ライフサイエンスコーパス: electrophilicity

1 y may be primarily attributed to an enhanced electrophilicity.

2 suggested the possibility of boron-centered electrophilicity.

3 unusual methylation substrates due to their electrophilicity.

4 , one with greater and the other with lesser electrophilicity.

5 ules by virtue of their dual nucleophilicity/electrophilicity.

6 the driving force to obtain increased alkyl electrophilicity.

7 e poles of three helices, for increasing its electrophilicity.

8 anine, effects did not correlate at all with electrophilicities.

9 d phenyl propargyl alcohols having different electrophilicities.

10 To enhance the carbonyl electrophilicity, an alpha-difluorinated analogue (R = H

11 lpropenoyl)oxazolidin-2-ones, featuring high electrophilicity and conformational homogeneity, are syn

12 shift values; it also leads to an increased electrophilicity and higher reactivity for catalysts up

13 ic and electronic factors that influence the electrophilicity and reversibility of Michael acceptors.

14 plet to singlet intersystem crossing and the electrophilicity) and on the medium (formation of a comp

15 arity/polarizability, hydrogen-bond acidity (electrophilicity), and hydrogen-bond basicity (nucleophi

16 rd halogen bond formation by enhancing their electrophilicity, and explain the absence of M-Cl...F-C

17 nslates to coordination distortion, may tune electrophilicity, and hence, reactivity.

18 ion in reactivity reflects the difference in electrophilicity between the various rhodium carbenoid i

19 Electrophilicity can be conferred by both enzymatic and

20 zhydrylium ions are on the same log k2 vs E (electrophilicity) correlation shows that both reaction s

21 A local multiorbital electrophilicity descriptor, the local electron attachme

22 humol also increased respiration, suggesting electrophilicity did not play a role.

23 otocyclization, consistent with the enhanced electrophilicity displayed by the ring-closed form.

24 While electrophilicities E correlate poorly with the LUMO ener

25 2) were found to correlate linearly with the electrophilicities E of the reference electrophiles, as

26 efficiencies were found to increase with the electrophilicity (EA) of the radical.

27 n = 3 (1.16), supporting the hypothesis that electrophilicity increases concomitantly with substituti

28 The computed natural charges reveal that electrophilicity increases upon both annelation and carb

29 e as the carbene stability decreases and its electrophilicity increases, and also as alkene reactivit

30 oorly with the LUMO energies and with Parr's electrophilicity index omega, good correlations were fou

31 died by evaluating their nucleophilicity and electrophilicity indices.

32 en discussed in terms of nucleophilicity and electrophilicity indices.

33 ophiles and the measured rate constants, the electrophilicities of the indol-3-ylmethylium ions 3(a-k

34 re enzyme catalysis, but rather exploits the electrophilicity of 1,3-BPG, was found by proteomic prof

35 nditions, consistent with an increase in the electrophilicity of a high-valent iron-oxo intermediate

36 Not all PLP enzymes require the electrophilicity of a protonated pyridine ring to enable

37 We found that the electrophilicity of AdoMet and its onium congeners follo

38 Both approaches capitalize on the electrophilicity of alpha-sulfonyl radicals and their pr

39 sess the primary coordination sphere and the electrophilicity of alphaKG.

40 ation of Ni (OH)2 to NiOOH by increasing the electrophilicity of catalytic interface.

41 ucleophilicity of the starting arene and the electrophilicity of cationic intermediates generated fro

42 By exploiting the inherent electrophilicity of diaryliodonium salts, we have found

43 The observed reactivity is opposite to the electrophilicity of polar carbonyl groups resulting from

44 s that MtbB and MttB may exploit the unusual electrophilicity of pyrrolysine during catalysis.

45 er surface can affect the reactive sites and electrophilicity of SO2.

46 reduction are positively correlated with the electrophilicity of the active site pyrazine unit and ca

47 cs over distinct time domains by varying the electrophilicity of the acylating reagent.

48 iazeniumdiolate group greatly suppresses the electrophilicity of the adjacent C horizontal lineN carb

49 The trifluoromethyl group increased the electrophilicity of the adjacent carbonyl group and decr

50 oselectivity observed is a result of greater electrophilicity of the alpha-keto ester toward the Bres

51 through ring strain, salicylates reduce the electrophilicity of the aryl ester through an intramolec

52 ctroscopy provides no evidence for increased electrophilicity of the beta-vinyl carbons (the presumed

53 f the imidazole component that increases the electrophilicity of the C-2 position on the imidazole.

