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2 em here using the example of monitoring drug efflux from a monolayer of cancer cells with microvoltam
4 eleration phenomenon (e.g., increased tracer efflux from a vesicle caused by increased substrate conc
5 apoA-I-mediated cholesterol and phospholipid efflux from ABCA1-expressing cells without altering the
11 se G, both stimulates plasma membrane Ca(2+) efflux from and inhibits ATP-stimulated Ca(2+) influx in
20 n oligosaccharides, rapidly inhibits lactate efflux from breast carcinoma cells; down-regulation of e
21 (3,4,5)P(3) is capable of stimulating Ca(2+) efflux from Ca(2+)-loaded plasma membrane vesicles prepa
22 common cause of MDR involves increased drug efflux from cancer cells mediated by members of the ATP-
23 onship allowed us to successfully predict Zn efflux from Cd data gathered from aquatic species belong
25 transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholestero
27 , higher PS exposure, and higher cholesterol efflux from cells by both ABCA1-dependent and ABCA1-inde
28 A-I loses its ability to promote cholesterol efflux from cells by the ATP-binding cassette transporte
33 cellular zinc availability by promoting zinc efflux from cells or into intracellular vesicles, while
35 A1 (encoded by ABCA1) regulates cholesterol efflux from cells to apolipoproteins A-I and E (ApoA-I a
36 ABCA1) is a pivotal regulator of cholesterol efflux from cells to apolipoproteins, whereas sterol-res
37 er G1 in macrophages and apoE in cholesteryl efflux from cells to cholesterol ester-rich (CE-rich) HD
38 ester, stimulation of free cholesterol (FC) efflux from cells to HDL and phospholipid vesicles, and
40 ed quantitatively with decreased cholesterol efflux from cells via the ATP-binding cassette transport
42 eruloplasmin in determining the rate of iron efflux from cells with mobilizable iron stores and has p
52 inib, a potent tyrosine kinase inhibitor, is effluxed from cells by the breast cancer resistance prot
54 e is known about how metals such as iron are effluxed from cells, a necessary step for transport from
55 lodextrin (CYCLO), a modifier of cholesterol efflux from cellular membrane and endo-lysosomal compart
58 )/apoE(-/-) mice, and attenuated cholesterol efflux from cholesterol-loaded macrophages to plasma in
62 deprivation has no effect on the rate of CQ efflux from CQR lines implying that mutant PfCRT does no
63 f ABC1 reduces apolipoprotein-mediated lipid efflux from cultured cells, and increasing expression of
65 lix 10) abolished ABCA1-mediated cholesterol efflux from cultured RAW mouse macrophages treated with
66 ermal HA and a marked increase in neutrophil efflux from cutaneous blood vessels were observed in Has
69 tem was used to continually monitor soil CO2 efflux from December 2010 through November 2011 in each
70 hese changes was a 66% increase in (86)Rb(+) efflux from diabetic choroid plexus compared with contro
71 creted AIBP positively regulates cholesterol efflux from endothelial cells and that effective cholest
72 nding protein (AIBP) accelerates cholesterol efflux from endothelial cells to HDL and thereby regulat
74 absorption, namely via ferroportin-dependent efflux from enterocytes, and thus offers potential as a
75 ethanol significantly inhibited cholesterol efflux from fibroblasts to HDL and to apolipoprotein A-I
76 roplets filled with only buffer, the rate of efflux from filled droplets to empty droplets was depend
77 efficient in mediating cellular cholesterol efflux from foam cell macrophages and to identify the ce
78 has enhanced ability to promote cholesterol efflux from foam cells in an ABCG1-dependent pathway due
79 is is likely to reduce the rate of glutamine efflux from glia and result in the observed decrease of
80 nt outward-rectifying K+ channels mediate K+ efflux from guard cells during stomatal closure and from
83 y, SAA, but not apoA-I, promoted cholesterol efflux from HepG2 cells in an SR-BI-dependent manner as
84 onstrate that TO-901317 restores cholesterol efflux from HIV-infected T lymphocytes and macrophages.
86 cular mechanisms of ritonavir on cholesterol efflux from human macrophage-derived foam cells, which i
87 lipopolysaccharide impaired (3)H-cholesterol efflux from human macrophages to apolipoprotein A-I and
88 on and we demonstrate that increased lactate efflux from hypoxic cancer cells favors the growth of no
89 ding of integrin beta2 to promote macrophage efflux from inflammatory sites, and the release of solub
91 istine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells.
92 metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary ce
94 led for a short period, suggesting defective efflux from intracellular stores but not from the plasma
98 evels of ABC1 mRNA, protein, and cholesterol efflux from J774 mouse macrophages +/- exposure to a cAM
101 lied to observe the mechanism of sphingosine efflux from large and giant unilamellar vesicles; a grad
102 alization of ABCA1 and decreased cholesterol efflux from late endosomal cholesterol pools, providing
103 ase is characterized by impaired cholesterol efflux from late endosomes and lysosomes and secondary a
106 l understood, including the route of sucrose efflux from leaf mesophyll cells and transport across va
107 profiles revealed significantly higher drug efflux from leukemic SP cells than from non-SP cells.
