ライフサイエンスコーパス: elaboration

1 oam cell formation and inflammatory cytokine elaboration.

2 d its metabolic baggage at the moment of its elaboration.

3 nctionality as a handle for further chemical elaboration.

4 ogenesis and oligodendrocyte progenitor cell elaboration.

5 neurogenesis and oligodendrocyte progenitor elaboration.

6 metabolic and developmental signals for leaf elaboration.

7 ion can limit the evolution of sexual signal elaboration.

8 ation of kctd12 genes causes excess neuropil elaboration.

9 Kctd12 proteins reduces asymmetric neuropil elaboration.

10 tic volume changes and astrocytic structural elaboration.

11 regions function similarly during search and elaboration.

12 acting on neurons to enhance dendritic arbor elaboration.

13 ators, but their importance warrants further elaboration.

14 ation of content generation deserves further elaboration.

15 s was associated with iNOS expression and NO elaboration.

16 cting on neurons to increase dendritic arbor elaboration.

17 genous miR-34a expression enhances dendritic elaboration.

18 he levels of oig-8 results in an increase in elaborations.

19 ay neuron-type-specific patterns of membrane elaborations [1-3], but it is not well understood how su

20 aken at three different times throughout the elaboration: after fermentation, after post-fermentation

21 Statistical data elaboration allowed determining the main processes occur

22 activation of macrophages enhanced cytokine elaboration alone, as well as in combination with LPS or

23 tion of negative emotions requires cognitive elaboration and closure, whereas hedonistic reward is co

24 g the olfactory receptors contributed to the elaboration and development of the electronic smell syst

25 Neural development requires both synapse elaboration and elimination, yet relatively little is kn

26 nols provides numerous avenues for synthetic elaboration and exciting opportunities for bioisosteric

27 , tissue remodeling, apoptosis, and cytokine elaboration and highlight pathways that may be operative

28 monitoring of marine environments and in the elaboration and management of future conservation plans.

29 Leaf shape elaboration and organ separation are critical for plant

30 LH) innate immune response to control Chi3l1 elaboration and pulmonary metastasis.

31 nd hue, with the latter allowing faster data elaboration and real-time display of the results.

32 nderstanding energetic costs of evolutionary elaboration and reduction of the mouthparts and insect d

33 ritical for early activity-dependent circuit elaboration and refinement in the mammalian visual syste

34 technique to quantitatively characterize the elaboration and refinement of RGC axon arbors in the dLG

35 Hts/Adducin, influencing actin-based synapse elaboration and spectrin-based synapse stabilization.

36 This work has first consisted in the elaboration and the characterization of a robust and rep

37 or of tumor progression and metastasis whose elaboration and tissue effects are abrogated by RLH inna

38 The present study aimed at the elaboration and validation of a method to determine PAs

39 inflammatory processes (e.g., interleukin-6 elaboration) and epithelial alterations that contribute

40 lude secondary metabolite production, enzyme elaboration, and a sophisticated oxylipin host crosstalk

41 new synthetic strategies for heteroaromatic elaboration, and are useful in their own right in pharma

42 nextricably interwoven, allowing distortion, elaboration, and even total fabrication.

43 that our target article and the criticisms, elaborations, and extensions of the commentators can be

44 Two data elaboration approaches for evaluating olive oils authent

45 de the first experimental evidence for vocal elaboration as a male-specific strategy to maintain soci

46 via this route provide a useful platform for elaboration, as demonstrated by the preparation of a var

47 ments for the synthesis were flexibility for elaboration at C5 and suitability for large scale prepar

48 yloxazole is a useful scaffold for synthetic elaboration at the 2-methylene position thereby affordin

49 e as a superior template (vs purine) and its elaboration by introduction of C4-benzenesulfonamide and

50 r aSMase (particularly S-SMase) in chemokine elaboration by pro-inflammatory cytokines and highlight

51 Metabolite tracking and chemical elaboration combined with 3D-quantitative structure-acti

52 naling in vitro and in vivo alters dendritic elaboration: Dendrites are longer and more complex when

53 This explanation and elaboration document describes the rationale; clarifies

54 A more detailed explanation and elaboration document, describing the interpretation and

55 conjunction with the TRIPOD explanation and elaboration document.

