ライフサイエンスコーパス: electrophilic

1 athways for attacking the aromatic ring: (a) electrophilic (2e(-)) attack by a bis(mu-oxo)-diiron(IV)

2 (mu-oxo)-diiron(IV) species (Q pathway); (b) electrophilic (2e(-)) attack via the sigma* orbital of a

3 When such electrophilic activation for functionalization is not ne

4 Electrophilic activation of alkynylphosphine oxides and

5 The electrophilic activation of amides, especially by the ac

6 The electrophilic activation of double bonds in the bicyclic

7 The C-terminal electrophilic activation of peptides by alpha-thioesteri

8 Together, these observations show that more electrophilic active-oxygen species (i.e., lower-energy

9 roperoxy derivative 7'' that evolved into an electrophilic acyl azolium, opening to the aldehyde-to-e

10 rresponding carbonyl ylide resulted from the electrophilic addition of diaminocarbene to the carbonyl

11 a vinyl cation from arylglyoxal and alkyne, electrophilic addition of the vinyl cation to the ipso c

12 as synthesized using a straightforward click/electrophilic addition or click/oxidative coupling tande

13 The electrophilic addition reaction of sulfur monochloride a

14 re include (1) propargyl-cobalt complexes as electrophilic agents for C-C and C-Nu coupling; (2) the

15 mixture of a squaramide and a lipophilic and electrophilic aldehyde is shown to synergistically trans

16 al Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl m

17 s, with alpha,beta-unsaturated aldehydes and electrophilic alkenes proceed with total periselectivity

18 ions between diazo compounds, pyridines, and electrophilic alkenes to give alkaloid-inspired tetrahyd

19 Although transfer of electrophilic alkoxyl ("RO+") from organic peroxides to

20 as dienophiles in Diels-Alder reactions and electrophilic alkylating agents are described.

21 hiles offers a strategy for replacing toxic, electrophilic alkylating reagents.

22 and readily available 1,1-dibromo-1-alkenes, electrophilic alkyne precursors, are used as coupling pa

23 via selective C-N bond formation on the more electrophilic alkynyl carbon through 6-endo-dig cyclizat

24 In recent years, methods based on electrophilic alkynylation with hypervalent iodine reage

25 ngly, this strand scission process leaves an electrophilic alpha,beta-unsaturated aldehyde residue em

26 e prepared through a highly enantioselective electrophilic alpha-amination step in the presence of eu

27 ide by reaction of vinylzinc bromide with an electrophilic alpha-chloro sulfide, and last by ring-clo

28 An electrophilic amide activation of a readily available C2

29 ntly, when considering base additives during electrophilic amide activation, more hindered alpha-quat

30 d is dependent on the generation of a potent electrophilic aminating agent released by in situ deprot

31 to realize a double functionalization via an electrophilic amination followed by nucleophilic trappin

32 distinctive O-benzoylhydroxylamine-promoted electrophilic amination of alkenes.

33 flow protocol for the direct stoichiometric electrophilic amination of aromatic hydrocarbons and the

34 n and allows, for the first time, a general, electrophilic amination of boronic acids at ambient temp

35 describe a chiral phosphoric acid catalyzed electrophilic amination of enecarbamates with dibenzyl a

36 ly formation of the heterotricyclic core, an electrophilic amination, and the stereoselective hydroge

37 well-explored use of hydroxylamine esters as electrophilic amine sources in related copper-catalyzed

38 ucleophilic attack by carbonyl oxygen on the electrophilic amine to produce isoxazole products, as co

39 ease is correlated with stabilization of the electrophilic aminoacrylate intermediate.

40 n and chemically intuitive to assign cations electrophilic and anions nucleophilic reactivity, respec

41 ir molecular analogues because they are less electrophilic and dynamic, as revealed by their (13)C NM

42 depends strongly on the distance between the electrophilic and nucleophilic carbon atoms and the stru

43 Ketones possess both electrophilic and nucleophilic functionality, which allo

44 ent classes of persistent carbenes, the more electrophilic and nucleophilic ones, in particular, a cy

45 complexes with beta-diketiminate ligands in electrophilic and nucleophilic oxidation reactions is re

46 otif continues to intrigue chemists with its electrophilic and nucleophilic sites.

47 ble to quantitation of other nucleophilic or electrophilic and perhaps even more reactive metabolites

48 ) anhydride, enables the formation of highly electrophilic and reactive intermediates, lending themse

49 on states of iodine are known to be strongly electrophilic, and thus the I(-)/I2/I(+) redox processes

50 w chemical concept of "dipole-discriminating electrophilic anions."