108 ally, SCP-2 expression also inhibited sterol efflux from lipid droplets, an effect related to decreas
109 ons; (ii) lipoprotein-mediated sterol uptake/efflux from lipid rafts/caveolae and caveolae was rapid
110 e rate and lipoprotein specificity of sterol efflux from lipid rafts/caveolae or caveolae to lipoprot
114 that gp120 alone can alter CD4(+) influx and efflux from lymph nodes in a fashion consistent with the
117 ding cassette A1, which promotes cholesterol efflux from macrophage foam cells in the arterial wall.
118 acrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fract
119 its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding ca
120 protein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of t
122 h-density lipoprotein to promote cholesterol efflux from macrophage foam cells, direct experimental s
125 sporter ABCA1 is a key player in cholesterol efflux from macrophages and has been shown via human gen
126 ency of CETP (CETP-D) to promote cholesterol efflux from macrophages and have evaluated the role of A
128 s ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in
130 I therapies and the promotion of cholesterol efflux from macrophages by the ABCA1 and ABCG1 transport
136 were to determine whether LeTx-induced K(+) efflux from macrophages is mediated by toxin effects on
138 stronger potential for promoting cholesterol efflux from macrophages than from wild-type mice (p < 0.
139 1 have a major role in promoting cholesterol efflux from macrophages to apolipoprotein A-1 and HDL an
140 ciency led to a markedly reduced cholesterol efflux from macrophages to apoM-deficient HDL compared t
141 e found that IL10 also increases cholesterol efflux from macrophages to protect against toxicity of f
142 ABCA1-mediated cholesterol and phospholipid efflux from macrophages when ABCA1 was induced by a cAMP
144 e binding transporter A1 (ABCA1) cholesterol efflux from macrophages, a potentially pro-atherosclerot
145 , vascular tone in aortic rings, cholesterol efflux from macrophages, and expression of SMC phenotypi
146 ular energy status can influence cholesterol efflux from macrophages, and that miR-33 reduces cholest
147 Inhibited RCT was downstream of cholesterol efflux from macrophages, since macrophage efflux of a fl
148 lays a central role in promoting cholesterol efflux from macrophages, thereby reducing the risk of fo
149 ansgenes can result in increased cholesterol efflux from macrophages, unaccompanied by changes in pla
150 ritonavir significantly inhibits cholesterol efflux from macrophages, which may be mediated by mitoch
158 correlate with the magnitude of cholesterol efflux from macrophages; more understanding of the contr
159 rowth results from the decreasing fatty acid efflux from membranes with increasing phospholipid conte
161 endoplasmic reticulum arises through Ca(2+) efflux from mitochondria during brief openings of the mi
163 ay be controlled by calcium accumulation and efflux from mitochondria in their immediate vicinity.
164 at polyunsaturated fatty acids induce Ca(2+) efflux from mitochondria, an action that may deplete [Ca
167 Thus, although rHDL stimulated cholesterol efflux from most tissues and increased net cholesterol m
168 in the molecule to ABCA1-mediated FC and PL efflux from mouse J774 macrophages and human skin fibrob
169 igher level of isotopic and mass cholesterol efflux from mouse peritoneal macrophages labeled with [(
170 obucol inhibited ABCA1-dependent cholesterol efflux from mouse primary hepatocytes, and this effect w
171 n-dependent DA release and non-exocytotic DA efflux from mouse striatal slices and extracellular, int
172 cellular glycolysis during anoxia to lactate efflux from muscle during sustained, aerobic contraction
176 ate that vigabatrin induces spontaneous GABA efflux from neighboring cells via reversal of GABA trans
177 ransporter type A1), but reduces cholesterol efflux from neuronal cells leading to the accumulation o
178 int to a primary role of MtMATE67 in citrate efflux from nodule cells in response to an Fe signal.
179 have previously demonstrated that spermidine efflux from oocytes is a simple electrodiffusive process
180 he apical membrane inner monolayer, and drug efflux from P-gp into the apical chamber, as well as the
184 that may be responsible for net cholesterol efflux from peripheral cells as well as the rapid hepati
188 ary cells or VPAC(1) receptor-dependent cAMP efflux from pinealocytes but strongly inhibited GHRH-sti
189 evidence that pendrin mediates apical iodide efflux from polarized mammalian cells loaded with iodide
191 a1-syntrophin expression reduced cholesterol efflux from primary skin fibroblasts by 50% while decrea
193 ound that zinc gluconate inhibited potassium efflux from RBC exposed to total venom or purified porin
194 ical pathway for the regulation of potassium efflux from RBCs is the Gardos channel, a calcium-activa
195 processes, one of them being increased drug efflux from resistant cells which leads to a decreased i
196 was identical in a genotype showing citrate efflux from root apices (cv Carazinho) to one that lacke
197 es, and 15-25% higher glucose-derived carbon efflux from roots, suggesting that SWEET2 has a role in
203 e present study, [3H]ryanodine binding, Ca2+ efflux from skeletal sarcoplasmic reticulum (SR) vesicle
204 ediate apoplastic phloem loading and sucrose efflux from source leaves in Arabidopsis and agricultura
207 de anions and suggest that hypoxia-evoked CA efflux from the adrenal medulla contributes, in part, to
208 (prebeta-1 HDL) and its role in cholesterol efflux from the artery wall, offer a means of assessing
210 absorption, perhaps by mediating cholesterol efflux from the basolateral surface of enterocytes, it r
211 rotein creates a situation where net protein efflux from the bead is thermodynamically favorable.
