ライフサイエンスコーパス: electronegative

1 brane, while the opposite surface is largely electronegative.

2 However, small electronegative 2'-O-substituents, while enhancing the R

3 ing and in vitro activity, (2) small, highly electronegative 4'-substituents such as hydroxy, fluoro,

4 bserved in a protein, despite the ability of electronegative 4S substituents to enforce the more comm

5 For electronegative adsorbates, such as O and Cl, both mu(S)

6 f galactose behaves as an H-bond donor to an electronegative amino acid side chain in the SH1 binding

7 r to identify whether specific cluster(s) of electronegative amino acids in pro-Crp4-(20-43) are resp

8 To test whether specific cluster(s) of electronegative amino acids in pro-Crp4-(20-43) have spe

9 However, growth is dependent only on electronegative and electropositive properties near the

10 -defined electronegative cavity and confined electronegative and hydrophobic patches.

11 protein-protein complex in which Ugi mimics electronegative and structural features of duplex DNA.

12 Oxygen, for example, is highly electronegative, and for energies of approximately 10-30

13 structure-activity relationships showed that electronegative aromatic substituents in the para-positi

14 nformer of the cation to be stabilized by an electronegative atom at C-3.

15 Other analogs in which the electronegative atom was moved to different positions su

16 arbon atom acts as the hydrogen donor and an electronegative atom Y (Y=N, O or S) acts as the accepto

17 with 3-HPC to the alpha-effect, where tandem electronegative atoms exhibit exceptionally high nucleop

18 s consistent with coordination of lithium to electronegative atoms on adjacent molecules in the solid

19 stabilizing electrostatic interactions with electronegative atoms on the 3'-side, are responsible fo

20 he coumarin lactone of 2, we identified that electronegative atoms placed at the meta-position of the

21 l that outer-sphere Mg(2+) are positioned by electronegative atoms, hydration layers, and a preferenc

22 y fluorinated compounds with a set number of electronegative atoms, the overall absorption in the IR

23 a deep peptide-binding groove comprising two electronegative B- and E-pockets that coincide with the

24 This suggests that the electronegative benzylic oxygen of veratryl alcohol incr

25 results from preferential association of the electronegative beta-globin chains with the alpha(M)-glo

26 ucture of riboflavin-bound TmRibU reveals an electronegative binding pocket at the extracellular surf

27 hifting mutations in RS1 consistently caused electronegative bright-flash ERG, delayed flicker respon

28 Electronegative but lone pair-donating groups NR2, OR, a

29 DL was fractionated into L1-L5, increasingly electronegative, by ion-exchange chromatography.

30 the electronegative CO4' oxygen for the less electronegative carbon in 4-6 presumably reduces the cap

31 bon-nitrogen bond is formed between the more electronegative carbon of the alkyne and the terminal, e

32 lpha-helical segments forming a well-defined electronegative cavity and confined electronegative and

33 acophore maps (one cationic nitrogen and two electronegative centers) for the two dopamine receptors,

34 macophore map (one cationic nitrogen and two electronegative centers) of the D1A DA receptor.

35 ning the magnitude of beta: smaller and more electronegative central atoms better accommodate a pair

36 dent protein kinase (PKG) caused (i) a large electronegative charge shift of each enzyme on ion excha

37 rylation or cGMP-binding alone causes (i) an electronegative charge shift on ion exchange chromatogra

38 sn) mutant proteins have incorporated a more electronegative Cl- in place of the Asp carboxylate.

39 The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in th

40 e stable than zebularine, replacement of the electronegative CO4' oxygen for the less electronegative

41 geometry is impetus enough to make even the electronegative cobalt weaken the N-N bond of N(2).

42 by Isenman and coworkers have implicated an electronegative "concave" surface on C3d in the binding

43 Dark-adapted ERG responses showed an electronegative configuration, with b-wave reduction in

44 ectropositive platform in the ATPase and the electronegative Cu(+) chaperone.

45 hain (H95) stabilized the orientation of the electronegative cyano group of the hapten.