56 We hypothesized that structural elaborations during learning are restricted to discrete

57 nd includes latent functionality for further elaboration (e.g., aliphatic alcohols, alpha,beta-unsatu

58 is, which include dendritic arbor growth and elaboration followed by retraction and pruning.

59 rs of Maillard reaction (MR) in black garlic elaboration, followed by the determination of furosine b

60 otivation intensity theory--in particular an elaboration from the theory concerned with fatigue influ

61 ranscription factors, whereas other marginal elaboration genes are dispensable for its maintenance.

62 y of the thiol-alkynylation in postsynthetic elaboration has been demonstrated through the facile ins

63 put screening with structure-guided compound elaboration has yielded a tool compound that may serve a

64 nificantly above chance, but the more recent elaborations have achieved relatively little performance

65 to identify candidate genes involved in the elaboration, hydroxylation, and glycosylation of the tri

66 rophil infiltration and host defense peptide elaboration in lesions.

67 ators to monitor the process of black garlic elaboration in order to obtain high quality products.

68 is a major regulator of dendrite growth and elaboration in the developing brain.

69 re in accord with the THP ring formation and elaboration in thiomarinol following a similar order to

70 s a key regulator of astrocyte morphological elaboration in vivo.

71 oth active site specialization and new motif elaborations in protein and RNA subunits.

72 Subsequent elaboration included two sequential cyclizations to comp

73 orate calls, they are less selective as call elaboration increases, because preference is based on st

74 Thus, as call elaboration increases, both relative attractiveness and

75 t contains the checklist and explanatory and elaboration information to enhance the use of the checkl

76 Further elaboration into a polycyclic ring system via alcohol ox

77 amides with the possibility of their further elaboration into a variety of biologically important het

78 urther demonstrate their potential for rapid elaboration into complex structural motifs.

79 icateins are promising candidates for future elaboration into efficient and selective biocatalysts fo

80 mo-2,2'-bipyridine, useful intermediates for elaboration into more complex ligands through metal-cata

81 id foundation for successful structure-based elaboration into potent inhibitors.

82 ydro-Diels-Alder reaction-with their in situ elaboration into structurally complex benzenoid products

83 d isocyanides are ideally functionalized for elaboration into synthetic targets as illustrated by the

84 Weinreb carboxamide, further chemoselective elaboration leads to the efficient formation of librarie

85 llographic structures were used to guide the elaboration/linking of the fragment, ultimately leading

86 motor cortex to brainstem nuclei, to complex elaborations, mediated by high-order cognition and foste

87 fragment-based drug design that all fragment elaboration must be based on the parent crystal structur

88 Despite persistent cytokine elaboration, no host cell cytotoxicity was observed exce

89 and is expressed in the skin to control the elaboration of "menorah"-like dendrites of mechanosensor

90 Further synthetic elaboration of 8TQ yielded a small molecule compound (35

91 en together with genetic data, implicate the elaboration of a functional T6S apparatus with a marked

92 in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype.

93 Overall, these results enabled the elaboration of a more accurate catalytic cycle and led t

94 nterfered with the differentiation-dependent elaboration of a signature invasive-vascular remodeling

95 s (DMPK) properties was initiated based upon elaboration of a simple pyridone core.

96 ell lineages to occur concomitantly with the elaboration of a three-dimensional body plan during gast

97 In contrast, in Sapria it is derived from elaboration of a unique ring structure located between t

98 bnormalities are likely a consequence of the elaboration of a variety of inflammatory cytokines gener

99 binding to short DNA molecules, allowing the elaboration of a variety of intercalator displacement as

100 and electrophysiological assays and (2) the elaboration of actin-based, filopodia-like protrusions t

101 d will simplify the synthesis and structural elaboration of amine-containing targets.

102 , particular attention has been given to the elaboration of an "aberrant spectra" detection strategy

103 ma, reaching a higher level of awareness and elaboration of an active prevention plan is mandatory.

