ライフサイエンスコーパス: elongating

1 Recently we demonstrated that elongating a segment of colon releases nitric oxide (NO)

2 By elongating a single pillar axis we are able to significa

3 , the 150 dimer complex can be attributed to elongating a T=4 capsid along its 5-fold axis by adding

4 itates delivery of new actin subunits to the elongating actin filament.

5 in stereocilia widening by preventing newly elongating actin filaments from depolymerizing.

6 (VASP) can catalyze actin polymerization by elongating actin filaments.

7 ating activity of the Arp2/3 complex and the elongating activity of Ena/VASP proteins for the formati

8 triole length by counteracting the centriole-elongating activity of several centriole duplication pro

9 ar differences in the characteristics of the elongating aggregates, depending on the specific identit

10 verlapping microtubules at the centre of the elongating anaphase spindle.

11 tegy to comprehensively map the positions of elongating and arrested RNA polymerase II (RNAPII) at nu

12 go a limited number of cell divisions before elongating and differentiating.

13 matocytes and the acrosomal region of round, elongating and elongated spermatids.

14 ular in-plane direction, with the cells both elongating and intercalating along the converging axis.

15 m is flexible and capable of patterning both elongating and nonelongating tissues, and hence converti

16 immunolocalized to sieve elements, while for elongating and recently elongated internodes, SUTs also

17 ay accumulate Suc from the stem apoplasms of elongating and recently elongated internodes, whereas Sb

18 ies of four pyridine-terminated molecules by elongating and then compressing gold point contacts in a

19 l pole by secondary mesenchyme cells and the elongating archenteron during gastrulation; Cadherin (G

20 ignment and fusion of interstitial ZYP1 loci elongating at zygotene so synapsis at centromeres is a c

21 at is covalently attached (lipidated) to the elongating autophagosomal membrane.

22 that is unable to keep pace with the rapidly elongating axial skeleton of the tail.

23 ity" prior to tubulin incorporation into the elongating axoneme.

24 s converted into the mature RS at the tip of elongating axonemes.

25 rs on the growth cone at the leading edge of elongating axons play critical guidance roles by recogni

26 erate filament nucleation then remain on the elongating barbed end and modulate filament elongation.

27 and remains processively associated with the elongating barbed end while driving the addition of prof

28 cating that AtFH14 moves processively on the elongating barbed end.

29 ut is notably less effective at processively elongating barbed ends than most well studied formins.

30 m bud position and low R:FR and decreased in elongating buds.

31 Lamprey is incapable of elongating C22 substrates.

32 rocess, whereas the switching probability to elongating cell type increases with increasing pressure.

33 pressures where bacterial cells switch to an elongating cell type.

34 ]O(2) and Golgi membranes were isolated from elongating cells at the base of the developing leaves, (

35 is governed by time, not cell size, rapidly elongating cells do not divide more frequently than slow

36 y between meristem cell identity and rapidly elongating cells of the shoot.

37 These rapidly elongating cells require tip-focused endomembrane traffi

38 In contrast, treatment of elongating cells with amdinocillin, which inhibits penic

39 In asymmetrically elongating cells, dynein-dependent spindle anchoring at

40 binding sites in the cell walls of expanding/elongating cells.

41 ls do not divide more frequently than slowly elongating cells.

42 lpha-helical polypeptides can be produced by elongating charge-containing amino-acid side chains to p

43 oral events of neural differentiation in the elongating chick body axis to provide the first analysis

44 rowth kinetics of the germinating embryo and elongating coleoptile, which consequently enhances anaer

45 and longer, essentially the same as a stable elongating complex.

46 Bacterial NusA interacts with elongating complexes and the nascent RNA transcript in w

47 GreB binds to actively elongating complexes at nearly diffusion-limited rates b

48 However, the interactions of elongating complexes with these regulators did not diffe

49 incorporated complexes, and not in correctly elongating complexes.

50 r NusA domains contribute to NusA binding to elongating complexes.

51 es, rather than functional specialization of elongating complexes.

52 ombination mechanisms can avert lethality by elongating critically short telomeres.

53 TCAs, adding de novo dendritic segments, and elongating dendritic length, while maintaining dendritic

54 cleavage of the nascent transcript from the elongating DNA-dependent RNA ploymerase II.

