ライフサイエンスコーパス: elite controller

1 ndetectable HIV RNA levels without therapy ("elite controllers").

2 ith slow disease progression (also known as "elite controllers").

3 control HIV exists, and these are known as 'elite controllers'.

4 erved in sera from long-term nonprogressors (elite controllers).

5 of CD4 T cells from an unselected cohort of elite controllers.

6 individuals termed elite suppressors (ES) or elite controllers.

7 alization-resistant variants predominated in elite controllers.

8 , termed long-term nonprogressors (LTNPs) or elite controllers.

9 ne protection and viral containment in human elite controllers.

10 range, patients are predicted to behave like elite controllers.

11 cularly CCR5, is impaired in Nef clones from elite controllers.

12 rolled by antiviral therapy for >2 y or from elite controllers.

13 ntrolling chronic viral replication in these elite controllers.

14 We identified 149 elite controllers (0.4%) among 34 354 persons in care.

15 .1% of hospitalizations) but were rare among elite controllers (2.7%), in whom cardiovascular hospita

16 mu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*

17 ivated (CD38(+)HLA-DR(+)) T cells between 30 elite controllers, 47 HIV-uninfected individuals, 187 HI

18 A total of 68 elite controllers, 68 ART recipients with suppressed vir

19 omplex (MHC) class I allele Mamu-B*08 become elite controllers after infection with simian immunodefi

20 However, elite controllers also harbor a population of HIV-specif

21 standardized uptake value, 1.53 [0.56]), the elite controller and ART-suppressed groups had intermedi

22 Here, we quantify plasma HIV-1 RNA in elite controllers and correlate this with specific immun

23 4(+) T cell resistance to HIV in a cohort of elite controllers and explored transcriptional signature

24 CD4(+) T-cell counts were similar between elite controllers and HIV-negative controls but signific

25 measure of T-cell exhaustion in a cohort of elite controllers and in chronic progressors.

26 -level viremia is present in the majority of elite controllers and is associated with higher HIV-1-sp

27 e a mechanism of host resistance to HIV-1 in elite controllers and may open novel perspectives for cl

28 onents of immune protection against HIV-1 in elite controllers and offer novel perspectives for the m

29 Monocytes from elite controllers (and ART recipients with suppressed vi

30 While HIV "elite controllers" and uninfected individuals had simila

31 gh and stable levels in most noncontrollers, elite controllers, and antiretroviral-treated subjects,

32 ightly differ among HIV-1 progressors, HIV-1 elite controllers, and HIV-1-negative persons.

33 V, termed long-term nonprogressors (LTNP) or elite controllers, and patients with progressive HIV inf

34 Elite controllers are a distinct group, even when compar

35 Human immunodeficiency virus type 1 (HIV-1) elite controllers are able to control virus replication

36 Elite controllers are hospitalized more frequently than

37 nd HIV-1-negative persons, CD4+ T cells from elite controllers are less susceptible to HIV-1 infectio

38 to initiation and discontinuation of ART in elite controllers are unknown.

39 These "elite" controllers are of high interest as they may prov

40 "Elite controllers" are individuals that durably control

41 ncy virus (HIV)-infected individuals, termed elite controllers, are able to spontaneously control HIV

42 ed to HIV-associated mortality, differ among elite controllers, ART recipients with suppressed viremi

43 against HIV-1 infection in CD4+ T cells from elite controllers by inhibiting a cyclin-dependent kinas

44 (HAART)-treated HIV-infected subjects or in elite controllers compared to HIV-uninfected subjects.

45 factor levels were significantly elevated in elite controllers, compared with those in ART recipients

46 We performed a longitudinal study of 46 elite controllers, defined as HIV-seropositive, antiretr

47 A longitudinal analysis of 31 elite controllers demonstrated 2-5-fold fluctuations in

48 HIV-specific B cells derived from elite controllers displayed greater amounts of gp120-spe

49 Control of HIV replication in elite controller (EC) and long-term nonprogressor (LTNP)

50 HIV-1 elite controllers (EC) are rare individuals who are able

51 Nef clones derived from elite controllers (EC) have been shown to be attenuated

52 Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below the limit

53 Elite controllers (EC) of human immunodeficiency virus t

54 ronically infected subjects (chronic), and 7 elite controllers (EC) were used.