104 Our findings allow elaboration of an evolutionary model of early biochemist

105 largely the same developmental program or by elaboration of an existing root program in the common an

106 that multiple S100 proteins can repress the elaboration of an oncogenic bacterial surface organelle.

107 rning ecosystemic PAH transfer motivated the elaboration of an original small-scale exposure chamber

108 utral polyiodinated linkers are used for the elaboration of anion organic frameworks, by analogy with

109 ction is a "privileged architecture" for the elaboration of aptamers into split aptamers, as it provi

110 nt of richly exuberant arbors but rather the elaboration of arbors prepositioned in the proper locati

111 tork et al. (2014) report that extension and elaboration of astrocyte processes in Drosophila is cont

112 roughout development - from migration to the elaboration of axons and dendrites - that are correctly

113 role for protein quality control during the elaboration of bacterial biofilm in the context of an in

114 h, the same strategy has been applied to the elaboration of biosensors for D-sorbitol, D-glucose and

115 riod plasticity is strongly dependent on the elaboration of brain-derived neurotrophic factor (BDNF),

116 l hit-to-lead optimization assumes that upon elaboration of chemical structure, the ligand retains it

117 instructs the distinct, neuron-type-specific elaboration of ciliated endings of different olfactory n

118 These data suggest that regulation of the elaboration of compound leaves and serrations is context

119 les for Eph signaling, first in limiting the elaboration of cortical neuronal dendrites and then in c

120 n evolution; (ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven

121 ossible to explore factors that regulate the elaboration of critical glycans.

122 alysis was followed by extensive statistical elaboration of data, literature data mining, and gene on

123 iking and opposite effects on the growth and elaboration of dendrites among major classes of brain ne

124 plant form is achieved through differential elaboration of developmental pre-patterns during postemb

125 The left-sided parapineal promotes the elaboration of dHbl character in the left habenula, albe

126 m tips and shoulders of the clusters for the elaboration of different quality wines.

127 ervating motor neuron subtypes parallels the elaboration of digits.

128 t an adaptive developmental strategy for the elaboration of direction-selective responses, one in whi

129 ield of biomarkers in AD and to consider the elaboration of disease-modifying strategies in the manag

130 While the size, shape, number and elaboration of each of these organ types can be quite di

131 Signal elaboration of edited spectra was combined with multivar

132 can provide a new, much needed, tool for the elaboration of effective public health intervention plan

133 recent achievements and progress toward the elaboration of efficient O2 reducing cathodes.

134 New functions commonly evolve by elaboration of existing scaffolds, for example, via doma

135 that probiotics alter gut flora and lead to elaboration of flora metabolites that influence health t

136 4b, opening interesting perspectives on the elaboration of fluorescent cavity-based systems for the

137 urs that could be used as ingredients in the elaboration of foods with a good nutritional profile.

138 imal model initially developed to facilitate elaboration of genetic influences on behavior.

139 carbon nanotubes (vaCNT) have been used for elaboration of glucose/O2 enzymatic fuel cells exploitin

140 stration of this point was facilitated by an elaboration of Hall's allosteric two-state model; this n

141 t causes profuse watery diarrhea through the elaboration of heat-labile and/or heat-stable toxins.

142 of others that resulted in an age-dependent elaboration of hedonic-response-specific circuitry despi

143 utilized as versatile intermediates for the elaboration of heterodi- and -tripeptides.

144 This report details the elaboration of hit 8 with the goal of achieving and main

145 of modern medicine and allostasis, a further elaboration of homeostasis, has been defined as stabilit

146 provement of technological processes for the elaboration of hypocaloric and functional beverages.

147 to activation of the NLRP3 inflammasome and elaboration of IL-18.

148 in circulation serve as neo-epitopes for the elaboration of immunoglobulins, thereby providing an ass

149 multiple lipid-binding proteins lead to the elaboration of increasing layers of the SSR and uncover

150 nce shows the central role of macrophages in elaboration of inflammatory mediators such as TNF-alpha

151 ntations in humans, presumably involving the elaboration of inhibitory circuits, is dependent on expe

152 p8 is an important factor for initiation and elaboration of inner ear development.