51 esis method, compared with the conventional, electrophilic approach and in the reduced mass of admini

52 Electrophilic aromatic substitution (EAS) represents one

53 In the remaining cases, the site of electrophilic aromatic substitution can be explained by

54 te or transition state, giving rise to novel electrophilic aromatic substitution chemistry.

55 mechanism featuring the sequence of initial electrophilic aromatic substitution followed by transest

56 gh the nature of the oxidants that carry out electrophilic aromatic substitution has been deduced fro

57 Electrophilic aromatic substitution is one of the most i

58 dal position, in agreement with the proposed electrophilic aromatic substitution mechanism.

59 ther or when the reaction is intermolecular, electrophilic aromatic substitution occurs instead of C-

60 The electrophilic aromatic substitution of a C-H bond of ben

61 yphenylacetic acid) which reacts with MGO by electrophilic aromatic substitution of the ortho-dipheny

62 with concomitant loss of water, to a formal electrophilic aromatic substitution of the ortho-positio

63 Here we perform an abiotic electrophilic aromatic substitution reaction, which is d

64 gement and subsequent 6-exo-trig cyclization/electrophilic aromatic substitution reaction.

65 s and underscore the importance of including electrophilic aromatic substitution reactions in atmosph

66 culated NMR shifts to predict the outcome of electrophilic aromatic substitution reactions on differe

67 A counterintuitive approach to electrophilic aromatic substitution with silicon electro

68 ryptophan synthases, which direct biological electrophilic aromatic substitutions by preorganizing di

69 roup has only a small effect on the rates of electrophilic aromatic substitutions.

70 rings can be exploited to precisely control electrophilic aromatic substitutions.

71 indicates that (phosphino)phosphinidenes are electrophilic as expected for an electron-deficient spec

72 of three catalysts with the kinetics of the electrophilic attack and reveal the significance of CH-p

73 lized "sophomore textbook" image of stepwise electrophilic attack on the alkene and subsequent nucleo

74 ssential step in the mechanism that makes an electrophilic attack on the olefin bond possible as the

75 ic addition partner activates the alkene for electrophilic attack.

76 he cysteine is reactive and is accessible to electrophilic attack; cysteine S-thiosulfonate is formed

77 is a superior and safe alternative to other electrophilic azide reagents in use today.

78 y an intermolecular C-N bond formation using electrophilic azidoiodinane.

79 renes (2, 9, and 12) react with the strongly electrophilic borane B(C6F5)3 in consecutive 1,1-carbobo

80 st example of a boryl-Heck reaction using an electrophilic boron reagent.

81 resence of a commercially available external electrophilic boron source (B-chlorocatecholborane) in g

82 We also show for the first time that an electrophilic borylene such as 1 can react with N2 rever

83 nyl scaffold via successive nucleophilic and electrophilic bromination of the 2-oxidocyclopentenyl ca

84 This reagent behaves both as an electrophilic bromine source as well as amine to react w

85 Taken together the data fully support an electrophilic C-F hydroxylation mechanism.

86 ) boronate esters are readily synthesized by electrophilic C-H borylation producing bench stable crys

87 nts are used for sequential nucleophilic and electrophilic C-N bond formations, with the latter effec

88 4+1]-cycloaddition between diazooxindoles as electrophilic C1 synthons and 1,3-heterodienes for the c

89 nation, the pentacyclic core was accessed by electrophilic C19-amide activation and transannular spir

90 tional reactions, such as methyl transfer to electrophilic carbon atoms, sulfur to Calpha atom thioet

91 containing a nucleophilic nitrogen atom and electrophilic carbonyl group provided some initial evide

92 ves, a useful strategy for enantioselective, electrophilic catalysis, generally leads to a lower leve

93 ligands can be exploited for the purpose of electrophilic catalysis.

94 With the view of developing self-activating electrophilic catalysts, we are now investigating comple

95 Dianion [1](2-) shows both nucleophilic and electrophilic catalytic reactivity upon activation of O2

96 ctron-rich NacNac patterns for taming highly electrophilic centers are showcased.

97 inetics, consistent with the presence of two electrophilic centers in NO2-CLA located on the beta- an

98 h molecular orbital analysis, which suggests electrophilic character at the nitride functionality.

