ライフサイエンスコーパス: elucidation

1 prioritization prior to nontarget structural elucidation.

2 em MS information useful for lipid structure elucidation.

3 causing increased expression of TRPV4 await elucidation.

4 emical formulas determination and structural elucidation.

5 full-length SMN has so far evaded structural elucidation.

6 e protons are not essential to the structure elucidation.

7 th are poorly understood and require further elucidation.

8 -defined products that assist in mechanistic elucidation.

9 , their relevance in humans requires further elucidation.

10 roved appetite and increased body size, need elucidation.

11 ation principle, which eventually led to its elucidation.

12 nital cataracts, but the pathobiology awaits elucidation.

13 dynamics during tissue regeneration require elucidation.

14 tified biclusters and co-expression networks elucidation.

15 a powerful and efficient tool for structure elucidation.

16 res generated by computer-assisted structure elucidation.

17 signaling, but several aspects of MSP await elucidation.

18 by mechanogenomic processes that now require elucidation.

19 ssistance in challenging cases of structural elucidation.

20 Its elucidation 50 years ago inspired tremendous multidiscip

21 applications in target discovery, functional elucidation and bio-production.

22 and basic scientists, which resulted in the elucidation and understanding of the unique pathophysiol

23 or basic NMR applications, such as structure elucidation and verification in synthetic, medicinal, an

24 umber of insights relevant to the modelling, elucidation, and engineering of biochemical pathways wit

25 lite annotation and identification, pathways elucidation, and further crop improvement.

26 We describe the isolation, structure elucidation, and total synthesis of the novel marine nat

27 The structure elucidation, biosynthesis, and biological activity of ma

28 widely deployed for targeted lipid structure elucidation but its application to high throughput and l

29 a powerful tool in natural product structure elucidation, but our ability to directly correlate fragm

30 le preparation for high-resolution structure elucidation by cryo-EM.

31 However, their solution-structure elucidation by NMR presents several challenges, includin

32 n using standard computer-assisted structure elucidation (CASE) and is followed by fully automated de

33 his compound presented significant structure elucidation challenges due to the large number of hetero

34 Structural elucidation, feeding experiments, and quantum chemical c

35 fied two novel products, and their structure elucidation gave 22-hydroxy-MaR1 and 14-oxo-MaR1.

36 se processes, which are in various stages of elucidation, have implications for screening and risk pr

37 h-throughput experimentation for mechanistic elucidation is also described.

38 Biomolecular structure elucidation is one of the major techniques for studying

39 Regulon elucidation is the basis for studying the bacterial glob

40 A basic question that awaits elucidation is: how representative are kcat values for t

41 ation of 144 TP candidates and the structure elucidation of 101 of these resulted in a comprehensive

42 Tentative structural elucidation of 13 phlorotannin isomers from EAF was obta

43 We describe the isolation and structure elucidation of 20 anabaenopeptins, including 13 novel co

44 majucin, these pursuits have resulted in the elucidation of a complex radical cascade process for ins

45 The recent elucidation of a product of the mechanistic probe 5-fluo

46 o 7 million years ago (Ma) is crucial to the elucidation of African ape and human origins, but few fo

47 ities in the neural processes underlying the elucidation of ambiguous tasks across species.

48 Elucidation of amino-polyketide derivatives from a speci

49 oring of Vgsc CN in wild populations and the elucidation of association between the Vgsc CN and insec

50 erials could be more widely expanded via the elucidation of biointerfacial structure/property relatio

51 exposure assessment and the straightforward elucidation of biological effects.

52 le tool for biomarker identification and the elucidation of biological processes.

53 is key to successful integrative structural elucidation of biological systems.

54 bromodomains are required to facilitate the elucidation of biology associated with these important e

55 hanism remains a challenge, and will require elucidation of both the structures of the OEC in the dif

56 The elucidation of cancer pathogenesis has been hindered by

57 the major driver and passenger events in the elucidation of cancer progression and development.

58 Further elucidation of carbon and nitrogen metabolism mechanisms

59 n to be a successful analytical tool for the elucidation of cellular functions and their correspondin

60 ot provide fragmentation patterns that allow elucidation of certain structural features, including ac

61 sequence composition, paving the way for the elucidation of circRNA functions.

62 l regulation and less amenable to systematic elucidation of complete networks than originally hoped.

