1 Thus, highly addictive opiate drugs
elude a fundamental mode of physiological regulation tha
2 many aspects of decision behavior that have
eluded a common explanation.
3 ts neural underpinnings that previously have
eluded a common explanation.
4 Up to now, this organelle has
eluded a detailed analysis of the dynamics of its consti
5 ed new light on phenomena that have thus far
eluded a formal description, such as attention and the l
6 ential importance in biotechnology, but have
eluded a full description of their multistep assembly an
7 the quantum spin ice candidate Yb2Ti2O7 have
eluded a global understanding and even the presence or a
8 Sepsis is a devastating problem that has
eluded a solution, despite the introduction of highly ef
9 e activators on eukaryotic transcription has
eluded a solution, largely because of the technical diff
10 These disorders have
eluded a unique molecular explanation, and therapy has p
11 he dynamics of molecules in HB systems still
eludes a comprehensive understanding.
12 may be the mechanism by which S. Typhimurium
eludes a strong inflammatory response to establish a car
13 tion on apolipoprotein A-I folding which had
eluded all previous approaches.
14 central position in metabolism, has largely
eluded analysis in profiling studies.
15 ower" organisms seems so far to have largely
eluded analysis.
16 ersed-phase liquid chromatography (RPLC) has
eluded analytical chemists for decades.
17 ally extended chaotic systems have generally
eluded analytical solution, leading researchers to consi
18 Cancer cells
elude anti-tumour immunity through multiple mechanisms,
19 Crucial issues still nowadays
elude biosensors to enter the market, such as sensitivit
20 Such a basic quantity
eludes both theory and observation, because of an imperf
21 ding the ability to autotomize body parts to
elude capture.
22 abling the formation of escape variants that
elude CAR T cell targeting.
23 makeup of diverse bacterial communities that
elude cell culturing, researchers face two primary chall
24 DNA damage that
eludes cellular repair pathways can arrest the replicati
25 on, the biosynthesis and function of NM have
eluded characterization because of lack of an experiment
26 l-ligand multiple bonding but has previously
eluded characterization in an isolable molecule.
27 zyme responsible for this transformation has
eluded characterization.
28 lls' origins and developmental pathways have
eluded characterization.
29 rane deformations during fusion have largely
eluded characterization.
30 -catalyzed cross-coupling of nitroarenes has
eluded chemists for decades.
31 In the past, these connections have
eluded clear definition because of the sheer numerical c
32 They may
elude clinical detection and have the potential to be le
33 The origins of schizophrenia have
eluded clinicians and researchers since Kraepelin and Bl
34 urette syndrome and other tic disorders have
eluded clinicians and scientists for decades.
35 rotein, suggesting that autoreactive B cells
elude clonal deletion during development.
36 n, the mechanically gated ion channels, have
eluded cloning efforts.
37 Until recently this transporter had
eluded cloning.
38 3-binding proteins in microorganisms able to
elude complement-mediated host defense.
39 y different subtypes, several of which still
elude complete characterization.
40 hydration, fluoride ions in water typically
elude complexation by neutral Lewis acids.
41 that underlie the capacity for control have
eluded consensus, with various executive control regions
42 retrospective testing of designer drugs that
elude conventional drug tests.
43 nterfacial protein secondary structures that
elude conventional techniques.
44 ragmentation, and changes were observed that
eluded conventional detection methods.
45 understand how closely related arenaviruses
elude cross-species neutralization by investigating the
46 ntensive efforts, a MutS.ATP.DNA complex has
eluded crystallographic analysis.
47 ideal candidate for these methods, as it has
eluded crystallographic characterization despite extensi
48 ars ago, the ferric enterobactin complex has
eluded crystallographic structural characterization.
49 Several variants
eluded CTL recognition by genetic loss of the hemizygous
50 microbial sample, the vast majority of which
elude cultivation.
51 ichia coli or other model organisms and have
eluded culturing and manipulation in the laboratory.
52 n epigenetic mechanism by which cancer cells
elude cytotoxic insult by chemotherapy, and provide a ba
53 chanism in mammalian appetite regulation has
eluded definition.
54 t, the structural basis for this process has
eluded definition.
55 or (EGFR) is activated upon dimerization has
eluded definition.
56 nt(s) required for c-myc autorepression have
eluded definition.
57 outcomes, although this disease continues to
elude definitive cure.
58 These corepressors, however, have previously
eluded definitive identification.
59 The human naive ES cell state has
eluded derivation without the use of transgenes, and for
60 with one site exposed and one FPA intact has
eluded description.
