ライフサイエンスコーパス: elimination

1 we call DISE (death induced by survival gene elimination).

2 kidney-injury had strongest impact on DY-654 elimination.

3 ng-term treatment of lung cancer through TIC elimination.

4 he regression was performed without variable elimination.

5 and a carbon-halogen bond-forming reductive elimination.

6 d eliminated spines, indicative of a synapse elimination.

7 ation of beneficial microbes and in pathogen elimination.

8 chromatin in the break regions prior to DNA elimination.

9 f senescent cells enables their preferential elimination.

10 ectively via ring opening followed by proton elimination.

11 A has been pursuing the goal of tuberculosis elimination.

12 iagnosis and access to care preclude disease elimination.

13 mplex followed by stereospecific syn or anti elimination.

14 ran Africa and keep areas malaria-free after elimination.

15 e to significant reductions in beta-hydrogen elimination.

16 Personal View we explore next steps towards elimination.

17 ollowed by migratory insertion and reductive elimination.

18 ological inhibitors led to striking podosome elimination.

19 might produce superior tumour reduction and elimination.

20 s vital for Africa as she marches on towards elimination.

21 omplex, 1,2-metalate rearrangement, and beta-elimination.

22 hydroxylation step occurs prior to chloride elimination.

23 called RGIFE: Rank Guided Iterative Feature Elimination.

24 ermally induced (70-90 degrees C) anthracene elimination.

25 en great progress towards disease control or elimination.

26 was the preferred nucleophile for acrylamide elimination.

27 btained by an SVM based on recursive feature elimination.

28 a rapid distribution followed by first-order elimination.

29 c which contributed to synapse silencing and elimination.

30 g how they can support the drive for malaria elimination.

31 gnals, and discuss consequences for pathogen elimination.

32 on, the goal is now to drive malaria towards elimination.

33 in reductive ring opening and hydroxy-group elimination.

34 ilic addition; and solvent-assisted methanol elimination.

35 available for either alpha- or beta-hydride elimination.

36 -PyC3A injection to monitor distribution and elimination.

37 lls to surface antigens for subsequent tumor elimination.

38 effective to inhibit undesired beta-hydrogen elimination.

39 ctly delivers the intermediate for reductive elimination.

40 ies will need to be navigated on the path to elimination.

41 mitochondria-targeted endonuclease, retarded elimination [8].

42 his approach is an epimerization of C5 by an elimination-addition sequence leading to l-ido disacchar

43 gion, which has motivated a regional malaria elimination agenda.

44 complexes, this suppression of beta-hydrogen elimination allows for the direct polymerization of ethy

45 stepwise catalyzed degradation and eventual elimination along the mercapturic acid pathway.

46 es, will facilitate progress towards measles elimination and eradication.

47 evalence and low-intensity areas approaching elimination and in monitoring where disease emergence or

48 omising intervention for malaria control and elimination and long-term prevention of reintroduction.

49 At this point elimination and rearomatization occurs with neopentyl bo

50 knowledge of metabolic pathways, kinetics of elimination and tissue distribution.

51 and development agenda to accelerate malaria elimination and, in the longer term, transform the malar

52 vity), S84A (good kcat but high Km for l-THA elimination), and S84N mutants (nearly WT efficiency for

53 r innovation to achieve these goals, sustain elimination, and free the world of malaria is greater th

54 time of EVR introduction, CNI reduction and elimination, and risk for graft rejection; (C) antiproli

55 statistical model in which bouton addition, elimination, and size changes are described probabilisti

56 ung cells, which are the primary site of CO2 elimination, are incompletely understood.

57 C (5.88 +/- 12.60 kg, P = 0.056) and the TAC elimination arms (4.76 +/- 9.94 kg, P = 0.007).

58 It is targeted for global elimination as a public health problem.

59 ancial commitment for the success of malaria elimination as ultimate goal.

60 e products derive from facile alpha-fluoride elimination at the 3-coordinate Pd(II) complex.

