ライフサイエンスコーパス: efficacy

1 he filter, thereby increasing its safety and efficacy.

2 human receptors and enhance its therapeutic efficacy.

3 , resulting in production problems and lower efficacy.

4 bacillus bacteria, a threefold difference in efficacy.

5 ies to maximize and sustain opioid analgesic efficacy.

6 ded for adequate studies of their safety and efficacy.

7 mbers of residual stem cells may limit their efficacy.

8 that these interactions affect potentiating efficacy.

9 pe E (B/E) proteins demonstrated 31% vaccine efficacy.

10 A-evoked Popen , suggesting impaired agonist efficacy.

11 -selective inhibitors with enhanced cellular efficacy.

12 -fold improvement of its cancer cell-killing efficacy.

13 the sample, potentially limiting application efficacy.

14 pment strategies, immune disorders, and drug efficacy.

15 planned to allow the study to stop early for efficacy.

16 gibility would improve lung cancer screening efficacy.

17 re are limited data validating their vaccine efficacy.

18 completion of clinical trials demonstrating efficacy.

19 ited data are available regarding safety and efficacy.

20 ment for combinatorial agents, and extent of efficacy.

21 cells can be further engineered to maintain efficacy.

22 ystemic drug exposure is crucial for in vivo efficacy.

23 e complex mechanisms of actions and improved efficacy.

24 ever, the study was not powered for clinical efficacy.

25 able valine-citrulline [VC(S)] linker on ADC efficacy.

26 nly few studies have been conducted on their efficacies.

27 To evaluate therapeutic efficacy, 2 groups of mice received the radiopharmaceuti

28 hotypes and those without these morphotypes (efficacy 68.62% vs 76.72%; pinteraction=0.652); or betwe

29 tment groups were assumed to have equivalent efficacy above 90%.

30 lear cells or T cells enhanced the antitumor efficacy achieved by the parental counterpart.

31 ion are known contributors to variability in efficacy across different clinical indications of deep b

32 titis C virus (HCV) therapies with excellent efficacy across genotypes and in diverse populations.

33 ality of health-care delivery, and treatment efficacy across various disease settings.

34 LY3023414 demonstrates efficacy against EAC in a preclinical model, establishin

35 ystem for quantitatively assessing the probe efficacy; an ideal probe exhibits high reactivity with i

36 Efficacy analyses were done in the intention-to-treat po

37 en before screening were included in primary efficacy analyses.

38 The primary efficacy analysis included all participants who received

39 The efficacy analysis included all patients who received at

40 her research is needed to assess longer-term efficacy and adverse effects.

41 GBCAs have shown efficacy and are safe to use with most patients; however

42 formulations were evaluated for transfection efficacy and cytotoxicity to a range of human HCC cells

43 However, vaccine efficacy and direct effectiveness estimates have varied,

44 rotection against HIV-1 acquisition, but the efficacy and immune memory were inadequate.

45 vo significantly enhances chemo-radiotherapy efficacy and improves survival of rats and mice orthotop

46 olizing enzymes, resulting in decreased drug efficacy and increased resistance.

47 aded (D)CDX-RBCNPs have superior therapeutic efficacy and markedly reduced toxicity as compared to th

48 l promise for migraine therapy, although its efficacy and mechanism of action are unclear.

49 jective of the trial was designed to measure efficacy and not haemolysis in relation to G6PD genotype

50 To evaluate the efficacy and ocular and systemic safety of netarsudil 0.

51 ily consist of glucocorticoids, have limited efficacy and present safety concerns.

52 We demonstrate SynapTRAP's efficacy and report local translation in the cortex of m

53 ntenance period were included in the primary efficacy and safety analyses.

54 gulatory agencies, and for this reason their efficacy and safety are rarely proven.

