ライフサイエンスコーパス: electrophile

1 on (the cross-coupling of two different aryl electrophiles).

2 hich of these two regimes occurs for a given electrophile.

3 tomic substitutions that activated the ester electrophile.

4 ilitates reaction with the ferric superoxide electrophile.

5 of the boron-bound oxygen atoms by a second electrophile.

6 ketone moiety and the alpha,beta-unsaturated electrophile.

7 nic centers derived from the nucleophile and electrophile.

8 govern the outcome of the reaction for each electrophile.

9 ctivity of H2Sn as both a nucleophile and an electrophile.

10 ponent iteratively as a dienophile and as an electrophile.

11 e transfer from the benzene pi-system to the electrophile.

12 eophiles for reactions with the allyliridium electrophile.

13 enabled assessment of their reactivity with electrophile.

14 of bond formation between a nucleophile and electrophile.

15 ould react as a nucleophile instead of as an electrophile.

16 these species to react selectively with the electrophile.

17 a,omega-oligosilanyl dianion and as a latent electrophile.

18 oranes rely on the reactivity of boron as an electrophile.

19 he framework that makes it accessible and an electrophile.

20 phenol nucleophiles and terpene diphosphate electrophiles.

21 cales to react directly with a wide range of electrophiles.

22 orita-Baylis-Hillmann-type allyl bromides as electrophiles.

23 the direct reductive coupling of two carbon electrophiles.

24 ations with a range of carbon and heteroatom electrophiles.

25 y to improve enantioselectivity with certain electrophiles.

26 and intramolecular ring-closing with dihalo electrophiles.

27 Au(I) complexes, these complexes react with electrophiles.

28 irst manganese-catalyzed coupling with alkyl electrophiles.

29 onically biased iodobenzene and bromobenzene electrophiles.

30 small molecules was probed by reactions with electrophiles.

31 tilize organometallic nucleophiles and alkyl electrophiles.

32 , but are unreactive toward a range of other electrophiles.

33 s involving diaryliodonium and aryldiazonium electrophiles.

34 ch was hitherto limited to the use of halide electrophiles.

35 tituted cyclopentenes wherein enynals act as electrophiles.

36 reactions of C-amino-1H-1,2,4-triazoles with electrophiles.

37 ch undergo efficient reactions with numerous electrophiles.

38 activate CYP2C9 transcription in response to electrophiles.

39 along with kinetic data for a broad array of electrophiles.

40 the carbonyl carbon of chloromethyl carbonyl electrophiles.

41 ective addition of indoles to pyrone-derived electrophiles.

42 alkylcarbastannatrane nucleophiles with acyl electrophiles.

43 n secondary zinc organometallics and silicon electrophiles.

44 l amides followed by reaction with different electrophiles.

45 dly than an electron-poor ring with suitable electrophiles.

46 d in ca. 50 examples involving a plethora of electrophiles.

47 ing of the intermediate enolate with various electrophiles.

48 pG) sites enhances reactivity of DNA towards electrophiles.

49 the catalyst toward cross-coupling of carbon electrophiles.

50 selective reactions of relatively unreactive electrophiles.

51 edge, kinetic experiments indicated that the electrophiles 1-bromobutane or ClSiMe3 in Et2O reacted a

52 With electrophiles, a faster reaction of Z- than of E-isomers

53 m cycloalkanones, malononitrile, and allylic electrophiles, abundantly available reagent classes.

54 early with the parameters E of the reference electrophiles according to the linear free energy relati

55 trophilicity parameters E of these reference electrophiles, according to the linear-free-energy relat

56 and provides spatial and temporal control of electrophile activation through irradiation.

57 ling under these conditions and that a TEMPO-electrophile adduct can be isolated.

58 y help elucidate key aspects of mitochondria electrophile adduct excretion and cell endocytic and exo

59 roducing a suitable carbon- or silicon-based electrophile after the base-mediated 1,2-elimination rea

60 ep, by variation of the concentration of the electrophile, allow the conversion of dienamines to be o

61 ng of the arylation reaction in situ with an electrophile allowed ready incorporation of functionalit

62 ent with a cooperative mechanism in which an electrophile and a nucleophile are simultaneously activa

63 Formaldehyde (HCHO), a strong electrophile and a rapid and reversible inhibitor of hyd

64 n between an inhibitor containing a terminal electrophile and an active site cysteine (Cys-909).