61 ity refine cortical circuits through synapse elimination, but little is known about the activity patt

62 Prevention is the holy grail of cancer elimination, but making this a reality will take a funda

63 ected cells enhanced their susceptibility to elimination by ADCC.

64 ngly suggest that PSR causes paternal genome elimination by disrupting at least three histone marks f

65 llowing fertilization, while PSR avoids self-elimination by evading two of these marks.

66 , epithelial tumors were more susceptible to elimination by immunotherapy than corresponding mesenchy

67 requirements for dynamic instability and its elimination by MTAs have yet to be defined.

68 which likewise undergoes redox-mediated Kemp elimination by P450-BM3.

69 AES elimination by radiofrequency ablation results in ECG no

70 Thus, Abeta oligomer elimination by RD2 treatment may be also beneficial for

71 cells and to escape from the recognition and elimination by the reticuloendothelial system.

72 ticular how HIV-infected cells escape immune elimination by the TRAIL:TRAILshort receptor axis.

73 protects healthy mitochondrial domains from elimination by unchecked PINK1-Parkin activity.

74 nce and the impact of visceral leishmaniasis elimination campaigns.Parasitemia has been considered th

75 vesicles fusion-competent, and their genetic elimination causes a complete block of synaptic transmis

76 o the health system was critical for meeting elimination criteria of blinding trachoma.

77 The feasibility of elimination crucially depends on the effects of multiple

78 oscopies limit the implementation of empiric elimination diets in patients with eosinophilic esophagi

79 that IMP2 overexpression stimulates and IMP2 elimination diminishes proliferation by 50-80%.

80 S84N mutants (nearly WT efficiency for l-Ser elimination) displayed intermediate activity, all showin

81 may contribute significantly to the hydrogen elimination dissociative ionization yield.

82 able for three-dimensional locomotion, their elimination dramatically decreases the frequency of cell

83 surgery are undermining the global trachoma elimination effort.

84 transmission models to inform onchocerciasis elimination efforts in Africa and residual foci in Latin

85 would represent a serious threat to malaria elimination efforts.

86 be prioritized alongside congenital syphilis elimination efforts.

87 rgoes at -90 degrees C accelerated reductive elimination enantioselectively and exclusively without t

88 trol tactics will be insufficient to achieve elimination, even if maximized.

89 d angiopathy appears to be in part a protein elimination failure angiopathy and that this dysfunction

90 We report a C-F reductive elimination from a characterized first-row aryl metal fl

91 he two aryl rings result in faster reductive elimination from Ar-Au(X)-Ar and lead to the pi-complexa

92 rane-catalyzed formal C(sp(3))-CF3 reductive elimination from Au(III) that accesses these compounds b

93 biomarker entry into vasculature, biomarker elimination from plasma, and subject-specific tumor grow

94 CPD100 elimination from the circulation after injection in mous

95 olume of distribution (17.4mL/kg).Total drug elimination from the circulation after the administratio

96 bulin E do not accurately identify foods for elimination from the diets of patients with eosinophilic

97 -135 may have originated for l-THA-like beta-elimination function in earlier evolutionary variants, a

98 The ensuing reductive elimination furnishes the desired arylated product.

99 tons into two hydrides, from which reductive elimination generates H2.

100 (III) undergoes separate, but fast reductive elimination, giving rise to Ni(I) species.

101 can play a pivotal role in achieving disease elimination goals.

102 (T1/2el = 0.90 h), mavacoxib has a prolonged elimination half-life (T1/2el = 135 h) following oral ad

103 mean maximum plasma concentration (C max ), elimination half-life and area under concentration-time

104 me (tmax) between 1.5 h and 4 h, with a mean elimination half-life between 86 h and 118 h.

105 renes are not generated and thus a reductive elimination has occurred.

106 es with N-retinylidene-N-retinylethanolamine elimination in a cell-based model of macular degeneratio

107 egies in public health for its role in polio elimination in India.

