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9 All test drugs evoke fluoxetine-sensitive efflux of [(3)H]5-HT from synaptosomes, but d-fenflurami
10 In vitro assays were performed to measure efflux of [(3)H]5-HT in rat brain synaptosomes and trans
15 icate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from
21 ol efflux from macrophages, since macrophage efflux of a fluorescent cholesterol analog (BODIPY-chole
22 r1-3 (multidrug resistant) strains, cellular efflux of a known substrate of ATP-binding-cassette tran
23 solateral membrane, mediating the sinusoidal efflux of a metabolite from the hepatocytes to systemic
24 rther studies revealed that Q2 inhibited the efflux of a range of fluorescent substrates (rhodamine 1
25 sical perturbations and coincided with rapid efflux of a small-molecule fluorophore, suggesting that
30 tained by the high internal pH caused by the efflux of acetic acid and exchange with AR-67, which und
32 es match local NAADP concentrations with the efflux of acrosomal calcium, thereby ensuring complete f
33 c22a1, we uncovered a role of SLC22A1 in the efflux of acylcarnitines from the liver to the circulati
34 plication of NBTI/dipyridamole prevented the efflux of adenosine resulting from block of adenosine ki
35 kinase-1 and 2 (ERK-1/2), which promotes the efflux of adenosine triphosphate (ATP) from the macropha
36 ciated with transmembrane proteins mediating efflux of administered drugs, thereby keeping their intr
37 curves and through imaging of the uptake and efflux of Ag+ by living fibroblast cells in real time.
38 which this vestibule controls the entry and efflux of agonists from the orthosteric site and agonist
40 utilizes energy from ATP hydrolysis for the efflux of amphipathic anticancer agents from cancer cell
43 and its homologues are major players in the efflux of anti-microbials out of Gram-negative bacteria.
44 adaptor protein and TolC exit duct to drive efflux of antibiotics and enterotoxin STII out of the ba
45 ane transporter involved in energy-dependent efflux of anticancer/antiviral nucleotide agents and of
46 ability of sessile cells to actively mediate efflux of antimicrobial compounds has a profound impact
48 ombination of decreased defensin binding and efflux of any peptide which enters the cytoplasm may exp
50 e outer cell layer of the root, facilitating efflux of arsenic as arsenite back into the soil to limi
55 he caspase-activated Panx1 channels mediated efflux of ATP, but also ADP and AMP, with the latter two
57 l lines to show that gefitinib inhibited the efflux of BCRP and MDR1 substrates and restored vincrist
59 energy-dependent protein responsible for the efflux of bile acids from hepatocytes, it was hypothesiz
60 ression of bile acid synthesis and increased efflux of bile acids into blood for renal excretion as w
65 suggest that MRP4 is involved in the luminal efflux of both adefovir and tenofovir, but it makes only
66 significantly increased soil respiration and efflux of both CO2 and CH4 with a concomitant reduction
68 protein provided strong evidence for active efflux of Ca(2+) by LmrP with an apparent K(t) of 8.6 mu
69 and inhibited DHPR and SERCA, inducing a net efflux of Ca(2+) from loaded microsomes, whereas BPA exh
70 inantly a function of the rate of influx and efflux of Ca2+ across the plasma membrane, but that a re
72 Hence, the second messenger NAADP, promoting efflux of calcium from lysosome-like compartments and on
74 ugh the TCR display impaired influx, but not efflux, of calcium, and ER calcium stores are increased
75 sistance protein MRP4 may play a role in the efflux of cAMP from exocrine cells and neurokinin recept
77 er from Lactococcus lactis that mediates the efflux of cationic amphiphilic substrates from the cell
78 ression of ABCG1 specifically stimulates the efflux of cellular cholesterol by a process that is depe
79 rtant event in cholesterol metabolism is the efflux of cellular cholesterol by apolipoprotein A-I (ap
80 ver expression of ABCG1 results in increased efflux of cellular cholesterol to HDL or phospholipid ve
84 act at the plasma membrane to facilitate the efflux of cellular sterols to exogenous high-density lip