55 centrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evolocumab,

56 The efficacy and safety of 0.005% calcipotriol ointment comb

57 To compare the efficacy and safety of 2 sclerosants used to treat retic

58 Evidence exists for the efficacy and safety of 6-month isoniazid monotherapy, ri

59 Purpose To evaluate the efficacy and safety of a clofarabine-based combination (

60 We aimed to assess the efficacy and safety of ceftazidime-avibactam in patients

61 We assessed the efficacy and safety of ceritinib versus platinum-based c

62 We aimed to analyse the efficacy and safety of clemastine fumarate as a treatmen

63 The efficacy and safety of fixed-dose combination of AM and

64 We aimed to test the efficacy and safety of graded exercise delivered as guid

65 We sought to evaluate the efficacy and safety of grass pollen intradermal immunoth

66 We aimed to assess the efficacy and safety of idelalisib in combination with a

67 Conclusion The durable clinical efficacy and safety of MR imaging-guided HIFU were demon

68 mized, double-blind trial designed to assess efficacy and safety of nintedanib plus chemotherapy as f

69 ssment and modelling are required to monitor efficacy and safety of ongoing strategic vitamin D forti

70 We aimed to assess the efficacy and safety of pacritinib versus best available

71 This phase 2 study was designed to test the efficacy and safety of pembrolizumab, a humanized PD-1-b

72 To evaluate the efficacy and safety of ranibizumab 0.5 mg treat-and-exte

73 We assessed the efficacy and safety of re-treating malaria patients with

74 studies strengthen the evidence base for the efficacy and safety of sublingual immunotherapy in patie

75 We investigated the efficacy and safety of switching to a single-tablet regi

76 This trial evaluated the efficacy and safety of tezepelumab (AMG 157/MEDI9929), a

77 We summarise efficacy and safety results from 13 polypill trials (905

78 The efficacy and safety were assessed for up to 4 months.

79 inical studies are needed to determine their efficacy and safety, as well as the appropriate patient

80 stribution is essential for evaluating their efficacy and safety.

81 ))-100 and CoVaccineHT(TM), enhanced vaccine efficacy and sterile protection following malaria challe

82 oduction that can be used to promote vaccine efficacy and the treatment of infections and malignancy

83 rter 2 inhibitor that demonstrated favorable efficacy and tolerability in the treatment of tardive dy

84 o-controlled, parallel design, we tested the efficacy and tolerability of 4-wk intranasal OXT treatme

85 ires myeloma physicians to carefully balance efficacy and toxicity profiles for each individual patie

86 Therapeutic efficacy and tumor necrosis area were compared by using

87 hly differentiated therapeutics with greater efficacy and/or improved safety profiles.

88 Vaccines are under development, but efficacies are variable.

89 syndrome (TSS), but its frequency of use and efficacy are unclear.

90 Re-treatment with the same ACT shows similar efficacy as recommended rescue treatments and could be c

91 icacy is generally modest and differences in efficacy between antidepressant therapies are small.

92 Differences in efficacy between drugs were often greater than the diffe

93 gs were often greater than the difference in efficacy between treatments and placebo.

94 is crossed the prespecified overall survival efficacy boundary.

95 duled physician visits and increases in self-efficacy, but definitive conclusions could not be reache

96 variable effects on metabolic stability and efficacy, but the most effective members of this series

97 cant drawbacks with respect to stability and efficacy, but the permanent surfaces may have an edge in

98 r the need to maximize breadth and antiviral efficacy by combining bnAbs for therapeutic indications.

99 ments, is consistent with increased synaptic efficacy caused by ATP.

100 cumin may provide superior anti-inflammatory efficacy compared to standard curcumin.

101 ist treatment associated with differences in efficacy compared with opioid taper or psychological tre

102 INTERPRETATION: Ozanezumab did not show efficacy compared with placebo in patients with ALS.

103 Rituximab's lack of efficacy could be due to a considerable placebo effect;

104 t follow-up while control arm patients' self-efficacy declined.

105 or oral cancer does not provide satisfactory efficacy due to drug resistance or reduced EGFR level.

106 ormulated intranasal insulin to evaluate its efficacy during acute abstinence from smoking.

107 ncy (pEC50 values between 9.53 and 9.78) and efficacy (Emax values between 130 and 160%).

108 The primary efficacy end point was a composite of adjudicated cardio

109 The primary efficacy end point was change in serum phosphate concent

110 ificantly more likely to achieve the primary efficacy end point: in trial A, 188 of 254 (74.0%) vs 21

111 would require confirmation using traditional efficacy end points.

