ライフサイエンスコーパス: embryonic cell

1 paucity of molecular material in the single embryonic cell.

2 king processes observed in oocytes and early embryonic cells.

3 size, as originally reported for C. elegans embryonic cells.

4 M and H2AX exhibit nonredundant functions in embryonic cells.

5 issues is functionally distinct from Sdc2 in embryonic cells.

6 edd8 conjugation pathway components in early embryonic cells.

7 1 mRNA is distributed equally throughout all embryonic cells.

8 f the polycomb group repressive complexes in embryonic cells.

9 essing of let-7 family microRNAs (miRNAs) in embryonic cells.

10 n differentiated but not in undifferentiated embryonic cells.

11 blocks the processing of pri-let-7 miRNAs in embryonic cells.

12 a transfer of Eomes protein between adjacent embryonic cells.

13 nd cytoplasmic/cortical cell compartments in embryonic cells.

14 with Dnmt3a or Dnmt3b but not with Dnmt1 in embryonic cells.

15 with act-2 for cytoplasmic function in early embryonic cells.

16 ically plastic, sharing many properties with embryonic cells.

17 olecules determines the fate and movement of embryonic cells.

18 fferentiation in a manner similar to that in embryonic cells.

19 ed injection of Mos arrests rapidly dividing embryonic cells.

20 tiation and maintenance of X inactivation in embryonic cells.

21 implantation, because they lack pluripotent embryonic cells.

22 tion in FN-null, but not in wild-type, mouse embryonic cells.

23 ay a role in POP-1 asymmetry for other early embryonic cells.

24 ry events defines the developmental fates of embryonic cells.

25 other genes characteristically expressed in embryonic cells.

26 s complicated by lethality of Chk1-deficient embryonic cells.

27 yosin II all localize to the cortex of early embryonic cells.

28 ic cells but not of random X inactivation in embryonic cells.

29 the expression of diverse proteins in single embryonic cells.

30 ormation and increased rates of apoptosis in embryonic cells.

31 to the domain of metabolites between single embryonic cells.

32 re mediate instruction of early cell fate in embryonic cells.

33 ate regulatory networks in human and primate embryonic cells.

34 n induce viral restriction pathways in early embryonic cells.

35 e of the body, is an evanescent attribute of embryonic cells.

36 against decapentaplegic homolog 2 (Smad2) in embryonic cells.

37 n, which is required in highly proliferating embryonic cells.

38 constructs were microinjected into zebrafish embryonic cells.

39 uring Ras(V12) immortalization of Drosophila embryonic cells, a phenomenon not well characterized.

40 es that progressively instruct proliferating embryonic cells about their identity and behavior.

41 paired-end Illumina sequencing in C. elegans embryonic cells, adult somatic cells, and a mix of adult

42 During the short interphase of early embryonic cells, AL are rapidly delivered into the nucle

43 Embryonic cell and tissue generated forces and mechanica

44 FP reporter was expressed cytoplasmically in embryonic cells and also was incorporated into contracti

45 t worms is due to two defects, starvation of embryonic cells and general developmental defects.

46 rotects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle.

47 resulted in expression of beta(m)-globin in embryonic cells and in a significant decrease in express

48 Here we demonstrate in primary human embryonic cells and in the chicken embryo that thalidomi

49 It is essential in embryonic cells and in the hematopoietic lineage yet dis

50 GAA.TTC triplet-repeat instability occurs in embryonic cells and involves the highly active mismatch

51 of X inactivation in both extraembryonic and embryonic cells and is accompanied by H3-K27 methylation

52 ive role in oncogenesis and is found only in embryonic cells and malignancies.

53 that mediates oriented migration of multiple embryonic cells and mice deficient for Sdf1 or its recep

54 eth can form from cell mixtures that include embryonic cells and populations of postnatal dental pulp

55 the spliced repertoire of RNAs in mammalian embryonic cells and primordial cells.

