemethin) side chains, are efficacious.
5 ntive compounds that may not be sufficiently efficacious.
6 for which available therapies are not fully efficacious.
7 herapy in acute chemical injury, are equally efficacious.
8 with EBOV GP (rVSV-EBOV) is safe and highly efficacious.
9 cines should be easily applicable, safe, and efficacious.
10 in low doses, is usually well tolerated and efficacious.
11 D-Ib but the G6PC promoter/enhancer was more efficacious.
12 ining questions about whether the therapy is efficacious across the diverse populations included.
18 ication, however, FimH antagonists should be efficacious against all physiologically relevant conform
19 mg/kg/day was clinically and radiologically efficacious against deep IH in the proliferative stage,
22 s of P. falciparum and P. vivax in vitro, is efficacious against P. falciparum in in vivo rodent mode
23 1) virus-like particles (VLP) and are highly efficacious against the development of cervical cancer p
25 ro(8)OXT taxon-specific variants act as equi-efficacious agonists for the Gq-dependent pathway but ar
28 equency and bilateral rTMS might be the most efficacious and acceptable interventions among all rTMS
30 t education programmes have been shown to be efficacious and cost-effective in promotion and facilita
31 VSVDeltaG pseudovirion vaccines may prove as efficacious and have better safety, but they have not be
33 salvage regimen can potentially serve as an efficacious and safe alternative to platinum-based chemo
34 hed in this study are expected to provide an efficacious and safe CRISPR/Cas9 antimicrobial, broadly
36 ir + dasabuvir, and SOF plus daclatasvir was efficacious and safe in LT, KT, and DLK transplant recip
37 combination of tezacaftor and ivacaftor was efficacious and safe in patients 12 years of age or olde
38 in patients with atherosclerotic disease is efficacious and safe in patients with and without diabet
40 blingual immunotherapy (SLIT) is a potential efficacious and safe treatment option for patients with
42 ses, reaffirming trastuzumab emtansine as an efficacious and tolerable treatment in this patient popu
43 The combination of GLE and PIB was highly efficacious and well tolerated in patients with HCV geno
44 rapy and in combination with fluoxetine, was efficacious and well tolerated in the treatment of adult
45 emtricitabine, and tenofovir alafenamide was efficacious and well tolerated in virologically suppress
47 showed that both doses of SCIg IgPro20 were efficacious and well tolerated, suggesting that SCIg can
52 TH17) pathway with ustekinumab represents an efficacious and, based on its proinflammatory cytokine p
54 tions which may be painful, are incompletely efficacious, and represent a significant treatment burde
58 eplace Bacille Calmette-Guerin vaccines with efficacious anti-tuberculosis (TB) vaccines have prompte
59 nd offers the best chance of making safe and efficacious antibiotics available to the public ahead of
60 of depression and subsequently develop more efficacious antidepressant drugs, multiple theories have
64 Intentional bacterial infections can produce efficacious antitumor responses in mice, rats, dogs, and
65 le in support of further studies identifying efficacious antivirals for use in in vivo studies of LRV
66 erved isoniazid and rifapentine (3HP), is as efficacious as 9 months of isoniazid, with a greater com
68 escents have demonstrated that tiotropium is efficacious as an add-on therapy to inhaled corticostero
69 ivities, and the 3-hydroxypropylamide was as efficacious as fulvestrant in suppressing cell prolifera
70 However, whether psychodynamic therapy is as efficacious as other empirically supported treatments is
71 t of Emotional Disorders (UP) is at least as efficacious as single-disorder protocols (SDPs) in the t
72 ients with HIV, tenofovir alafenamide was as efficacious as tenofovir disoproxil fumarate, with reduc
74 Single-dose praziquantel appears to be as efficacious as the standard 3 x 25 mg/kg regimen for the
75 bunits that were previously shown to be more efficacious at inhibiting Ca(2+)-triggered exocytotic re
76 odies specific for antigenic site O are more efficacious at preventing RSV infection than antibodies
80 ]oxazine class was further explored, seeking efficacious backup compounds with improved solubility an
81 owever, the kidney capsule was slightly more efficacious because all 800 (n = 5) and 1200 islets (n =
83 ties and challenges to achieve selective and efficacious BRD4 inhibitors as a viable therapeutic stra
84 d cHL allo-HCT patients appears to be highly efficacious but frequently complicated by rapid onset of
86 eas gel-forming DF sources were consistently efficacious (but with very few comparisons).The overall
87 In this study, we sought to develop highly efficacious candidate vaccines against all AHSV serotype
91 trials, tildrakizumab 200 mg and 100 mg were efficacious compared with placebo and etanercept and wer
94 the working hypothesis, PAL1045 was the most efficacious compound in restoring surface expression and
96 papillomavirus vaccination may represent an efficacious, cost-effective, readily available, and well
97 ECT), which, by exploiting the use of highly efficacious CRISPR/Cas-blocking mutations in two rounds
100 the dendrimer, enabled administration of an efficacious dose of SN-38, achieving significant regress
101 ing the complexity of AD and for identifying efficacious drug candidates to treat this devastating di
104 ng methods to relate diseases to potentially efficacious drugs through various molecular features is
105 tanoprost, and travoprost are among the most efficacious drugs, although the within-class differences
108 thiazolino 2-pyridone amides that are highly efficacious (EC50 </= 100 nM) in attenuating infectivity
110 in determining which antibodies may be most efficacious following active immunization or passive adm
113 VPI and whether a statistical model might be efficacious for advance warning of impending hypotension
116 ased pre-exposure prophylaxis (PrEP) is high efficacious for HIV prevention among women with high adh
118 idence exists on which antipsychotic is more efficacious for patients with treatment-resistant schizo
123 In vitro, LY2828360 was a slowly acting but efficacious G protein-biased CB2 agonist, inhibiting cAM
124 distribution that should inform methods for efficacious gene therapy over a broad range of applicati
126 ivers of mice treated with a panel of highly efficacious hepatotoxic or non-hepatotoxic LNA ASOs.
