ライフサイエンスコーパス: elongation

1 or proper junctional actin regulation during elongation.

2 Klp9, which is required for anaphase spindle elongation.

3 nductance states by repeated compression and elongation.

4 te 2) is associated with polyubiquitin chain elongation.

5 ic model of Ena/VASP-mediated actin filament elongation.

6 epidermis are critical in driving embryonic elongation.

7 af1 on Pol2 are sufficient for transcription elongation.

8 accomplish twenty cycles of polyketide chain elongation.

9 odon usage establishing the speed of protein elongation.

10 t diameter was not related to genotypic root elongation.

11 ibrio invasion, and a zonal mode of predator elongation.

12 ERONIA-dependent inhibitory response in root elongation.

13 ion in substrate selection and polySia chain elongation.

14 eavage site by undergoing two phases of cell elongation.

15 eneration and is sufficient to drive spindle elongation.

16 retion of IL1B2 during the time of conceptus elongation.

17 IF5A and polyamines in promoting translation elongation.

18 modulate intraflagellar transport and cilia elongation.

19 genitors in order to facilitate orderly axis elongation.

20 fy cell behavior and tissue movements during elongation.

21 tubule network coupled with enhanced process elongation.

22 piRNA precursors by promoting transcription elongation.

23 are specifically impaired in auxin-mediated elongation.

24 y rate-limiting step required for productive elongation.

25 ransient activity in sheaths precedes faster elongation.

26 ine how both aspects contribute to embryonic elongation.

27 for neuron survival but required for neurite elongation.

28 ical Site 2 responsible for subsequent chain elongation.

29 nucleation and processively mediate filament elongation.

30 g by chromatin structure and transcriptional elongation.

31 in the growth plate, which counteracts bone elongation.

32 their enhanced expression by transcriptional elongation.

33 ed cortical microtubules and suppressed cell elongation.

34 EI9 had distinct consequences on pollen tube elongation.

35 global requirement for Spt5 in transcription elongation.

36 mational requirements for fibril and nucleus elongation.

37 id into the myoid during the course of myoid elongation.

38 ely stable attachments that restrain spindle elongation.

39 the Drosophila egg chamber instructs tissue elongation.

40 n and branching activity competed with chain elongation.

41 initiation site before beginning productive elongation.

42 ome Interacting Factor 4 (PIF4) on hypocotyl elongation.

43 dent (non-genomic) activity of auxin in cell elongation.

44 ulation during Caenorhabditis elegans embryo elongation, a process driven by asymmetric epidermal cel

45 he bio-elastomers without compromising their elongation ability.

46 ponding amino acids in FPPase enhanced chain-elongation activity, while similar mutations in the acti

47 High-temperature-mediated hypocotyl elongation additionally involves localized changes in au

48 ese cases, which would limit efficient chain elongation after insertion of a fluorinated monomer.

49 r to correlate with differences between cell elongation (anaerobic conditions) versus cell division (

50 igenetic role for KDM5B in regulating RNAPII elongation and alternative splicing, which may support t

51 nse of endometrium to IL1B2 during conceptus elongation and attachment to the uterine surface.

52 is, showing that glycolysis facilitates body elongation and balances neural and mesodermal differenti

53 rsity of a neural network requires regulated elongation and branching of axons, as well as the format

54 iggers extensive and unexpected Schwann cell elongation and branching to form long, parallel processe

55 , excessive RAD51 activity slows replication elongation and causes double-strand breaks.

56 NA unwinding but is defective in replication elongation and CMG binding.

57 Crawling results from successive bouts of elongation and contraction of the whole leech body.

58 ds from the cleavage site in a two-step cell elongation and demonstrate the role of myosin efflux in

59 f TOP2A cleavage in regulating transcription elongation and gene activation.

60 tial roles of enhancer RNAs (eRNAs) in early elongation and highlight that transcriptional enhancers

61 PAF1C), which is involved in transcriptional elongation and histone modifications.

62 cus on the reduction of ethanol use in chain elongation and improve the recovery efficiency of the ex

63 EN deletion greatly restricts mammary ductal elongation and induces aberrant alveolar side-branching.

64 l microtubules are required for such spindle elongation and its maintenance.