61 th, where fragments of ancient material have
eluded destruction by tectonic and surface processes ope
62 action, O((3)P) + H2 --> OH(X(2)Pi) + H, has
eluded detailed experimental study because of its high a
63 de hydrolase family 12, which had previously
eluded detailed structural analysis.
64 II/2, GII/5, GII/6, and GII/n) are likely to
elude detection by the Dako kit.
65 sortia over short spatiotemporal scales that
elude detection by traditional analytical approaches.
66 result in protein unfolding and may in fact
elude detection by traditional spectroscopic techniques.
67 er, more subtle conformational changes often
elude detection, since the resulting changes of the exte
68 cular mechanism for initiating signaling has
eluded detection because none of the molecules in this p
69 Mikrocytids have
eluded detection because of their small size, intracellu
70 phorylation, a protein modification that has
eluded detection by conventional MS/MS methods.
71 various tissues are so low that the cDNA has
eluded detection by standard library screening approache
72 However, such intermediates have
eluded detection for decades, preventing the unambiguous
73 astic scattering of neutrinos off nuclei has
eluded detection for four decades, even though its predi
74 However, its signal has
eluded detection for the past 50 years.
75 ate (5-Me-PCA), a reactive compound that has
eluded detection in most laboratory samples.
76 its highly unusual electrophoretic mobility
eluded detection in previous studies.
77 lain why the axonal transport of tubulin has
eluded detection in so many other studies.
78 e produces Criegee intermediates, which have
eluded detection in the gas phase until very recently.
79 , VapC-mt4 (also known as VapC4), which have
eluded detection using conventional approaches.
80 al expectancy effects in attention that have
eluded detection using neuroimaging methods such as EEG.
81 he fact that key reactive intermediates have
eluded detection.
82 ated endogenous plant miRNA targets may have
eluded detection.
83 l respiratory chemoreceptors have themselves
eluded detection.
84 (SOCs) is crucial to Ca2+ signaling but has
eluded detection.
85 dependent cytotoxicity, which had previously
eluded detection.
86 dily detected, the active mature cathepsin K
eludes detection by in vitro methods due to its shorter
87 nspecific block to the IRF-3 pathway, WNV-NY
eludes detection by the host cell at early times postinf
88 in the form of an Mg ion-radical cage, which
eludes detection in trapping experiments by reacting qui
89 PAGE), a characteristic that accounts for it
eluding detection until now.
90 *P(i) state, the structure of this state has
eluded determination both in isolated form and in muscle
91 structures of disease-related oligomers have
eluded determination.
92 This infection had previously
eluded diagnosis despite extensive microbiological testi
93 used to try and enrich for gene space while
eluding difficulties associated with repetitive DNA.
94 ll, sub-kilometre-sized, Kuiper belt objects
elude direct detection, but the signature of their occul
95 These ephemeral species, however, often
elude direct experimental characterization.
96 m the so-called Bloch-Siegert shift that has
eluded direct and exclusive observation in solids.
97 bulk behaviour of materials, but has to date
eluded direct detection and experimental scrutiny at a m
98 over the past 40 years, but has, until now,
eluded direct determination.
99 for two parameter regimes that have thus far
eluded direct experimental observation: (1) highly visco
100 mediators of energy dissipation have so far
eluded direct observation.
101 the catalytic intermediate for this step has
eluded direct observation.
102 ctrophilic carbenoid intermediates that have
eluded direct observation.
103 However, this conjecture has
eluded direct observational confirmation since it was fi
104 eatures in the XGG or XAG region of duplexes
elude discovery by NMR methods (especially because of th
105 s most eukaryotes, however, have by-in-large
eluded discovery at the molecular level.
106 mains or biosedimentary fabrics--has to date
eluded discovery in the extensively-recrystallized rocks
107 ction of the genomes of many organisms, they
eluded discovery through the first half century of genet
108 nd inferred protein isoforms that previously
eluded discovery using established experimental, predict
109 ars for this class of supernovae have so far
eluded discovery.
110 duction of miR-21 may enable cancer cells to
elude DNA damage-induced apoptosis and enhance the metas
111 nucleoside analogs, thus offering a means to
elude drug resistance.
112 A clinically efficacious Ras inhibitor has
eluded drug-discovery efforts for decades.
113 ronments, long considered a "black box," has
eluded ecologists.
114 pain following herpes zoster (shingles) that
eludes effective treatment in many patients.
115 cilitate the study of SCD in HF, which still
eludes effective treatment.
