ライフサイエンスコーパス: elongation factor 2

1 protein synthesis caused by inactivation of elongation factor 2.

2 ptide is identical to residues 581 to 589 of elongation factor 2.

3 nslocates to the cytosol and ADP-ribosylates elongation factor 2.

4 ocates into the cytosol where it inactivates elongation factor 2.

5 synthesis by ADP-ribosylation of eukaryotic elongation factor 2.

6 ible for the trimethylation of lysine 509 on elongation factor 2.

7 re toxin to reach the cytosol and inactivate elongation factor 2.

8 bosyltransferase activity against eukaryotic elongation factor 2.

9 found in archaeal and eukaryotic translation elongation factor 2.

10 single amino acid substitution in eukaryotic elongation factor 2.

11 NAD-dependent ADP-ribosylation of eukaryotic elongation factor 2.

12 sleep-related gene encoding the translation elongation factor 2.

13 ding of the C domain of DT to its substrate, elongation factor-2.

14 cells via ADP-ribosylation of the eukaryotic elongation factor-2.

15 inase in turn phosphorylates and inactivates elongation factor-2, a key mediator of ribosomal transfe

16 tresses on the phosphorylation of eukaryotic elongation factor 2 also differed: oxidative stress elic

17 reduced phosphorylation levels of eukaryotic elongation factor 2 and also requires the presence of el

18 ation but increases the association of human elongation factor 2 and human heterogeneous nuclear ribo

19 catalyzed the ADP-ribosylation of eukaryotic elongation factor 2 and inhibited protein synthesis.

20 ates to the cytosol where it ADP-ribosylates elongation factor 2 and inhibits protein synthesis.

21 ranslation by stimulating GTPase activity of elongation factor-2 and removal of deacylated tRNA.

22 tes and inactivates eukaryotic translational elongation factor-2, and thus can modulate the rate of p

23 osomal protein S4, malate dehydrogenase, and elongation factor 2, as well as two novel parasite prote

24 tep in the posttranslational modification of elongation factor-2 at His(715) that yields diphthamide,

25 4 resulted in increased dephosphorylation of elongation factor 2, but had no effect on phosphorylatio

26 kills by ADP-ribosylation of the translation elongation factor 2, but many of the host factors requir

27 Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationall

28 (P < 0.05) and phosphorylation of eukaryotic elongation factor 2 decreased (P < 0.05) after exercise

29 esent on archaeal and eukaryotic translation elongation factor 2, diphthamide represents one of the m

30 regions of endogenous eukaryotic translation elongation factor 2 (eEF-2) gene] using the Clustered Re

31 y increase the phosphorylation of eukaryotic elongation factor 2 (eEF-2) in extracts of NIH3T3 cells.

32 demonstrated that the activity of eukaryotic elongation factor 2 (eEF-2) kinase was markedly increase

33 thesis through phosphorylation of eukaryotic elongation factor 2 (eEF-2).

34 ion of the diphthamide residue of eukaryotic elongation factor 2 (eEF-2).

35 ulin-dependent phosphorylation of eukaryotic elongation factor-2 (eEF-2) by eukaryotic elongation fac

36 d autophagy, whereas silencing of eukaryotic elongation factor-2 (eEF-2) kinase, a protein synthesis

37 induced the phosphorylation of a eukaryotic elongation factor-2 (eEF-2) kinase, radiation sensitivit

38 eased level of phosphorylation of eukaryotic elongation factor-2 (eEF-2) was observed in the brains a

39 at phosphorylates and inactivates eukaryotic elongation factor 2 (eEF2 kinase; eEF2K) is subject to m

40 in 1 (4EBP1 Thr37/46; 14 +/- 3%), eukaryotic elongation factor 2 (eEF2 Thr56; -47 +/- 4%), extracellu

41 Furthermore, we found that eukaryotic elongation factor 2 (eEF2) and its kinase eEF2K are key

42 Protein synthesis elongation factor 2 (eEF2) catalyzes the translocation o

43 Eukaryotic translation elongation factor 2 (eEF2) facilitates the movement of t

44 an target of rapamycin (mTOR) and eukaryotic elongation factor 2 (eEF2) in the mPFC, effects recently

45 Translocation of the IRES by elongation factor 2 (eEF2) is required to bring the firs

46 diphthamide on human eukaryotic translation elongation factor 2 (eEF2) is the target of ADP ribosyla

47 kade of NMDAR at rest deactivates eukaryotic elongation factor 2 (eEF2) kinase (also called CaMKIII),