65 bidopsis thaliana, these include marked stem elongation and leaf elevation, responses that have been

66 rocessivity and expression level on telomere elongation and length maintenance.

67 iation of Okazaki fragment synthesis and its elongation and maturation, respectively.

68 spacing is sufficient to promote cell shape elongation and migration parallel to the ECM, or contact

69 on the number of lateral branches, internode elongation and phyllotaxy.

70 ceptor genes underlies delayed outer segment elongation and possibly mispositioning of cone nuclei in

71 et-induced obese mice reverses mitochondrial elongation and reduces obesity.

72 In mice, early VV formation is marked by elongation and reorientation ("organization") of Prox1(h

73 pon UV irradiation, a slowdown of transcript elongation and restriction of gene activity to the promo

74 hosts, but significantly promoted germ tube elongation and sclerotium production.

75 ation and eight miRNAs were related to fiber elongation and secondary wall biosynthesis.

76 y, the outcome is determined by phosphoester elongation and siloxane contraction along the pulling ax

77 Thus, through controlling both mRNA elongation and sn/snoRNA synthesis, the 7SK snRNP is a k

78 cripts are associated with signals of stable elongation and splicing that extend into the gene body,

79 n coordinating the kinetics of transcription elongation and splicing.

80 We conclude that eIF5A functions broadly in elongation and termination, rationalizing its high cellu

81 se that fully describes loading, initiation, elongation and termination.

82 shows that the BM is instructive for tissue elongation and the determinant is relative rather than a

83 ls lateral root and root hair initiation and elongation and the synthesis of other receptors.

84 , we report a much broader role for eIF5A in elongation and uncover a critical function for eIF5A in

85 -zone hypothesis to explain endocytic tubule elongation and vesicle scission in fission yeast.

86 ranslation complexes stalled at the level of elongation and/or termination.

87 II occupancy, transcriptional initiation and elongation, and alternative splicing events in ES cells.

88 is required for confinement-induced spindle elongation, and both chemical and physical centrosome re

89 eosome dis- and re-assembly, transcriptional elongation, and mRNA processing.

90 cells increased tumor cell velocity, induced elongation, and promoted actin stress fiber organization

91 gulate tubulogenesis and vascular branching, elongation, and pruning.

92 olyamine requirement for general translation elongation, and that this activity is independent of the

93 and fundamental mechanisms of transcription elongation are conserved, the initiation stage of the tr

94 also provide evidence that variable rates of elongation are not a significant source of differential

95 chemistry approach to oligonucleotide probe elongation as a novel approach to specifically detect a

96 These data therefore reveal transcription elongation as a point of regulatory control for speciali

97 such as JQ1, linked BRD4 to context-specific elongation at a limited number of genes associated with

98 l.% Ap-SFRP remains ductile with 7% flexural elongation at lower temperatures (-50 degrees C).

99 ride is suitably protected for further chain elongation at positions 3, 4, and 6 of the terminal mann

100 lass of molecules that license transcription elongation at targeted genomic loci.

101 roduction from mixed organic waste via chain elongation at this current, early stage of technological

102 chondrial fission and promotes mitochondrial elongation, at least in part, via suppression of the mit

103 In turn, the elongation, barrier properties, soluble mass and opacity

104 telomerase positive cells exhibited similar elongation between leading and lagging strands.

105 omains are sufficient to accelerate filament elongation, but in the presence of profilin, proline-ric

106 he long bones, the growth plates (GPs) drive elongation by generating a scaffold progressively replac

107 sodermal progenitors (NMPs) that fuel embryo elongation by generating spinal cord and trunk mesoderm

108 es that PLA1 stimulates the duration of leaf elongation by maintaining dividing cells in a proliferat

109 ate but not the coding strand of genes block elongation by RNA polymerase II (RNAPII).