128 l functions.IMPORTANCE The development of an efficacious HIV-1 vaccine remains a global priority to p
129 ope (Env) antigens (Ag) for more long-lived, efficacious HIV-1 vaccine-induced B-cell responses.
132 size was 47 patients; maintenance was deemed efficacious if at least 19 patients were progression-fre
133 i-cancer therapeutic effects have been shown efficacious, implying the use of the described nanoplatf
134 , we show that the lead compounds are orally efficacious in a 4 day murine model of malaria disease b
135 levels in plasma in vivo and was shown to be efficacious in a bleomycin-induced pulmonary fibrosis mo
136 apone augmentation of antidepressants is not efficacious in a broadly representative population of pa
137 ic inhibitor from this class was shown to be efficacious in a cellular model of viral infectivity.
138 ignaling, and therapeutic LXB4 treatment was efficacious in a chronic model of the common neurodegene
140 le is very potent in PK/PD assays and highly efficacious in a mouse collagen-induced arthritis model.
142 of S1P1 with selectivity over S1P3 and were efficacious in a pharmacodynamic model of suppression of
144 G) and D265A, N297G (DANG) variants that are efficacious in attenuating effector function in primates
145 OCT2-targeted therapeutic strategy would be efficacious in both major subtypes of DLBCL while avoidi
148 ting that folinic acid treatment may be more efficacious in children with ASD who are FRAA positive.
151 eroidal anti-inflammatory drugs (NSAIDs) are efficacious in closing PDA, but the effectiveness of NSA
153 , brincidofovir is well-tolerated and highly efficacious in controlling adenoviremia during the lymph
154 oxacin backbone regimen that could be highly efficacious in disseminated tuberculosis in children.
158 the same treatment strategies, MEAN was more efficacious in inhibiting tumor growth in mice than sora
161 lthough tinnitus retraining therapy (TRT) is efficacious in most patients, the exact mechanism is unc
162 y-induced neuropathic pain and may be highly efficacious in neuropathic pain states that are refracti
163 ing dinaciclib and niraparib was also highly efficacious in ovarian, prostate, pancreatic, colon, and
164 tezacaftor-ivacaftor or ivacaftor alone was efficacious in patients with cystic fibrosis who were he
167 esicle (OMV)-based cholera vaccine is highly efficacious in preventing intestinal colonization in the
168 that PIV5-based RSV vaccine candidates were efficacious in preventing lower respiratory tract infect
169 RSV immunoprophylaxis during infancy is efficacious in preventing RSV-related hospitalizations a
170 nation with forskolin, treprostinil was most efficacious in raising intracellular cAMP levels in muri
172 of the CCR6 chemokine receptor, CCX2553, was efficacious in reducing multiple aspects of psoriasis in
175 ortant for developing vaccines that would be efficacious in sub-Saharan Africa, where clade C infecti
176 trongly suggests that CN2097 could be highly efficacious in targeting complex secondary injury proces
180 f linezolid and moxifloxacin was found to be efficacious in the hollow fiber system model of pediatri
181 t increase KLF2 in the carotid bodies may be efficacious in the treatment of respiratory and autonomi
182 that trigger cell differentiation are highly efficacious in treating certain cancers, but such approa
183 neutralize IL-17 or its receptor have proven efficacious in treating moderate-to-severe psoriasis, co
184 th severe side effects, and whether they are efficacious in treatment of chronic nonmalignant pain re
186 1:3)] and [Rep/PEI-40,000 (1:2)/(Arg)9] were efficacious in vivo in mice and pigs, where specific CD8
187 rized cognitive training (CCT) is a safe and efficacious intervention for cognition in older adults.