56 TERT is highly expressed in undifferentiated embryonic cells and silenced in the majority of somatic

57 a novel regulator of Snail1-dependent EMT in embryonic cells and suggest that multiple defects in FAK

58 d Smad2/3 signaling occurs preferentially in embryonic cells and transformed cells.

59 raced heritable L1 insertions to pluripotent embryonic cells and, strikingly, to early primordial ger

60 ily member Xnr2 is secreted efficiently from embryonic cells, and a new method of tissue recombinatio

61 n microscopy study of intact vitrified mouse embryonic cells, and in an ultrastructural mapping of a

62 in two major forms: tNASP, found in gametes, embryonic cells, and transformed cells; and sNASP, found

63 Invaginations in the membranes of embryonic cells appear to orient cell division in sea sq

64 how that rapidly proliferating early Xenopus embryonic cells are able to regulate replication licensi

65 Despite this hypoxia, the embryonic cells are able to undergo remarkable growth, m

66 Embryonic cells are expected to possess high growth/diff

67 Embryonic cells are highly distinct in their gene expres

68 cess in which a subset of dormant YPs within embryonic cells are reincorporated into the endocytic sy

69 Embryonic cells are tagged by AID(cre) in the submandibu

70 Mouse embryonic cells are unable to support the replication of

71 Early embryonic cells are, so far, not sensitive to the lack o

72 c mosaicism and variation in the fraction of embryonic cells bearing targeted alleles are observed, a

73 establish a population of truly pluripotent embryonic cells because of faulty reactivation of key em

74 Pluripotent embryonic cells become progressively lineage restricted

75 matrix (ECM) is synthesized and secreted by embryonic cells beginning at the earliest stages of deve

76 In humans and mice, including early embryonic cells, BRCA1 commonly associates with interpha

77 med approximately 1 to 2 h before S phase in embryonic cells but 6 h before S phase in somatic cells.

78 es of development of SMC from multipotential embryonic cells but did not elucidate the underlying mec

79 rotein turnover: ZFP809 protein is stable in embryonic cells but highly unstable in differentiated ce

80 ffect of MIF was absent in Cxcr7(-/-) murine embryonic cells but pronounced in CXCR7-transfected Madi

81 Depolarization of embryonic cells by misexpression of KCNE1 non-cell-auton

82 ted retroelements are potently restricted in embryonic cells by postintegration transcriptional silen

83 adult cells can be reprogrammed into that of embryonic cells by uncharacterized factors within the oo

84 Here, using a bioactivity test based on embryonic cells (C3H10T1/2) transfected with a BMP-respo

85 POP-1 asymmetry between the daughters of an embryonic cell called EMS results in part from a Wnt-lik

86 e shed new light on an elusive population of embryonic cells called neuromesodermal progenitors.

87 r endogenous nor exogenous sdc2 expressed in embryonic cells can compensate for knockdown of sdc2 in

88 Direct delivery of Syn into mouse embryonic cells conferred resistance to proapoptotic cas

89 f reprogramming when using donor nuclei from embryonic cells could be explained, at least in part, by

90 However, transplanted embryonic cells could provide factors that promote the s

91 the determination of lactate in a commercial embryonic cell culture medium providing excellent agreem

92 with genetically engineered mice as well as embryonic cell culture systems.

93 ve been employed to measure lactate level in embryonic cell culture, beverages, urine, and serum samp

94 actate is an essential metabolite present in embryonic cell culture.

95 iosensor for the detection of lactate within embryonic cell cultures media.

96 trated isoform-specific inhibition of PKC in embryonic cell cultures.

97 evel role for positive-feedback loops in the embryonic cell cycle and provides an example of how osci

98 ases during progression throughout the early embryonic cell cycle and shed new light on potential def

99 at cki-1 activity plays an essential role in embryonic cell cycle arrest, differentiation and morphog

100 d spatially regulated during the somatic and embryonic cell cycle by numerous mechanisms, including t

101 This implies that most of the first embryonic cell cycle can be bypassed in sperm genome rep

102 24% of control rates, depending when in the embryonic cell cycle injection took place.