110 xy-terminal Alanine and Threonine (CAT) tail elongation-can be recapitulated in vitro with a yeast ce

111 to DNA replication, telomere maintenance and elongation, cell cycle progression, signal transduction

112 Dual-assignment of codons as termination and elongation codons is used to expand the genetic code.

113 tRNAP and the nucleic acid components of the elongation complex (EC).

114 actor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and

115 ated histone H3 specifically recruited Super Elongation Complex (SEC), the transcriptional elongation

116 several components of the PAF1 transcription elongation complex contribute to Chd1 recruitment to hig

117 ci, Spt4/5 is recruited to the transcription elongation complex during early elongation within 500 ba

118 longation Complex (SEC), the transcriptional elongation complex essential for HIV-1 long terminal rep

119 -RNA interactions facilitate assembly of the elongation complex on transcribed genes when RNA emerges

120 Therefore, the RNAPII transcript elongation complex represents a platform for interaction

121 tors ELL1/2 are core components of the super elongation complex required for HIV-1 proviral transcrip

122 eras and their oncogenic cofactor, the super elongation complex.

123 pathway for the formation of a transcription elongation complex.

124 adenylation site triggers disassembly of the elongation complex.

125 nascent RNAs from all actively transcribing elongation complexes (ECs) in Escherichia coli and Sacch

126 ation sequencing, we identified locations of elongation complexes and transcription-repair coupling e

127 transcripts during transcription by stalling elongation complexes at catalytically dead EcoRIE111Q ro

128 motes proofreading by transcript cleavage in elongation complexes backtracked by nucleotide misincorp

129 port for the residence time of paused Pol II elongation complexes being much shorter than estimated f

130 These results indicate that individual elongation complexes do not engage in multiple rounds of

131 While effective, the distribution of elongation complexes using EcoRIE111Q requires laborious

132 und that, at the dose used, a single wave of elongation complexes was blocked within the first 25 kb

133 TCR occurred where the elongation complexes were blocked, and repair was associ

134 anscription to initiate a discrete "wave" of elongation complexes.

135 erved the dynamics of GreB interactions with elongation complexes.

136 t control contraction (DE-3 motoneurons) and elongation (CV motoneurons).

137 release of paused RNAPII or reducing RNAPII elongation decreased unwrapping.

138 of an eIF5A-depleted strain reveals a global elongation defect, with abundant ribosomes stalling at m

139 tiffness gradient, which fails to develop in elongation-defective mutants.

140 Strains lacking Paf1 show marked elongation defects, although low levels of Paf1 on Pol2

141 cycles, we found that Suc-induced hypocotyl elongation did not occur in tps1 mutants and overexpress

142 this technique, we show that vertebrate body elongation entails spatially varying tissue mechanics al

143 from replicated chromosome ends as a single elongation event.

144 The essential eukaryotic elongation factor 1A (eEF1A) delivers aminoacyl tRNAs to

145 Eukaryotic elongation factor 1A (EEF1A), is encoded by two distinct

146 reduced phosphorylation levels of eukaryotic elongation factor 2 and also requires the presence of el

147 n factor 2 and also requires the presence of elongation factor 2 kinase.

148 de in the specialized positive transcription elongation factor b (P-TEFb) activation mechanism that i

149 y reported effects on positive transcription elongation factor b and HMBA inducible protein-1.

150 e mutations in the gene encoding translation elongation factor eEF1A2 have recently been found to giv

151 ires diphthamide modification of translation elongation factor eEF2 and wobble uridine modifications

152 decreased phosphorylation of the eukaryotic elongation factor eEF2, reminiscent of the effects of ke

153 entral domain of Nmd3 mimics the translation elongation factor eIF5A, inserting into the E site of th

154 of the small subunit head domain within the elongation factor G (GDP)-bound ribosome complex.

