ライフサイエンスコーパス: efflux transporter

1 s MdtD, is now designated IceT (iron citrate efflux transporter).

2 auxin maxima via the PINFORMED1 (PIN1) auxin efflux transporter.

3 in this region, is a hitherto unknown urate efflux transporter.

4 auxin maxima via the PINFORMED1 (PIN1) auxin efflux transporter.

5 w to accurately measure the function of this efflux transporter.

6 indicating dependence on an apically located efflux transporter.

7 d-encoded membrane protein QacA, a multidrug efflux transporter.

8 es are consistent with a role for ALF5 as an efflux transporter.

9 en the gene family designation SET for sugar efflux transporter.

10 s transport substrates by the P-glycoprotein efflux transporter.

11 they were not substrates for the ABCB1 drug efflux transporter.

12 opsis thaliana, AtDTX50, functions as an ABA efflux transporter.

13 for nectar production and can function as an efflux transporter.

14 range even for cell lines expressing the Pgp efflux transporter.

15 from the brain and spinal cord by the Abcg2 efflux transporter.

16 , we identified a subfamily of SWEET sucrose efflux transporters.

17 and breast cancer resistance protein (ABCG2) efflux transporters.

18 udy investigates the status of the multidrug efflux transporters.

19 lence factors and multidrug resistance (MDR) efflux transporters.

20 ch copper is passed from ATOX1 to the copper efflux transporters.

21 -linking studies of bacterial and eukaryotic efflux transporters.

22 beta-catenin can influence the expression of efflux transporters.

23 ic phase I and II enzymes as well as hepatic efflux transporters.

24 ture of any MFPs associated with heavy-metal efflux transporters.

25 wo homologues of the SMR family of multidrug efflux transporters.

26 by decreasing the expression of cholesterol efflux transporters.

27 presence and absence of known inhibitors of efflux transporters.

28 s have been shown to be capable of bypassing efflux transporters.

29 e of compounds that are substrates for these efflux transporters.

30 ed here are likely employed by the multidrug efflux transporters.

31 essing large arsenals of predicted multidrug efflux transporters.

32 n of several cytochromes P450 (CYP) and drug efflux transporters.

33 E) family, which has homology with bacterial efflux transporters.

34 mediated by the ABCB1, ABCC1, and ABCG2 drug-efflux transporters.

35 nd MRP1, which are established cellular drug efflux transporters.

36 te major xenobiotic-metabolizing enzymes and efflux transporters.

37 generated by the PIN-formed family of auxin-efflux transporters.

38 iated by the ATP-binding cassette (ABC) drug efflux transporters.

39 oxidative stress and to eliminate silver via efflux transporters.

40 chieved through a system of auxin influx and efflux transporters.

41 of sinusoidal uptake versus that of biliary efflux transporters.

42 ounding member of a family of bacterial drug efflux transporters.

43 Multidrug efflux transporters--a common and powerful resistance me

44 e promoter of the major cellular cholesterol efflux transporter, ABCA1, in LNCaP prostate cancer cell

45 duced inhibition of the multidrug-resistance efflux transporter ABCB1, which is frequently expressed

46 Three ABC efflux transporters (ABCB1, ABCC3, and ABCB5) showed sig

47 ke increase in the activity of the multidrug efflux transporter ABCB1a.

48 The drug efflux transporter ABCB5 identifies cancer stem-like cel

49 te that genetic variation within an ABC-drug efflux transporter (Abcb5) affected susceptibility to HI

50 The ubiquitous efflux transporter ABCC5 (ATP-binding cassette subfamily

51 in the ABCC6 gene, which encodes a putative efflux transporter, ABCC6.

52 polymorphic variant of the chemotherapy drug efflux transporter ABCG2, which contributes to normal ti

53 , metabolic (G6PD, TKT, PPARgamma), and drug efflux transporter (ABCG2, MRP3, MRP4) genes.

