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1 ned using a variety of TLR-transfected human embryonic 293 cell lines, while the PF-deficient mutants
2 s to define the steps required for the first embryonic abscission in Caenorhabditis elegans Our findi
3 of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adult fly heart revealed that the Nedd4 pr
5 c stem cells (ESCs) but becomes activated in embryonic and adult tissues while TET1FL is expressed in
7 ows widespread chimeric contribution to both embryonic and extraembryonic lineages in vivo and permit
8 esis requires intricate interactions between embryonic and extraembryonic tissues to orchestrate and
9 enome expression in 67 first trimester human embryonic and fetal ovaries and testis and confirmed by
10 were robustly generated from multiple human embryonic and induced pluripotent stem cell lines and ha
13 upernumerary mammary buds and normalizes the embryonic and postnatal hyperbranching phenotype of Eda
15 egulators acting in the molecular control of embryonic bilateral symmetry.Retinoic acid (RA) regulate
16 development, during the integration of post-embryonic-born GABAergic neurons into the circuit, produ
17 genomic imprinting in the 12-day-old chicken embryonic brain and liver by examining ASE in F1 recipro
19 th this, introduction of TRBP into the mouse embryonic brain in utero increased the fraction of cells
20 e damage in human cortical organoids and the embryonic brain of the ZIKV-induced mouse microcephaly m
21 (+/+) and Slc6a4 (+/-) mice and post-stress embryonic brains were assessed for whole genome level pr
22 mors arising from SS18-SSX expression in the embryonic, but not postnatal, Myf5 lineage share an anat
25 e for GDF6 and BMP signaling in governing an embryonic cell gene signature to promote melanoma progre
26 stream cranial neural crest or from multiple embryonic cell populations evolving most quickly and int
27 vestigate the role of Utf1 (Undifferentiated embryonic cell transcription factor 1) in mouse germ cel
29 itro expansion, and at ratios >1:3 postnatal:embryonic cells, they inhibit the ability of embryonic d
30 niotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular
31 rant egg morphology and a maternal-effect on embryonic chromosome segregation and survival, which was
33 ontrast, fetal steady-state hematopoiesis at embryonic day (E) 14.5 was not affected by homozygous Mo
34 inences (CGEs) between preterm-born [born on embryonic day (E) 29; examined on postnatal day (D) 3 an
36 use RGCs shortly after they differentiate at embryonic day 12 and is essential for multiple aspects o
37 y, we isolated palatal mesenchyme cells from embryonic day 12.5 (E12.5) and E13.5 Osr2(RFP/+) and Osr
38 recipitation against Lmx1b in mouse limbs at embryonic day 12.5 followed by next-generation sequencin
40 rebrain neuron cell body size is apparent in embryonic day 15.5 fetuses, and persists until postnatal
41 wn that the proliferation of late gestation (embryonic day 19) fetal rat hepatocytes is mitogen-indep
42 ryo serotonin levels and neurodevelopment at embryonic day E14.5, when peripheral sources of 5-HT pre
46 embryonic cells, they inhibit the ability of embryonic dental mesenchyme cells to induce tooth format
48 conditions, including tumor suppression [2], embryonic development [3, 4], tissue repair [5-8], and o
50 rupting properties, may pose a risk to early embryonic development and cellular homeostasis during ad
52 g of how heart formation is initiated during embryonic development and for applying stem cell biology
54 regulator of WNT signaling, involved in both embryonic development and homeostasis of adult organs.
55 The expression of survivin proceeds during embryonic development and in addition has already been d
56 mooth muscle progenitor cells emerges during embryonic development and is maintained postnatally at a
57 esults demonstrate that UTF1 is required for embryonic development and regulates male germ cell devel
58 te the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis
59 by the down-regulation of genes involved in embryonic development and vasculogenesis, and up-regulat
60 mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in f
62 nery, and that Donson is essential for early embryonic development in mice as well, suggesting an ess
68 diameter, density/growth, and branching from embryonic development to three months, spanning the dura
69 rter for Cu acquisition and is essential for embryonic development, a homologous protein, Ctr2, has b
70 ignaling pathway plays a central role during embryonic development, and its aberrant activation has b
72 of several key biological processes, such as embryonic development, disease progression and aging.
73 ygotic expression of gdf3 is dispensable for embryonic development, while maternally deposited gdf3 i
74 wever, the SASP has also been shown to favor embryonic development, wound healing, and even tumor gro
89 Activity-dependent pruning also occurs at embryonic Drosophila neuromuscular junctions (NMJs), whe
90 8 represents an early and specific marker of embryonic dSPNs and the Sox8-EGFP BAC transgenic mice ar
91 we present the molecular characterization of embryonic duck bill, which we show contains a high densi
93 ers during differentiation of Neurogenin3(+) embryonic endocrine progenitors, regardless of the speci
95 r embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system.