112 The primary efficacy endpoint was the percentage of patients with a

113 The primary efficacy endpoint, analysed in the per-protocol populati

114 In the efficacy-evaluable population, the overall response rate

115 to identify suitable candidates for in vivo efficacy evaluation.

116 e checkpoint blockade to enhance therapeutic efficacy for human cancers.

117 results suggest that rehabilitative training efficacy for improving manual skills is mediated by syna

118 rs (BSFs) and assess the long-term (9 month) efficacy for particulate and Escherichia coli removal un

119 disease's course and lead to new markers of efficacy for prevention and treatment trials.

120 esent a new ruthenium catalyst with a unique efficacy for the selective oxidation of a single hydroxy

121 uprenorphine) associated with differences in efficacy for treating prescription opioid dependence, an

122 ese results demonstrate clinical therapeutic efficacy from gene therapy for ADA-deficient SCID, with

123 ed in settings with near-perfect SP curative efficacy (>99%) based on the most recent estimates of re

124 Its safety and efficacy have been extensively demonstrated in clinical

125 nducing obesity therapeutics, despite modest efficacy, have safety concerns that underscore the need

126 EEF efficacies in wheat and maize systems were more complica

127 laying excellent pharmacokinetic profile and efficacy in a human PTEN-deficient LNCaP prostate carcin

128 s having published evidence of antiepileptic efficacy in animal models than expected by chance (P-val

129 cleotide RTI inhibitor tenofovir (TDF), show efficacy in blocking K103 RT.

130 gether with the available evidence for their efficacy in cellular and animal models of human inflamma

131 hibition has been shown to exert therapeutic efficacy in chronic obstructive pulmonary disease (COPD)

132 eins for their immunogenicity and protective efficacy in cotton rats and African green monkeys, which

133 new paradigm, combinatorial chemoprevention efficacy in familial adenomatous polyposis (FAP), signal

134 mmunication support program recipients' self-efficacy in knowing what questions to ask their doctor s

135 he bivalent HPV-16/18 vaccine has protective efficacy in men.

136 Knowledge of Survivorship Issues, Perceived Efficacy in Patient-Physician Interactions, and Satisfac

137 Conversely, evidence for efficacy in people with dementia is weak and limited to

138 e pharmacodynamics readouts to monitor their efficacy in preclinical models and in HD patients.

139 However, its safety and efficacy in preventing acute GVHD in settings of heighte

140 ase and impulse control disorders have shown efficacy in randomised controlled trials.

141 On the contrary, 1F11 showed efficacy in several models of inflammation yet was less

142 x and benznidazole, two drugs that have poor efficacy in the chronic phase and are rather toxic.

143 there may, or may not, have been protective efficacy in the RV144 vaccine trial have important socie

144 mide and dexamethasone has shown significant efficacy in the setting of newly diagnosed myeloma.

145 rowth factor (VEGF) therapy has demonstrated efficacy in treating human metastatic cancers, but thera

146 (PTSD) in many states of the union, yet its efficacy in treating PTSD symptoms remains uncertain.

147 We analyzed its safety and efficacy in treatment of CD in a phase 2a study.

148 We show that ENb-TRAIL has therapeutic efficacy in tumor cells from different cancer types whic

149 vorable for both cell types, the therapeutic efficacy in vivo was remarkably different.

150 palladium showed the greatest antimicrobial efficacy in zone of inhibition (ZoI) assays.

151 posure to orthosteric ligands with different efficacies, in the absence and presence of the Gs hetero

152 nisms for homeostatic regulation of synaptic efficacy, including heterosynaptic plasticity, gain cont

153 ioural interventions alone have shown little efficacy, indicating limited success in modulating neuro

154 es are considering non-abstinent outcomes as efficacy indicators in clinical trials, including reduct

155 re in MYB33 correlated with strong silencing efficacy; introducing mutations to disrupt either SL att

156 tastatic Prostate Cancer: Evaluation of Drug Efficacy is a randomized controlled trial using a multia

157 cording to aggregate measurements, treatment efficacy is generally modest and differences in efficacy

158 a large-vessel occlusion, although treatment efficacy is highly time-dependent.