103 CSF establishment in oocytes and the normal embryonic cell cycle is unknown.

104 so, causes damage-dependent delays in early embryonic cell cycle progression and subsequent lethalit

105 We use a model of the embryonic cell cycle to illustrate the approaches that c

106 f Emi2, but it is resynthesized in the first embryonic cell cycle to reach levels 5-fold lower than d

107 after egg fertilization, or during the early embryonic cell cycle, arguing against a role for B-Raf i

108 orylation is restricted throughout the early embryonic cell cycle, not just during M-phase, and how T

109 role for Sin3a in regulating the pluripotent embryonic cell cycle.

110 mical circuits in the context of the Xenopus embryonic cell cycle.

111 essential for CDK1 oscillations in the early embryonic cell cycle.

112 arrest first appears during the seventeenth embryonic cell cycle.

113 s the timing of the M-phase entry during the embryonic cell cycle.

114 rA(Thr-295) phosphorylation during the early embryonic cell cycle.

115 stablish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function

116 pose a model in which GNU normally regulates embryonic cell cycles by promoting transient dimerizatio

117 Fast, early embryonic cell cycles have correspondingly fast S phases

118 Early embryonic cell cycles in Drosophila consist of rapidly a

119 gs, which normally proceed through the early embryonic cell cycles in the absence of functional check

120 eminin slows down, but neither arrests early embryonic cell cycles nor affects endogenous geminin lev

121 cle 14 and the midblastula transition, rapid embryonic cell cycles slow because S phase lengthens, wh

122 , we extend an earlier mathematical model of embryonic cell cycles to include experimentally motivate

123 ngth are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepressio

124 During embryonic cell cycles, B-cyclin-CDKs function as the cor

125 activity and INCENP oscillated in subsequent embryonic cell cycles.

126 rol of cyclin B translation and of the early embryonic cell cycles.

127 s of PAN GU kinase, which is crucial for S-M embryonic cell cycles.

128 y is due to a requirement for DmBlm in early embryonic cell cycles; embryos lacking maternally derive

129 In cultured S2 embryonic cells, Ddok tyrosine phosphorylation is Src de

130 nsumption does not appear to be triggered by embryonic cells declining to a critically small size.

131 d may have also occurred in the germ line or embryonic cells developmentally upstream to germline spe

132 aling occurred similarly in all species once embryonic cell diameter reduced to 140 mum.

133 imes opposite outcomes that help to generate embryonic cell diversity.

134 elated, but the association breaks down when embryonic cell division ceases.

135 ngest specific suppressors rescued the early embryonic cell division defects in rfl-1(or198ts) mutant

136 specific enhancers did not affect the early embryonic cell division defects observed in rfl-1(or198t

137 s, an act-2 deletion did not result in early embryonic cell division defects, suggesting that additio

138 Variable post-embryonic cell division failures in ventral cord motoneu

139 e lengths of the first 8 out of 10 rounds of embryonic cell division in Caenorhabditis elegans, we id

140 The most potent block in early embryonic cell division was obtained by RNAi of the poly

141 les, and in the most severe case, absence of embryonic cell division.

142 d concentrates at the cleavage furrow during embryonic cell division.

143 that RUB1/2 proteins are essential for early embryonic cell divisions and that they regulate diverse

144 ne lineage tracing through the last round of embryonic cell divisions and we applied these methods to

145 of AURKB, to support both meiotic and early embryonic cell divisions.

146 as it separates from the soma during initial embryonic cell divisions.

147 rk for proteins involved in C. elegans early-embryonic cell divisions.

148 ial for zygotes to progress beyond the first embryonic cell divisions.

149 caused defects in oocyte formation and early embryonic cell divisions.

150 xpression of proteins with critical roles in embryonic cell divisions.

151 e chiral twist that takes place during early embryonic cell divisions.