86 ells seem to escape this effect by increased efflux of cGMP, as clinical studies have shown that extr
88 al protein) binding to MDR1 resulting in the efflux of chemotherapeutic drugs (e.g. doxorubicin and p
91 e (by up-regulating scavenger receptors) and efflux of cholesterol (by activating the PPARgamma-LXR-A
92 se data, ABCG1 had a major role in promoting efflux of cholesterol and 7-KC in cultured human aortic
93 ain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving ac
94 oprotein retention within the arterial wall, efflux of cholesterol and other harmful lipids from plaq
95 transporters ABCA1 and ABCG1, which promote efflux of cholesterol and oxysterols from macrophages, h
96 a membrane-bound protein that regulates the efflux of cholesterol derived from internalized lipoprot
97 for years, to their capacity to promote the efflux of cholesterol from activated cholesterol-loaded
99 nsporter ABCG1 was recently shown to promote efflux of cholesterol from macrophages to high-denisty l
102 erlapping functions in astrocytes, promoting efflux of cholesterol, desmosterol, and possibly other s
104 monstrated that ATP7B regulates the cellular efflux of cisplatin (DDP) and controls sensitivity to th
106 y, dCK overexpression blunted ABCG2-mediated efflux of clofarabine by increasing the formation of clo
107 e in surface alkalinity drives a net air-sea efflux of CO(2), reducing surface dissolved inorganic ca
108 ed stress responses, up-regulation of active efflux of Co(II), Ni(II), Cu(II), and Zn(II), down-regul
109 roles of efflux pumps in both the influx and efflux of compounds in P. aeruginosa and to aid the chem
115 rane transporter that regulates the cellular efflux of cyclic nucleotides (cAMP and cGMP) involved in
116 isorder characterized by defective lysosomal efflux of cystine due to mutations in the CTNS gene enco
123 ovel method, which enabled us to enhance the efflux of dDCs from islet preparations, resulted in a pr
124 wn, in vitro, to participate in the cellular efflux of desmosterol and amyloid-beta peptide (Abeta).
125 Overexpression of Abcg1 or Abcg4 promoted efflux of desmosterol and cholesterol from cells to HDL,
127 re we show that surprisingly, MdfA catalyses efflux of divalent cations, provided that they have a un
128 periments revealed a constitutive, anomalous efflux of dopamine, and electrophysiological analyses id
129 where CK2 inhibition decreased MRP1-mediated efflux of doxorubicin and increased doxorubicin cytotoxi
130 cer resistance protein (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma mem
133 the membrane, and the influx of mediator and efflux of encapsulant after puncture could be observed.
137 specifically bound to Cdr1p and blocked the efflux of entrapped fluorescent dyes from the AR (Gu5) i
140 s that adenosine is released into the venous efflux of exercising muscle and that adenosine is respon
141 ults, we conclude that FrvA functions in the efflux of Fe(II), and not heme during listerial infectio
142 if changes in P-glycoprotein (P-gp)-mediated efflux of flumazenil at the blood-brain barrier may conf
145 ), a psychogenic stressor, on the concurrent efflux of four major neurotransmitters within the FC in
151 TP2B1 mediate glutamate exchange, uptake and efflux of glutamate were investigated in Xenopus laevis
152 sults suggest that PfMRP plays a role in the efflux of glutathione, CQ, and QN and contributes to par
154 ells survive a heavy oxidant burden by rapid efflux of GSSG, which is lethal if trapped within the ce
155 al achieved by breathing 40% O(2) attenuates efflux of H(+) and lactate, thereby decreasing the contr
156 ermeability allowing slow influx of acid (or efflux of HCO(3)(-)), a NBC-like Cl(-)-independent Na(+)
157 ylase (HDAC) molecules, resulting in nuclear efflux of HDAC and consequent activation of the transcri
158 a specific activator of Epac, caused nuclear efflux of HDAC4-GFP, opposite to the effect of PKA.
160 1 (MDR1) transporter was responsible for the efflux of Hoechst from SP cells in our MYC-driven model.
161 binding cassette (ABC) transporter mediated efflux of Hoechst substrates (side population assay).