48 roteasome-targeted degradation of eukaryotic elongation factor 2 (eEF2) kinase and activation of the

49 MDA receptors at rest deactivates eukaryotic elongation factor 2 (eEF2) kinase, resulting in reduced

50 an inhibitory phosphorylation of eukaryotic elongation factor 2 (eEF2) kinase, which in turn promote

51 Eukaryotic elongation factor 2 (eEF2) mediates translocation in pro

52 A catalyzes the trimethylation of eukaryotic elongation factor 2 (eEF2) on Lys-525.

53 elongation is phosphorylation of eukaryotic elongation factor 2 (eEF2) on threonine 56 (T56) by eEF2

54 In addition, eukaryotic elongation factor 2 (eEF2) phosphorylation was significa

55 ing protein (Tbp) and eukaryotic translation elongation factor 2 (Eef2) were not affected by inflamma

56 increasing the phosphorylation of eukaryotic elongation factor 2 (eEF2), a key component of the trans

57 The eukaryotic translation elongation factor 2 (eEF2), a member of the G-protein su

58 also increased phosphorylation of eukaryotic elongation factor 2 (eEF2), a process known to inhibit p

59 and found that phosphorylation of eukaryotic elongation factor 2 (eEF2), a ribosomal translocase whos

60 ion (inactivation) of eukaryotic translation elongation factor 2 (eEF2), an important molecule for pr

61 6k), ribosomal protein S6 (rpS6), eukaryotic elongation factor 2 (eEF2), and eukaryotic initiation fa

62 es the involvement of eukaryotic translation elongation factor 2 (eEF2), the phosphorylation of which

63 f the diphthamide modification on eukaryotic elongation factor 2 (eEF2), we generated an eEF2 Gly(717

64 n this study, we demonstrate that eukaryotic elongation factor 2 (eEF2), which catalyzes the GTP-depe

65 controlled by phosphorylation of eukaryotic elongation factor 2 (eEF2), which inhibits its activity

66 ar target has been identified as translation elongation factor 2 (eEF2), which is responsible for the

67 esis by impairing the function of eukaryotic elongation factor 2 (eEF2).

68 e now identify as the eukaryotic translation elongation factor 2 (eEF2).

69 ein kinase and phosphorylation of eukaryotic elongation factor 2 (eEF2).

70 osphorylation and inactivation of eukaryotic elongation factor 2 (eEF2).

71 the translocation intermediate stabilized by elongation factor 2 (eEF2).

72 receptor-dependent suppression of eukaryotic elongation factor-2 (eEF2) phosphorylation thus reversin

73 Here, we identify eukaryotic elongation factor-2 (eEF2), which catalyzes ribosomal tr

74 protein synthesis, which specifically impair elongation factor 2 (EF-2) function.

75 longation factor G (EF-G) in prokaryotes and elongation factor 2 (EF-2) in eukaryotes].

76 Elongation factor 2 (EF-2) plays a key role in the essen

77 ffects did not stem from ADP-ribosylation of elongation factor 2 (EF-2).

78 the endothelium, promotes phosphorylation of elongation factor-2 (EF-2) and prostacyclin production,

79 Elongation factor-2 (EF-2) kinase (calmodulin kinase III

80 DT transfers the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive.

81 (4) genes responsible for protein synthesis (elongation factor-2 [EF-2], eukaryotic initiation factor

82 osttranslational modification on translation elongation factor 2 (EF2) in archaea and eukaryotes.

83 Elongation factor 2 (EF2) is an essential protein cataly

84 Elongation factor 2 (EF2) is phosphorylated and inhibite

85 hibitor Exotoxin A (ToxA), which ribosylates elongation factor 2 (EF2), upregulates a significant sub

86 large subunit ribosomal DNA and translation elongation factor 2 (EF2).

87 ication in archaeal and eukaryal translation elongation factor 2 (EF2).

88 ation on eukaryotic and archaeal translation elongation factor 2 (EF2).

89 2 is unable to ADP ribosylate and inactivate elongation factor-2 (EF2), owing to a low level of DPH4

90 g cells by ADP-ribosylating and inactivating elongation factor-2 (EF2).