63 mental spectroscopy or X-ray studies for the elucidation of complex (bio)molecular structures includi

64 anding how sex impacts immunity requires the elucidation of complex interactions among sex hormones,

65 long-read sequence data also facilitated the elucidation of complex rearrangements in a mutagenized s

66 embly of a large complex genome, and (2) the elucidation of complex rearrangements.

67 e way for new avenues of research toward the elucidation of critical stages of this disease, such as

68 use of laser-capture microdissection allowed elucidation of differential gene regulation within disti

69 e for understanding complex inheritance, the elucidation of disease mechanisms, and the discovery of

70 viding a powerful substrate for experimental elucidation of disease mechanisms.

71 olvement of cell-matrix forces could lead to elucidation of disease mechanisms.

72 es that are broadly applicable for efficient elucidation of disease-causing mutations in bacterial pa

73 re targeted by AbetaOs may contribute to the elucidation of disease-relevant mechanisms.

74 increasingly appreciated variability of SS, elucidation of distinct operating pathways in relation t

75 dy presents a general approach for structure elucidation of disulfide-rich peptides.

76 isk of acute vascular complications although elucidation of downstream pathways will be necessary to

77 was conducted for the qualitative structural elucidation of electrolyte main constituents with a spec

78 To date, the application of native MS to the elucidation of endogenous protein complexes has been lim

79 The elucidation of enigmatic enzymatic chlorination timing i

80 incubations of primary rat hepatocytes; the elucidation of expected and unexpected degradation produ

81 Ag-specific CD4(+) T cell responses and that elucidation of Francisella epitopes that elicit high-avi

82 argues that further studies are required for elucidation of functional implications of such noncanoni

83 H2 PAD can also facilitate elucidation of fundamental biochemical mechanisms within

84 and Enterococcus faecalis In conclusion, the elucidation of GAC biosynthesis in S. pyogenes reported

85 identify a novel genetic variant for further elucidation of genetic underpinning of positive affect t

86 potential for rapid and complete structural elucidation of glycan chains at a site-specific level.

87 The elucidation of Gp45-involved molecular interactions not

88 of guard cell metabolites is fundamental for elucidation of guard cell signaling pathways.

89 ve made an enormous contribution towards the elucidation of human disease, it has hitherto not been p

90 iculation processes holds promise for better elucidation of human physiology and disease, and paves t

91 uring on and in planta growth, following the elucidation of infection structures requiring cell wall

92 Here we report on elucidation of intraluminal pressure patterns using High

93 Elucidation of involved neural systems is critical for p

94 ribe the discovery of TOR and the subsequent elucidation of its cellular role.

95 on the unique ABC ion channel, CFTR, hinders elucidation of its functional mechanism and correction o

96 Confirmation of this association and elucidation of its underlying mechanisms are needed to p

97 Elucidation of key members of the microbial community in

98 This allows for the elucidation of lifetime distributions, which may be expe

99 s9 target sites, marks cells and enables the elucidation of lineage relationships via the patterns of

100 discuss challenges and prospects for further elucidation of lncRNA mechanisms.

101 microscopy (cryo-EM) is a key technology for elucidation of macromolecular structures.

102 Elucidation of mechanisms at play during epilepsy develo

103 The elucidation of mechanisms in semilunar valve development

104 This protocol will allow elucidation of mechanisms of resistance and enable preci

105 dentification of reaction intermediates, and elucidation of mechanisms).

106 biochemical analyses coupled with structural elucidation of metabolites revealed that acylsugar assem

107 Elucidation of MF-CNPs provides a new dimension of analy

108 actions derives mostly from studies in which elucidation of microbe-microbe interactions is difficult

109 Elucidation of modifiable risk factors at young ages may

110 structural chemokine receptor models for the elucidation of molecular determinants of chemokine recep

111 s to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development

112 direct examination of these steps, including elucidation of molecule-to-molecule variability.

113 f the derivatized imine compounds led to the elucidation of multiple combinations of mobile and stati

114 ysis could have implications for the further elucidation of mycofactocin biosynthesis.

115 Complete structural elucidation of natural products is often challenging due

116 ntral pattern generators (CPGs) requires the elucidation of neurons and pathways involved in activati

117 pathways and provide evidence for structural elucidation of new resolution moduli.

118 of CYP2B35 and CYP2B37 that will aid in the elucidation of new structure-activity relationships.