155 The translation factors, elongation factor G and ribosome recycling factor, are k

156 bromo-adjacent homology and transcriptional elongation factor S-II domain, which we named REPRESSOR

157 DSIF or Spt4/5) is a conserved transcription elongation factor that both inhibits and stimulates tran

158 lecting cognate aminoacyl-tRNAs delivered by elongation factor Tu (EF-Tu).

159 omplex with its cognate immunity protein and elongation factor Tu (EF-Tu).

160 The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is methylated by PR

161 ing as a histone chaperone and transcription elongation factor, Spt6 counteracts repression by opposi

162 cells via ADP-ribosylation of the eukaryotic elongation factor-2.

163 ects by suggesting that codon recognition by elongation factor-bound aminoacyl-tRNA is initiated by h

164 tin, RNA polymerase (Pol) II associates with elongation factors (EFs).

165 ed sequence-specific synthetic transcription elongation factors (Syn-TEFs).

166 Transcript elongation factors (TEFs) are a heterogeneous group of p

167 transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated

168 action of the sarcin ricin loop with the two elongation factors and (iii) networked information excha

169 However, RNAPII is decorated with elongation factors as it transcribes the genome.

170 affold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core components of the sup

171 Although elongation factors promote pause release leading to tran

172 requires the recruitment of transcriptional elongation factors to rapidly induce innate response gen

173 rate when confined, suggesting that similar elongation forces can be generated independent of bioche

174 a two-step conformational transition: first, elongation from compact to linear form, and subsequently

175 uced SMALL AUXIN UP RNA (SAUR) genes promote elongation growth and play a key role in PM H(+)-ATPase

176 bypasses the normal requirement of auxin for elongation growth by increasing the mechanical extensibi

177 -induced SAUR expression and auxin-dependent elongation growth were closely correlated.

178 anscription factors promoting initiation and elongation have been characterized in each domain, but t

179 en identified, those affecting transcription elongation have not been broadly investigated.

180 -D motif impacted early changes in host cell elongation; however, the degree of elongation was compar

181 , and immunofluorescent detection of peptide elongation in acute slices demonstrates robust translati

182 ogue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causin

183 PDN1 also inhibited L1-CAM-dependent neurite elongation in cerebellar granule neurons, a pathway prev

184 d datasets suggests a role for translational elongation in coupling mRNA structures to translation in

185 ppresses ectopic outgrowth and promotes cell elongation in different regions of the hypocotyl.

186 signal that underlies Suc-induced hypocotyl elongation in light/dark cycles.

187 t both inhibits and stimulates transcription elongation in metazoans.

188 A, a major determinant in facilitating polar elongation in mycobacterial cells.

189 during division and at the side-wall during elongation in rod-shaped and ovococcoid Gram-positive ba

190 The GLV E-2-hexenal inhibits root elongation in seedlings and, using this phenotype, we is

191 binds tightly to barbed ends, where it slows elongation in the absence of profilin and allows, but do

192 rofilin and allows, but does not accelerate, elongation in the presence of profilin.

193 cleotides to assess RNA Pol II transcription elongation in vitro.

194 d to impaired splicing and defects in RNAPII elongation in vivo on a splicing reporter construct.

195 electively during longitudinal contractions, elongations in response to light, and radial contraction

196 ubiquitin ligase essential for autophagosome elongation, in macrophages impaired the restriction of L

197 L, which also plays a role in xylan backbone elongation, indicate the presence of xylan in pollen wal

198 nvolve cellular mechanisms that include cell elongation, intercalation, convergent extension, prolife

199 shown to decrease its rate of nucleation and elongation into amyloid-like fibrils linked to amyotroph

200 transition from transcription initiation to elongation is a key regulatory step in gene expression,

201 al fibril formation, but the stage of fibril elongation is affected mainly by the length of C-termina

202 egulation of mRNA translation initiation and elongation is essential for the survival and function of

203 of paused RNA polymerase II into productive elongation is highly regulated, especially at genes that

204 itor studies that RNA polymerase II (Pol II) elongation is important for establishing memory in this