55 we attempted viral sequencing from 95 HIV-1 elite controllers (EC) who maintained plasma viral loads

56 Here, nef clones from 45 elite controllers (EC), 46 chronic progressors (CP), and

57 infected rhesus macaques (RM) classified as Elite Controllers (EC), and those with Low, Intermediate

58 solated from a rare subset of HIV-1-infected elite controllers (EC), with the ability to suppress vir

59 s levels (TxHIV), and therapy-naive aviremic elite controllers (EC).

60 es RNA/ml without treatment have been termed elite controllers (EC).

61 n without antiviral therapy have been termed elite controllers (EC).

62 viral load as a result of natural immunity (elite controller [EC]) or with uninfected control (HIV-)

63 levels without antiretroviral therapy (ART) (elite controllers [EC]) have the capacity to upregulate

64 eplication without antiretroviral treatment (elite controllers [EC]).

65 Elite controllers (ECs) are a rare group of HIV seroposi

66 tion is reduced by as much as 10,000-fold in elite controllers (ECs) compared with typical progressor

67 A subset of HIV-infected individuals termed elite controllers (ECs) maintain CD4(+) T cell counts an

68 True long-term nonprogressors (LTNPs)/elite controllers (ECs) maintain durable control over HI

69 These elite controllers (ECs) mounted a broad SIV-specific CD4

70 (HDs), 40 PHI patients, 17 Chronics, and 13 Elite controllers (ECs) were studied.

71 These subjects, termed elite controllers (ECs), are known to have stronger immu

72 ingly, B-cell responses were investigated in elite controllers (ECs), who maintain undetectable HIV l

73 d in macaques that control SIVmac239, termed elite controllers (ECs).

74 eks postinfection; two of four macaques were elite controllers (ECs).

75 mponent in the control of HIV replication in elite controllers (ECs).

76 HIV integration increased over time in both elite controllers (ECs; n = 8) and noncontrollers (NCs;

77 suppress viremia without treatment (termed "elite controllers" [ECs]).

78 )IW9- and Vif(66-73)HW8-specific clones from elite controllers effectively suppressed SIV replication

79 on in rhesus macaques and HIV-1 infection in elite controllers, elevated levels of PD-1 expression we

80 istent viral replication occurs in untreated elite controllers even in the absence of detectable plas

81 number of HIV-infected individuals known as elite controllers experience low levels of chronic phase

82 Most of these elite controllers express the histocompatibility alleles

83 In addition, elite controllers had a significantly higher proportion

84 Elite controllers had favorable time to development of A

85 In conclusion, the vast majority (98%) of elite controllers had measurable plasma HIV RNA, often a

86 andable epitope-specific CD8(+) T cells from elite controllers had strong virus inhibitory capacity a

87 We found that elite controllers have a high proportion of potentially

88 contribute to this natural resistance: some elite controllers have CD4(+) T cells that produce high

89 or healthy persons not infected with HIV-1, elite controllers have circulating myeloid dendritic cel

90 ntaining undetectable plasma HIV RNA levels (elite controllers) have high HIV-specific immune respons

91 However, rare patients, termed elite controllers, have a natural ability to control HIV

92 fic T-cell responses among a large cohort of elite controllers (HIV-RNA < 75 copies/ml), "viremic" co

93 Among untreated individuals, including both elite controllers (ie, persons with a viral load of </=4

94 We examined groups of elite controllers (ie, subjects with plasma HIV RNA leve

95 The single elite controller in the cohort was an outlier on several

96 but did not significantly differ from other elite controllers in terms of HLA class I alleles, HIV-1

97 Other HLA class I alleles more common in elite controllers included HLA-B*13, HLA-B*58, and HLA-B

98 two ineffective CD8(+) T-cell clones from an elite controller into TCR-expressing lentivectors.

99 very of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope sugg

100 might play in viral control, we depleted two elite controller macaques of CD4(+) cells.