119 e CPCs toward chondrogenesis may help in the elucidation of new treatment strategies for cartilage ti

120 mediating infectious disease has led to the elucidation of numerous autoinducers and their correspon

121 C. elegans, and establish a paradigm for the elucidation of obesity-relevant mechanisms.

122 Elucidation of optimal dosing and treatment content is c

123 Elucidation of organoarsenical biotransformations by S.

124 r pollution exposure have been investigated, elucidation of outcomes associated with nanomaterial exp

125 Elucidation of pathogenic mechanisms could lead to new t

126 The structural elucidation of pectin is aided by digestion assays with

127 ive determination of binding mechanisms; and elucidation of physical factors that control binding rat

128 y of research on these clusters has involved elucidation of physical properties.

129 ial of such production systems to facilitate elucidation of plant biosynthetic pathways has been unde

130 in this protocol and can be widely used for elucidation of potential function in interactions betwee

131 cies, which should greatly contribute to the elucidation of PPI biology under different disease state

132 developed in the total synthesis allowed the elucidation of previously unexplored structure-activity

133 resholds provided in the literature, further elucidation of processes that impact the safety and effe

134 Detailed structural elucidation of protein glycosylation is a tedious proces

135 studying intermediates or contribute to the elucidation of reaction mechanisms.

136 nding of MIA pathway evolution hindering the elucidation of remaining pathway enzymes and the improve

137 ticides, but are also frequently used in the elucidation of resistance mechanisms.

138 ble to provide detailed insights for further elucidation of RNA editing affecting miRNAs, especially

139 The phenotypic and genetic elucidation of SET and its relationship with SDW support

140 properties of Shigella Moreover, structural elucidation of several IpaD-VHH complexes provided criti

141 By elucidation of several XylO crystal structures (in compl

142 ganisms have successfully contributed to the elucidation of signals controlled through GPCRs and othe

143 A clear elucidation of structural feature of whole lignin in pla

144 Elucidation of such insights on high surface area oxide

145 d a powerful method for the rapid structural elucidation of such molecules.

146 Elucidation of taurine's neurochemical roles and importa

147 Lack of structural information has precluded elucidation of the allosteric basis for the decreased DN

148 w how such an "NMR toolbox" has assisted the elucidation of the allosteric molecular basis for diseas

149 explain this phenomenon even with the recent elucidation of the AT1R crystal structure.

150 This paper provides a systematic elucidation of the bactericidal mechanisms of AgNPs (sil

151 Elucidation of the BaP mechanism of action is required i

152 They also enable elucidation of the binding mode of an allosteric small-m

153 ss target identification, and validation and elucidation of the binding site in drug discovery.

154 Elucidation of the biochemical pathway(s) involved in pu

155 Here, we report the elucidation of the biological characteristics of the two

156 The importance of complete elucidation of the biological functions of phosphoinosit

157 cation of genes would greatly facilitate the elucidation of the biological mechanisms underlying depr

158 s not been previously propagated, preventing elucidation of the biology of this virus.

159 In this study, we report the elucidation of the biosynthesis of cladofulvin, an asymm

160 -C from oryzalexin D, essentially completing elucidation of the biosynthesis of this family of rice p

161 ncement of tools for functional genomics and elucidation of the biosynthesis of triterpenoid from thi

162 ization may provide the key link to complete elucidation of the biosynthetic pathways of ingenol mebu

163 Elucidation of the bound ligand crystal structure showed

164 Elucidation of the carotenoid biosynthetic pathway has e

165 and the catalysis of DMSP cleavage, enabling elucidation of the catalytic mechanism, in which the res

166 althy controls will be useful in the further elucidation of the causal role of reflux in erosive toot

167 However, whether their use may obscure the elucidation of the cellular and molecular mechanisms inv

168 st MAS conditions to provide atomistic-level elucidation of the complex heterogeneous structure of bo

169 This categorization would help to improve elucidation of the complex mechanisms involved in B-cell

170 robustness of fractional-dose vaccination by elucidation of the conditions under which dose fractiona

171 Elucidation of the conformational transitions that the H

172 characterization of this esterase including elucidation of the crystal structure was performed.