189 isk HIV-1-uninfected individuals is a highly efficacious intervention to prevent HIV-1 acquisition an
190 f-regulation and illuminates how even highly efficacious interventions may be culturally bounded in t
191 one and combined with bevacizumab was highly efficacious, leading to complete tumor regressions, redu
192 and divalproex were adequately tolerated and efficacious; lithium was associated with a greater reduc
194 ign and discovery of a novel, potent, orally efficacious liver X receptor beta (LXRbeta) agonist (17)
197 leaning practices, and organic matter, as an efficacious measure to interrupt disease transmission fr
201 ndicate the feasibility of producing a safe, efficacious, multivalent vaccine against the encephaliti
202 rther development of clinically relevant and efficacious nanotherapeutics intended to reduce plaque i
205 apeutic CD40-CD40L blocking agents may prove efficacious not only in early and established RA, but al
208 ed similar signaling profiles, being equally efficacious on Gq and beta-arrestin, while Val(3)Pro(8)O
210 tch-induced hypertrophy, and predict further efficacious pairs of drug targets in the network through
212 ribe one set of universal conditions for the efficacious polymerization of acrylates, methacrylates a
214 To determine whether participation in an efficacious prevention program designed to enhance suppo
215 pes simplex virus 2 (HSV-2), and to date, an efficacious prophylactic vaccine has not met the rigors
219 RSV vaccine candidate.IMPORTANCE A safe and efficacious respiratory syncytial virus (RSV) vaccine re
220 While immune checkpoint blockade elicits efficacious responses in many patients with cancer, it a
222 In this study, we provide evidence that efficacious responses to this drug can be heightened sig
226 ction, Talpha1 has strong potential to be an efficacious single-molecule-based therapeutic agent for
227 ls are a potent cell population dedicated to efficacious skeletal muscle regeneration, but their ther
230 nal opioid agonist-NK1R antagonist may be an efficacious strategy in developing future analgesics tha
231 eted siRNA-based therapy represents a novel, efficacious strategy to reestablish redox homeostasis an
233 rug concentrations lower than the MTD are as efficacious, suggesting that lowering the total amount o
234 2D (10% and 27%, respectively), and a highly efficacious superagonist at GluN1/2C receptors (353%).
236 dual-targeted nanoplatform that generates an efficacious template for further development of a sustai
240 ationale for why this approach could be more efficacious than conventional continuous deep brain stim
241 ng in two protein transporter molecules more efficacious than currently commercially available agents
243 .14, -0.27 to -0.01) were significantly more efficacious than haloperidol, but the evidence was very
244 an anti-CD52 antibody, is proven to be more efficacious than interferon beta-1a in the treatment of
246 ion at lower doses-has been shown to be more efficacious than maximum tolerated dose treatment in pre
248 e show that targeting truncal events is more efficacious than targeting private events in reducing th
249 14-restricted activity is substantially more efficacious than the subdominant HLA-B*14-restricted Gag
250 (RR: 1.64, 95% CI: 1.17-2.28) were both more efficacious than usual care, whereas in-hospital behavio
252 es for the development of Esc(1-21)-1c as an efficacious therapeutic alternative against pulmonary P.
255 to have biomarkers that can predict the most efficacious therapies or measure response to therapy ear
263 mbination of route, was found to be the most efficacious to suppress the tumor growth and lead to a p
265 vulsive therapy (ECT) is considered the most efficacious treatment available for individuals with sev
267 ecal microbiota transplant (FMT) is a highly efficacious treatment for recurrent CDI; however, a numb
270 eroid cultures, they may enable the safe and efficacious treatment of otherwise unresponsive tumour r
271 RT)-based combination therapies are the most efficacious treatment of uncomplicated Plasmodium falcip
272 rizotinib, and establish ceritinib as a more efficacious treatment option compared with chemotherapy
273 educed-dose ipilimumab might be a tolerable, efficacious treatment option for patients with advanced
278 mortality in patients because of the lack of efficacious treatments targeting renal manifestations of
283 tologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeuti
284 = .37); however, IIV remained significantly efficacious until data became sparse at the end of the s
285 mune responses present a major hurdle to the efficacious use of oncolytic adenoviruses as cancer trea
288 lobal infectious disease problem, and a more efficacious vaccine is urgently needed for the control a
290 ucosal responses are induced when developing efficacious vaccines and prevention strategies for infec
293 addition to stringent sterile techniques, an efficacious way to prevent this destructive complication
295 cer Database, adjuvant chemotherapy remained efficacious when started 7 to 18 weeks after non-small-c
299 enolate mofetil immunosuppressive regimen is efficacious, with a low incidence of PTDM and a manageab
300 actionated radiotherapy seems to be safe and efficacious without impairing quality of life for elderl
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