55 s are ribonucleotide reductase M1 (RRM1) and elongating DNA.

56 Using direct biophysical measurements of elongating Drosophila egg chambers, we document robust m

57 ) for the incorporation of a nucleotide into elongating dsDNA in solution (DeltaG(o)(incorporation)).

58 Furthermore, cells within elongating ducts oriented both their protrusions and the

59 patially enriched in cells near the front of elongating ducts, whereas phosphorylated AKT was ubiquit

60 cell migration speeds from rear to front of elongating ducts, with the front characterized by both h

61 th leading to large bulbous sacs in place of elongating ducts.

62 rease in chromatid arm length by transiently elongating during anaphase/telophase.

63 y be catalyzed by specialized initiating and elongating E2 enzymes, but the functional significance f

64 the conserved Ube2S as a K11-specific chain elongating E2 for human and Drosophila APC/C.

65 nd activates its specialized ubiquitin chain-elongating E2 UBE2S in ways that differ from current par

66 e conjugated structures which are capable of elongating effective conjugation, reducing the optical b

67 This includes ES at the Sertoli cell-elongating/elongated spermatid interface, which is known

68 n that anchors and maintains the polarity of elongating/elongated spermatids (step 8-19 spermatids) i

69 to the failure of spermiogenesis because no elongating/elongated spermatids were detected in any of

70 ursors, located towards the posterior of the elongating embryo.

71 In many elongating embryonic structures, tissue lengthening is d

72 y influencing the SMAD response in the TE of elongating embryos.

73 sive 3D cancer cell migration via both actin-elongating Ena/VASP proteins and the Scar/WAVE complex,

74 olymer configuration suggests that the chain-elongating enzyme (rubber transferase; EC 2.5.1.20) is a

75 rved that AUX1 in lateral root cap (LRC) and elongating epidermal cells greatly enhance auxin's shoot

76 During this process the elongating epithelial cells and their earliest fibre cel

77 , the lens fulcrum, where the apical tips of elongating epithelial cells constrict to form an anchor

78 ty complex, disrupts the apical junctions in elongating epithelial cells so that the lens fulcrum fai

79 e two major peptidoglycan synthases in live, elongating Escherichia coli cells and after perturbation

80 olymerization by nucleating new filaments or elongating existing ones.

81 copy number and transcript abundance in the elongating fiber cells of Upland cotton (Gossypium hirsu

82 2 was expressed by lens epithelial cells and elongating fibers but was degraded during the later stag

83 formation about mechanical properties of the elongating fibrils.

84 apu once it is bound to the barbed end of an elongating filament.

85 nucleation and binding to the barbed end of elongating filaments by the C-terminal half of Capu (Cap

86 llows direct examination of both the fate of elongating filaments upon instantaneous suppression of A

87 can (PG) hydrolase (PGase), which allows the elongating flagellar rod to penetrate through the PG lay

88 We find that elongating follicles undergo repeated rounds of circumfe

89 r removal or bypass, but does not inactivate elongating forks.

90 e consequences of re-replication at actively elongating forks.

91 rate the DSB marker gammaH2Av is enriched at elongating forks.

92 eurons to extend the regeneration-associated elongating form of axon growth but had no impact on axon

93 in, we report that IKKalpha travels with the elongating form of ribonucleic acid polymerase II togeth

94 In WT mES cells, the elongating form of RNA pol II accumulates near Vezf1 bin

95 gher chromatin assortativity of the actively elongating form of RNA polymerase 2 (RNAPII) compared wi

96 both p21 mRNA levels and the presence of the elongating form of RNA polymerase II (RNAPII) toward the

97 that there is no discernable decrease in the elongating form of RNA polymerase II in either mutant.

98 We identify a possible role for the elongating form of RNAPII in mediating interactions amon

99 injury signal in regulation of the intrinsic elongating form of sensory axon regeneration.

100 There was greater abundance of the active/elongating form of the RNA polymerase-II enzyme (RNAPII-

101 uring latency but was converted to an active elongating form upon reactivation induced by Rad21 deple

102 ctive polymerase at CYC1 into a productively elongating form.