205 Rather, the onset of RNA chain elongation is inhibited because TRIM25 prohibits the mov

206 godendrocytes in vivo and that myelin sheath elongation is promoted by a high frequency of [Ca(2+)]i

207 igenomic state and cell division versus cell elongation is suggested, as no differences in DNA methyl

208 icated in both inhibition and stimulation of elongation, is dispensable for promoter-proximal pausing

209 ment by mdivi-1 occurs without mitochondrial elongation, is not mimicked by Drp1 deletion, and is obs

210 r the first time, translation initiation and elongation kinetics with single-transcript resolution an

211 the engagement of Pol II in transcriptional elongation, leading to promoter-proximal accumulation of

212 mall molecule that engages the transcription elongation machinery.

213 an withstand the mechanical stress of embryo elongation; mistiming of epithelium formation leads to d

214 Throughout vertebrate trunk elongation, motile mesodermal progenitors undergo an ord

215 lorescence stem undergoes rapid growth, with elongation occurring predominantly in the apical approxi

216 Whether this elongation occurs primarily through tubulin assembly at

217 rod OS swelling response reached a saturated elongation of 10.0 +/- 2.1%, at a maximum rate of 0.11%

218 nsile strength of 2.4-2.6 GPa, a significant elongation of 4-10% and a good fracture toughness (K1C)

219 hat adjacent VASP molecules synergize in the elongation of a single filament.

220 Phase 2 started with the distinct elongation of a single sarcomere, the so-called sarcomer

221 onstrated that PrP(C) specifically inhibited elongation of Abeta fibrils, most likely by binding to t

222 he nanoscale crosspoint device suggests that elongation of an Ag nanoparticle under voltage bias foll

223 obe to study real-time dynamics of HG during elongation of Arabidopsis pollen tubes and root hairs.

224 A) onto chromatin, as well as initiation and elongation of DNA replication.

225 actin polymerases that drive the processive elongation of filament barbed ends in membrane protrusio

226 of cellular sugar-sensing mechanisms in the elongation of hypocotyls in response to Suc.

227 caffolding protein, Wag31, involved in polar elongation of mycobacterial cells.

228 lms ranging from 10 to 35 nm display a giant elongation of out-of-plane lattice parameter, which corr

229 x assembly and disassembly before productive elongation of Pol II is achieved at most genes in the ye

230 We demonstrate significant elongation of primary cilia in IS patient bone cells.

231 SV-1 lytic transcription by facilitating the elongation of RNA Pol II and preventing silenced chromat

232 tudies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII).

233 Processive elongation of RNA Polymerase II from a proximal promoter

234 ransferase, which enables a more efficiently elongation of RNA synthesis in vitro.

235 ns that control the efficiency of transcript elongation of subsets of genes by RNA polymerase II (RNA

236 Removal of CTC1 results in elongation of the 3 overhang on the G-rich strand.

237 n occur mainly in the axial direction, where elongation of the axial Co-CN bond and Co-NIm bond on a

238 Elongation of the body axis is a key aspect of body plan

239 matin into an extended linear array promotes elongation of the chromosome, whereas topo-II promotes c

240 eased the tensile strength and increased the elongation of the films.

241 in and phosphatidylethanolamine halve during elongation of the Gram-positive bacterium Listeria innoc

242 Cgl2760/Rv0227c plays a critical role in the elongation of the mannan backbone of mycobacterial and c

243 laborated post assembly by in situ epitaxial elongation of the membrane building blocks to produce mi

244 Elongation of the newly formed branch and final maturati

245 The elongation of the pi-conjugated system via additional et

246 ALT cells exhibited preferential elongation of the telomeric lagging strands, whereas tel

247 ydroxyacyl-coA dehydratases are required for elongation of very long chain fatty acids, and HACD1 has

248 ate or presence of additional GABs, filament elongation on a surface invariably proceeded with the sa

249 nzhousaurus had a rapid rate of tooth enamel elongation or amelogenesis at 0.24 mm/day with dental ti

250 those contacts during the transition to the elongation phase.

251 served, suggesting that the fatty acid chain elongation process was not affected.