152 te that the two daughter cells of many early embryonic cell-doubling events contribute asymmetrically

153 ation and proper differentiation of specific embryonic cells during development.

154 for Geminin, a nuclear protein expressed in embryonic cells, during neural fate acquisition from mou

155 In many types of Notch-activated embryonic cells, ectopic ELT-2 is sufficient to drive ex

156 molecular programs of age-matched noncardiac embryonic cells, embryonic stem cells, adult cardiomyocy

157 ivation of the anaphase-promoting complex as embryonic cells exit mitosis and return to interphase.

158 e both are expressed at around the time that embryonic cells exit the cell cycle, cki-2 also shows ma

159 from the Nkx2.1 locus to follow the fate of embryonic cells expressing these genes within the arcuat

160 Stem and embryonic cells facilitate programming toward multiple d

161 al Wnt signaling pathway and are crucial for embryonic cell fate and bone formation.

162 We propose that the role of LEC1 in embryonic cell fate control requires auxin and sucrose t

163 One of the first embryonic cell fate decisions (that is, mesendoderm dete

164 ignaling protein Notch, which is crucial for embryonic cell fate decisions, has 36 extracellular EGF

165 zoans, the T-box genes are involved in early embryonic cell fate decisions, regulation of the develop

166 ch retinal determination cascade involved in embryonic cell fate determination.

167 The role of microRNAs in embryonic cell fate specification is largely unknown.

168 egulating germline stem cell totipotency and embryonic cell fate specification.

169 The NOTCH1 gene, which is essential for key embryonic cell-fate decisions in multicellular organisms

170 kinase gene, named YODA, that promotes extra-embryonic cell fates in the basal lineage.

171 nsplanted Spemann's organizer induces dorsal embryonic cell fates such as the nervous system and somi

172 elopment is to establish embryonic and extra-embryonic cell fates.

173 in primary cultures derived from Drosophila embryonic cells follows the same developmental course as

174 case study we choose Drosophila melanogaster embryonic cells, for which both data types are available

175 In response to microenvironmental cues, embryonic cells form adhesive signaling compartments tha

176 f increased cellular transformation of mouse embryonic cells from the DFF/CAD-null mice and significa

177 In addition, early embryonic cells from this strain fail to establish embry

178 e for GDF6 and BMP signaling in governing an embryonic cell gene signature to promote melanoma progre

179 e first evidence that GRP78 is essential for embryonic cell growth and pluripotent cell survival.

180 ion of the Trap220/Med1 gene in mice impairs embryonic cell growth, yet the underlying mechanism is u

181 C. elegans embryonic cells have a common anterior/posterior (a/p) p

182 y during the first few cell divisions, later embryonic cells have an ability to generate POP-1 asymme

183 In contrast to embryonic cells, however, Chk1 is not required to delay

184 of ChIP-seq data from human cancer and mouse embryonic cells identified a significant number of putat

185 ine the specification of embryonic and extra-embryonic cell identities.

186 of embryogenesis, involved in the control of embryonic cell identity by currently unknown mechanisms.

187 When tested in vitro with cultured zebrafish embryonic cells, IGFBP-1 itself had no mitogenic activit

188 g preimplantation development is to maintain embryonic cells in a pluripotent state, little is known

189 ion as a fundamental property of pluripotent embryonic cells in vivo.

190 ipient models that may permit engraftment of embryonic cells include the use of submyeloablated or ge

191 le copy of K-ras oncogene in cultured murine embryonic cells induced the expression of a high level o

192 ns follow the ancestral pattern in which all embryonic cells inherit YPs from the egg cytoplasm.

193 nd that coinjection of CK2 beta and Mos into embryonic cells inhibits the ability of Mos to arrest ce

194 Mouse embryonic cells isolated from focal adhesion kinase (FAK

195 e sheddases for six EGFR ligands using mouse embryonic cells lacking candidate-releasing enzymes (a d

196 clonal striatal cells, PC12 cells and rodent embryonic cells lacking cathepsin D.