65 act with a nucleophile to yield an activated electrophile and an aryloxide anion.

66 The dual mode of activation of both the electrophile and nucleophile by in situ generated cataly

67 19:1 in all cases) over a wide range of aryl electrophiles and aliphatic olefins.

68 phase II detoxifying enzyme that metabolizes electrophiles and carcinogens including 4-hydroxy-2-none

69 oss-coupling of azaallyls with vinyl bromide electrophiles and delivers allylic amines in excellent y

70 bases) yield stronger surface organometallic electrophiles and for this reason have higher benzene hy

71 exocyclic nitrogen atom preferably bonds to electrophiles and its electron-donating character is mar

72 Various electrophiles and lysine-based nucleophiles were investi

73 zed cross-coupling reactions between organic electrophiles and nucleophiles serve as particularly pow

74 etermined by the structure and the nature of electrophiles and nucleophiles.

75 This protocol describes targetable reactive electrophiles and oxidants (T-REX)-a live-cell-based too

76 Herein, using T-REX (targetable reactive electrophiles and oxidants), an approach aimed at select

77 eral methodology, T-REX (targetable reactive electrophiles and oxidants), is established by (1) const

78 s described that employs diaryliodonium salt electrophiles and secondary aliphatic amine nucleophiles

79 kylation of allenes using alkyl triflates as electrophiles and silane as a hydride source.

80 ycanates, isothiocyanates and ketenimines as electrophiles and subsequent hydrolytic workup resulted

81 e active toward the coupling of sp(3)-carbon electrophiles and that well-controlled, light-driven cou

82 an asymmetric ortho lithiation with aldehyde electrophiles and utilizes the chiral memory of a preori

83 phile coupling is the first to use a C(sp)-X electrophile, and appears to proceed via an alkynylnicke

84 lds, depending on the choice of nucleophile, electrophile, and work-up conditions.

85 es to environmental toxicants and endogenous electrophiles are causative factors for human diseases i

86 og k(20 degrees C) = sN(N + E) (eq 1), where electrophiles are characterized by one parameter (E), wh

87 o solvent-dependent parameters N and sN, and electrophiles are characterized by one parameter, E.

88 ad range of nitrogen nucleophiles and carbon electrophiles are compatible coupling partners in this r

89 ross-coupling reactions of unactivated alkyl electrophiles are emerging as a powerful tool in organic

90 complexity harboring weak, but activatable, electrophiles are matched with the protein(s) they react

91 e or by subsequent addition of two different electrophiles are possible and lead to polyfunctional am

92 nd a variety of aliphatic, cyclic and aryl P-electrophiles are tolerated in reasonable to excellent y

93 ion provides an effective shielding if large electrophiles are used.

94 therefore mostly constant, concentrations of electrophiles are very much dependent on the ratio of NO

95 nol, but is due to the absence of a reactive electrophile as long as a significant fraction of cycloh

96 ng processes had used either aryl or alkenyl electrophiles as one of the coupling partners.

97 ven their ability to employ a wider range of electrophiles as well as promote stereospecific or stere

98 continues further via facile reactions with electrophiles as well as Stille and Suzuki cross-couplin

99 both species are found to be reactive toward electrophile at catalytically relevant rates.

100 proceed with rate-determining attack of the electrophile at the nucleophilic carbon center of the yl

101 No evidence for initial attack of the electrophiles at the enolate oxygens of these nucleophil

102 often defeated by destruction of the sulfur electrophile because the S(VI) Cl bond is exceedingly se

103 and reacted with carbon, fluorine, or sulfur electrophiles before the Grignard addition so as to gene

104 ons i-iii, the acetylenic bond behaves as an electrophile being attacked at the beta-position by the

105 The allyl moiety provides not only the electrophile but also a coordinating ligand to Cu, which

106 ient K(+)-free intermediate reacts with this electrophile but not with the weak C-H bonds in 1,4-cycl

107 react readily with carbonyls and imines (pi-electrophiles), but are unreactive toward a range of oth

108 m tight ion pair and activation of the enone electrophile by a hydrogen bond from the catalyst's hydr

109 gives a protonated amine that activates the electrophile by Bronsted acid catalysis, while the urea

110 Alternative electrophiles can also be used in place of trifluorometh

111 ioselective conjunctive coupling of C(sp(3)) electrophiles can be accomplished with Ni catalysis.