173 In the biopharmaceutical industry, elucidation of the cysteine connectivities is a necessit

174 Therefore, elucidation of the effects of ACh on the excitability of

175 iver mutations in cancer and other diseases, elucidation of the effects of sequence variants on prote

176 The elucidation of the elementary steps of this process will

177 Elucidation of the enzymatic mechanism of this unprecede

178 sistance in several cancer types; therefore, elucidation of the epigenetic mechanisms that underlie d

179 Elucidation of the evolutionary history and interrelated

180 However, elucidation of the exact mechanisms associated with E-ca

181 lar, a nanoLC/EI-MS method was developed for elucidation of the free fatty acid profile in mussel sam

182 available P. chromatophora cultures excluded elucidation of the full metabolic capacity and occurrenc

183 Elucidation of the function of synaptonemal complex (SC)

184 all individual loci may greatly enhance the elucidation of the genetic architecture of quantitative

185 The elucidation of the genetic code remains among the most i

186 he characterization of these compounds is an elucidation of the genetic regulatory mechanisms that ov

187 Elucidation of the genetic underpinnings for these adapt

188 Elucidation of the genetic variants involved in SD cases

189 for larger meta-analyses, which will enable elucidation of the genetics of thrombotic diseases, and

190 precision oncology approaches require robust elucidation of the genomic landscape of a patient's canc

191 m coupled with prior knowledge for automated elucidation of the glycan structure within a glycopeptid

192 Elucidation of the immune requirements for control or el

193 has been exhaustively characterised, however elucidation of the interactions between biomolecules pro

194 Structure elucidation of the isolates was achieved by means of NMR

195 Elucidation of the isoprenoid metabolic pathways is indi

196 Elucidation of the key parameters and limitations of the

197 This is the first elucidation of the kinetic mechanism of a two-component

198 Elucidation of the lamina structure provides insight int

199 s enabled total synthesis and stereochemical elucidation of the marine sponge metabolites (4R,6R)-pla

200 tal validation of the offline hypothesis and elucidation of the means by which the protein might dict

201 Elucidation of the mechanism by which chemical denaturan

202 structure provides a starting point for the elucidation of the mechanism by which PhoP regulates the

203 Elucidation of the mechanism by which PS1 regulates beta

204 However, elucidation of the mechanism by which secretory cargoes

205 Drug target identification and elucidation of the mechanism of action (MoA) of hits fro

206 free and in immobilized form, along with the elucidation of the mechanism of action, represent challe

207 Better elucidation of the mechanism of action, the impact of ch

208 nction of the domain is critical for further elucidation of the mechanism of immunosuppression mediat

209 Elucidation of the mechanism of intracellular dynamics o

210 Further elucidation of the mechanism of PSD may ultimately lead

211 studies of reverse transcriptase led to the elucidation of the mechanism of retrovirus replication,

212 Elucidation of the mechanism of suppression can lead to

213 Elucidation of the mechanism of the reaction of NO with

214 Recent elucidation of the mechanism of the viral double-strande

215 Elucidation of the mechanisms controlling HPV replicatio

216 The elucidation of the mechanisms of aggressive NFPAs in bon

217 Elucidation of the mechanisms that distinguish between h

218 The elucidation of the mechanisms underlying folate action h

219 t changes in metabolite oxidation states and elucidation of the mechanisms whereby the redox state in

220 Design of antiviral treatment options and elucidation of the mechanistic basis of disease pathogen

221 n essential precedent that will allow future elucidation of the mechanistic causes of mitochondrial a

222 ly, the prediction and even the experimental elucidation of the micellar mixing behavior of surfactan

223 essor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomp

224 Elucidation of the molecular bases for strain-specific h

225 Elucidation of the molecular details of the interplay be

226 The elucidation of the molecular mechanism of IPU catabolism

227 The elucidation of the molecular mechanisms by which soluble

228 Elucidation of the molecular mechanisms that define envi

229 Elucidation of the molecular outcomes of the disease-cau

230 However, elucidation of the multiple pathophysiologic mechanisms

231 Elucidation of the mutational landscape of human cancer

232 The approach allows further elucidation of the natural history of the disease and ma

233 tudies on the selected compounds enabled the elucidation of the NMR structures of the C-terminal doma

234 els of inflammatory EBA that facilitated the elucidation of the pathogenesis of autoantibody-induced,

235 upled with isolation and detailed structural elucidation of the pathway intermediates by spectroscopi

236 By structural elucidation of the pathway metabolite scytalone in A. ni

237 Elucidation of the patterns and controls of carbon (C) f

238 expected to become valuable tools in further elucidation of the physiological role of FPR2 in health

239 y, and the collateral benefits have included elucidation of the pivotal roles of mTOR signaling in th

240 afety of nanoscale particles, as well as the elucidation of the possible beneficial use of these part

241 dertaken toward the isolation and structural elucidation of the prodiginine family of natural product

242 copper electrodes prevents a straightforward elucidation of the reaction mechanism and the design of

243 nd may warrant further investigation for the elucidation of the reasons for these differences.