99 clobutenones, can display radical, anion, or electrophilic character because of the existence of an o

100 nally simple approach takes advantage of the electrophilic character of an oxidized selenocysteine (S

101 similar effect was achieved by changing the electrophilic character of the para-substituent of the s

102 gations is the development of catalysts with electrophilic character that transfer electrophilicity t

103 The respective nucleophilic and electrophilic characters of the participant anion radica

104 two-electron oxidation of chloride anions to electrophilic chlorine species reacting with arenes in a

105 he presence of bifunctional units comprising electrophilic chloroquinoline and electron-rich carbazol

106 proceeds via the Pd(II)/Pd(II) redox-neutral electrophilic cleavage (EC) pathway for all studied subs

107 (E=S, Se) dianion, which can be reacted with electrophilic [ClP(mu-NR)]2 to give P(III) /P(V) hexamer

108 ethod to monitor the metabolic regulation of electrophilic cofactors and discover novel types of elec

109 (i.e., N-sulfinyl metallodienamine) and the electrophilic component (i.e., Michael acceptor).

110 et al. identified Rpn13 as the target of an electrophilic compound (RA-190) that was selectively tox

111 hese results reveal a mechanism involving an electrophilic Compound I species that reacts with nucleo

112 are functional because they responded to the electrophilic compounds allyl isothiocyanate and cinnama

113 An additional role for OxyR in detecting electrophilic compounds is possible.

114 ication of KEAP1 cysteine residues, but such electrophilic compounds lack selectivity and may be asso

115 an enzyme that catalyzes the conjugation of electrophilic compounds with glutathione to facilitate t

116 forms covalent bonds between GSH and various electrophilic compounds, through covalent adduct formati

117 -Hiyama-Kishi reaction involving a ketone as electrophilic coupling partner was developed.

118 yl iodides were found to be a more efficient electrophilic coupling partner.

119 s occurs to access a uniquely effective acyl electrophilic coupling partner.

120 example of the use of phenol derivatives as electrophilic coupling partners in photoredox/nickel dua

121 ds and alkyl halides as the nucleophilic and electrophilic coupling partners, respectively.

122 employ unactivated tertiary alkyl halides as electrophilic coupling partners, which is still relative

123 N-alkylamides and N-alkylphthalimides to the electrophilic cumyloxyl radical (CumO(*)) has been carri

124 hydroxyflavone, is chemically masked with an electrophilic cyanate motif in order to construct a fluo

125 Employing the electrophilic cyanating reagent N-cyano-N-phenyl-p-tolue

126 An electrophilic cyanation of aryl Grignard or lithium reag

127 This rhodium-catalyzed electrophilic cyanation presents a novel approach to pre

128 inolines and azido-iodo-pyranoquinolines via electrophilic cyclization of o-alkynylaldehydes in the p

129 d by another molecule of nitrile followed by electrophilic cyclization to deliver the desired product

130 induced activation of the alkyne followed by electrophilic cyclization, as opposed to S-B sigma bond

131 ts new role as an alkynophilic Lewis acid in electrophilic cyclization/dealkylation reactions.

132 Nucleophilic and electrophilic cycloadditions to La2@C80 were experimenta

133 The angular methyl groups were attached by electrophilic cyclopropanation-ring opening.

134 propane hydrolase activity that converts the electrophilic cyclopropane of the colibactins into an in

135 tiated by an unconventional copper-catalyzed electrophilic dearomatization, this process features reg

136 , not being subject to tunneling, retains an electrophilic-dependent reactivity trend, as revealed ex

137 sphirene (1) was prepared by treatment of an electrophilic diamidocarbene with tert-butylphosphaalkyn

138 ion of chlorine gas followed by Cl2-mediated electrophilic dichlorination.

139 These electrophilic difluorocarbenes were shown to undergo ins

140 oups 1 and 17, resulting in nucleophilic and electrophilic disila vinyl groups, respectively, are the

141 e, the inactive analog of DMF that lacks the electrophilic double bond of fumarate, is unable to inhi

142 Examples of electrophilic drugs include covalent kinase inhibitors t

143 an approach to confer kinetic selectivity to electrophilic drugs.

144 t umpolung via N-oxide addition generates an electrophilic enolonium species that can be coupled with

145 Herein, the anti-neoplastic effects of the electrophilic fatty acid nitroalkene derivative, 10-nitr

146 These observations reveal that electrophilic fatty acid nitroalkenes react with more al

147 Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammato

148 D and provides new insights into the role of electrophilic fatty acids in the control of cutaneous im

149 ical withCH)(eta(5) -C5 Me5 )(dppe)] with an electrophilic fluorinating agent (NFSI) results in the f

150 as nucleophiles, with Selectfluor II as the electrophilic fluorinating agent, to afford alkylfluorid

151 ruthenium via an unprecedented outer-sphere electrophilic fluorination mechanism.