54 he yeast (Saccharomyces cerevisiae) arsenite efflux transporter ACR3 into Arabidopsis to evaluate how

55 imals, constitutively produces the multidrug efflux transporter AcrB (AcrB(HI)).

56 is toxic only in cells lacking the multidrug efflux transporter AcrEF.

57 ssion of nutrient transporters and polarized efflux transporter activity.

58 cytochrome P450 mono-oxygenase system, drug efflux transporter adenosine triphosphate-binding casset

59 e P-gp knockout mouse provided evidence that efflux transporters affected the amount of Abeta lowerin

60 Here, we have cloned ABCB5, a rhodamine efflux transporter and novel member of the human P-glyco

61 lasma membrane and functions as a nucleotide efflux transporter and thus plays a role in the regulati

62 of the Small Multidrug Resistance family of efflux transporters and actively expels positively charg

63 ytokinins mediated by the PIN class of auxin efflux transporters and AHP6, an inhibitor of cytokinin

64 hanisms include the regulation of uptake and efflux transporters and buffering of the free metal conc

65 of the anticancer drug vinorelbine with drug efflux transporters and cytochrome P450 3A drug-metaboli

66 cerevisiae strain lacking sodium ion (Na(+)) efflux transporters and increased salt tolerance of wild

67 RACURVATA 2 or FKBP42, associates with auxin efflux transporters and is essential for their biologica

68 ecent reports on the structures of multidrug efflux transporters and their cognate regulators have su

69 C30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations b

70 PIN-FORMED (PIN) proteins are proposed auxin efflux transporters, and auxin fluxes can seemingly be p

71 ellular drug concentrations mediated by drug efflux transporters, and permeability barriers associate

72 ROPIC DRUG RESISTANCE TRANSPORTER9, an auxin efflux transporter; and two APETALA2/ETHYLENE RESPONSE F

73 expression alters the trafficking of 2 auxin efflux transporters-Arabidopsis PM-located auxin efflux

74 Sugar efflux transporters are essential for the maintenance of

75 lood-brain barrier (BBB); one or both of the efflux transporters are inhibitable by probenecid.

76 nce and encodes the Al-activated root malate efflux transporter associated with tolerance.

77 educe recognition by P-glycoprotein, the key efflux transporter at the blood-brain barrier.

78 ants acting through AhR to target xenobiotic efflux transporters at the blood-brain barrier and thus

79 ATP-driven efflux transporters at the blood-brain barrier both prot

80 ABC (ATP Binding Cassette) efflux transporters at the blood-brain barrier, P-glycop

81 nt models of epilepsy suggest that multidrug efflux transporters at the blood-brain barrier, such as

82 oss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (

83 acrophage cholesterol by targeting the lipid efflux transporters ATP binding cassette (ABC)A1 and ABC

84 The copper efflux transporters ATP7A and ATP7B sequester intracellu

85 cimetidine, colchicine) and also affinity to efflux transporters (atropine and chloramphenicol) are t

86 ubstrates of the Bacillus subtilis multidrug efflux transporter Bmr, induce the expression of Bmr thr

87 in plants is regulated in part by the borate efflux transporter Bor1, a member of the solute carrier

88 interaction of erlotinib with the multidrug efflux transporters breast cancer resistance protein (hu

89 negatively regulates PIN-FORMED (PIN) auxin efflux transporters by affecting their plasma membrane l

90 SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metaboli

91 that rte encodes a membrane-localized boron efflux transporter, co-orthologous to the Arabidopsis th

92 lC is a constitutively expressed, tripartite efflux transporter complex that functions as the primary

93 The chromosomally encoded Tet38 efflux transporter confers resistance to tetracycline an

94 M. sedula mutant lacking the primary copper efflux transporter, CopA, became copper sensitive.

95 Multidrug-efflux transporters demonstrate an unusual ability to re

96 including those encoding putative multidrug efflux transporters, detoxification proteins, extracytop

97 an Arabidopsis (Arabidopsis thaliana) boron efflux transporter displayed boron deficiency phenotypes

98 hat the inhibition of ABCB and ABCC-types of efflux transporters disrupts the ordered distribution of

99 ia coli MacAB-TolC is a tripartite macrolide efflux transporter driven by hydrolysis of ATP.