159 clear evidence in support of their long-term efficacy is leading many patients who could benefit from

160 verse array of novel targets whose potential efficacy is tied to specific neurotransmitters and neuro

161 throidine, suggests that loss of cholinergic efficacy may also be the result of an age-related subuni

162 The primary efficacy measure was the proportion of patients achievin

163 tudy drug and had at least one post-baseline efficacy measurement.

164 otherapies resulting in superior therapeutic efficacy.MEK inhibition in breast cancer is associated w

165 ticipants in the Vi-PS group to give vaccine efficacies of 54.6% (95% CI 26.8-71.8) for Vi-TT and 52.

166 uptake of (177) Lu-PPNs greatly enhanced the efficacies of RT and/or PDT.

167 No definitive comparative studies of the efficacy of 'awake' deep brain stimulation (DBS) for Par

168 the first cohort assessed for the safety and efficacy of 12 weeks of sofosbuvir plus ribavirin for th

169 I 2545-2759) per QALY gained for a treatment efficacy of 20% and euro4243 per QALY gained for treatme

170 % and euro4243 per QALY gained for treatment efficacy of 50%.

171 We found that the efficacy of 9 out of 24 drugs showed significant associa

172 ar Mtb, providing proof of principle for the efficacy of a "release and kill" strategy.

173 The results of this study support the efficacy of a fixed combination of pepsin and amino acid

174 embling ability) of small molecules with the efficacy of a molecule process against cancer cells, thi

175 his randomized controlled trial examined the efficacy of a novel gaze-contingent music reward therapy

176 ose of the current study is to determine the efficacy of a PI3K/mTOR dual inhibitor, LY3023414, on es

177 irst randomised controlled trial to document efficacy of a remyelinating drug for the treatment of ch

178 We tested the efficacy of adalimumab in the treatment of JIA-associate

179 Efforts to improve the efficacy of adoptive T-cell therapies and immune checkpo

180 Such fusion proteins can enhance the efficacy of allergen-specific immunotherapy.

181 ss North America to determine the safety and efficacy of allogeneic human mesenchymal stem cells (MSC

182 ngly, we observed the aggregation inhibitory efficacy of alpha/beta and alpha/gamma BSBHps, but not o

183 Here, we evaluated the safety and efficacy of an adoptive CD4(+) T-cell therapy using an M

184 firm that HDAC6 inhibition augments in vitro efficacy of anti-CD20 mAbs and improves survival of mice

185 s) measured by RNA sequencing to predict the efficacy of anti-HER2 agents.

186 this conversion significantly increased the efficacy of anti-PD-1 checkpoint blockade.

187 llular Leishmania donovani infection and the efficacy of antimony (Sb) chemotherapy.

188 study the impact of hypoxic necrosis on the efficacy of antimycobacterials and drug candidates, we s

189 The efficacy of antiviral treatment for chronic hepatitis C

190 uate the feasibility, safety, and short-term efficacy of bariatric embolization, a recently developed

191 e more insight into the long-term safety and efficacy of bariatric embolization.

192 causing little skin irritation, vaccination efficacy of BCG-MNAs was comparable to that of intraderm

193 f HPAI A(H5) viruses in Vietnam, the vaccine efficacy of bivalent poultry vaccine formulations should

194 unometabolic adjuvants to safely enhance the efficacy of cancer immunotherapy, radiotherapy, or 'immu

195 (A Clinical Trial to Demonstrate the Efficacy of Cangrelor [PCI]: NCT00305162; Cangrelor Vers

196 mmonly discussed bony defects when comparing efficacy of CBCT versus intraoral radiographs (IRs).

197 hers previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (

198 s CGRP to trigger migraine in humans and the efficacy of CGRP receptor antagonists that evidently do

199 d with clinical outcomes and may predict the efficacy of chemotherapy and human epidermal growth fact

200 that targeting endothelial LPP enhances the efficacy of chemotherapy in ovarian cancer.