112 ling between 9-BBN borate complexes and aryl electrophiles can be accomplished with Ni salts in the p

113 We show that the reactivity of these electrophiles can be finely tuned by varying the substit

114 Glyoxal (gx) is a bifunctional electrophile capable of cross-linking DNA.

115 of its concentration) with an excess of the electrophiles ClSiMe3, 1-bromobutane (n-BuBr), or 1-iodo

116 We show that higher electrophile concentration can lead to elevated enantios

117 2-nonenal (HNE), an endogenous lipid derived electrophile, contributes to stress signaling and cellul

118 Simultaneous electrophile control allows sequential chemoselective cr

119 oining of two different electrophiles, cross-electrophile coupling (XEC), is presented with an emphas

120 A strategy for cross-electrophile coupling has been developed via the merger

121 This reductive cross-electrophile coupling is the first to use a C(sp)-X elec

122 the first example of a stereospecific cross-electrophile coupling of a secondary benzylic ester is d

123 The first enantioselective cross-electrophile coupling of aryl bromides with meso-epoxide

124 ol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, th

125 The stereospecific reductive cross-electrophile coupling reaction of 2-aryl-4-chlorotetrahy

126 The stereospecific reductive cross-electrophile coupling reaction of 2-vinyl-4-halotetrahyd

127 knowledge, this is the first reported cross-electrophile coupling reaction of an alkyl fluoride.

128 While cross-coupling and reductive cross-electrophile coupling reactions of alkyl halides are typ

129 Nickel-catalyzed cross-electrophile coupling reactions of benzylic esters and a

130 ew ligand classes for nickel-catalysed cross-electrophile coupling.

131 ew of the catalytic joining of two different electrophiles, cross-electrophile coupling (XEC), is pre

132 We found that soft electrophile DBPs could be an important predictor of com

133 reactivity and additive toxicity among soft electrophile DBPs.

134 Subsequent trapping with electrophiles delivered a wide range of alpha-functional

135 Reactions with several electrophiles demonstrated the nucleophilicity of the C=

136 i/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is

137 ppaB pathway, supporting the notion that the electrophile, DMF, acts via covalent modification.

138 ma-lactone 1a has been contemplated as allyl electrophile donor for allylic arylation via pi-allyl pa

139 ng because the carboxyl moiety is not a good electrophile due to the negative charge it carries.

140 and phenoxide salts) and fluorine-containing electrophiles (e.g., acid fluoride, fluoroformate, benze

141 re the abilities of an agent to 1) act as an electrophile either directly or after metabolic activati

142 The squarate diester used as an electrophile enabled sequential amidation and provided a

143 umpolung reactions of imines with the carbon electrophile enals.

144 are traditionally thought to be closed-shell electrophiles featuring an empty orbital rich in p chara

145 cell activation in cases in which whole-cell electrophile flooding fails to stimulate ARE induction p

146 molecular bromine (Br2) to be more effective electrophile for the C(sp(2))-H halogenation than I2.

147 isubstituted allylic phosphates are suitable electrophiles for asymmetric allylation.

148 drogen as a combined source of electrons and electrophiles for carbon monoxide coupling at high tempe

149 Esters are valuable electrophiles for cross-coupling due to their ubiquity a

150 These studies enhance the scope of electrophiles for nitroarene arylations and benzylations

151 are found to be selectively addressable bis-electrophiles for sulfur(VI) fluoride exchange (SuFEx) c

152 e catalyst that prevents the approach of the electrophile from the more hindered side.

153 ample of the Ni-catalyzed generation of aryl electrophiles from bench-stable amides with potential ap

154 ry tract diseases, must cope with a range of electrophiles generated in the host or by endogenous met

155 Increasing electrophile hardness should increase the probability of

156 A tetracationic electrophile has been generated in superacid and shown t

157 n of vinylarenes employing allylic phosphate electrophiles has been achieved through a copper hydride

158 lective allylation of trisubstituted allylic electrophiles has been developed.