46 H2 helix and L1 loop of p53 interact with an electronegative domain on the N-terminal alpha-helix of

47 There were no other causes of an electronegative electroretinogram identified in any of t

48 other murine night-blindness models with an electronegative electroretinogram response, which is als

49 he preference in FCCX systems, where X is an electronegative element from Period 2, is widely exploit

50 The electronegative elements in such compounds form a polyat

51 Halogens are among the most electronegative elements, and the variations in size and

52 acceptor in Photosystem I (PS I) is a highly electronegative (Em = -705 mV) interpolypeptide [4Fe-4S]

53 As the electronegative entrance is widely conserved in the TolC

54 The electronegative entrance is widely conserved throughout

55 lasmic domain (CD) that provides a favorable electronegative environment for cations.

56 halogen's electron-deficient sigma-hole and electronegative equatorial band.

57 ribution of Kir2.1 channel activity in these electronegative ERG potentials.

58 oreceptor-degenerated mice (hrhoG/hrhoG), an electronegative ERG wave recorded with K+X+A, was conver

59 The Rs1h-KO functional deficit results in an electronegative ERG waveform that is characteristic of h

60 old had substantial b-wave loss and strongly electronegative ERGs; three had overt macular atrophy.

61 o through a corresponding interaction of the electronegative exocyclic substituent with O5 (exo-anome

62 Direct repulsion between the electronegative exon 7-encoded residues of the heparin b

63 near the TF binding site, and (iii) a large electronegative exosite which is in a position analogous

64 In addition, electronegative features located around the A-, B-, or C

65 onferred on the acceptor centre by the small electronegative fluoride ligands compared to the heavier

66 The addition of an electronegative fluorine atom at the 2-position of dI lo

67 aligned triaxially, clustering three highly electronegative fluorine atoms in close proximity.

68 lective than F, despite the lack of strongly electronegative fluorine atoms.

69 shape, branching, symmetry, and presence of electronegative fragments, can modulate the hepatoprotec

70 erately polarized bonding between Ba and the electronegative framework.

71 A conserved electronegative funnel connects this region to the intra

72 brane, and propose that PelC functions as an electronegative funnel to guide the positively charged P

73 to lipoprotein interaction with these highly electronegative glycoconjugates.

74 from the N-terminal domain active site to an electronegative groove on the C-terminal domain that wou

75 placement of the H-atom in CH(4) with a less electronegative group makes the H(b)-abstraction transit

76 fect of substituting the 24 hydrogen with an electronegative group such as hydroxyl or fluorine was i

77 f a H-atom in a methane molecule with a more electronegative group tends to make the H(b)-abstraction

78 the presence of the alkyne with an attached electronegative group.

79 converted to their borohydrides by replacing electronegative groups (e.g., OR, halogen) with hydrogen

80 e substrates with electropositive groups and electronegative groups have different conformational pre

81 The overlap of this ketone with electronegative groups of other 2C9 substrates suggests

82 ing at site 1 requires substrates with three electronegative groups.

83 ng of compound 3 (B/P = 1/33) with different electronegative groups.

84 Less electronegative halogens such as bromine increase the ac

85 ct, which is attributed to the preference of electronegative halogens to be attached to a more highly

86 m polyhedron, 12 atoms of which are the more electronegative Hg.

87 data confirm a role for the highly conserved electronegative/hydrophobic residues along ACP helix alp

88 obic surface feature that interacts with the electronegative/hydrophobic residues along helix alpha2

89 A) ERG (11.0 candela.sec.m(-2)) waveform was electronegative in 62% of group A eyes and 100% of group

90 ATPase underneath the basal region also have electronegative interiors.

91 sidues of the heparin binding domain and the electronegative L1 loop found only in Nrp2 is found to s

92 opositive alkali elements for the former and electronegative later 2p elements for the latter, respec

93 One circulating subfraction, electronegative LDL (LDL(-)), which is increased in fami

94 ined whether it mediates EC uptake of L5, an electronegative LDL abundant in dyslipidemic but not nor

95 Electronegative LDL has been shown to be highly enriched

96 L5, a circulating electronegative LDL identified in patients with hypercho

97 Electronegative LDL may underlie downregulation of KChIP

98 ly abolishes the proapoptotic effects of the electronegative LDL on vascular endothelial cells.

99 ent binding of Hb fragments and formation of electronegative LDL particles (LDL-).

100 atic attraction between the cationic dye and electronegative LDL rather than from dye binding to amyl

101 erformance liquid chromatography analyses of electronegative LDL species, described as LDL- and LDL2-

102 E-deficient mice, and (4) pretreatment of an electronegative LDL subfraction isolated from hyperchole

103 and examined the distribution of L5-the most electronegative LDL subfraction-in total LDL (i.e. L5%).