108 to better understand the mechanism of carbon elimination in kerf which can aid the design of better p

109 Our analysis supports the view that DNA elimination in nematodes silences germline-expressed gen

110 strong-field ionization followed by hydrogen elimination in the hydrocarbon series C2D2, C2D4 and C2D

111 ion, we carried out in-depth analyses of DNA elimination in the parasitic nematode of humans, Ascaris

112 ility of DEC salt treatment for achieving LF elimination, in comparison with other current and propos

113 we report a novel pathway for mitochondrial elimination, in which these organelles undergo Parkin-de

114 Reductive elimination is accelerated by electron-donating substitu

115 Unless elimination is achieved, mass drug administration has to

116 carbonates as chemoselective copper-hydride elimination is faster with an achiral Cu-alkyl species.

117 > 6) as long as the half-life for metabolic elimination is long relative to the time scale of relati

118 ) cross coupling, implying that beta-hydride elimination is not a significant process in this transfo

119 These results also imply that beta-F elimination is not an important catalyst deactivation re

120 Methanol elimination is predicted to be the turnover-limiting ste

121 A cornerstone of malaria elimination is the effective management of Anopheles mos

122 25 via rate-determining, first-order methane elimination (KIE approximately 8.7).

123 us has been on optimal approaches to achieve elimination, less attention has been paid to how to meas

124 ay not allow sufficient activation for tumor elimination, making the majority of T cells suboptimal f

125 Inappropriate dietary eliminations may impair quality of life, affect children

126 )-mediated reductive dechlorination and E1CB elimination mechanism during alkaline hydrolysis) where

127 The oxidative addition-reductive elimination mechanism via an unstable Cu(III) intermedia

128 esis (C-H bond activation followed by beta-H elimination) occurs on Ti, followed by olefin metathesis

129 For example, beta-H elimination of (Phebox)Ir(OAc)(n-octyl) (2-Oc) proceeded

130 r 3b into 4a or 4b occurs via a beta-hydride elimination of 1a or 1b to regenerate NBD.

131 s due to the appearance, drift, and ultimate elimination of a genetic modifier of mutation rate.

132 ngs present opportunities for both selective elimination of a medically and financially devastating d

133 and metastatic tumors, leading to apoptotic elimination of advanced invasive and metastatic disease.

134 of increased quality of life because of the elimination of adverse events.

135 Primary end point was identification and elimination of AES leading to ECG pattern normalization

136 ropanoid pathway catalyzing the nonoxidative elimination of ammonia from l-phenylalanine to give tran

137 tudies will focus on therapeutic options for elimination of bacterial biofilm in the equine uterus.

138 ions) requiring lack of effector function or elimination of binding to Fcgamma receptors.

139 -Alder cycloaddition followed by an addition-elimination of bromo-ethylmalonate and a retro-Diels-Ald

140 Notably, elimination of cancer cells by T cells is critically dep

141 In addition, the elimination of cardiopulmonary bypass may reduce the ris

142 cidate the consequences of acute and chronic elimination of cell-cycle proteins, we generated and cha

143 etween NKG2D and its ligands facilitates the elimination of cells under cellular stress, such as tumo

144 message (48%), appointment near home (46%), elimination of copay (46%), and transportation to appoin

145 Elimination of CVB3 led to a downregulation of these ala

146 ter products (MS(4) experiments) resulted in elimination of diagnostic neutral molecules CO2 (44 Da)

147 After the elimination of dominated options, we estimated expected

148 rug strategy was implemented to ensure rapid elimination of drug candidates to minimize systemic GR a

149 s well as virulence factor secretion and the elimination of drugs.

150 understand the consequences of the complete elimination of E2F regulation, we profiled the proteome

151 on triggered recessive mechanisms leading to elimination of effector cells and, simultaneously, a dom

152 Finally, elimination of Erf resulted in impaired repopulation abi

153 including the crossing of axon projections, elimination of exuberant projections, and myelination of

154 Elimination of filariasis requires a macrofilaricide tre

155 alterations in the system in response to the elimination of flow between the Great Salt Lake's north

156 tes fungal cell recognition and promotes the elimination of fungal pathogens.