54 ture/activity relationships suggest that the electrophilicity of the C2-C3 olefin is critical for the

55 is structural modification leads to enhanced electrophilicity of the carbene center with retention of

56 The electrophilicity of the carbonyl group in the resulting

57 red to as the "axial gateway", maintains the electrophilicity of the catalyst by shielding the reacti

58 ridinyl nitrogen of the PLP, influencing the electrophilicity of the cofactor.

59 , O-transfer-reactivity follows the relative electrophilicity of the complexes, whereas the correspon

60 n contrast to penicillin, which enhances the electrophilicity of the cyclic amide through ring strain

61 We show that the electrophilicity of the diazofluorene appears to be a si

62 t in choline oxidase, His(466) modulates the electrophilicity of the enzyme-bound flavin and the pola

63 flavinylation of the protein, the decreased electrophilicity of the flavin, and the consequent loss

64 Due to the electrophilicity of the fluorinated amide, this palladiu

65 uction in activity is due to the decrease in electrophilicity of the FMN.

66 hetic study with different nucleophiles, the electrophilicity of the intermediate iminium ion was est

67 finding was explained in terms of the higher electrophilicity of the iron center and the higher avail

68 Electrophilicity of the ligand-binding Mg ion is increas

69 This effect increases electrophilicity of the metal and lowers the calculated

70 This protonation enhances the electrophilicity of the methyl group, in agreement with

71 These data suggest that the two-electron electrophilicity of the Mn(O) valence tautomers dominate

72 adical to damage dipeptides increases as the electrophilicity of the phenyl radical increases.

73 However, the high electrophilicity of the phosphorus center has so far pre

74 entatives has been attributed to the extreme electrophilicity of the putative C-NacNac adducts.

75 f the radicals studied was determined by the electrophilicity of the radical, which can be characteri

76 A systematic increase in the electrophilicity of the radicals by modification of the

77 The electrophilicity of the radicals does not appear to have

78 strongly dependent on both the polarity and electrophilicity of the solvent and (ii) solvatochromic

79 oordination number and polarity may tune the electrophilicity of zinc.

80 The critical role of the carbene electrophilicity on the outcome of reactions is discusse

81 The higher the electrophilicity (or EA) of the radical, the greater the

82 allowed for the quantification of benzyne's electrophilicity parameter.

83 cted to a correlation analysis to derive the electrophilicity parameters E for acceptor-substituted b

84 N) allowed us to calculate 15 new empirical electrophilicity parameters E for Michael acceptors 1 an

85 the diffusion-clock method and also provides electrophilicity parameters E for other substituted aryn

86 nzhydrylium ions correlate linearly with the electrophilicity parameters E of the benzhydrylium ions

87 in CH3CN solution and used to determine the electrophilicity parameters E of the cations defined by

88 termined in this work were combined with the electrophilicity parameters E of the corresponding catio

89 It was, therefore, possible to calculate the electrophilicity parameters E of the different positions

90 fferent quinones correlate linearly with the electrophilicity parameters E of the quinones, which hav

91 d from the linear plots of log k2 versus the electrophilicity parameters E of these reference electro

92 The electrophilicity parameters E thus determined can be use

93 With electrophilicity parameters from E = -10.69 (Ar = p-MeOC

94 Despite that electrophilicity parameters have now been established fo

95 It is proposed that modulation of cofactor electrophilicity plays a central role in controlling rea

96 Group nucleophilicity and electrophilicity profiles help describe the bond-breakin

97 The radicals' different electrophilicities result in variations in the reaction

98 alyst generates an iminium ion of sufficient electrophilicity to enable 1,2-attack by an alcohol.

99 s with electrophilic character that transfer electrophilicity to silicon by Si-H activation.

100 QMs' spectroscopic properties and electrophilicity were both significantly affected by bet

101 Six reactive groups with modulated electrophilicity were combined with 11 nonreactive moiet

102 idifying effect on peptide backbones and its electrophilicity which allows site-specific thiol ligati