244 Elucidation of the regulatory mechanisms is crucial for

245 Here, we report the full elucidation of the Rhodiola salidroside biosynthetic pat

246 Although addressed in numerous studies the elucidation of the role of CBM and active site aromatics

247 lits exhibit little surface charge, allowing elucidation of the role of steric effects.

248 nance of oriented samples, thus allowing for elucidation of the role played by lipids in shaping memb

249 promising therapeutic interventions, further elucidation of the roles of Eph receptors in the tumor i

250 -throughput technologies is essential to the elucidation of the roles played by lipids in cellular fu

251 Elucidation of the selection mechanism is likely to bene

252 SNOTRAP is a direct tagging tool for global elucidation of the SNO-proteome, providing functional in

253 on in cell-based therapy, and permit further elucidation of the stem cell-mediated craniofacial skele

254 The resulting elucidation of the structural and chemical evolution of

255 or the refinement of computer models and the elucidation of the structure and dynamics of complex bio

256 Considering the unusual peptide chain, the elucidation of the structure presented here sets the bas

257 ication of the responsible substitutions and elucidation of the underlying mechanisms provide unique

258 very of this mutualistic association and the elucidation of the underlying regulatory mechanisms sets

259 s Review focuses on research oriented toward elucidation of the various aspects that determine adsorp

260 cations) has been investigated, allowing the elucidation of the vibrational Raman fingerprint of thro

261 X-ray crystallographic elucidation of theCjLPMO10A catalytic module revealed th

262 ion of thiol isomerase substrates and better elucidation of their cellular functions.

263 The identification of these proteins and the elucidation of their characteristics and the biological

264 odent neocortical circuits, allowing further elucidation of their functions.

265 ification of functional genetic variants and elucidation of their regulatory mechanisms represent sig

266 However, elucidation of their structures has been an arduous task

267 The elucidation of these clock-controlled immunomodulatory m

268 Elucidation of these endotypes warrants further investig

269 value of the NMR technique in the structural elucidation of these molecules, they were fully characte

270 Elucidation of these pathways has inspired the design an

271 Further elucidation of these pathways might provide therapeutic

272 Elucidation of these pathways promises to identify targe

273 study, we describe the characterization and elucidation of these processes through the combination o

274 However, the elucidation of this complicated shape formation is chall

275 Exposition and elucidation of this method and a protocol for use is the

276 Elucidation of this process is critical to understanding

277 Elucidation of this process is important for future drug

278 Their identification is an essential step in elucidation of transcriptional regulatory networks.

279 Elucidation of tumor biology principles, most notably a

280 iation action spectroscopy for the structure elucidation of tyrosine peptide cation radicals produced

281 Elucidation of underlying biology and molecular pathways

282 l range makes the method ideal for structure elucidation of unknown peptides from the bioprospecting

283 SCLC with increased malignant potential, the elucidation of which may enable earlier prognosis and po

284 ical advances in glycan analysis, structural elucidation of WTAs remains challenging due to their com

285 e role of the RAS in modulating AKI requires elucidation, particularly because stimulating type 1 ang

286 dical outcomes; unfortunately, the structure elucidation process of unknowns is often a major bottlen

287 etry (LC-MS); and MS-FINDER 2.0, a structure-elucidation program that uses a combination of 14 metabo

288 (QTOFMS) has been mainly used for structural elucidation purposes, its potential for fast screening o

289 Interestingly, isolation and structure elucidation revealed the identification of a C(3)-prenyl

290 Mechanistic elucidation reveals an unprecedented chemical process fo

291 s and the use of computer-assisted structure elucidation software.

292 direct bioautography hyphenated to structure elucidation techniques is a straightforward bioanalytica

293 e foldamers, their amenability to structural elucidation, their relative ease of synthesis, and the p

294 nd most routinely used in solution structure elucidation, this fast and efficient two-criterion metho

295 n between the kinome and EMT require further elucidation to define targetable conduits.

296 X-ray diffraction are presented as structure elucidation tools for analytical chemistry of natural pr

297 Additionally, HR-MS analysis and structure elucidation tools such as diagnostic ions, isotopic matc

298 UHPLC-MS-SPE) followed by de novo structural elucidation using 1D/2D nuclear magnetic resonance (NMR)

299 For elucidation, we conducted this prospective study.

300 used in physical chemistry for 3D structure elucidation with computational chemistry support.