96 t cells, the HBBP1-BGLT3 region contacts the embryonic epsilon-globin gene, physically separating the
99 l structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized
101 thylation (H3K27me3) in both Pten null mouse embryonic fibroblasts (MEFs) and Pten null mouse prostat
103 of PDAC cancer cells and SerpinB2(-/-) mouse embryonic fibroblasts (MEFs) resulted in increased tumou
104 n initiation factor 2alpha (eIF2alpha) mouse embryonic fibroblasts (MEFs); moreover, ECD mRNA levels
106 G12V))-induced premature senescence in mouse embryonic fibroblasts and normal human bronchial epithel
107 ogen-driven immortalization of primary mouse embryonic fibroblasts and recapitulates early steps of c
108 ratio was rescued in FKBP65-deficient murine embryonic fibroblasts by reconstitution with wild-type b
110 -related GTPase (IRGM1) was overexpressed in embryonic fibroblasts from dynamin1 like (DNM1L) protein
111 epithelial tissues from patients with CD and embryonic fibroblasts from mice, along with enteroids an
112 ysis of cultured mesoderm explants and mouse embryonic fibroblasts from null mutants shows that the m
113 vestigate integrin beta3 and paxillin in rat embryonic fibroblasts growing on two different extracell
115 s are abrogated in lamin A/C-deficient mouse embryonic fibroblasts that recapitulate the defective nu
119 poptotic signaling pathways and formation of embryonic gene clusters, whereas the NS5A TCR activation
120 l genome loss disrupts the normal pattern of embryonic gene expression blocking development at the mo
121 ent and types of genetic variation impacting embryonic gene expression, and their interactions with d
124 The expression of Dmrt1 was induced in ZW embryonic gonads that were masculinized by aromatase inh
125 To elucidate Grh functions we identified embryonic Grh targets by ChIP-seq and gene expression an
126 miR-1 produces defects in somatic muscle and embryonic heart development, which have been partly attr
127 concomitant with specific cell ablation and embryonic heart transplantation studies, we identified a
128 ong these lincRNAs, 564 are expressed in the embryonic heart, and 730 are expressed in the adult hear
129 ular endothelial growth factor in Hyal2(-/-) embryonic hearts, suggest that HYAL2 is important to inh
132 t DONSON is expressed in progenitor cells of embryonic human brain and other proliferating tissues, i
133 stems analysis revealed similarities between embryonic implantation and cancer cell adhesion, which s
134 enoside Ro was the most potent in inhibiting embryonic implantation within non-cytotoxic concentratio
136 mouse development is the segregation of the embryonic inner cell mass and the extra-embryonic trophe
137 ium imaging shows that the beta-cells in the embryonic islet become functional during early zebrafish
139 expression of Mac-1 on the surface of human embryonic kidney (HEK) 293 cells induced their adhesion
143 tivation and arrestin-3 recruitment in human embryonic kidney 293 cells confirmed that norbuprenorphi
147 ctions and dynamics directly in living human embryonic kidney cells using fluorescence fluctuation sp
148 ated neutrophils and 5-LOX-transfected human embryonic kidney cells, propofol attenuated the producti
151 man airway epithelia (HAE) in vitro In human embryonic kidney HEK293 cells, the transfection of a dup
153 hown to be transcriptionally active in 293T (embryonic kidney), Vero (African-green monkey kidney epi
154 whole-body deletion of the p32 results in an embryonic lethal phenotype, mice heterozygous for p32 ar
155 ctivated kinase 4 (PAK4) in the mouse causes embryonic lethality associated with heart and brain defe
158 use model and found that loss of Fdxr led to embryonic lethality potentially due to iron overload in
159 h GATA genes, but not either alone, leads to embryonic lethality prior to the onset of their expressi
161 es viability of the individual (for example, embryonic lethality) or results in profound loss of fitn
162 at disruption of both CRTC2 and CRTC3 causes embryonic lethality, and that a single allele of either
163 Ssb1/Ssb2 double knockout (DKO) caused early embryonic lethality, whereas conditional Ssb1/Ssb2 doubl
165 olyploid giant cancer cells (PGCCs) acquired embryonic-like stemness and were capable of tumor initia
166 uman embryo culture and in the derivation of embryonic-like structures from human pluripotent stem ce
169 e hepatocyte and cholangiocyte lineages from embryonic liver progenitor cells and their subsequent ma
174 -cycle deficits of radial glial cells in the embryonic mouse cortex and human forebrain organoids.
176 individual proteins encoded by ZIKV into the embryonic mouse cortex, we show that expression of ZIKV-
187 l surface markers for GSC are developed from embryonic or neural stem cell systems; however, currentl
188 cy in mice resulted in a partially penetrant embryonic or perinatal lethal phenotype, with the produc
189 ted the major CLP gene Irf6 only in the late embryonic oral epithelium ( Irf6 cKO), bypassing the rol
192 ally regarded as nonskeletogenic, and so the embryonic origin of trunk denticle odontoblasts remains
195 onstrate distinct expression patterns in the embryonic ovary and interact with each other and other o
196 a has been challenging due to the absence of embryonic phenotypes in murine loss-of-function studies.