252 ng telomeric overhangs derived from telomere elongation processes that mostly occur during S phase.

253 Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and leukocyte receptor

254 distachyon, we quantified root diameter and elongation rate in response to inhibitors of cellulose (

255 t governing root penetration stress and root elongation rate in soils of greater strength.

256 air cell's somatic force with respect to its elongation rate varies along the cochlear length.

257 We measured the spatial gradients for elongation rate, osmotic pressure, cell wall thickness,

258 io was correlated with higher genotypic root elongation rate, whereas root diameter was not related t

259 cupancy, and decreased RNAPII initiation and elongation rates at active genes and at genes marked wit

260 production, by (i) influencing transcription elongation rates, (ii) binding to pre-mRNA to recruit sp

261 olding protein B binding to faulty procapsid elongation reactions mediated by external scaffolding pr

262 s regulating transcription during productive elongation remain poorly understood.

263 deling in the mammary gland involving ductal elongation, resolution into the mature epithelial bilaye

264 frequently recover and restart their speedy elongation, resulting in a repetitive stop-and-go growth

265 ns: a core general function in transcription elongation, satisfied by the lowest Paf1 levels, and a r

266 lise T/Bra expression to one end and undergo elongation similar to the posterior region of the embryo

267 ungal systems, but its effect on translation elongation speed in animal systems is not clear.

268 ality has been shown to regulate translation elongation speed in fungal systems, but its effect on tr

269 The pauses occur during the elongation step, but the mechanism that triggers ribosom

270 lifetime of POLRMT on terminally mismatched elongation substrate is increased in the presence of TEF

271 hate 3'-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DNA damage repai

272 BET degradation prompts a collapse of global elongation that phenocopies CDK9 inhibition.

273 omote pause release leading to transcription elongation, the role of epigenetic modifications during

274 tte inserted to prevent RNA transcripts from elongation through KvDMR1.

275 Telomere elongation through telomerase enables chromosome surviva

276 frictional barrier for lipid diffusion; tube elongation thus builds local membrane tension until the

277 ating Pol II's engagement in transcriptional elongation, thus deciphering a novel regulatory pathway

278 then initiates the second cycle of filopodia elongation to produce the long filopodia.

279 he engagement of Pol II into transcriptional elongation) to the coding sequence of an active gene, AD

280 ations significantly decreased initiation-to-elongation transition by RNAP.

281 reby explaining the details of initiation-to-elongation transition on atomic level.

282 , defense-related GO terms of 'translational elongation', 'translation factor activity', 'ribosomal s

283 p geometry and root diameter influences root elongation under different levels of soil strength and t

284 We found that Suc-induced hypocotyl elongation under light/dark cycles does not involve anot

285 bberellin signaling in Suc-induced hypocotyl elongation under short photoperiods.

286 parallel kinetic pathways during translation elongation, underscoring the ability of E-site codons to

287 ify the tissue-specific contribution to axis elongation using 3D volumetric techniques, then quantify

288 The strength of nucleation and elongation varies widely across formins.

289 host cell elongation; however, the degree of elongation was comparable across all strains at later ti

290 Chain elongation was the dominant activity during the N-termin

291 a novel biorefinery process, that is, chain elongation, was developed to convert mixed organic waste

292 roviding a higher tensile strength and lower elongation when compared to films based on native and si

293 rminal ABD1 blocks actin filament barbed-end elongation, whereas ABD2 and ABD3 do not show any activi

294 ed that this module catalyzes two successive elongations with different outcomes.

295 ranscription elongation complex during early elongation within 500 base pairs of the transcription st

296 py, we report unusual room-temperature super-elongation without softening in face-centred-cubic silve

297 m-specific MIZ1, both acting specifically in elongation zone cortical cells.

298 elastic compliances of cell walls along the elongation zone, but plots of growth rate versus wall co

299 root segment, which we identify as the root elongation zone, followed by rapid colonization of that

300 t, triggering bending of the root tip at the elongation zone.