101 By contrast, virus in elite controller macaques showed little evidence of vari

102 Elite controllers maintain control of plasma HIV viremia

103 Elite controllers maintain high CD4(+) T-cell counts and

104 Elite controllers maintain undetectable levels of HIV-1

105 Human immunodeficiency virus type 1 (HIV-1) elite controllers maintain undetectable levels of viral

106 Rare individuals ('elite controllers') maintain very low levels of HIV RNA

107 It remains unclear whether elite controllers manifest T-cell exhaustion similar to

108 suggest that the T cells of these particular elite controllers may be naturally resistant to HIV infe

109 The majority of these elite controllers mount high-frequency virus-specific CD

110 Peripheral blood mononuclear cells from HIV elite controllers (n = 10), progressors (n = 12), and an

111 at the peptide level in four subject groups: elite controllers (n = 16; viral load [VL], <75 copies/m

112 ients subdivided as follows: naive (n = 63), elite controllers (n = 19), long-term nonprogressors (n

113 ing those with levels of < 50 RNA copies/mL (elite controllers, n = 64), those with levels of 50-2000

114 The inability of elite controller Nef to fully remove CD4 from the surfac

115 pared with HIV-1-infected subjects including elite controllers, noncontrollers, and patients receivin

116 We present observations from a HIV-1 elite controller, not treated with combination antiretro

117 nlike most chronically infected individuals, elite controllers of HIV retain CD8(+) T-cell polyfuncti

118 nts without antiretroviral therapy (known as elite controllers or elite suppressors [ES]) is unknown.

119 natural control of HIV-1 infection known as elite controllers or suppressors (2) 72 samples from 18

120 Elite controllers or suppressors (ES) are a group of HIV

121 Elite controllers or suppressors (ES) are HIV-1-infected

122 Elite controllers or suppressors (ES) are HIV-1-infected

123 Elite controllers or suppressors (ES) are human immunode

124 A subset of HIV-1-infected patients known as elite controllers or suppressors (ES) control the virus

125 Elite controllers or suppressors (ESs) are HIV-1-infecte

126 ppressive antiretroviral therapy (ART) and 6 elite controllers or suppressors who were maintaining un

127 s not observed in subjects with spontaneous (elite controllers) or therapy-induced control of viral r

128 AIDS, whereas untreated animals exhibited an elite controller phenotype.

129 We demonstrate that a subgroup of elite controllers possess CD4(+) T cells that are specif

130 that is upregulated in CD4(+) T cells from "elite controllers," potently inhibited CDK2-dependent ph

131 t were differentially regulated in resistant elite controllers relative to healthy controls.

132 Elite controllers represent a distinct group of individu

133 Elite controllers represent a unique group of HIV-1-infe

134 imental blockade of p21 in CD4+ T cells from elite controllers resulted in a marked increase of viral

135 After peptide stimulation, elite controllers showed a greater number of previously

136 Furthermore, CXCR5(+) CD4(+) T cells from elite controllers showed a stronger ex vivo capacity to

137 Yet, a smaller proportion of elite controllers showed an alternative gene expression

138 Elite controllers spontaneously suppress human immunodef

139 following primary infection and enriched in elite controllers, suggesting a critical role for these

140 Elite controllers suppress human immunodeficiency virus

141 Viremic controllers and elite controllers/suppressors maintain control over HIV-

142 l inhibitory activity of CD8(+) T cells from elite controllers than from HIV-1 progressors supports t

143 study reports the development of bnAbs in an elite controller that, along with the help of T cells, w

144 l capacity of HIV-specific CD8(+) T cells in elite controllers to inhibit HIV infection.IMPORTANCE Th

145 pared hospitalization rates and causes among elite controllers to those of immunologically intact per

146 esponses in blood and rectal mucosa from 17 "elite controllers" (viral load < 75 copies/mL), 11 "vire

147 In elite controllers, virus was detected primarily in foci

148 For three elite controllers, we observed increased production of M

149 Forty percent of the elite controllers were HLA-B*57 compared to twenty-three

150 overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3%

151 transcriptional profiles for the majority of elite controllers were similar to those of ART-treated p

152 with different disease phenotypes, including elite controllers, who spontaneously control HIV-1 virem

153 , these data identify a specific subgroup of elite controllers whose immunological and gene expressio

154 ues control SIVmac239 replication and become elite controllers with chronic-phase viremia <1000 viral

155 e have resulted in the identification of HIV elite controllers with low or absent responses in which

156 Previous studies have shown that elite controllers with minimal effector T cell responses

157 These data indicate that elite controllers with minimal T cell responses harbor a

158 Elite controllers with the latter gene expression signat

159 lasma HIV-1 RNA levels were quantified in 90 elite controllers with use of a real time reverse-transc

160 HLA class I alleles are markedly enriched in elite controllers, with the highest association observed