159 ivity of beta-aminocarbonates as anisotropic electrophiles has been investigated with several phenols

160 ormation of C-C bonds from unactivated alkyl electrophiles have been described in recent years.

161 Over 20 unique electrophiles have been tested, highlighting the inheren

162 ucleophilic trifluoromethylation of benzylic electrophiles; however, current catalytic methods do not

163 ucleophilic isocyanide moiety with different electrophiles (i.e., isocyanates, isothiocyanates, cycli

164 ived from pyrazolin-5-ones have been used as electrophiles in asymmetric Mannich reactions with pyraz

165 g of borylated allylic sulfones with various electrophiles in both inter- and the less common intramo

166 robes can capture and identify protein-bound electrophiles in cells.

167 able the future application of this class of electrophiles in chemical proteomics.

168 ature recognizes the role of P(iii) and P(v) electrophiles in coordination chemistry, it has generall

169 es 1 and 2 in reactions with carbon-centered electrophiles in general.

170 riations of the Schmidt reaction with ketone electrophiles in hexafluoroisopropanol (HFIP) solvent ha

171 one methides have emerged recently as useful electrophiles in metal-free catalysis.

172 de, n-hexyl iodide, and n-dodecyl iodide, as electrophiles in model reactions.

173 which is the dominant scavenger of reactive electrophiles in serum.

174 act their abilities to function as effective electrophiles in synthetic reactions.

175 that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to

176 zetidin-3-one, reaction with a wide range of electrophiles, including alkyl, allyl, and benzyl halide

177 easily functionalized with a broad range of electrophiles, including palladium-catalyzed cross-coupl

178 nc pivalates with 18 polyfunctional druglike electrophiles (informers) in Negishi cross-coupling reac

179 We show that the electrophile is activated by the catalyst's protonated a

180 indoles with dimethyliminium chloride as the electrophile is as follows: fused BN indole II > natural

181 the selective enantiofacial approach of the electrophile is determined.

182 center with an aliphatic-substituted allylic electrophile is disclosed.

183 inhibitor Ibrutinib bearing a fumarate ester electrophile is vulnerable to enzymatic metabolism on a

184 reaction by using azodicarboxylate esters as electrophiles is also demonstrated.

185 and DNA alkylation by endogenously produced electrophiles is associated with the pathogenesis of neu

186 of C(sp(3))-H bonds of N-aryl amines by acyl electrophiles is described.

187 the nucleophilic fluorination of propargylic electrophiles is described.

188 ophiles with unsymmetric diaryliodonium salt electrophiles is described.

189 nion of readily available epoxides and allyl electrophiles is disclosed.

190 trophilic aromatic substitution with silicon electrophiles is disclosed.

191 amine-catalyzed reactions of aldehydes with electrophiles is often explained by simple steric argume

192 Lipid-derived electrophiles (LDEs) that can directly modify proteins h

193 The reaction on 2-(2-nitrovinyl) phenol as electrophile lead, in excellent yields and enantioselect

194 eact in a Friedel-Crafts fashion (cine) with electrophiles like perpivaloylated glucoside bromide and

195 ions between nitrogen nucleophiles and alkyl electrophiles, many such substitution reactions remain o

196 ity of purine nitrogen atoms towards various electrophiles, model systems composed of adenine or aden

197 A between Phe1 side chain and perfluoroaryl electrophile moiety are observed.

198 ile moiety and a tertiary carbon atom at the electrophile moiety.

199 arly attractive as a means to explore latent electrophiles not typically used in medicinal chemistry

200 ed than bond making at the transition state, electrophile-nucleophile electrostatic interactions are

201 pling efficiency was excellent even with the electrophile/nucleophile molar ratio = 1.0/1.1.

202 ansition metal catalysis and the addition of electrophiles/nucleophiles or radical species.

203 le (epoxide ring-opening by chloride) and an electrophile (O-acylation of the resulting alkoxide).

204 unctionalized nopoldiol is inert to aldehyde electrophiles of the sort found on protein-bound glyoxyl

205 investigated the impact of the nature of the electrophile on the C(sp(2))-H bond halogenation.