116 te exhibiting high heritability, has largely
eluded efforts to identify specific genetic variants und
117 roalanines, a unique transformation that had
eluded enzymatic characterization.
118 TB (bTB) is endemic in Irish cattle and has
eluded eradication despite considerable expenditure, ami
119 lows us to address scientific questions that
eluded examination just a few years ago.
120 tates under physiological conditions largely
elude experimental estimation.
121 ce for a theoretical concept that has so far
eluded experimental detection.
122 underlying polymer collapse transition, has
eluded experimental determination.
123 However, instantaneous velocity has
eluded experimental observation for more than a century
124 ion-acetylene addition (HACA) mechanism--has
eluded experimental observation.
125 mation from metal-doped graphite has largely
eluded experimental study, because harsh synthetic metho
126 ter molecules around a hydrated electron has
eluded explanation for more than 40 years.
127 symmetric springtime retreat of the cap have
eluded explanation.
128 ereas indirect effects, although documented,
elude explicit quantification in experiments.
129 avoidance mechanism allowing the species to
elude extinction.
130 r-suppressive effects that cancer cells must
elude for malignant evolution.
131 ex of the simplest hydrocarbon, methane, has
eluded full solution characterization.
132 losis, produces sulfated molecules that have
eluded functional characterization for decades.
133 e, has been known for over a century but has
eluded genetic and biochemical characterization.
134 n, yet its anaerobic microbial oxidation has
eluded geochemists and microbiologists for decades.
135 ve plate motions and hotspot volcanism still
eludes geophysicists.
136 dely acknowledged but its precise nature has
eluded geoscientists and remained controversial.
137 d can be highly maladaptive when individuals
elude harmless situations in anxiety disorders, but the
138 ion of these fusion protein TMDs have so far
eluded high-resolution structure characterization becaus
139 roteus, who could assume many forms and thus
elude his pursuers.
140 hronically infected cells in which virus can
elude host defenses, perpetuate infection, and escape er
141 ular factors that engage HIV after entry may
elude identification in less intensive knockdowns.
142 of human lice, its primary endosymbiont has
eluded identification and characterization.
143 depends on an early viral factor(s) that has
eluded identification for over 40 years.
144 strate of brain stimulation reward (BSR) has
eluded identification since its discovery more than a ha
145 The lateral signal has
eluded identification, so the mechanism by which lateral
146 This unusual protease has
eluded identification, though evidence suggests that the
147 diate these actions of C-1-P have, thus far,
eluded identification.
148 but the fragment cleaved from the porphyrin
eluded identification.
149 zymes responsible for this modification have
eluded identification.
150 d to a 0.5-cM region on chromosome 9q31, has
eluded identification.
151 ough the Himalayan process zone has hitherto
eluded imaging.
152 olecular targets that are used by viruses to
elude immune detection and destruction.
153 However, these cancers may also
elude immune surveillance and eradication through the ex
154 To
elude immune surveillance, tumors must develop mechanism
155 entation by infected macrophages and thereby
elude immune surveillance.
156 ulosis establishes a latent metabolic state,
eludes immune surveillance and responds to triggers that
157 engraftment of allogeneic cells necessitates
eluding immune-mediated rejection, which is currently ac
158 ested phagosome and depends upon necrosis to
elude immunity and disseminate.
159 suggested to contribute to their ability to
elude innate immune responses and successfully colonize
160 important "SIV isolates" that have thus far
eluded investigation.
161 s physiological importance have continued to
elude investigators.
162 Its cellular basis has
eluded investigators but now, using a molluscan model sy
163 ance of this dimeric structure, however, has
eluded investigators since its discovery in the late 196
164 ecific causative agent for this syndrome has
eluded investigators to date.
165 transmit or assay infectious KSHV has so far
eluded investigators.
166 ell culture model of uroepithelial cells has
eluded investigators.
167 fication of regulatory protein receptors has
eluded investigators.
168 d incidence of cancer and total deaths still
eludes investigators.
169 to their high reactivity, these species have
eluded isolation and spectroscopic characterization even
170 ovel site could be a productive strategy for
eluding Ispinesib-resistant tumors.
171 er millennial timescales, so has necessarily
eluded laboratory experiments.
172 ence insufficiency, and skew deviation) also
elude localization.
173 nd protein coding regions but has managed to
elude loss from arthropod genomes.
174 dynamics of this physiological response have
eluded mathematical modeling efforts.
175 -resistant TEM beta-lactamases (IRTs), which
elude mechanism-based inhibitors, such as clavulanate.