91 thetase, glutaminyl-transfer RNA synthetase, elongation factor 2, elongation factor 1delta, and eukar

92 The PCR was used to amplify the elongation factor 2 gene in both the tumor cells and the

93 ng vimentin, EH-domain-containing protein 2, elongation factor 2, glucose-regulated protein 78, trans

94 ene product, ribosomal protein S6, cyclin K, elongation factor-2, Grb2-associated protein 2, and othe

95 The translation elongation factor 2 in eukaryotes (eEF-2) contains a uni

96 m nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, inhibiting prot

97 Calmodulin (CaM)-dependent eukaryotic elongation factor 2 kinase (eEF-2K) impedes protein synt

98 Eukaryotic elongation factor 2 kinase (eEF-2K), the only calmodulin

99 We also used eukaryotic elongation factor 2 kinase (eEF2K) (also known as CaMKII

100 plitudes by reducing postsynaptic eukaryotic elongation factor 2 kinase (eEF2K) activity subsequent t

101 Eukaryotic elongation factor 2 kinase (eEF2K) is a Ca(2+)/calmoduli

102 Eukaryotic elongation factor 2 kinase (eEF2K) is the best-character

103 Elongation factor 2 kinase (eEF2k) phosphorylates and in

104 These findings also uncover eukaryotic elongation factor 2 kinase (eEF2K), a Ca(2)(+)/calmoduli

105 Eukaryotic elongation factor 2 kinase (eEF2K), an atypical calmodul

106 Here, we demonstrate that elongation factor 2 kinase (eEF2K), an evolutionarily co

107 It was purified and identified as eukaryotic elongation factor 2 kinase (eEF2K).

108 ch is controlled by the Ca(2+)/CaM-dependent elongation factor 2 kinase (eEF2K).

109 LPA regulates KLF5 expression via eukaryotic elongation factor 2 kinase (eEF2k).

110 d higher levels of phosphorylated eukaryotic elongation factor 2 kinase than were observed in Mtm1 p.

111 des the activation of eukaryotic translation elongation factor 2 kinase with a consequent inhibition

112 ering RNA (siRNA) to eEF2 kinase (eukaryotic elongation factor 2 kinase) blocked the dendritic MAP1B

113 ivation and downregulation of the eukaryotic elongation factor 2 kinase, which normally inhibits tran

114 n factor 2 and also requires the presence of elongation factor 2 kinase.

115 , rat, and Caenorhabditis elegans eukaryotic elongation factor-2 kinase (eEF-2 kinase) and found that

116 Eukaryotic elongation factor-2 kinase (eEF-2 kinase) is a highly co

117 gy by 2-DG was associated with activation of elongation factor-2 kinase (eEF-2 kinase), a structurall

118 Elongation factor-2 kinase (eEF-2 kinase), also known as

119 Elongation factor-2 kinase (eEF-2K) is a Ca(2+)/calmodul

120 We report here that eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulato

121 inase inhibitors against a mammalian enzyme, elongation factor-2 kinase (eEF-2K), and the effect of t

122 Eukaryotic elongation factor-2 kinase (eEF2K) relays growth and str

123 ic elongation factor-2 (eEF-2) by eukaryotic elongation factor-2 kinase (EF2K), which inhibits elonga

124 required protein translation and eukaryotic elongation factor-2 kinase activity.

125 -2 kinase and a putative nematode eukaryotic elongation factor-2 kinase also encode the catalytic dom

126 gments of homology present in rat eukaryotic elongation factor-2 kinase and a putative nematode eukar

127 d neurotrophic factor expression, eukaryotic elongation factor-2 kinase function, and increased surfa

128 This class includes eukaryotic elongation factor-2 kinase, Dictyostelium myosin heavy c

129 r endothelial cells by activating eukaryotic elongation factor-2 kinase.

130 The LOS1 gene encodes a translation elongation factor 2-like protein.

131 ot inhibit the phosphorylation of eukaryotic elongation factor 2 or augment subsequent expression of

132 chanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DD

133 city through ADP-ribosylation of translation elongation factor 2, predicated on binding to specific c

134 exogenous substrate (yeast protein synthesis elongation factor 2), primarily on Ser.

135 P dissociation inhibitor beta, ATP synthase, elongation factor 2, protein disulfide isomerase, nucleo

136 These genes have been designated EFR for Elongation Factor 2 Related.

137 Finally, analyses of elongation factor 2 sequences demonstrate a strong phylo

138 RNA reporter constructs with the 5'-TOP from elongation factor 2 showed decreased translational activ

139 osttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes

140 d to interfere with binding of the substrate elongation factor 2 to the enzymatic active site of the

141 itor that impairs the function of eukaryotic elongation factor 2, whereas the rpl40a and rpl40b null