206 the formation of a covalent bond between an electrophile on the ligand and a nucleophilic center in

207 ng the addition of both a nucleophile and an electrophile onto diazo compounds give a fast access int

208 The ability to couple alkyl electrophiles opens the door to a stereochemical dimensi

209 mino reactions with more than 1 equiv of the electrophile or by subsequent addition of two different

210 n, and hence fullerene can work either as an electrophile or nucleophile.

211 eteroaryl organometallic species and silicon electrophiles or direct, transition-metal-catalysed inte

212 te, such that oxidative addition to a carbon electrophile outcompetes potential beta-hydride eliminat

213 o be unreactive with the cycloheptyl bromide electrophile over the average turnover time of catalysis

214 diverse products when reacted with different electrophiles/oxidants.

215 hough the oxidants tested were unsuccessful, electrophiles, particularly NBS, enabled the coupling re

216 e- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct ary

217 athways, both [C-H...O]-hydrogen bonding and electrophile preorganization by coordination to a carbon

218 ionalization of the aromatic backbone of the electrophile prior to cross-coupling.

219 on-hydride/carbonyl complexes that enable an electrophile-promoted hydride migration process, resulti

220 ation of bulky catalyst subsystems and large electrophiles provides a shielding of one face and cause

221 Many genotoxicants and toxic electrophiles react with human serum albumin (albumin);

222 ividually counted, yielding a map of protein-electrophile reactions within the cell lipid milieu.

223 pon exposure to endogenous and exogenous bis-electrophiles, reactive oxygen species, and ionizing rad

224 rt on a knowledge of the factors influencing electrophile reactivity.

225 FS2 modified with an electrophile reacts with a cysteine near the peptide-bin

226 the multifunctional substrates and ambident electrophiles rendered some organocatalytic transformati

227 , 60 degrees C), without the need for strong electrophiles required for typical Lossen rearrangements

228 hesis), glyoxalase family proteins (reactive electrophile response) and ribosome modifying enzymes (t

229 The results document Keap1 as a promiscuous electrophile-responsive sensor able to respond with simi

230 emalononitriles) and two different propargyl electrophiles serve as carbon sources for assembling div

231 Since E-2-hexenal is a reactive electrophile species, which are known to influence the r

232 -BuLi/TMEDA and the order of addition of the electrophile strongly govern the outcome of the reaction

233 e starting materials, temperature, solvents, electrophiles, substituents located ortho or meta to the

234 h endogenously and following exposure to bis-electrophiles such as common antitumor agents.

235 The reactivity toward electrophiles such as MeOTf and selectfluor was also inv

236 ic acid tert-butyl ester dimethyl ester with electrophiles such as methyl chloroformate and methyl br

237 ormation in DNA following treatment with bis-electrophiles such as nitrogen mustards and cisplatin is

238 These observations reveal that lipid electrophiles such as NO2-OA mediate antihypertensive si

239 pling of secondary boronic esters with sp(2) electrophiles (Suzuki-Miyaura reaction) is a long-standi

240 cts are found to be stronger Lewis acids and electrophiles than the free ruthenium catalyst and DIBAL

241 w (1'-fluoro)vinyl cation equivalent, and an electrophile that previously eluded synthesis, capture a

242 These include a broad class of electrophiles that activate the channel through covalent

243 Enzymes create the strong electrophiles that are needed for these highly energetic

244 a variety of pi-systems using two different electrophiles that are sequentially activated with exqui

245 of human exposures is comprised of reactive electrophiles that cannot be measured in vivo because th

246 ave also discovered lysine-reactive fragment electrophiles that inhibit enzymes by active site and al

247 These chemotypes are electrophiles that react with GSH, and LC/MS determined

248 ally, enantioconvergent couplings of racemic electrophiles-that substantially enhances the already re

249 ng the yield and enantioselectivity were the electrophile (the last reagent to be added to the reacti

250 tope labeling demonstrates that the reactive electrophile, the cyclohexyl carbenium ion, is directly

251 Addition of C- or N-based electrophiles then allows conversion into sulfones and s

252 es in organometallic cross-coupling of alkyl electrophiles, there are few stereoselective reactions o

253 on-carbon bond-forming reactions with carbon electrophiles, thereby creating new opportunities for th

254 effect cross-couplings of an array of alkyl electrophiles, thereby greatly expanding the diversity o

255 synthesized by the reaction of the bivalent electrophile thiabicyclo[3.3.1]nonane dinitrate with a s

256 to facilitate detoxification of soft organic electrophiles through covalent binding at its cysteine (

257 dition of a racemic nucleophile to a racemic electrophile; through the choice of an appropriate heter

258 (-) species can be functionalized by a silyl electrophile to generate (CP(iPr)3)Fe-N2SiR3.