100 The high level of expression of efflux transporters (e.g., P-glycoprotein (P-gp) and bre

101 Increased activity of efflux transporters, e.g., P-glycoprotein (P-gp) and bre

102 ted by the plasma membrane localized citrate efflux transporter encoded by SbMATE.

103 gnificantly to the flux towards product, and efflux transporters ensure the accumulation of product i

104 Multidrug efflux transporters, especially those that belong to the

105 The PIN family of auxin efflux transporters exhibit polar plasma membrane (PM) l

106 th tls1 and rotten ear (rte), the proposed B efflux transporter, exhibit a dosage-dependent defect in

107 6 gene, which encodes ABCC6, a transmembrane efflux transporter expressed primarily in the liver.

108 own about the natural functions of multidrug-efflux transporters expressed by bacteria.

109 In this study, changes in efflux transporter expression are investigated in mice c

110 In other barrier and excretory tissues, efflux transporter expression is regulated by certain li

111 aused by increased P-glycoprotein (Pgp) drug efflux transporter expression.

112 ly of bacterial transporters, the SET (sugar efflux transporter) family, has been recently reported.

113 generated a conditional deletion of the iron efflux transporter ferroportin (Fpn) in astrocytes, and

114 TROPIC DRUG RESISTANCE9, encoding a putative efflux transporter for products from the phenylpropanoid

115 Multidrug efflux transporters, found in all living cells and prote

116 ere we utilized FrvA, a high-affinity Fe(2+) efflux transporter from Listeria monocytogenes, as an in

117 In Gram-negative bacteria, multidrug efflux transporters function in complexes with periplasm

118 tentatively identified as a truncated cation efflux transporter gene and a PbrR family regulator gene

119 egulates the expression of the bmr multidrug efflux transporter gene in response to myriad lipophilic

120 SNPs within the efflux transporter genes ABCC1 (ATP-binding cassette, su

121 Four sugar efflux transporter genes were modified in rice at high e

122 rchin eggs and embryos express low levels of efflux transporter genes with homology to the multidrug

123 s overexpress CDR1 and CDR2, two fluconazole efflux transporter genes, and a cdr1 mutation decreases

124 f the Neisseria gonorrhoeae mtrCDE multidrug efflux transporter genes.

125 Although the role of PIN auxin efflux transporters has been clearly assigned during emb

126 biological importance, the identity of sugar efflux transporters has remained elusive.

127 Although putative auxin-influx and -efflux transporters have been identified by using molecu

128 Ferroportin (FPN) is the sole iron efflux transporter identified to date in animals, and th

129 ABCG2 is recognized as an important efflux transporter in clinical pharmacology and is poten

130 results provide evidence of ABCA3 as an MLF efflux transporter in human macrophages and support its

131 Permeability-glycoprotein (P-gp), an efflux transporter in several organs, acts at the blood-

132 strate activities of the cyclic prodrugs for efflux transporters in Caco-2 cells and in the intestina

133 k exhibited very poor substrate activity for efflux transporters in Caco-2 cells.

134 all exhibited strong substrate activity for efflux transporters in Caco-2 cells.

135 The recent discovery of putative iron efflux transporters in Salmonella enterica serovar Typhi

136 r studies define a system of zinc influx and efflux transporters in the vacuole that play important r

137 arose from its strong substrate activity for efflux transporters in these biological barriers.

138 ast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expressio

139 Our study, using specific inhibitors of efflux transporters, indicates that the major activity i

140 and was negated by cotreatment with the drug efflux transporter inhibitor elacridar.