163 ted to MDR1/ABCB1 encoded P-gp mediating the efflux of immunosuppressants out of leukocytes, with dep
165 ume in response to hyposmotic stress via the efflux of inorganic and organic osmolytes is well docume
166 family that couples the import of G3P to the efflux of inorganic phosphate (P(i)) down its concentrat
167 that adenosine makes to exercise hyperaemia; efflux of inorganic phosphate and its contribution may l
168 us oocytes expressing either OAT4 or OATP2B1 efflux of intracellular [(14)C]glutamate could be stimul
169 alp3 inflammasome by silica required both an efflux of intracellular potassium and the generation of
170 were preceded by G1 or G2 APOL1-induced net efflux of intracellular potassium as measured by X-ray f
171 ermined by the net effect between influx and efflux of intraluminal cholesterol molecules crossing th
172 to estimate the active H(+) influx and H(+) efflux of isolated vacuolar vesicles, although there is
173 n mechanism in these channels for regulating efflux of K (+) ions through the selectivity filter.
174 ncentration and the depolarized PM drive the efflux of K(+) from the cell, resulting in loss of turgo
175 gh a type III secretion apparatus results in efflux of K(+) through glibenclamide-sensitive K(+) chan
176 The resulting net influx of Na(+) and net efflux of K(+), down their respective concentration grad
178 transporter that regulates the simultaneous efflux of L-glutamine out of cells and transport of L-le
179 ation of cancer cells, suggesting that rapid efflux of lactate and H(+), as enhanced by CAIX, contrib
180 pindles (1.54 < R/r < 10) that arise from an efflux of LCs from the GUVs during the shape transformat
181 undant vacuolar effluxers, which mediate the efflux of leucine and other amino acids resulting from a
185 Unexpectedly, we detected a reproducible efflux of lymphoma cells from spleen and bone marrow, co
186 acAB-TolC transporter has been implicated in efflux of macrolide antibiotics and secretion of enterot
187 ropose a "recycling" model that includes the efflux of macromolecules from the lysosome/vacuole as th
188 n controlling the early influx and the later efflux of macrophages out of the injured nerve, reduces
190 l vacuoles, specifically of K(+) and Mal(2-) Efflux of Mal(2-) from the vacuole is required for stoma
191 al electrical resistance, an increase in the efflux of mannitol across the monolayer, and a loss of i
192 C2) plays an important role in hepatobiliary efflux of many drugs and drug metabolites and has been r
193 locally intratumorally and did not cause an efflux of marrow-derived progenitors into circulation.
194 ll plasma membranes that allow for influx or efflux of mono- or divalent cations (e.g., Ca(2+)) impor
195 ition of mTOR strongly reduced the lysosomal efflux of most essential amino acids, converting the lys
196 bution to multidrug resistance by catalysing efflux of myriad structurally and chemically different a
197 of the pore is closed, reversible influx and efflux of Na(+) through the selectivity filter occurred
200 one did not cause overt disease, but induced efflux of neutrophils into the airway lumen and producti
202 ripheral blood lymphocytes revealed dramatic efflux of NK and memory CD8 T cells from the circulating
205 anism in renal epithelial cells enabling the efflux of one Ca(2+) ion and the influx of three Na(+) i
207 efflux transporters that mediates the apical efflux of organic anions from hepatocytes, enterocytes,
208 rter in mediating both epithelial uptake and efflux of organic cations in the secretory cells of sali
210 on of GPCRs facilitates the volume-dependent efflux of osmolytes from neural cells and permits them t
211 l to determine if plants can up-regulate the efflux of osmotically active substances into embolized v
212 al one, suggested that PAbetaN inhibited the efflux of other drugs by binding to the bottom of the di
215 e key cells involved in the accumulation and efflux of oxidized low density lipoprotein in the arteri
218 Our model considers the cellular uptake and efflux of PFOA via both passive diffusion and transport
219 these findings imply that mrp4 mediates the efflux of PGE(2) and concomitantly modulates cAMP mediat
220 orter ABCA1 under these conditions, cellular efflux of PL and cholesterol from liver cells was also r
224 Pdu microcompartment) while restricting the efflux of propionaldehyde, a toxic intermediate of 1,2-p