259 leophile with an unactivated secondary alkyl electrophile to generate a substituted carbamate, a proc

260 iles that efficiently intercept a variety of electrophiles to afford quaternary nitriles.

261 alpha-substituted carbanions with reference electrophiles to elucidate the effects of alpha-F, alpha

262 ted isocyanides are efficiently trapped with electrophiles to generate substituted isocyanides incorp

263 lic enamine that reacts in situ with various electrophiles to give highly functionalized products.

264 eine and subsequent quench with a variety of electrophiles to give products 11-13 and 16, 17, and 21

265 foxides are able to capture nucleophiles and electrophiles to give sulfonium salts, which subsequentl

266 spite the known propensity of small-molecule electrophiles to react with numerous cysteine-active pro

267 different bioactive lipid-derived signaling electrophiles to specific proteins in cells; (2) probing

268 an ensue upon addition of several classes of electrophiles to the intermittently generated high energ

269 e, we develop a target-protein-personalized "electrophile toolbox" with which specific intracellular

270 s largely due to the fact that imines act as electrophiles towards carbon nucleophiles in reactions t

271 hydrogen bonds with the nucleophile and the electrophile, transferring a proton to the aldehyde in c

272 giodivergent (alpha- and alpha'-) lithiation-electrophile trapping of N-thiopivaloyl- and N-(tert-but

273 ting anions react smoothly with a variety of electrophiles; treatment with DBU in PhMe at room temper

274 eophilicity, enabling addition to a range of electrophiles (tropylium, benzodithiolylium, activated p

275 ))-Si cross-coupling of aliphatic C(sp(3))-I electrophiles using a Si-B reagent as the silicon pronuc

276 f terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis.

277 limitation, a caged bromomethyl ketone (BK) electrophile was developed, which shows minimal cytotoxi

278 modification of the leaving group of allylic electrophiles, we found that trisubstituted allylic phos

279 patiotemporal response of the cell milieu to electrophiles, we have designed a fluorogenic BODIPY-acr

280 e scope of cross-coupling reactions of alkyl electrophiles, we have pursued a strategy wherein the nu

281 ocene nucleophiles to racemic allylic halide electrophiles were conducted using a combination of isot

282 tive arylation of diazo compounds over other electrophiles were demonstrated.

283 onditions, a broad range of nucleophiles and electrophiles were found to participate in this transfor

284 The structures of these new electrophiles were studied by means of NMR and theoretic

285 BCl3 is an inexpensive electrophile which induces the borylative cyclization of

286 tic quantities of S-acylthiosalicylamides as electrophiles, which are rapidly intercepted by amine re

287 Amides are known to be poor electrophiles, which is typically attributed to the reso

288 a commercially available reagent to allylic electrophiles, which undergo selective copper-catalyzed

289 tate of these intermediates usually react as electrophiles, while reactions of the triplet states of

290 omplexes are consumed upon reaction with the electrophile with concomitant generation of cross-couple

291 enantioselective coupling reactions of aryl electrophiles with alpha-fluoro carbonyl compounds have

292 ly available racemic tertiary alkyl chloride electrophiles with amines to generate fully substituted

293 nd the influence of various nucleophiles and electrophiles with different degrees of fluorination.

294 c fluorination of racemic, secondary allylic electrophiles with Et3N.3HF using a chiral-diene-ligated

295 generated easily and trapped with a range of electrophiles with high enantioselectivity, providing re

296 nd [(18)F]trifluoromethylthiolation of alkyl electrophiles with in situ generated difluorocarbene in

297 -alkynylthioanisole substrate and the ClBcat electrophile, with activation parameters of DeltaG(doubl

298 investigating the site of labeling of these electrophiles within complex proteomes identified p-chlo

299 that subsequent addition of an oxidant or an electrophile would remove an electron from the aromatic

300 confined within the framework, it becomes an electrophile yielding Aldol-Tishchenko selectivity.