141 P-glycoprotein (P-gp) is an efflux transporter involved in limiting the oral bioavai

142 tochemicals and is also one of the prominent efflux transporters involved in multidrug resistance (MD

143 The permeability-glycoprotein (P-gp) efflux transporter is densely expressed at the blood-bra

144 that the model of dual acid influx and acid efflux transporters is sufficient to account for pHi reg

145 ding cassette (ABC) membrane-associated drug efflux transporter, is known to localize at the blood-br

146 TSSC5 encodes an efflux transporter-like protein with 10 transmembrane do

147 d advances in structure determination of ABC efflux transporters, little is known regarding the locat

148 Mammalian P-glycoproteins are active drug efflux transporters located in the plasma membrane.

149 both the lsi2 mutant lacking the Si/arsenite efflux transporter Lsi2 and its wild-type cultivar, with

150 We show how auxin response genes and auxin efflux transporters may be affected by the presence of c

151 -3, and KB-3 cell lines that overexpress the efflux transporters MDR1 (KBV-1) and BCRP (KBH5.0).

152 otein genes (MRP1/MRP2, which encode for the efflux transporter Mrp1/Mrp2) and the multidrug resistan

153 ters Oatp1a/1b (Slco1a/1b(-/-)/(-/-)) or the efflux transporter Mrp2 (Abcc2(-/-)) were intravenously

154 ical multidrug-resistance-associated protein efflux-transporters (MRPs) in the renal proximal tubule

155 affect transport activity of two other major efflux transporters, multidrug resistance protein 2 and

156 Staphylococcus aureus utilizes efflux transporter NorA to pump out a wide range of stru

157 P-glycoprotein-ATPase is an efflux transporter of broad specificity that counteracts

158 AcrD is an efflux transporter of E. coli that provides resistance t

159 The AcrB trimeric multidrug efflux transporter of Escherichia coli pumps out a very

160 46% similarity with the plasmid-encoded TetK efflux transporter of S. aureus.

161 Overexpression of NorA, an endogenous efflux transporter of Staphylococcus aureus, confers res

162 lycoprotein functions as a broad specificity efflux transporter of structurally diverse natural produ

163 Our findings demonstrate that the efflux transporter of the siderophore SA contributes to

164 Multidrug efflux transporters of the ATP-Binding cassette (ABC) fa

165 t of varying the concentrations of the auxin efflux transporters on the sizes of the different root r

166 , various conjugating enzymes, ATP-dependent efflux transporters, oxidative detoxification proteins,

167 at selectively kill cells overexpressing the efflux transporter P-glycoprotein (MDR1, P-gp, ABCB1).

168 increases the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by ABCB

169 Abeta across the blood-brain barrier is the efflux transporter P-glycoprotein (P-gp) in the luminal

170 The drug efflux transporter P-glycoprotein (P-gp) is highly expre

171 nner that could occur with inhibition of the efflux transporter P-glycoprotein (P-gp).

172 oupled conformational cycle of the mouse ABC efflux transporter P-glycoprotein (Pgp; also known as AB

173 that substrates and inhibitors have with the efflux transporter P-glycoprotein has been the subject o

174 resistance gene (MDR1, which encodes for the efflux transporter P-glycoprotein).

175 However, the specific effect of VEGF on the efflux transporter P-glycoprotein, a critical component

176 n of the Abcb1b gene, which encodes the drug efflux transporter P-glycoprotein.

177 ing enzymes, shares many substrates with the efflux transporter P-gp.

178 ssion and transport activity of the key drug efflux transporter, P-glycoprotein (6 h EC(50) was appro

179 aline phosphatase (ALP), and presence of the efflux transporter, P-glycoprotein (P-gp, ABCB1).