104 Results showed that the serine of apoB100 in electronegative LDL was highly O-glycosylated, including

105 confirm the activation of SMase activity by electronegative LDL.

106 strongly attracted to specifically arranged electronegative ligands that desolvate the ion and the R

107 cent of XeO4 : an octet of electrons to bind electronegative ligands, and no low-lying acceptor orbit

108 illary ligands and becomes stronger for more electronegative ligands.

109 Incubation of plasma electronegative low-density lipoprotein (LDL) from UNx r

110 Electronegative low-density lipoprotein (LDL) has been s

111 Our data indicate that electronegative low-density lipoprotein (LDL) shows SMas

112 L5-highly electronegative low-density lipoprotein (LDL)-is signifi

113 much larger energy difference was found for electronegative meta substituents (up to 0.66 kcal/mol f

114 Our findings indicate that a highly electronegative, mildly oxidized LDL subfraction present

115 Removal of CBPs conferred a greater electronegative net surface charge than that which cells

116 e described mechanisms by which L5, the most electronegative of 5 recognized fractions of low density

117 level that outward rotation is preferred for electronegative or anionic substituents while electropos

118 Although the electronegative oxygen at the C8 position of 8-oxodG may

119 sitively charged sulfonium sulfur is near an electronegative oxygen in the ribose ring is common.

120 rizontal lineO](2+) intermediate unless more electronegative (oxygen containing) ligands are introduc

121 P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*0

122 e highest potency was achieved with polar or electronegative para-substituents, whereas neutral para-

123 mensional 1H NMR spectroscopy, identifies an electronegative patch created by the side chains of two

124 Furthermore, mutation of a specific electronegative patch on the CopZ surface abolishes the

125 Insect-selective neonicotinoids have an electronegative pharmacophore (tip) in place of the ammo

126 The neonicotinoid electronegative pharmacophore is nestled in an inverted

127 d selective interaction of the neonicotinoid electronegative pharmacophore with a unique subsite of t

128 plexation of otherwise mobile counterions in electronegative pockets in the grooves of DNA helices in

129 tially desolvated ions that are attracted to electronegative pockets on the RNA surface.

130 ional presence of chelation sites, which are electronegative pockets that selectively bind ions of an

131 By contrast, five electronegative pockets were identified in the moderate

132 ditional basic residues binding to the other electronegative pockets.

133 ENT3 and that the size, ionization state, or electronegative polarity at these positions is crucial f

134 Conversely, enhancing the electronegative potential (B-NRP2 R287E,N290D and R287E,

135 stingly, the channel interior with excessive electronegative potential creates an energy barrier for

136 Reduction of the electronegative potential of B-NRP2 by exchanging acidic

137 Effector proteins also have considerable electronegative potential patches on their surfaces.

138 The dramatic reduction in electronegative potential resulting from this mutation d

139 sites are dictated by coordination geometry, electronegative potential, avoidance of electropositive

140 Both vestibules of the channel are strongly electronegative, providing a cation-stabilising environm

141 that helices 5, 7, 8, 10, and 11 surround an electronegative putative active site ( approximately 830

142 esults suggest that the HHR folds to form an electronegative recruiting pocket that attracts high loc

143 anes, which makes the surface of these cells electronegative relative to the surface of noncancerous

144 Each mutation replaced an electroneutral or electronegative residue with one that was positively cha

145 rophobic pattern, preference for intervening electronegative residues and inhibition by leptomycin B.

146 Removal of these electronegative residues located less than 8 A from the

147 Exon 7-encoded electronegative residues make additional interactions wi

148 firmed by site-directed mutagenesis of these electronegative residues, resulting in loss of binding o

149 ixed cone and rod dysfunction and a scotopic electronegative response to bright flashes.

150 electroretinography testing that revealed an electronegative response.

151 alue for patients and families with scotopic electronegative responses to bright flashes.

152 n of the C-terminal domain to neutralize the electronegative site.