197 ctus and shown to play a role in controlling embryonic polarity and regulating the NF-kappaB signalin
199 tro into cardiac-lineage cells; and test the embryonic potency of iCPCs via injection into the cardia
203 developmentally regulated manner in chicken embryonic retinal pigment epithelium (RPE)/choroid in th
204 other during embryogenesis to establish the embryonic SAM and to specify cotyledon boundaries, and S
205 ain transcription factor signatures of their embryonic site of origin, the pallium and subpallium.
206 Transcriptional profiling of Ctip1 (-/-) embryonic skin identified altered expression of genes en
208 germline genes, not directly associated with embryonic somatic tissue genesis, is the one that encode
209 4 is expressed in the axonal growth cones of embryonic spinal commissural neurons, motoneurons, dorsa
210 n of alternative codon-derived DPRs in chick embryonic spinal cord confirmed in vitro data, revealing
212 dence of thermal local adaptation during the embryonic stage for developmental rate or survival.
214 g in the distal limb primes the ZRS at early embryonic stages maintaining a poised, but inactive stat
215 hereas comparative transcriptomic studies of embryonic stages of hemimetabolous insects are completel
218 romatin plays a critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency.
220 oma (EC) cells are malignant counterparts of embryonic stem (ES) cells and serve as useful models for
222 the gene expression dynamics of early mouse embryonic stem (mES) cell differentiation, uncovering di
223 ank of over 100,000 individual haploid mouse embryonic stem (mES) cell lines targeting 16,970 genes w
225 mide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting
226 blished several human stem cell lines: human embryonic stem cell (hESC) line carrying the common T158
230 ce-dependent activation of expression of the embryonic stem cell markers OCT4, NANOG, SOX2 and SSEA1
234 oduced RNA-genome interaction maps for human embryonic stem cells (ESCs) and human embryonic kidney (
236 of chimeras created by injecting tetraploid embryonic stem cells (ESCs) expressing green fluorescent
238 ene promoters upon differentiation of murine embryonic stem cells (ESCs) to neural progenitor cells (
239 of induction of differentiation of mammalian embryonic stem cells (ESCs), accumulation of the repress
243 We then found CX45 was expressed in human embryonic stem cells (hESCs) and human dermal fibroblast
245 ic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem
249 evelopment, applications of IDP-ASE to human embryonic stem cells and breast cancer cells indicate th
250 rs show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in p
251 astomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells.
252 ing the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal
253 e established synchronized cultures of mouse embryonic stem cells as they exit the ground state of pl
254 yst2/Kat7/Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to
255 e in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting
256 human fibroblasts as well as mesenchymal and embryonic stem cells for both two- and three-dimensional
258 aneous deletion of these shadow enhancers in embryonic stem cells leads to impaired activation of Hox
260 plantable insulin-producing cells from human embryonic stem cells or induced pluripotent stem cells i
262 a targeted autosome loss in aneuploid mouse embryonic stem cells with an extra human chromosome and
264 ethylation genome-wide in human cells, mouse embryonic stem cells, and Drosophila Biochemical analysi
265 o interrogate the 2-Mb POU5F1 locus in human embryonic stem cells, and identified 45 cis-regulatory e
266 ry response mechanism is not active in mouse embryonic stem cells, and in vitro differentiation promo
277 Furthermore, IFIH1(T946) mice manifested an embryonic survival defect consistent with enhanced respo
278 s severe consequences for egg production and embryonic survival, with important broader relevance to
281 nd Zeb2 plays a fundamental role in defining embryonic territories in the mouse, as E-cadherin needs
282 in normal physiological processes, including embryonic tissue boundary formation and directional guid
284 formed in situ hybridisation utilising human embryonic tissue, and observed expression in the develop
287 thought to play a central role in sculpting embryonic tissues, maintaining organ architecture and co
290 to identify transcriptome changes from late embryonic to adult mouse muscle and demonstrate that alt
292 Without Eed, the obligatory subunit of PRC2, embryonic urothelial progenitors demonstrate reduced pro
293 nomously and noncell-autonomously to control embryonic vascular tissue formation and root initiation,
294 ough they lacked apparent deformities in the embryonic vasculature and heart, the placental labyrinth
295 niscent of local activation of Toll in early embryonic ventral hypoderm, consistent with the hypothes
296 transcriptional activity is dispensable for embryonic viability in the first hour after fertilizatio
298 rdingly we suggest that for each nucleus the embryonic volume arises from a structural element contai
299 activity in a mouse atrial cell line and in embryonic zebrafish and differentially regulates PRRX1 e
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