201 administration did not impair the anticancer efficacy of cisplatin and radiotherapy in tumor-bearing

202 The efficacy of cold plasma for inactivation of food-borne p

203 al vaginosis and high adherence to PrEP, the efficacy of daily oral PrEP for HIV prevention did not d

204 The efficacy of dichroic targeting of chiral nanostructures

205 thematical framework is devised to allow the efficacy of different candidates to be directly compared

206 further studies should elucidate whether the efficacy of ectoparasite removal by cleaners is affected

207 several targeted therapies that enhance the efficacy of endocrine therapy; inhibitors of mTOR and in

208 Furthermore, to mimic the antagonistic efficacy of endothelial-derived prostacyclin, we determi

209 lly in their calcium channel composition and efficacy of excitatory inputs in the presence of dopamin

210 om 16 countries were included in analysis of efficacy of first-line therapies.

211 col development) will determine the clinical efficacy of fosfomycin as step-down oral therapy to trea

212 ale clinical trials are needed to assess the efficacy of gammaT supplements as a complementary or ste

213 The synergistic efficacy of gum arabic and sage polyphenols in stabilisi

214 Despite the efficacy of heterospecific pollination, the contribution

215 The efficacy of HIV pre-exposure prophylaxis (PrEP) relies o

216 effective anti-BTIC therapies and limit the efficacy of individual gene targeting.

217 ide improves tumor selectivity and antitumor efficacy of IP pro-apoptotic NWs.

218 al to evaluate the safety, tolerability, and efficacy of ledipasvir and sofosbuvir plus ribavirin in

219 th ledipasvir failure, pointing to a limited efficacy of ledipasvir in patients with genotype 3.

220 Antiallodynic efficacy of LY2828360 was absent in CB2 knockout (KO) mi

221 -2 in IGF2-overexpressing CRC models and the efficacy of MEDI-573, an IGF-1/2-neutralizing antibody.

222 The TA and PL data clearly illustrate the efficacy of MoS2 and likely other TMDC materials as ener

223 omposition of wetland GHG emissions, and the efficacy of multiscale flux measurement to overcome chal

224 ogenesis, candidate antiviral drugs, and the efficacy of new vaccines.

225 The efficacy of NHE inhibitors on the risk of cardiovascular

226 Moreover, the study demonstrates the efficacy of non-viral TUS-based hSef-b gene delivery app

227 d randomized controlled trials exploring the efficacy of oral tolerance induction in infancy for the

228 Further studies that explore the efficacy of oral tolerance induction to other common foo

229 opioid antagonism may boost the therapeutic efficacy of OT for enhancing social cognition.

230 othesized that MUC4 modulates corticosteroid efficacy of patients with CRSwNP.

231 ngiography (CTCA), and assess the safety and efficacy of percutaneous coronary interventions (PCIs).

232 Here we compare the efficacy of polyvalent phage PEf1 versus coliphage T4 in

233 Any RCT comparing mortality or clinical efficacy of prolonged (continuous or >/=3 h) versus shor

234 onses and to determine the immunosuppressive efficacy of RASF.

235 The efficacy of rehabilitation can be increased by 'plastici

236 oninferiority design the relative safety and efficacy of ridaforolimus-eluting stents (RESs) and slow

237 statistically significant difference in the efficacy of second-generation antidepressants (SGAs) ver

238 12-month intraocular pressure (IOP)-lowering efficacy of selective laser trabeculoplasty (SLT) as sol

239 resulted in intense efforts to evaluate the efficacy of several specific countermeasures developed t

240 Th1 or Treg cells mainly contributes to the efficacy of SIT by helping B cells to produce neutralizi

241 ose-dependently, while the anti-inflammatory efficacy of standard curcumin remained constant, suggest

242 We compared the relative efficacy of statin therapy in those at high genetic risk

243 Efficacy of statin-based therapies in reducing cardiovas

244 Herein, we assessed the efficacy of steroid dosing on sarcolemmal repair, muscle

245 However, the efficacy of such treatment is low and needs to be optimi

246 Despite evidence of efficacy of team-based surgical safety checklists in imp

247 rther studies are necessary to determine the efficacy of the intervention as part of a multi-componen

248 We aimed to evaluate the efficacy of the parenteral (intravenous or intramuscular

249 Uncontrolled studies have suggested efficacy of the proteasome inhibitor bortezomib, but no

250 f current policy frameworks and consider the efficacy of their implementation.