152 s of alpha-fluoro-beta-ketosulfides using an electrophilic fluorination method has been reported for

153 The reaction proceeds via an electrophilic fluorination of alpha-sulfenyl-beta-diketo

154 these new mesoionic compounds was granted by electrophilic fluorination of sigma-sydnone Pd(II) precu

155 Electrophilic fluorination of the beta-ketosulfonamides

156 Further electrophilic fluorination of this species yields the di

157 to that obtained with established asymmetric electrophilic fluorination protocols.

158 age of a highly efficient diastereoselective electrophilic fluorination reaction (94% yield; >50:1 dr

159 pared in five steps via a one-pot lithiation-electrophilic fluorination strategy.

160 nally designed imidazole derivatives through electrophilic fluorination with N-fluorobenzenesulfonimi

161 hthalein (cresol purple) were synthesized by electrophilic fluorination.

162 The use of electrophilic fluorine sources enabled new modes of gold

163 , and tricyclic compounds containing 3 as an electrophilic fragment and evaluated them as activators

164 onclusion, we demonstrate that 3 is a useful electrophilic fragment for exploring reversible covalent

165 s of monoaryl acetate derivatives containing electrophilic functional groups that are incompatible wi

166 xploited the reactivity of novel unsaturated electrophilic functions such as vinyl-sulfones, -ketones

167 ndings demonstrate that metabolically labile electrophilic groups can endow covalent drugs with kinet

168 Electrophilic groups that target amino-acid nucleophiles

169 (XB), the noncovalent interaction between an electrophilic halogen atom and a Lewis base, with highly

170 ssically, this reaction is performed with an electrophilic halogen source and leads to regioselective

171 hat contain nonafluoro-tert-butyl groups and electrophilic handles, mostly acrylates and acrylamides.

172 a cyclopropanation mechanism mediated by an electrophilic, heme-bound carbene species and a model is

173 he consistency between trends in Fukui-based electrophilic indices and the experimental profiles of c

174 n pairs, have been synthesized by the direct electrophilic insertion of a {Cp*Ru(+) } fragment into t

175 7) which Fukui analysis shows to proceed via electrophilic insertion of the nitride into the Si-H bon

176 e)-1,13,2,9-closo-Ru2 C2 B10 H11 ] by direct electrophilic insertion, promoted by the carborane subst

177 major line of defense to combat oxidative or electrophilic insults.

178 ons suppress the decomposition of the active electrophilic intermediate, an amino-acrylate, which aid

179 nd mechanistic studies suggest a short-lived electrophilic intermediate, which is likely to be PhINH

180 Radiolabeling was achieved via standard electrophilic iododestannylation in 60-90% radiochemical

181 terms of a novel mechanism called "concerted electrophilic ipso-substitution" (CEIS) in which the gol

182 Mechanistic investigations support that an electrophilic iron carbene mediates homolytic C-H cleava

183 Biliatresone is an electrophilic isoflavone isolated from Dysphania species

184 for both cannabinoid receptors, namely, the electrophilic isothiocyanate AM994 and the photoactivata

185 These substituents included the electrophilic isothiocyanate and photoactivatable azido

186 M4NC ratios cannot unambiguously confirm the electrophilic mechanism as the exclusive formation pathw

187 or 15PGDH, resulting in the formation of its electrophilic metabolite, 14-oxoDHA.

188 ch functionalized the aromatic C-H bonds via electrophilic metalation followed by concomitant intramo

189 ycloaddition reactions of enecarbamates with electrophilic metalloenolcarbenes in high yield with up

190 molecule-signal- and protein-target-specific electrophilic modifications in an otherwise unaffected c

191 nt (ARE) signaling is activated by selective electrophilic modifications on Keap1 protein, one of sev

192 philic cofactors and discover novel types of electrophilic modifications on proteins in human cells.

193 ether 1 which contains both nucleophilic and electrophilic moieties.