225 recombinant EMCV L triggers the unregulated efflux of protein cargo from preloaded HeLa cell nuclei
229 pcidin inhibits dietary iron absorption, the efflux of recycled iron from splenic and hepatic macroph
230 ors tariquidar and vinblastine prevented the efflux of rhodamine 123 (rh123) from hCMEC/D3 cells, ind
232 tiproliferative activities but modulated the efflux of rhodamine 123 mediated by the ABCB1 transporte
235 decrease efficiently Pgp mediated influx and efflux of rhodamine-123 (Rho) and to restore the cytotox
237 Endothelial cell-cell junctions control efflux of small molecules and leukocyte transendothelial
238 embrane machineries, or pumps, determine the efflux of small noxious molecules, such as detergents, h
242 uble proteins, a shift in equilibrium toward efflux of specific proteins from the brain, cell-mediate
243 ane lipid asymmetry, the cellular influx and efflux of sterols and phospholipids, and the egress of l
244 olesterol from modified lipoproteins and the efflux of stored cholesterol suggests that the process o
245 ) is an ATP-dependent pump that mediates the efflux of structurally diverse drugs and xenobiotics acr
247 ins (NBDs) to power the energetically uphill efflux of substrates by a dedicated transmembrane domain
248 cycle was active but was characterized by an efflux of substrates for use in biosynthetic pathways, p
249 ammary alveolar epithelia, where it mediates efflux of substrates into milk, and in the placental syn
250 ing in the inner membrane resulting in rapid efflux of succinate/fumarate and other dicarboxylates ca
251 cellular partitioning, and consequently, the efflux of sucrose from source leaves and the utilization
254 ially facilitate phloem loading by enhancing efflux of symplasmic Suc for subsequent active uptake in
257 e found that pdr8 mutants display defects in efflux of the auxin precursor IBA and developmental defe
259 ne conjugation of NO(2)-LA and MRP1-mediated efflux of the conjugates were associated with significan
260 porter, catalyzes arginine influx coupled to efflux of the decarboxylation product agmatine, effectiv
261 nts necessary for cell function/survival and efflux of the desired cellular product, specifically ins
265 markers, drug transporters and the efficient efflux of the Hoechst 33,342 dye (side population).
267 These dihydropyridines also inhibited the efflux of the known ABCG2 substrates, mitoxantrone and p
272 2 protein, required for directional cellular efflux of the phytohormone auxin, and identify cis- and
274 ED (PIN) membrane proteins, which facilitate efflux of the plant hormone auxin from cells, is importa
276 RMED (PIN) proteins involved in the cellular efflux of the quintessential phytohormone auxin plays a
277 ious in vitro evidence that SetA can promote efflux of the stress-causing glucose analog alpha-methyl
278 These data provide compelling evidence that efflux of the substrate molecule from the bilayer, which
279 Recently, we provided evidence that the efflux of the substrate molecules from the bilayer is th
280 ransporter previously implicated in cellular efflux of the synthetic auxin 2,4-dichlorophenoxyacetic
281 serve to protect the heart by mediating the efflux of toxic products of oxidative stress from mitoch
286 toxic compound extrusion family mediate the efflux of unrelated pharmaceuticals from the interior of
289 iminished capacities of (1) sodium-dependent efflux of vacuolar protons and (2) elicitor-triggered ov
290 idylcholine, and (2) a subsequent, transient efflux of vacuolar protons, resulting in a peak of cytos
291 displays variable activity in modulating the efflux of various drugs by P-gp, there is a correlation
293 promoted uptake of calcein AM and inhibited efflux of vinblastine with IC(50)'s of approximately 2 m
294 sponse to hyperosmotic stress involves rapid efflux of water and changes in intracellular ion and osm
295 exerts its antiedema effect by promoting an efflux of water from brain via the perivascular aquapori
296 ween the gating mechanism and the influx and efflux of water molecules in CrChR2, we have integrated
298 he phase III transporters, which mediate the efflux of water-soluble lipid metabolites from cells.
299 ng Cassette transporters are involved in the efflux of xenobiotic compounds and are responsible for d
300 y role in protecting the brain parenchyma by efflux of xenobiotics from capillary endothelial cells a
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