153 zes the C3'-endo conformation while the less electronegative SMe group stabilizes the C2'-endo confor

154 We aimed to examine whether the most electronegative subfraction of low-density lipoprotein (

155 r model, the initiating component is L5, the electronegative subfraction of low-density lipoproteins

156 ered carbohydrate rings when they contain an electronegative substituent at the C1 position of the ri

157 5, revealed an important additional internal electronegative substituent effect on 3JCC in saccharide

158 heterocyclic and imine planes, including the electronegative substituent in the trans configuration.

159 e or S,C-sulfonium ylide is stabilized by an electronegative substituent on N or C, respectively.

160 re of the alpha-heteroatom substituent, with electronegative substituents (F, OMe, Cl) favoring Cornf

161 l) favoring Cornforth structures, while less electronegative substituents (PMe(2), SMe, NMe(2)) favor

162 gioisomeric ratio = 87/13 to >95/5), whereas electronegative substituents (X = OH, OAc, F) showed a c

163 roline-pi interaction also demonstrated that electronegative substituents and the number of CH donors

164 Electronegative substituents arrayed in 1,3-relationship

165 Electronegative substituents on C-4 (that is, C(gamma))

166 relationship studies have demonstrated that electronegative substituents on the 2-phenyl portion of

167 pend not only on the relative orientation of electronegative substituents on the C1-C2 fragment but a

168 electron-poor hydrogens on one ring with the electronegative substituents on the other ring.

169 theory (DFT) calculations show that internal electronegative substituents perturb 3JCOCC Karplus curv

170 Substitution of the hydroxyl group with electronegative substituents such as fluoro, chloro, all

171 tracenes and pentacenes allow for additional electronegative substituents to induce unexpected redshi

172 Electronegative substituents with lone pairs, such as ha

173 including terminal alkynes, strained rings, electronegative substituents, or lone-pair-bearing heter

174 compound is especially important for geminal electronegative substitutents.

175 Electronegative substitution impacts the electronic prop

176 and Val-9) on the surface of prothrombin was electronegative, suggesting a role in the electrostatic

177 at the beta-sheet concavity is predominately electronegative, suggesting that the protein-protein int

178 CD3-delta has a more electronegative surface and a more compact Ig fold than

179 N-terminal positive clusters and the alpha3 electronegative surface dictate the secondary structure,

180 to its lipidation site positions the highly electronegative surface of PelC toward the periplasm.

181 A homology model of SmgGDS highlights an electronegative surface patch and a highly conserved bin

182 Structure-informed mutagenesis reveals an electronegative surface patch in AvrRps4(C) required for

183 ove flanked on one side by an area of strong electronegative surface potential.

184 mutagenesis to investigate the roles of six electronegative surface residues of the FMN module in el

185 t of mutating nine conserved hydrophobic and electronegative surface-exposed amino acids of SigE on S

186 en the polybasic 23-30 region and the alpha3 electronegative surface.

187 results highlight that both hydrophobic and electronegative surfaces are required for the function o

188 Structure-directed neutralization of electronegative surfaces on PsiB abrogates RecA inhibiti

189 14 and -584 mV, respectively, which are more electronegative than any previously studied Fds in which

190 for the hydrolytic step, despite being less electronegative than Co2+, the function of the metal ion

191 oxidized LDL and acetyl-LDL, which are more electronegative than native LDL, did not bind to either

192 2, S1, S1', S2', and S3' pockets and is more electronegative than rhizopuspepsin or endothiapepsin.

193 As X is made more electronegative, the magnitude of the apparent imbalance

194 The coplanar system between the electronegative tip and guanidine-amidine moiety extends

195 e usual neonicotinoid N-nitroimine (=NNO(2)) electronegative tip is replaced with N-nitrosoimine (=NN

196 d coplanarity and projection of the strongly electronegative tip.

197 Although carbon is too electronegative to affect the reduction of elements with

198 s determined to be -87 mV, which is the most electronegative value reported for Rd from any source.

199 e, and ERG recordings showed reversal of the electronegative waveform and restoration of the normal p

200 e PA103 pilin disulfide loop environment was electronegative, whereas that of strain 1244 pilin had a

201 re shows that this face of the FMN module is electronegative, whereas the complementary interacting s

202 Using a highly electronegative X is recognized as unwise, but it is not

203 ies observed for (BDI)AlX2 systems with more electronegative X(1-) ligands could be ascribed to a dec

204 epulsion between the plasma membrane and the electronegative X/Y linker.