176 of the binding to many sensor surfaces have
eluded mechanistic description due to complexities assoc
177 changes in work rate - a phenomenon that has
eluded mechanistic explanation for decades - data from (
178 EW: The cause of multiple sclerosis (MS) has
eluded medical science for over a century.
179 fusion state of gp41 ectodomain (e-gp41) has
eluded molecular and structural analysis, and thus asses
180 owever, the phosphate acceptor in G6Pase has
eluded molecular characterization.
181 other receptors of medical interest, it has
eluded molecular cloning since its discovery, and the ge
182 tively common among skeletal dysplasias, has
eluded molecular elucidation so far.
183 pes to produce unrivaled materials that have
eluded more conventional techniques.
184 Long-term survival still
eludes most patients with leukemia and non-Hodgkin's lym
185 the presence of moisture, a feat that still
eludes most synthetic polymers.
186 lar source of such high-enthalpy changes has
eluded neurobiologists and biophysicists.
187 of having seen at all is a problem that has
eluded neuroscience.
188 excitable cells, mitochondria have thus far
eluded optogenetic control.
189 ry information, even common household smells
elude our ability to name them.
190 detection of potentially novel drivers that
eluded over a dozen pan-cancer/multi-tumor type studies.
191 The molecule largely
eludes P glycoprotein-mediated drug efflux, and an analo
192 A synthetase (CysRS) in several archaea that
eluded previous annotation studies.
193 e fusions in 4 commonly used cell lines that
eluded previous approaches.
194 The intact and complete p53 molecule has
eluded previous attempts to obtain its structure, largel
195 ral range from zero to mid-infrared-that has
eluded previous attempts.
196 lar charge transfer on a time scale that has
eluded previous synchrotron studies.
197 onent of the transporter, a protein that has
eluded prior characterization.
198 Rare errors that
elude proofreading are extended into duplex DNA and exci
199 l borate (2-APB), the mechanism of which has
eluded recent scrutiny.
200 However, MCMV has evolved mechanisms to
elude recognition and clearance by NK cells.
201 as well as autonomic status epilepticus had
eluded recognition because emetic and other ictal autono
202 identified in choroid plexus (CP), but have
eluded regional localization within the brain parenchyma
203 n repair, compounds that react similarly but
elude repair are desirable.
204 bond to initiate catalysis has continued to
elude researchers.
205 tity of the mechanotransduction channels has
eluded researchers despite intensive investigations over
206 however, the use of calcium has historically
eluded researchers due to its high melting temperature,
207 The functions of quinone reductase 2 have
eluded researchers for decades even though a genetic pol
208 bility to dissolve nanotubes in solvents has
eluded researchers for over a decade.
209 to the microtubule-binding outer domain has
eluded researchers.
210 rare outer membrane proteins (OMPs) has long
eluded researchers.
211 lly active compound or compounds in MAO have
eluded researchers.
212 ogaster Y-linked fertility factors have long
eluded researchers.
213 NA (lncRNA) transcribed from telomeres, have
eluded researchers.
214 mycin amenable to analog derivatizations has
eluded researchers.
215 an MRP RNA locus, thereby attaining what has
eluded RNAi and RNase H experiments: elimination of MRP
216 The same unusual conformation that
eludes RNase H, thought to be a change in width of minor
217 common genetic neurological disorders, have
eluded scientists despite intensive search.
218 ns, have been a difficult challenge that has
eluded scientists for decades.
219 practically unobservable blue phase III have
eluded scientists for more than a century since it was d
220 ov and colleagues report an advance that has
eluded scientists for over a decade-the successful deriv
221 nely predictive ab initio model of water has
eluded scientists.
222 chlore and other sought-after lattices, have
eluded self-assembly.
223 The observed discrepancies
elude simple explanations but suggest that self-rated he
224 Although
eluding simple sequence comparisons, the DDBH2 domains s
225 ome 10) tumor suppressor gene functions that
eluded single mutant analyses, using a Caenorhabditis el
226 ss of 5% of renal transplants per annum, and
eludes specific therapies.
227 rogressive cerebellar dysfunction that might
elude standard diagnostic workup strategies for ataxia.
228 The potential introduction of drug-
eluding stents in the management of recurrent intracrani
229 ) and TB-like diseases in humans and animals
elude sterilizing immunity by residing within an intrace
230 of regulation is N-myristylation, which has
eluded structural and functional characterization so far
231 m native crystals of macromolecules has long
eluded structural biology.
232 rane (TM) domains that mediate assembly have
eluded structural characterization.
233 Thus far, S1 has
eluded structural determination.
234 ex crystal structures that some of them have
eluded structure determination for many years.