103 a clear distinction between the stalled and elongating forms of the polymerase.

104 nd H4K20me1 histone marks compared to slower elongating genes.

105 s occurs through examining the tips of young elongating Gossypium hirsutum (Gh) and G. barbadense (Gb

106 that varies most between rapidly and slowly elongating growth plates.

107 d axonal translation of GAP-43 mRNA supports elongating growth.

108 ht-sensing organ (cotyledons) and in rapidly elongating hypocotyls of Arabidopsis thaliana PIFs initi

109 ement of several candidate regulators in the elongating hypocotyls.

110 e photoreceptor layers across the fovea were elongating in albinism, albeit at a reduced rate, compar

111 eobox gene recruits polymerase II and begins elongating in all tissues and cell lines that we tested,

112 sulting in increased penetration stress when elongating in soils of greater strength.

113 to identify genes expressed in pollen tubes elongating in vitro; however, little is known of the tra

114 ve been reported in peripheral nerves and in elongating injured axons of sensory neurons in vitro, pr

115 ine morphogenesis begins from an actin patch elongating into a dendritic filopodium, which tip subseq

116 ved that both the phospho-Ser2 levels in the elongating isoform of Pol II and the loading of Spt5 and

117 ees toward the endo-fused cyclopropane bond, elongating it to r = 1.69 A.

118 Inversion of the M2 TMD, achieved by elongating its C-terminus, underscores the contribution

119 ancers, allowing the recruitment of the CDK9 elongating kinase.

120 f neuromast and ampullary organ formation by elongating lateral line placodes, and even of other zebr

121 We observed cells in elongating mammary ducts reorganize into a multilayered

122 d BAR-domain proteins drives the scission of elongating membrane tubules.

123 the growth of the secondary palate with the elongating midfacial complex.

124 the plus ends of the shortening, but not the elongating, MTs and retard MT depolymerization.

125 t embryos indicate that transient binding of elongating muscle to exploratory sites could be a genera

126 existence of two steps in the attachment of elongating muscles to specific tendon cells: transient a

127 Indeed, a slowly elongating mutant of RNAPII was able to rescue this defe

128 t which the ribosome adds amino acids to the elongating nascent chain influences the efficiency of th

129 During biosynthesis on the ribosome, an elongating nascent polypeptide chain can begin to fold,

130 t with previous work, our data indicate that elongating nascent transcripts are tethered to RNAP II o

131 nt with respect to the luminal vector of the elongating nephron.

132 osome has evolved an exit tunnel to host the elongating new peptide, protect it from proteolytic dige

133 rase act at each telomere when telomeres are elongating (nonequilibrium conditions).

134 that the vast majority of 80S monosomes are elongating, not initiating.

135 transfer from the supersaturated WL into the elongating NWs growing horizontally, dislocation- and ca

136 ing O-Man glycosylation and the major enzyme elongating O-Man glycans, the protein O-mannose beta-1,2

137 forks, it binds to only the matured (and not elongating) Okazaki fragments of stalled forks.

138 nterfaces sustained greater tension than non-elongating ones.

139 sults show that clathrin is not required for elongating or shaping the endocytic membrane invaginatio

140 itive versions of today's protein catalysts, elongating other such HP polymers as ribosomes would now

141 tion as SHH signaling centers to pattern the elongating palatal shelves.

142 cts as a rigid clamp, which holds the end of elongating ParM filaments while allowing entry of new AT

143 which ParR-parC complexes bind and stabilise elongating ParM filaments.

144 on ftrxn) that are initiating transcription, elongating, pausing, or awaiting termination.

145 characterized a pulling force exerted by the elongating pharynx (foregut) on the anterior epidermis d

146 m RNA/DNA hybrid structures (R-loops) behind elongating Pol II and are especially prevalent over G-ri

147 a model whereby kinetic competition between elongating Pol II and Sen1 helicase establishes the temp

148 lts suggest that kinetic competition between elongating pol II and the Xrn2 exonuclease is integral t

149 ymerase II (Pol II) on polytene chromosomes, elongating Pol II can persist on chromatin in the absenc

150 We find that elongating Pol II complexes complete transcription after

151 al transducers recruited to genes coupled to elongating Pol II may play a role in maintaining product

152 er2P in Pol II phosphorylated on Ser5 and in elongating Pol II near the ARG1 promoter.