157 In particular, these data suggest that elimination of GFAP might be possible and occurs more qu

158 D-38 is a promising therapeutic strategy for elimination of GSCs.

159 Evidence is provided to suggest that photo-elimination of H2 is one means by which the enhanced act

160 roup species that support the photoreductive elimination of halogens, we have synthesized [Cl3Sb(V)Pd

161 ed this effect, producing enhanced cytolytic elimination of HCV-infected Huh7.5A2 cells.

162 mechanism involving the homolytic reductive elimination of hydrogen.

163 Elimination of in vivo signaling by all six of these 'li

164 l to bind HIV-1 cell surface Env and promote elimination of infected CD4+ T cells by recruiting cytot

165 protein (Env) are a promising new weapon for elimination of infected cells and eradication of the vir

166 possibly due to insufficient immune-mediated elimination of infected cells.

167 Inducible elimination of integrin alpha5 abrogates the epithelial-

168 oxidase isoform (NOX2) are critical for the elimination of intracellular pathogens in many infection

169 itudinal monitoring of skin accumulation and elimination of IRDye 800-labeled therapeutic anti-epider

170 e c-axis self-assembled BaZrO3 nanorods, the elimination of large misoriented grains, and the suppres

171 8(+) T cells, a result with implications for elimination of latent HIV-1 infection by T cell-based va

172 s a form of cell interaction that causes the elimination of less fit cells, or losers, by wild-type (

173 e chronic myelogenous leukemia (CML) via the elimination of leukemia stem cells (LSCs) in mice.

174 drug regimen has potential to accelerate the elimination of lymphatic filariasis if high population c

175 arum poses a major threat to the control and elimination of malaria.

176 of older scientists, induced in part by the elimination of mandatory retirement in universities in 1

177 the advantage of a large sample size and the elimination of many biases typically associated with poo

178 lex (DPEphos)RhMeI2 (1) results in reductive elimination of MeI.

179 d Centers for Disease Control and Prevention elimination of mother-to-child HIV transmission goal of

180 nities are needed to monitor progress toward elimination of mother-to-child HIV transmission.

181 H to CD11b, which obstructed the homeostatic elimination of MPs from the subretinal space mediated by

182 hat has eluded RNAi and RNase H experiments: elimination of MRP RNA in the majority of cells.

183 Wild-type cells are required for the active elimination of mutant cells from the tissue, while utili

184 dependent neuronal development and decreased elimination of neuronal processes.

185 he most probable excited state that leads to elimination of nitrogen and Wolff rearrangement is one o

186 was correlated with the extent of selective elimination of nNOS interneurons.

187 of complement-dependent synaptic pruning and elimination of NPCs.

188 n-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis ha

189 In food matrices, the elimination of OTA by gamma-radiation was found more dif

190 ize with ART during pregnancy to achieve the elimination of pediatric HIV infections.

191 Our results indicate that the elimination of phenylalanine residue 211 or 213 abolishe

192 Elimination of pilus production in the isogenic carrier

193 We investigated whether elimination of PLP1-expressing cells compromises epithel

194 Elimination of PP2A substantially slows pigment dephosph

195 IgG MFI was analyzed after elimination of prozone effect, and complement-fixation w

196 In vitro studies implicate BRCA1 in elimination of R-loops, DNA-RNA hybrid structures involv

197 s occurred that has been largely mediated by elimination of racial differences in acute resuscitation

198 Mobilization of ADCC may facilitate elimination of reactivated latent HIV-1-infected cells t

199 Most early work focused on elimination of reactive oxygen species (ROS) after radia

200 erses hallmark features of disease including elimination of RNA foci among all conditions studied (DM

201 Although elimination of RORgammat prevents TH17 cell-mediated exp

202 Elimination of self-renewing cancer stem cells (CSCs) is

203 The elimination of senescent cells by suicide gene-meditated

204 ular senescence drives hepatic steatosis and elimination of senescent cells may be a novel therapeuti

205 Surprisingly, we found that elimination of Srebf-2 in hepatocytes of mice also marke

206 Furthermore, the genetic elimination of staphyloxanthin during AirR overproductio

207 rovides a potential therapeutic strategy for elimination of stem cells at both preleukemic and leukem

208 eron triggered by STING stimuli, through the elimination of STING and of interferon-inducible protein

209 Loss of function or elimination of T-bet-expressing Treg cells-but not of T-

210 e of 3HP for LTBI treatment could accelerate elimination of TB disease in the United States.