180 The multispecific efflux transporter, P-glycoprotein, plays an important r

181 ux transporters-Arabidopsis PM-located auxin efflux transporter PIN-formed 1 (PIN1) and Arabidopsis P

182 ed 1 (PIN1) and Arabidopsis PM-located auxin efflux transporter PIN-formed 3 (PIN3)-to the PM, thereb

183 Finally, both Arabidopsis thaliana auxin efflux transporter pin1 and influx transporter lax2 muta

184 recycling, and PM accumulation of the auxin efflux transporter PIN2 in Arabidopsis thaliana.

185 re in patients is associated with uptake and efflux transporter polymorphisms.

186 -family C member 6 (ABCC6), an ATP-dependent efflux transporter present mainly in the liver.

187 ABCC6 is an efflux transporter primarily expressed in liver facilita

188 Multidrug efflux transporters protect cells in the brain from pote

189 th reduced expression of a tonoplast sucrose efflux transporter, PtaSUT4, exhibit reduced shoot growt

190 As a substrate of the P-glycoprotein (P-gp) efflux transporter, quinacrine is actively exported from

191 ated levels of drug-metabolizing enzymes and efflux transporters, resulting from CAR activation in va

192 lls stably expressing specific uptake and/or efflux transporters revealed that OATP1B1, OATP1B3, and

193 ndings argue that the inhibition of the P-gp efflux transporter should improve the poor pharmacokinet

194 enger receptors showed lower and cholesterol efflux transporters showed higher expression in CXCL4- t

195 sistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-fam

196 lthough doxorubicin is a known substrate for efflux transporters such as P-glycoprotein (P-gp; MDR1,

197 tumor homing capabilities, MSCs overexpress efflux transporters such as P-glycoprotein and are highl

198 l lines, both of which do not express common efflux transporters such as P-glycoprotein at the plasma

199 named Xa13 or OsSWEET11, a member of sucrose efflux transporter SWEET gene family).

200 We provide evidence that the efflux transporters TAT1, LAT3 and LAT4 are present in t

201 stance-associated protein 1 (MRP1) is a drug efflux transporter that has been implicated in the patho

202 The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestina

203 ly downregulated the expression of BCRP1, an efflux transporter that is highly expressed in the CNS v

204 gp), an endogenous blood-brain barrier (BBB) efflux transporter that is involved in brain-to-blood tr

205 is a proton motive force-dependent multidrug efflux transporter that recognizes multiple toxic chemic

206 Escherichia coli AcrB is a multidrug efflux transporter that recognizes multiple toxic chemic

207 Escherichia coli AcrB is a multidrug efflux transporter that recognizes multiple toxic chemic

208 that SLC30A10 is a cell surface-localized Mn efflux transporter that reduces cellular Mn levels and p

209 auxin within tissues are regulated by auxin efflux transporters that are polarly localized in cells.

210 s/regulators, soluble chaperones, and influx/efflux transporters that control the Cu(+) levels in P.

211 r of the ATP binding cassette superfamily of efflux transporters that mediates the apical efflux of o

212 Although Pgp is generally thought to be an efflux transporter, the mechanism of action remains elus

213 n, composition and assembly of the triclosan efflux transporter TriABC-OpmH from Pseudomonas aerugino

214 of the wheat (Triticum aestivum) root malate efflux transporter underlying Al resistance, TaALMT1.

215 that the barriers are tightened selectively (efflux transporter upregulation) by oxidative stress, pr

216 rugs and thus their substrate activities for efflux transporters, we synthesized cyclic prodrugs of t

217 pression, and localization of the PIN1 auxin efflux transporter, were intact in bps1 mutants, suggest

218 bacterial heterodimeric ATP-binding cassette efflux transporter, were used to demonstrate the protein

219 owth and differentiation, and the ABCG2 drug efflux transporter will be presented.

220 s, restrictive barrier formation, influx and efflux transporters with relevance to understanding peri

221 ticular, impairment of the astrocyte lactate efflux transporter, with resultant decrease of spinal co

222 Little is known about iron efflux transporters within bacterial systems.

223 pressing a native expressed endogenous auxin efflux transporter (ZmPIN1a) fused to yellow fluorescent