153 assive expansion of the cortical surface and elaboration of its connections in humans originates from

154 Alternatively, elaboration of l-serine gave the corresponding enantiopu

155 ght into these principles by considering the elaboration of locomotor circuits across evolution.

156 Elaboration of lymphangiogenic growth factors and matrix

157 These findings are based on the elaboration of mathematical tools for analyzing confocal

158 d form of consciousness is necessary for the elaboration of meaningful associations.

159 from C1 and fixation of MHC-C drove further elaboration of MHC-C-specific KIR, as exemplified by chi

160 of vocal displays afforded by the preceding elaboration of monosynaptic corticobulbar tracts, giving

161 ors is a important synthetic pathway for the elaboration of more sophisticated systems.

162 Myelination, the elaboration of myelin surrounding neuronal axons, is ess

163 The elaboration of nascent synaptic connections into highly

164 een found in a high concentration during the elaboration of natural green olives.

165 an ancestral SoxE gene may have facilitated elaboration of NC lineages.

166 utations in vertebrate homologues, promoting elaboration of NC traits.

167 erged as a major regulator of the growth and elaboration of neural processes.

168 al cortical function depends upon the proper elaboration of neurons, including the initial extension

169 ebrafish are robustly asymmetric, with dense elaboration of neuropil only in the left lateral subnucl

170 nolic content they could be suitable for the elaboration of new ingredients with different industrial

171 le liposomes and polymersomes called for the elaboration of new synthetic methodologies.

172 al curiosities to important reagents for the elaboration of organic molecules.

173 nditions for the cross-coupling, and for the elaboration of orthogonal cross-coupling methodologies o

174 the formation of cilia, followed by abnormal elaboration of OS and rapid degeneration.

175 that cannot die by apoptosis because of the elaboration of pathogen-encoded caspase inhibitors.

176 ii genome but co-culture is required for the elaboration of PDGA depolymerase activity.

177 d by genes that control cell division in the elaboration of plant architecture, functional analysis o

178 These findings indicate that the precise elaboration of plant form is dependent on the cumulative

179 vascular tissues for normal organization and elaboration of plant vascular tissue.

180 ces in developing generic approaches for the elaboration of PPI inhibitors are highlighted.

181 cell numbers and neuronal cell types to the elaboration of progenitor populations and their prolifer

182 enesis, is a key regulator of the growth and elaboration of pyramidal cell dendrites in the developin

183 eaction of 5 followed by tautomerization and elaboration of R to give silylated furanonaphthols 4 bea

184 T cells regulate blood pressure through the elaboration of reactive oxygen species and vasoactive cy

185 proaches described in the literature for the elaboration of reagentless biosensors.

186 ial importance in modern engineering for the elaboration of safety regulations in structural design o

187 each isoform has a distinct function in the elaboration of sexually dimorphic circuitry and behavior

188 ocial living, as well as the maintenance and elaboration of social life.

189 tion is particularly challenging because the elaboration of specific shapes is in essence a question

190 resumed underuse of epilepsy surgery and the elaboration of strategies to address this treatment gap

191 Ackermann et al. outline a model for elaboration of subcortical motor outputs as a driving fo

192 nic plasticity of plant development, and the elaboration of such pre-patterns leads to remarkable het

193 These results correlate the elaboration of symmetric SAC dendritic morphology and as

194 ve TH2 inflammation or to suppress the local elaboration of TH2-promoting epithelial factors, such as

195 sociality, and we begin our response with an elaboration of that definition and a defense of our argu

196 This paper proposes an elaboration of the AoP Natural Resources.

197 es and carbamates, and thus allows for rapid elaboration of the beta-alkynyl esters into a variety of

198 bryos refocus from increasing cell number to elaboration of the body plan.