211 Moreover, we show that elimination of the ACT-PLA activity abrogates ACT toxici

212 Astrocyte-specific elimination of the astrocytic d-serine-synthesizing enzy

213 xposure to UV light affords, after reductive elimination of the entire PCO group, the unprecedented [

214 oth faster rates of activation gating and an elimination of the fast component of gating charge movem

215 Using a rat model of PD, partial elimination of the functional interaction between FKBP12

216 inducible caspase 9 safety switch to enable elimination of the HA-1 TCR T cells in case of toxicity;

217 Elimination of the intestinal microbiota during establis

218 extinction of Kras(mut) resulted in specific elimination of the Kras(mut) subpopulation in primary an

219 severe liver cancer that is associated with elimination of the mutant CUGBP1.

220 ion, (iii) rational cooling adjustment, (iv) elimination of the nonthermostated capillary part, (v) i

221 d cycling performances are attributed to the elimination of the P2-O2 phase transition upon cycling t

222 inistration to infected mice induces a total elimination of the parasite charge in mice faeces 1-2-fo

223 ecrease in QRS duration (P<0.001) along with elimination of the right bundle branch block QRS morphol

224 impaired, in part preventing containment or elimination of the tumor.

225 Elimination of these reservoirs through the administrati

226 o be in the mid to high 10(16) cm(-3) range, elimination of this donor from the drift layer of Ga2O3

227 Elimination of this often contentious distinction would

228 ignaling in donor T cells and inhibiting the elimination of thymic ILCs improved thymopoiesis in an I

229 The elimination of Tm and subsequent re-infection of mice wi

230 sis loss-of-function lines revealed that the elimination of toxic reactive carbonyl species during ge

231 s specific to goals of morbidity control and elimination of transmission.

232 First, the elimination of TrkA signaling in mice harboring mutant T

233 resistance is a substantial threat to global elimination of tuberculosis.

234 ctor through a mechanism involving reductive elimination of two [Fe-H-Fe] bridging hydrides to make H

235 Since the complete elimination of uncertainties is impossible, LCA results

236 lity-control pathway, which is essential for elimination of unhealthy mitochondria.

237 munity in metazoans, including the selective elimination of viral components.

238 nificant challenge to HIV eradication is the elimination of viral reservoirs in germinal center (GC)

239 underlying mechanism for microglia-mediated elimination of virally transduced cells in the central n

240 Cellular cytotoxicity is essential for the elimination of virus-infected and cancerous cells by NK

241 Previous work assumed that the elimination of visual input was sufficient to enhance pl

242 We thus suggest that elimination of Wolffian ducts in female embryos is activ

243 5-5 and beta-O-4 linkages, showed major 1,2-eliminations of neutral compounds containing one, two, o

244 An Eyring plot for beta-hydride elimination-olefin rotation-reinsertion is constructed f

245 tree-nut allergy, necessitating either their elimination or the performance of oral food challenges (

246 progress towards the desired endpoint (e.g., elimination) or increase the chances of success.

247 y available, resulted in sustained cockroach elimination over 12 months and was associated with impro

248 deprivation (BD), increased dendritic spine elimination over 3 days in the binocular region of 4-wee

249 metal ion of possible relevance to reductive elimination/oxidation addition reaction chemistry of tra

250 d (JackiePhos, 10 mol%) controlling the beta-elimination pathway.

251 sient cell groups that may undergo wholesale elimination perinatally.

252 tic regression models with backward stepwise elimination (Proc Logistic procedure in SAS).

253 The Singapore Tuberculosis (TB) Elimination Program (STEP) was set up in 1997, and the b

254 mportant missing components of the kala-azar elimination program.

255 parameters estimated were Cmax, Tmax, t1/2, elimination rate constant, AUC0-t and AUC0-inf.