153 modifying enzymes like Set2 that travel with elongating Pol II remain largely unknown beyond their in

154 initiation factor TFIIF from free pol II and elongating pol II.

155 and Hos2) in promoting Spt6 interaction with elongating Pol II.

156 transcribed region were similar to those of elongating Pol II.

157 ts transducers to Gck gene synchronized with elongating Pol II.

158 ture is not properly restored in the wake of elongating Pol II.

159 mmunication between synergid cells and a tip-elongating pollen tube (PT) for the successful delivery

160 transcripts specifically enriched in in vivo-elongating pollen tubes.

161 hetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosy

162 Recruitment of PER complexes to the elongating polymerase at Per and Cry termination sites i

163 , dependent on its physical association with elongating polymerase II (Pol II) phosphorylated on the

164 hromatin modification and mRNA maturation to elongating polymerase II (Pol II).

165 he Sen1-Nrd1-Nab3 termination complex to the elongating polymerase.

166 nlarge, a result that is simply explained if elongating polymerases become immobilized in transcripti

167 for linking ubiquitin (UB) to substrates and elongating polyUB chains, respectively.

168 changes associated with decreased levels of elongating pre-mRNA and less efficient splicing.

169 n (ACP) from fatty acid synthases sequesters elongating products within its hydrophobic core, but thi

170 simple DNA segregating machines that use an elongating protein filament between sister plasmids.

171 tter access to its target when Pol is in the elongating rather than terminating mode.

172 d through stop codons in a regulated manner, elongating rather than terminating the nascent peptide.

173 ks, suggesting that the RNAP peaks reflected elongating, rather than initiating, complexes.

174 helps in the local displacement of SSB by an elongating RecA filament.

175 and increasing fluidity toward its posterior elongating region.

176 nker of the MCM helicase and Polalpha at the elongating replication fork--first, to coordinate the ac

177 We found that SMARCAL1 travels with elongating replication forks, and its absence leads to M

178 e translational block, demonstrating that an elongating ribosome can disrupt the interaction.

179 ecular aspects of viomycin inhibition of the elongating ribosome using pre-steady-state kinetics.

180 ial uS3 promote the helicase activity of the elongating ribosome, suggesting that uS3 contacts with m

181 equences within the CHOP uORF serve to stall elongating ribosomes and prevent ribosome reinitiation a

182 -1 PRF induces a subset of elongating ribosomes to shift their translational readin

183 hifting (-1 PRF) is a mechanism that directs elongating ribosomes to shift-reading frame by 1 base in

184 consecutive Pro codons pose a challenge for elongating ribosomes.

185 1 (GYS1), was preferentially associated with elongating ribosomes.

186 of the multistep transcription process, the elongating RNA polymerase (RNAP) is dislodged from the D

187 Slippage of elongating RNA polymerase (RNAP) on homopolymeric A/T tr

188 Elongating RNA polymerase and the associated nascent RNA

189 By precisely tracking the waves of elongating RNA polymerase II (Pol II) during gene activa

190 ermined the X-ray crystal structure of yeast elongating RNA polymerase II (Pol II) in complex with a

191 While CHD1 colocalizes with elongating RNA polymerase II (Pol II) on polytene chromo

192 High density elongating RNA polymerase II (RNAP II) is detected in S

193 Given that the elongating RNA polymerase II (RNAPII) stalls at this wel

194 )-DNA cleavage complexes are known to arrest elongating RNA polymerase II (RNAPII), triggering a prot

195 for recruitment of RNA processing factors to elongating RNA polymerase II (RNAPII).

196 phorylated form of the CTD characteristic of elongating RNA polymerase II and contains a phospho-CTD-

197 TREX accompanies the elongating RNA polymerase II and facilitates RNP assembl

198 ted nucleotides, and coincide spatially with elongating RNA polymerase II and splicing components.