235 inase domain is the only one that has so far
eluded structure determination.
236 teasomes of all organisms, but have thus far
eluded study because of the technical limitations encoun
237 heavy-fermion compound URu(2)Si(2) has long
eluded such identification.
238 ns in biochemistry and biotechnology but has
eluded supramolecular chemists for decades.
239 r, the perfect valve substitute continues to
elude surgeons after almost four decades of clinical exp
240 identified recurrent molecular lesions that
elude syndromic classification and whose disease manifes
241 ivalent, and an electrophile that previously
eluded synthesis, capture and characterization.
242 from arylboronic acids, a reaction that has
eluded synthetic chemists for decades.
243 tional alleles in genes that have previously
eluded targeting using conventional methods.
244 steronomas because of their small size often
elude techniques to locate them.
245 ts into how HIV, and possibly other viruses,
elude the host immune response during primary infection.
246 (Vsg) expression allow Trypanosoma brucei to
elude the immune response.
247 Malignant cells often
elude the immune system by lacking costimulatory signals
248 noevasive, the capacity of CSCs to similarly
elude the immune system remains controversial, potential
249 a virulence mechanism of M. tuberculosis to
elude the oxidative attack of macrophages.
250 tered cell that has acquired the capacity to
elude the proliferation-suppressive effects of polymeriz
251 oblasts is characterized by their ability to
elude the proliferation-suppressive properties of polyme
252 True "cures"
elude the surgeon all too often.
253 Nevertheless, most tumors have
eluded the effects of inhibition of a single kinase by a
254 The design of an effective AIDS vaccine has
eluded the efforts of the scientific community to the po
255 oration of the genome, discovery science has
eluded the functional neuroimaging community.
256 indings of disease whose diagnoses have long
eluded the medical community.
257 tion of highly selective JAK3 inhibitors has
eluded the scientific community.
258 an elicit virus-neutralizing antibodies, HIV
eludes the immune system.
259 se data support a model in which C. burnetii
eludes the primary ROI killing mechanism of activated PM
260 quilibrium effect is inverse (< 1), this KIE
eludes the traditional interpretation of 2 degrees KIEs.
261 e substrates, products, or intermediates are
eluding the common detection techniques or as a method a
262 elucidated an influenza viral mechanism for
eluding the IFNAR signaling pathway, which could provide
263 ning in their practices that would otherwise
elude them by reading their patients' charts as if they
264 mune response, viruses can either attempt to
elude them or confront them.
265 progressive, and fatal disease that has long
eluded therapy.
266 aracteristics of this organization that have
eluded these previous studies.
267 Here we present CopywriteR, which
eludes these problems by exploiting 'off-target' sequenc
268 In contrast, IPF fibroblasts
eluded this restraint, displaying a pathological pattern
269 fically mast cells in their pathophysiology,
eluding to a potential role for these cells in the patho
270 l mechanisms subserving this feat appears to
elude traditional approaches to functional brain data an
271 cromolecular structures, including some that
elude traditional direct methods.
272 I-MPR also recognizes lysosomal enzymes that
elude UCE maturation and instead display the Man-P-GlcNA
273 ial cannot be observed from Earth, so it has
eluded unambiguous characterization.
274 set and offset of mechanical stimulation has
eluded understanding for decades.
275 Thebe extension behaves differently and has
eluded understanding.
276 e enhanced stability of these proteins still
elude us and such studies have the potential to further
277 the precise roles of critical players still
elude us due to our lack of specific and temporal contro
278 grasp of pathogenic mechanisms continues to
elude us.
279 , the accurate mapping of which continues to
elude us.
280 standing of its natural history continues to
elude us.
281 almost all scientific disciplines, yet they
elude us.
282 the dynamics of complex systems continues to
elude us.
283 However, a key aspect that has
eluded us is the point in the trypanosome life cycle whe
284 ntation of a scientific advancement that has
eluded us to date--a highly effective vaccine.
285 ted to cause changes in development has long
eluded us.
286 Although the precise function of ERG1
eludes us presently, its unique pattern of expression in
287 gulating Abeta metabolism and toxicity still
eludes us.
288 nd cyclooxygenase-2 in these processes still
eludes us.
289 uclear hormone receptors (NHRs) have largely
eluded utility in heterologous gene regulation applicati
290 Most of the available SNP data have
eluded valid population genetic analysis because most po
291 e potential for mix-and-read workflows, have
eluded widespread acceptance due to interferences in bio
292 constitution of the theta phase has thus far
eluded workers in the field and remains a challenge for