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1                                                             Eligible patients had a clinical diagnosis of achondroplasia,
2                                                             Eligible patients had a confirmed acute hepatic porphyria dia
3                                                             Eligible patients had a documented mIDH1 tumour based on loca
4                                                             Eligible patients had a haematological malignancy (leukaemia,
5                                                             Eligible patients had a National Early Warning score of 2 poi
6                                                             Eligible patients had a streptococcal PJI that was managed wi
7                                                             Eligible patients had a urinary albumin-to-creatinine ratio (
8                                                             Eligible patients had active ankylosing spondylitis, fulfille
9                                                             Eligible patients had adequate end-organ function, an Eastern
10                                                             Eligible patients had an Eastern Cooperative Oncology Group p
11                                                             Eligible patients had atrial fibrillation, CHA(2)DS(2)-VASc (
12                                                             Eligible patients had been enrolled at one centre in the AURA
13                                                             Eligible patients had biopsy-proven oesophageal cancer that w
14                                                             Eligible patients had clinical onset after age 18 years, 36 o
15                                                             Eligible patients had CLL, were previously treated, were aged
16                                                             Eligible patients had confirmed colonic disease with duration
17                                                             Eligible patients had Eastern Cooperative Oncology Group perf
18                                                             Eligible patients had FIP1L1-PDGFRA-negative HES, experienced
19                                                             Eligible patients had had laboratory-confirmed EVD and had th
20                                                             Eligible patients had hematologic malignancies treatable by a
21                                                             Eligible patients had HER2-positive advanced gastric cancer a
22                                                             Eligible patients had histologically confirmed localised pros
23                                                             Eligible patients had histologically confirmed relapsed or re
24                                                             Eligible patients had HIV-1 RNA concentrations of at least 10
25                                                             Eligible patients had IVT started within 4.5 hours of stroke
26                                                             Eligible patients had Lansky (if aged <=16 years) or Karnofsk
27                                                             Eligible patients had MBC with measurable disease and germlin
28                                                             Eligible patients had measurable disease (per RECIST version
29                                                             Eligible patients had measurable or evaluable non-measurable
30                                                             Eligible patients had metastatic prostate cancer and a PSA le
31                                                             Eligible patients had metastatic renal cell carcinoma (RCC),
32                                                             Eligible patients had moderate-to-very-severe COPD and at lea
33                                                             Eligible patients had multiple myeloma and had relapsed or we
34                                                             Eligible patients had newly diagnosed glioblastoma confirmed
35                                                             Eligible patients had non-cystic fibrosis bronchiectasis, had
36                                                             Eligible patients had previously untreated acute myeloid leuk
37                                                             Eligible patients had previously untreated, histologically co
38                                                             Eligible patients had progressed on or after, or been intoler
39                                                             Eligible patients had recurrent measurable LGSOC after >= 1 p
40                                                             Eligible patients had submassive or massive pulmonary embolis
41                                                             Eligible patients had to have completed the SIROCCO or CALIMA
42                                                             Eligible patients had two functioning kidneys and a preoperat
43                                                             Eligible patients had untreated chronic lymphocytic leukaemia
44       Of the 331 patients enrolled during 2005 to 2010, 321 eligible patients had central histopathologic review.
45                                               Additionally, eligible patients had at least one of the following within th
46                                        Patients and Methods Eligible patients had locally advanced or metastatic ccRCC th
47                              For the dose-escalation phase, eligible patients had histologically or cytologically confirm
48                        For the basket dose-expansion phase, eligible patients had advanced or metastatic solid tumours or
49    All patients were tested for CFTR genotype at screening; eligible patients had to have the F508del-CFTR mutation on bo
50 double-blind, parallel-group, randomised, controlled trial, eligible patients had COPD, post-bronchodilator forced expira