199 for building more complex molecules via the elaboration of the carbon-boron bonds into other carbon-

200 identify three "working edges" for fruitful elaboration of the Chunk-and-Pass proposal: (a) accounti

201 n module from which to consider evolutionary elaboration of the circuitry to serve more intricate val

202 leavage of the triazole ring enables further elaboration of the condensation products.

203 Our results thus require an elaboration of the currently prevailing model for ON mot

204 ting of Centrosomin to Golgi outposts during elaboration of the dendrite arbor creates a local system

205 d by a Stille cross-coupling is used for the elaboration of the desired substituted dienes which will

206 ication, polycyclic systems have arisen from elaboration of the diene motif.

207 hly branched core oligosaccharides relied on elaboration of the disaccharide Hep-Kdo core as basis fo

208 erges over the first few years of life as an elaboration of the earlier, and more open-ended, intuiti

209 ge storage and information processing or the elaboration of the electrochemically switchable devices.

210 algranulin A/B) binds zinc and represses the elaboration of the H. pylori cag type IV secretion syste

211 attributed to the evolutionary expansion and elaboration of the human cerebral cortex.

212 phila melanogaster embryos, we show that the elaboration of the interphase Cnn scaffold defines a maj

213 Elaboration of the lactam cores via amidation enabled sy

214 enes encode the activities that initiate the elaboration of the Manalpha1-3 and Manalpha1-6 arms, res

215 rs, the ensheathment of axons and subsequent elaboration of the myelin sheath.

216 Elaboration of the N-O moiety of one member of this libr

217 However, elaboration of the neurochemical pathways that govern ag

218 on of a highly interactive interface and the elaboration of the notion of this map of medicine acting

219 his coordination is the centrocone, a unique elaboration of the nuclear envelope that houses the mito

220 Subsequent elaboration of the pendant allyl group into an alpha-dia

221 Due to extensive elaboration of the photoreceptor cilium to form the oute

222 Further elaboration of the physical properties of the lead compo

223 entifies a downstream component required for elaboration of the pre-pattern.

224 ral whorls and is best interpreted as a late elaboration of the region between the petals and stamens

225 intramolecular N-arylation strategy for the elaboration of the requisite nine-membered lactam ring a

226 The elaboration of the resorcin[4]arene's aromatic cavity pr

227 "pyridylic" C-O bond in this tetracycle and elaboration of the resultant hydroxy ketone to a diketon

228 matically derived cis-1,2-dihydrocatechol 3, elaboration of the resulting adduct to the tricyclic ket

229 Elaboration of the resulting substituted N-hydroxy-2-aze

230 HADSF subfamily having the least structural elaboration of the Rossmann fold catalytic domain was th

231 (1) Elaboration of the scope of diversity of disulfide foldi

232 Consistent with its function in the elaboration of the sieve areas, CHER1 has a sustained, p

233 al of the directing SO2Py allows for further elaboration of the silylation products.

234 7 pairs (14%), the binding mode changes upon elaboration of the smaller ligand.

235 n brain evolution has been attributed to the elaboration of the subventricular zone (SVZ) and the ass

236 Further in situ elaboration of the sulfinate intermediates leads to the

237 Here, we present results on the elaboration of the synthesis of five classes of ATP anal

238 thiolactone ring is a suitable position for elaboration of the TLM scaffold, and the structure-activ

239 of disease and patient participation in the elaboration of the treatment plan is expected to substan

240 Two strategies have been examined for elaboration of the unsaturated tetrahydrofuranyl ring fr

241 ng the mechanisms that control induction and elaboration of the vertebrate central nervous system (CN

242 is novel fold suggest that it would be a new elaboration of the widespread CSalpha/beta scaffold, thu

243 Elaboration of these beta,gamma-diamino and alpha-hydrox

244 The origins and subsequent elaboration of these compartments represent a key aspect

245 Elaboration of these compounds to target binding hotspot

246 Elaboration of these diastereoisomeric lactones through

247 The elaboration of these structures toward the asymmetric sy

248 Several examples demonstrate further elaboration of this functionality.

249 of complex gyral connectivity by continuous elaboration of this grid structure.

250 A logical elaboration of this idea leads to a dynamical neural arc

251 ated yields (>90%), thereby enabling further elaboration of this molecule.