194 dium(II) species with O2 to produce a highly electrophilic monomethyl Pd(IV) transient that is involv

195 In the same pot, addition of electrophilic N, S, or P reagents and a copper(I) cataly

196 h is triggered by oxidative initiation at an electrophilic N-based component and employs "standard" o

197 AalphaC undergoes bioactivation to form electrophilic N-oxidized metabolites that react with DNA

198 uctome and potential biomarker applications, electrophilic N-terminus functionalization is likely to

199 very low yields with the corresponding less electrophilic N-tert-butanesulfinyl derivative.

200 The electrophilic nature of CLAmP enables the addition of le

201 e demonstrated that, by virtue of the strong electrophilic nature of S-adenosyl-l-methionine, the tra

202 The electrophilic nature of the [B12 Cl11 ](-) anion is conf

203 The success of this pathway is due to the electrophilic nature of the Cp ligand in the cation, [OR

204 biosilica was partially quenched due to the electrophilic nature of the nitro (-NO2) groups on the T

205 -), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO2 -FAs), such as nitr

206 ron-donating substituents that yields a less electrophilic nitrogen atom and a decreased amount of cy

207 ces with diacetoxyiodobenzene to generate an electrophilic nitrogen center.

208 eductant, and O-benzoylhydroxylamines as the electrophilic nitrogen source.

209 resembles a loosely bound complex between an electrophilic nitrosyl bromide (BrNO) molecule and an el

210 proved safety profiles compared to the known electrophilic Nrf2 inducers.

211 Either an electrophilic or a photoactivatable group was introduced

212 to transient allylmetal species that display electrophilic or nucleophilic properties.

213 ddition (1,3-DC), original methods including electrophilic or palladium-mediated cyclization of unsat

214 m-based pinacolatoboryl nucleophile with the electrophilic organoboranes, 9-BBN and Ph3 B, provide fa

215 intermediate to be ambiphilic, acting as an electrophilic oxidant in the initial N-hydroxylation of

216 idence is provided that reactions involve an electrophilic oxidant, and this element is employed in p

217 osts accumulate lipid bodies (LB) containing electrophilic oxidatively truncated (ox-tr) lipids.

218 The deuterium labeling studies supports electrophilic palladation of aromatic C-H over activatio

219 The electrophilic palladium salt Pd(CH3CN)4(BF4)2 was effect

220 hydrogen bonding (HB) a nucleophilic and an electrophilic partner form a new bond that is based on a

221 ted that the iminium ion intermediate is the electrophilic partner.

222 and acyclic allylic carbonates are competent electrophilic partners furnishing the products in excell

223 of sulfur intermediates as nucleophilic and electrophilic partners in total synthesis is elegantly d

224 tion using trifluoroacetimidoyl chlorides as electrophilic partners.

225 recapitulates that observed from whole-cell electrophilic perturbation.

226 ns (PGs) inhibited the enzyme, including non-electrophilic PGE1 and PGE2, currently used in clinical

227 brary of compounds containing redox-directed electrophilic pharmacophores employing the Stress & Toxi

228 of pinacolborane through addition across the electrophilic phosphorus and nucleophilic N-methylanilid

229 rates through a range of interactions (e.g., electrophilic pi-allyl complex formation, Lewis acid act

230 most nucleophilic (sigma donating) and also electrophilic (pi-accepting) stable carbenes known to da

231 g their superior dienophilic, enophilic, and electrophilic power.

232 he side chains of serine and cysteine, using electrophilic probes.

233 '-(2-phosphoryl-1,4-dioxobutane) (DOB) is an electrophilic product of the C5'-radical.

234 formation of chemically diverse reactive and electrophilic products provides a novel paradigm for und

235 rgets the same cysteine residue and that our electrophilic quinazolines modulate the function of V-AT

236 Some of the electrophilic quinazolines selectively and potently inhi

237 We have discovered electrophilic quinazolines that covalently modify a solu

238 We synthesized and characterized a series of electrophilic quinazolines to target this unique, reacti

239 s, deactivating these bonds toward HAT to an electrophilic radical such as CumO(*), indicating that c

240 re found between the experimentally observed electrophilic reactivities of 44 Michael acceptors and t

241 In order to quantify the electrophilic reactivities of common Michael acceptors,

242 echanisms and to elucidate the origin of the electrophilic reactivities.

243 the method of choice for a rapid estimate of electrophilic reactivities.

244 position of the enamide moiety endows unique electrophilic reactivity.

245 tion reaction using substrate 2 as a 1,3-bis-electrophilic reagent.

246 roxyl group derivatization with a variety of electrophilic reagents are discussed.