256 1, and this effect is mediated by l-arginine elimination rather than metabolite generation.

257 mic polymerization based on Michael addition-elimination reaction of structurally diverse beta-ketoen

258 ex undergoes a clean photoreductive chlorine elimination reaction which produces [Cl2Sb(IV)Pd(I)Cl(o-

259 n, whereas cross-linking resulting from beta-elimination reactions had a negligible effect.

260 stem crossing for the multichannel, addition-elimination reactions of unsaturated hydrocarbons with O

261 as residue and attributed to the dynamics of elimination reactions.

262 enotoxic stress, tumor suppression, pathogen elimination, regulation of immunity and inflammation, ma

263 arbinyl)nickel complex, which upon reductive elimination releases the cyclopropane.

264 Both synapse silencing and elimination required de novo transcription, but only sil

265 ondary cases per infection, using 4 methods; elimination requires maintaining R at <1.

266 ions are charge-remote Maccoll and retro-ene eliminations resulting in the cleavage of a beta-O-4 lin

267 eviously shown that maternal cow's milk (CM) elimination results in downregulation of CM-specific IgA

268 DY-654 showed organ specific and determined elimination routes in both healthy and diseased animals.

269 ngle pot dipolar cycloaddition reaction/Cope elimination sequence was developed to access novel 1,4,6

270 scade Michael addition-Dieckmann cyclization-elimination sequence, offers rapid and convenient access

271 s in renal clearance efficiency in the early elimination stage, because the smaller AuNCs are more re

272 catalyzed chemistry (selective beta-hydrogen elimination step).

273 An NHC-catalyzed nitro-Stetter/elimination/Stetter reaction sequence employs nitroalken

274 e epidemiology, burden of liver disease, and elimination strategies of hepatitis B in sub-Saharan Afr

275 aran Africa, and recommends several priority elimination strategies that address the need both to pre

276 irect-acting antivirals is a prospective HCV elimination strategy.

277 mutant displays a dramatic reversal of beta-elimination substrate specificity in favor of l-serine o

278 e monitoring in high-risk IDU and MSM if HCV elimination targets are to be realized.

279 l karyotypes generate a signal for their own elimination that may serve as a means for cancer cell im

280 Following addition/elimination, the resulting transoid alpha-(1'-fluoro)-be

281 easing mortality in the zoophilic cycle, the elimination threshold can be reached.

282 now levelled off and remains well above the elimination threshold.

283 (mf) prevalence from 1% mf to site-specific elimination thresholds more quickly than the other inves

284 tion, migratory insertion, and C-F reductive elimination to achieve a net C-C bond construction.

285 r to form a hemiacetal, which then undergoes elimination to cyclohexanone and phenol/alkanol products

286 kyl halide oxidative addition, and reductive elimination to enable alkyl-alkyl fragment coupling.

287 vity of the arene and changes from reductive elimination to pi-complexation for arenes bearing strong

288 ubstitution; alkaloids, through Hofmann-type elimination; tropolone and furan, through cycloaddition;

289 lly weaker centromeres that result in genome elimination upon outcrossing, show a binding pattern on

290 digestion; (iv) release of O-glycans by beta-elimination using ammonia in the presence of 1-phenyl-3-

291 overed that ZIP14 is essential for manganese elimination via the gastrointestinal tract, and a lack o

292 es, indicating that mechanisms of uptake and elimination were not saturated at the tested doses.

293 substituted cyclopentenones via beta-carbon elimination, whereas the latter result in the 4-alkyl su

294 Genome elimination, which is not in the interests of the restri

295 t example of a rhodium-mediated beta-sulfide elimination, which represents a new mode of reactivity f

296 forces that promote these disparities, their elimination will likely require quantitative and qualita

297 moral Tregs were preferentially targeted for elimination, with the remaining Tregs exhibiting a less

298 gered by C-C bond activation and beta-carbon elimination, with the review concentrating on developmen

299 ts in the management of hepatitis C have put elimination within reach, but several difficulties will

300 s expected for random virus segregation, and elimination within six cell doublings, consistent with a