251 e devastating consequences on the safety and efficacy of therapeutic proteins.

252 The efficacy of these compounds also was demonstrated in thr

253 Previous studies confirmed the efficacy of this combination.

254 -host interaction can be employed to enhance efficacy of this vector system.

255 we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onse

256 ribute to better interpreting the off-target efficacy of TKIs in tumors and to envisaging strategies

257 To review the published literature on the efficacy of topical atropine for the prevention of myopi

258 The efficacy of TPO in stabilizing refined olive (ROO) and s

259 method for oxygen generation to enhance the efficacy of treatments that depend on the presence of ox

260 Limited data are available for the efficacy of triple therapy with two long-acting bronchod

261 ned to systemically investigate the anti-HCC efficacy of WA.

262 previous studies to have superior antitumor efficacy on various solid tumors.

263 r having published evidence of antiepileptic efficacy or lacking such evidence, we demonstrated that

264 protease inhibitor plus NRTI in virological efficacy or safety.

265 val of new diagnostic assays used to measure efficacy or to predict response.

266 re unsuccessful because of toxicity, lack of efficacy, or both.

267 The primary efficacy outcome was all-cause mortality within 30-35 da

268 dependency (modified Rankin Scale (mRs) >/=3;efficacy outcome), in patients with acute ICH randomised

269 was not superior to placebo with respect to efficacy (P=0.06 for superiority).

270 We summarize treatment efficacy, quality of life, and adherence of the cohort o

271 tions or neo-antigens, and maximal treatment efficacy requires that targeted alterations are present

272 Despite its efficacy, resistance to the drug is increasing.

273 tate cancer, has shown favourable safety and efficacy results in single-arm phase 1 and 2 studies.

274 To compare the efficacy, safety, and risk factors for failure of standa

275 class of direct inhibitors that offer better efficacy, selectivity, and safety could be discovered by

276 Biofilm antibiotic efficacy studies should be assessed using various models

277 ficantly predicted ketamine's antidepressant efficacy, suggesting an adverse metabolic state.

278 is Resource Management checklist, and a self-efficacy survey instrument.

279 al and cosmetics industries for preservative efficacy testing (PET).

280 ated bioluminescent strains for preservative efficacy tests using benzalkonium chloride (BKC).

281 (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent bond with BTK Cys481.

282 tive rho1 subunits are needed to impart full efficacy to the partial GABA agonists.

283 ng-term changes in cortico-striatal synaptic efficacy under the control of the amygdala.

284 enced HAI-specific antibodies and protective efficacy using a broadly protective vaccine candidate.

285 plore the possibility of extracting NAI drug efficacy using only the observed viral titer decay rates

286 Efficacy was assessed according to MET status.

287 TILs contained tumor progression, and their efficacy was enhanced by PDL-1 blockade.

288 Efficacy was estimated from published studies and incorp

289 No statistically significant vaccine efficacy was found against the non-laboratory-confirmed

290 PrEP efficacy was not significantly different between women w

291 not the same, neither mortality nor clinical efficacy was reported, only pharmacokinetic or pharmacod

292 with TRAP-based viral vectors and protective efficacy was significantly enhanced.

293 per year), thus in early-start patients the efficacy was sustained to month 48.

294 Potential moderators of efficacy were analyzed by meta-regression.

295 Immunogenicity and protection efficacy were better than that observed with a commercia

296 f primary immunization route with respect to efficacy were s.c. >/= mucosal > i.m.

297 Hc TLQP-62 infusion had rapid antidepressant efficacy, which was reduced in BDNF floxed mice injected

298 tions to disrupt either SL attenuated miR159 efficacy, while introducing complementary mutations to r

299 and EGFR genes and association of cetuximab efficacy with these mutations was investigated by using

300 Current efforts to enhance RTS,S/AS01E efficacy would benefit from learning about the vaccine-i