199 eEF1A1 then associates with elongating RNA polymerase II and the 3'UTR of HSP70 mRNA

200 romoting chromatin reassembly in the wake of elongating RNA polymerase II and transcriptional elongat

201 n of the dimer with naked DNA in the wake of elongating RNA polymerase II at the coding sequence of t

202 of Rpb1p is critical for the disassembly of elongating RNA polymerase II at the DNA lesion in vivo.

203 ARP plays a role in removing nascent RNA and elongating RNA polymerase II from sites of DNA damage.

204 nstrate that Rpb1p but not other subunits of elongating RNA polymerase II is specifically degraded in

205 CHD3 colocalize with elongating RNA polymerase II on salivary gland polytene

206 histone deacetylase complex is recruited by elongating RNA polymerase II to remove histone acetylati

207 r, which is correlated to the association of elongating RNA polymerase II with active GAL genes.

208 einitiation complex assembly, association of elongating RNA polymerase II, and recruitment of mRNA ca

209 CSB and UVSSA proteins, as well as actively elongating RNA polymerase II, are required for this proc

210 is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner.

211 omplexes recruited by activator proteins and elongating RNA polymerase II.

212 by acetylation permissive to the passage of elongating RNA polymerase II.

213 By observing single H-NS filaments and elongating RNA polymerase molecules using atomic force m

214 ion factors from the NusG family bind to the elongating RNA polymerase to enable synthesis of long RN

215 g, which is determined by the ability of the elongating RNA polymerase to recognize the sequence of t

216 H activates gene expression by tethering the elongating RNA polymerase to the ribosome.

217 by multiple upstream events associated with elongating RNA polymerase.

218 ined action determines the level of actively elongating RNA polymerase.

219 ation and in recruiting other factors to the elongating RNA polymerase.

220 gulatory activity and how they interact with elongating RNA polymerase.

221 either sensitive to frequent dislodgement by elongating RNA polymerases (RNAPs) from the target promo

222 eported that NusA, an essential component of elongating RNA polymerases, interacts with DinB.

223 argets DNA lesions that block progression of elongating RNA polymerases.

224 Our results reveal that DksA effects on elongating RNAP are very different from those of GreB, s

225 Elongating RNAP forms a transcriptional bubble in which

226 Recruitment of additional factors to elongating RNAP may be another conserved function of thi

227 identify a cohort of genes marked by PRC and elongating RNAPII (S5p(+)S7p(+)S2p(+)); they produce mRN

228 actor-binding phospho-epitopes on the CTD of elongating RNAPII and directly through binding to specif

229 s throughout the gene bodies that track with elongating RNAPII and the leading edge of RNA synthesis.

230 indicate that positive torsion generated by elongating RNAPII causes transient loss of histone-DNA c

231 show that, upon TGFbeta treatment, JMJD3 and elongating RNAPII colocalize extensively along the intra

232 urthermore, Ccr4-Not interacts directly with elongating RNAPII complexes and stimulates transcription

233 ancy on highly active genes mirrored that of elongating RNAPII extending through the bodies and 3' en

234 nd TFIIS copurified with each other and with elongating RNAPII, while P-TEFb was not among the intera

235 riptional coactivator that functions through elongating RNAPII.

236 a functional association between SNAPC1 and elongating RNAPII.

237 elevated steady state auxin concentration in elongating root cells is up-regulation of cell wall remo

238 elevated steady state auxin concentration in elongating root cells is upregulation of cell wall remod

239 red that the pectin network is reoriented in elongating root epidermal cells.

240 B1/2 accumulate in the tip-growing domain of elongating root hairs.

241 T4 uniquely becomes localized to the tips of elongating root hairs.

242 ted with gradients of cell length in rapidly elongating roots and dark-grown hypocotyls.

243 portantly, this amplification is asymmetric, elongating runs in favorable directions and abbreviating

244 rrelation between Vezf1 binding and peaks of elongating Ser2-P RNA polymerase (Pol) ll, reflecting Ve

245 manchette, a unique structure at the base of elongating spermatid that directs formation of the flage

246 g deformed acrosomal formation, degenerative elongating spermatids and irregular head morphology in p

247 ization was not changed in the few remaining elongating spermatids of Meig1-deficient mice.