212 ic subjects, which suggests that these cells efflux from the blood into the airways in patients with
213 ot only reduces influx but also mediates the efflux from the brain back to the blood compartment, wit
214 reased levels of Abeta in plasma, suggesting efflux from the brain into the vascular compartment.
216 ssociated protein (MRP) responsible for drug efflux from the cancer cells (pump resistance) and (b) B
217 ntent of Ca(2+) release and therefore Ca(2+) efflux from the cell as a consequence of wave propagatio
219 R calcium release, resulting in reduced Ca2+ efflux from the cell leading to increased SR calcium con
220 r the proposed role of MCT4 in mediating the efflux from the cell of glycolytically derived lactic ac
221 r Ca(2+) transient activates a larger Ca(2+) efflux from the cell that balances the increased influx.
231 ts suggest that HMA2 is responsible for Zn2+ efflux from the cells and therefore is required for main
232 composed of glucose-derived mannose and its efflux from the cells can account for most of the mannos
233 sette (ABC) transporters mediate cholesterol efflux from the cells to apolipoprotein A-I (apoA-I) and
237 y bed compared to arterial blood, indicating efflux from the CNS into the peripheral blood (p < 0.000
238 stent with viability depends not only on NH3 efflux from the cytoplasm but also on the conversion of
241 sal Ca(2+) influx required to balance Ca(2+) efflux from the cytoplasm through ATP- and proton-couple
242 riplasmic protein, which together coordinate efflux from the cytoplasmic membrane across the outer me
243 We examined the effect of hypoxia on Ca(2+) efflux from the cytosol in single Fura-2-loaded pulmonar
250 in mice inhibits the accelerated macrophage efflux from the inflammatory site to the lymphatics, but
251 The slow accumulation of TPP+ and its slow efflux from the lens under conditions known to depolariz
252 e hypothesize that by allowing dicarboxylate efflux from the matrix, PTP opening during reperfusion m
253 This study provides evidence that Ca(2+) efflux from the mitochondria in vascular endothelial cel
254 ere, we show that the time required for Smac efflux from the mitochondria of cells subjected to staur
255 physiologically that PINK1 regulates calcium efflux from the mitochondria via the mitochondrial Na(+)
256 tein raises cellular iron by inhibiting iron efflux from the monocytemacrophage cell line THP-1, and
257 ed induction of cholesterol and phospholipid efflux from the murine macrophage RAW264 cell line to li
259 talyzed prodrug conversion (k(1)(app)), 5-FU efflux from the observable tumor volume (k(2)(app)), and
260 verage sea surface temperature driving a CO2 efflux from the ocean, but our data do not allow specifi
262 y electrodes are used to measure cholesterol efflux from the plasma membrane surface of a single neur
263 of Al(3+) in the rhizosphere induces citrate efflux from the root apex of the Al-tolerant maize (Zea
267 ume is possible when this is offset by a net efflux from the t-system to the cell and thence to the E
268 to the thylakoid membrane, and allows proton efflux from the thylakoid lumen by proton/potassium anti
269 imarily by altering the resistance of proton efflux from the thylakoid lumen, whereas modulation of p
270 Kcne2 deletion doubled the rate of free I(-) efflux from the thyroid following ClO(4)(-) injection, a
273 , AVT4, and AVT6, are involved in amino acid efflux from the vacuole and, as such, are the first to b
276 iation with vesicles and peptide-induced dye efflux from the vesicle lumen were examined experimental
278 8F]FBWAY ([18F]4b) showed an early rapid net efflux from the whole brain, clearing with a biological
281 (13)C-BV IXdelta and BV IXbeta products are effluxed from the cell by an as yet unidentified transpo
282 onic lipophilic compounds, many of which are effluxed from the cell by QacA via the proton motive for
286 igate the mechanism of ABC-1-dependent lipid efflux from these cells, apo A-1 was preincubated in the
290 ine habitats, but the carbon dioxide (CO(2)) effluxes from these net heterotrophic systems contribute
291 from bulk endosomes, indicating that calcium efflux from this compartment is critical for this proces
292 5 mumol/L) significantly reduced cholesterol efflux from THP-1 and peripheral blood mononuclear cells
294 e and has been shown to suppress cholesterol efflux from virus-infected macrophages by inducing Nef-d
296 le (rHDL(apoA-I)) binding to and cholesterol efflux from wild-type (WT) and mutant forms of the HDL r
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