247 extension (SHAPE) chemistries exploit small electrophilic reagents that react with 2'-hydroxyl group

248 heterocycles are easily functionalized using electrophilic reagents, enabling divergent access to var

249 that we have observed with many traditional electrophilic reagents.

250 e of a net attractive interaction between an electrophilic region associated with a halogen atom in a

251 ble selectivity for C(sp(3))-centers with an electrophilic SCF3 source and pivalic acid as an additiv

252 sition-metal catalyst, instead proceeding by electrophilic selenation or iodination of a vinyl borona

253 nge of hydrosilation mechanisms that feature electrophilic silicon centers.

254 Additionally, other electrophilic silicon species, such as silylene complexe

255 oyed as a well-defined scaffold for a highly electrophilic single-site d(0) Zr-benzyl catalytic cente

256 s and post-functionalization to introduce an electrophilic site at the 3' end of tRNA analogues.

257 e use of ES(r), one can identify the various electrophilic sites within a molecule and correctly pred

258 Electrophilic small molecules are an important class of

259 onal sites and can frequently be targeted by electrophilic small molecules.

260 Metabolic activation of drugs to electrophilic species is responsible for over 60% of bla

261 visible light, probably due to formation of electrophilic species such as QMs.

262 These highly electrophilic species undergo polarized radical addition

263 Quinones are electrophilic species which can react with various nucle

264 1,n-enynes catalyzed by gold(I) proceed via electrophilic species with a highly distorted cyclopropy

265 As electrophilic species, they could also play the role of

266 The electrophilic spiroepoxide intermediate formed a stable

267 ytoprotective genes in response to oxidative/electrophilic stress.

268 al mediator of defense against oxidative and electrophilic stress.

269 eries of novel adenosine derivatives bearing electrophilic substituents was synthesized, and four com

270 omine (HOBr) was found to react with DOM via electrophilic substitution (</=40%), forming AOBr, and t

271 gated terminal alkyne toward Lewis-activated electrophilic substitution and led to the isolation of F

272 investigate the importance of aqueous-phase electrophilic substitution of 3-methylcatechol with nitr

273 conventional synthesis method, involving an electrophilic substitution of a trialkylstannane precurs

274 ns as well as provide new strategies for the electrophilic substitution of aromatic rings.

275 The chlorination pathway of electrophilic substitution of Cl at the ortho or para po

276 The key step involves the BF3-mediated electrophilic substitution of indoles with N-alkyl-subst

277 led) by chlorine to HOBr, leading to further electrophilic substitution of unaltered DOM sites and ch

278 the chiral forms were monofunctionalized via electrophilic substitution on the carbazole unit.

279 alkylethenes were generated by a sequence of electrophilic substitution, 1,2-metalate rearrangement,

280 e suggests the formation of these species by electrophilic substitution.

281 xidative addition of a nickel complex to the electrophilic substrate.

282 acidic and therefore require highly reactive electrophilic substrates to be effective.

283 nantioselective, cyclization of phenols with electrophilic sulfenophthalimides onto isolated or conju

284 tones examined here reacted readily with the electrophilic sulfur center in the sulfenyl amide residu

285 n anchors the organometallic proximal to the electrophilic, tetrasubstituted sulfone to override comp

286 ly activating the alkyne, despite being less electrophilic than other known alkyne-activating reagent

287 bond models, which confirm a change from an electrophilic to a nucleophilic mechanism through a chan

288 The latter reactions typically proceed by electrophilic transamination and/or addition-elimination

289 cid derivatives has been developed employing electrophilic transannular cyclizations of 8-, 9-, and 1

290 Weiss diketone by simultaneous deprotonation/electrophilic trapping of both oxo functions, and the ca

291 des has been developed by using a lithiation/electrophilic trapping sequence.

292 axial-ligand, and this reverses the natural electrophilic trend, as revealed through calculations wi

293 theses of popular nucleophilic, radical, and electrophilic trifluoromethylation reagents with complet

294 a new approach to easily and safely perform electrophilic trifluoromethylselenolation starting from

295 and in the presence of CuCl can be used for electrophilic trifluoromethylthiolation of indoles, pyrr

296 The key advantage of the electrophilic tris(carboxylato) bismuth(III) compounds i

297 that JWU-A021 is one of the most potent non-electrophilic TRPA-1 channel agonists yet to be reported

298 Anionic amphiphiles, U73343 (a less electrophilic U73122 analogue) and a range of kinase inh

299 relevant conditions via isomerization to an electrophilic vinyl sulfone.

300 inding ligands with appropriately positioned electrophilic warheads.