248 localizes to the manchette in the remaining elongating spermatids of Pacrg-deficient mice, indicatin

249 In the elongating spermatids of wild-type mice, PACRG colocaliz

250 levels in pachytene spermatocytes and early elongating spermatids without affecting H3K9me3 levels.

251 m of wild-type mice, and in the manchette of elongating spermatids, but in the Meig1 or Pacrg-deficie

252 In elongating spermatids, CnnT forms speckles on the giant

253 f the cytoplasm is incomplete in Ube2j1(-/-) elongating spermatids, compromising the release of matur

254 that Se concentrated near the lumen side of elongating spermatids, where structural components of sp

255 that Brdt colocalizes with acetylated H4 in elongating spermatids.

256 s a wave of "zippering" that passes down the elongating spinal axis, uniting the neural fold tips in

257 al progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoder

258 During anaphase, the elongating spindle physically segregates the sister chro

259 possibly other signals that emanate from the elongating spindle.

260 igid components of the outer membrane of the elongating stalk, concurrent with stalk synthesis.

261 We also show that the pointed-end has a non-elongating state that dominates the observed filament ki

262 jor role in the hydraulic systems of leaves, elongating stems, and roots.

263 substrate selectivity was identified for the elongating step than in preceding acylation.

264 es to selectively interrogate the donor (the elongating strand) and acceptor (Lipid II) sites.

265 to nucleoli, which prevents telomerase from elongating telomeres.

266 lonal analysis correlate with shaping of the elongating tentacles.

267 ension (GBE), a convergent-extension process elongating the body axis.

268 tion potential of the Co(II)/Co(I) couple by elongating the bond between the cobalt and its upper axi

269 an overstretching transition at about 65 pN, elongating the DNA to about 1.7-fold.

270 t this hypothesis, we examined the effect of elongating the extracellular region of the CD28 ligand,

271 The identity of the enzyme further elongating the glycan to generate the final trisaccharid

272 We found that elongating the helices at their extremities by adding mo

273 itching factor by repeatedly compressing and elongating the molecular junction.

274 cranial self-stimulation in rats showed that elongating the N-alkyl chain decreased abuse-related eff

275 end in sequential discontinuous pulses, each elongating the nucleoid by 5%-15%.

276 ly(A) tail will remain untranslated, whereas elongating the poly(A) tail permits protein production.

277 They occur in the leaflets, usually elongating them, and also in the submitral apparatus, wi

278 actin networks, with factors such as formins elongating these filaments into filopodia.

279 lastoderm"), and posterior fates arise in an elongating tissue (called the "germband").

280 (2) The elongating tissue is composed of cells that prefer to be

281 me1 modifications showed that they appear in elongating to condensing spermatids and predominantly as

282 early and late endolysosomal markers to the elongating tPCs.

283 Using native elongating transcript analysis (NET-seq), we show that t

284 uclear fractions, including mammalian native elongating transcript sequencing (mNET-seq).

285 Here, by use of native elongating transcript sequencing (NET-seq) and a variant

286 and powerful approach for performing native elongating transcript sequencing (NET-seq) in human cell

287 a coli by a novel approach, combining native elongating transcript sequencing (NET-seq) with RNase fo

288 ls at single-nucleotide resolution by native elongating transcript sequencing (NET-seq).

289 Consequently, we have developed native elongating transcript sequencing technology for mammalia

290 uence reads than ChIP-seq or NET-seq (native elongating transcript sequencing).

291 Here we present an approach (native elongating transcript sequencing, NET-seq), based on dee

292 quantitative fluorescence assays and native elongating transcript sequencing.

293 Second, using 5' merodiploid native-elongating-transcript sequencing, 5' mNET-seq, we assess

294 gnals cause disassembly of the highly stable elongating transcription complex (EC) over windows of tw

295 nsitions between the poised, initiating, and elongating transcriptional states.

296 etic switch through premature termination of elongating transcripts due to collisions between RNA pol

297 mation of the gaps, the force exerted by the elongating tubes to permit passage was determined using

298 Based on previous analyses of fast and slow elongating VASP proteins by in vitro total internal refl

299 ental properties of CMTs observed in rapidly elongating wild-type cells as well as the defective CMT

300 the difficulty of collecting pollen that is elongating within the solid maternal gynoecium.