252 Elaboration of this simple functionalization allows prep

253 Elaboration of this topic can lead to a better understan

254 the coordination of tissue polarity and the elaboration of tissue structure in the developing subman

255 Rugose biofilm development involves the elaboration of two distinct bacterial populations and in

256 of antibiotic-associated colitis through the elaboration of two large clostridial toxins and other vi

257 resistances, this choice was preceded by the elaboration of two leading edges with a faster extension

258 ucleotides is a critical initial step in the elaboration of type I IFN.

259 egistration of the jaws and the evolutionary elaboration of variable jaw morphologies and designs.

260 n of vimentin filaments in repair cells, the elaboration of vimentin-rich protrusions, and wound clos

261 m tips and shoulders of the clusters for the elaboration of wines with different qualities.

262 halon could be simplified by viewing them as elaborations of a much more finite group of developmenta

263 The various elaborations of corolla tube attributes, such as length,

264 Our results reveal novel evolutionary elaborations of the G-tail-binding protein in Saccharomy

265 r synthesis in land plants, and suggest that elaborations of the linear polymer, such as branching or

266 stic understanding of the formation of these elaborations of the lining of the gut, essential for pro

267 Structural elaborations of these highly substituted isoxazoles by S

268 Future elaborations of this concept to extend its capabilities

269 es in pathway structure could have underlain elaborations of this learned motor behavior.

270 ed stem cells, cell fusion, and neurotrophin elaboration--offer renewed hope for development of cell-

271 These elaborations often differ dramatically among closely rel

272 rest evolution postulate vertebrate-specific elaborations on an ancestral neural plate border program

273 gage the same neural regions during a detail elaboration phase that younger adults engage during memo

274 However, during the later elaboration phase, the same posterior regions were assoc

275 memory search phase and a subsequent detail elaboration phase.

276 r studies the impact of the strawberry puree elaboration process on the chemical composition of the f

277 the different steps of production, for three elaboration processes and two harvests (2011 and 2012).

278 We also need to improve model elaboration, refinement and coarse graining procedures t

279 vides examples of good reporting, as well as elaborations regarding the rationale for new checklist i

280 a similar developmental synaptic pruning and elaboration strategy is used at both sites to generate t

281 Despite undergoing different O-glycosylation elaboration, TcMUC reporters yielded quite similar resul

282 d products are amenable to further synthetic elaboration through manipulation of the olefinic functio

283 yclization yields a novel cyclopentenone for elaboration to 1.

284 unctionalized aza-octahydropentalene and its elaboration to a model tetracyclic core structure of cal

285 ic synthesis of tylactone and its subsequent elaboration to complete the first total synthesis of the

286 ed C-H arylation reactions, allowing for the elaboration to diversely functionalized building blocks.

287 ranging from neurite outgrowth and dendritic elaboration to neuronal survival.

288 selective way and used for further synthetic elaboration to produce, for example, a CF3-substituted 2

289 aturated esters gave a range of diamines for elaboration to T1-T8 via a sequence involving reduction

290 t phase and spatial positions, suggesting an elaboration to the Energy Model that incorporates spatia

291 The key step in the elaboration to the final products is the conversion of a

292 ing metathesis to afford enol ether 8, whose elaboration to the targeted QRSTU ring system 4 required

293 , has been accomplished along with synthetic elaboration to their C14-epimers starting from d-glucose

294 phosphine products as substrates for further elaboration was demonstrated with a platinum-catalyzed a

295 nventional chemical analysis and chemometric elaboration were used to assess quality and to define an

296 es by a combination of selective pruning and elaboration, whereas laminar restriction results from bi

297 les, could be further utilized for synthetic elaboration, which is advantageous for biological evalua

298 enamines could be further used for synthetic elaboration, which proved to be highly advantageous for

299 onclude that Ulk2 activity promotes neuropil elaboration while Kctd12 proteins limit Ulk2 activity as

300 rough a click reaction, which allows further elaboration with streptavidin-conjugated dyes or other m