197 sive cancer cells, expressing a multipotent, embryonic cell-like phenotype, engage in a dynamic recip

198 peat type galectin was characterized from an embryonic cell line (Bge) and circulating hemocytes of t

199 eras were transiently expressed in the human embryonic cell line HEK-293T.

200 ms for differential cell division timing and embryonic cell lineage differentiation evolved before 55

201 Specification of an embryonic cell lineage is driven by a network of interac

202 cells, but they are derived from a different embryonic cell lineage, and little is known of the mecha

203 -dependent imprinting is largely lost in the embryonic cell lineage, but at least five genes maintain

204 these features we determined the C. briggsae embryonic cell lineage, using the tools StarryNite and A

205 tain their imprinted expression in the extra-embryonic cell lineage.

206 conserved phenotypes and divergent genomes: embryonic cell lineages and gene expression patterns are

207 ciple, can provide insights into early human embryonic cell lineages and their contributions to adult

208 stem cells (iPSCs) efficiently generate all embryonic cell lineages but rarely generate extraembryon

209 ify and define a key function of Rb in extra-embryonic cell lineages that is required for embryonic d

210 MATER complex provides a molecular marker of embryonic cell lineages, but it remains to be determined

211 ge with establishment of the trophoblast and embryonic cell lineages.

212 bryogenesis and the initial establishment of embryonic cell lineages.

213 unoprecipitation (ChIP)-seq in two different embryonic cell lines and found that AGO2 localizes to eu

214 ling of exosome by ChIP-seq in two different embryonic cell lines reveals extensive and specific over

215 med damage to the squamous epithelium, these embryonic cells migrate toward adjacent, specialized squ

216 t for 3D migration in other settings such as embryonic cell migration and wound healing.

217 e essential for cytoskeletal reorganization, embryonic cell migration, and morphogenesis.

218 neural crest is an excellent model to study embryonic cell migration, since cell behaviors can be st

219 ent model to better understand mechanisms of embryonic cell migration.

220 to collect and analyze live imaging data of embryonic cell migration.

221 ecovery, we employed an in vitro primary rat embryonic cell model of oligodendrocyte progenitor cells

222 To assess the function of Tid1 in embryonic cells, mouse embryonic fibroblasts with the ho

223 c and conserved role for Git2 in controlling embryonic cell movements.

224 Throughout animals, embryonic cells must ultimately organize into polarized

225 rter activity during formation of sea urchin embryonic cells necessary for the production of gametes,

226 that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but

227 inetochore-associated ends of spindle MTs in embryonic cells of the nematode, Caenorhabditis elegans.

228 dherin at the cell surface of either Xenopus embryonic cells or Colo 205 cultured cells, demonstratin

229 cient but is more efficient when nuclei from embryonic cells or embryonic stem cells (ECNT) are emplo

230 we show that a discrete population of these embryonic cells persists in adult mice and humans at the

231 Through cell fusion the embryonic cell phenotype can be imposed on somatic cells

232 2 belongs to the recently described group of embryonic cell Polycomb group (PcG)-marked genes that ma

233 Neural crest cells (NCC) are a transient, embryonic cell population characterized by unusual migra

234 Transient maintenance of a pluripotent embryonic cell population followed by the onset of multi

235 The neural crest is a transient, multipotent embryonic cell population in vertebrates giving rise to

236 Neural crest cells are an embryonic cell population that is crucial for proper ver

237 To define the early embryonic cell population that responds to Mesp1, we per

238 ment of the neural crest, a highly migratory embryonic cell population whose behavior has been likene

239 st cells, a highly migratory and multipotent embryonic cell population, whose behaviour has been like

240 sttranscriptional signaling cascades in this embryonic cell population.

241 in Xenopus neural crest, a highly migratory embryonic cell population.

242 stream cranial neural crest or from multiple embryonic cell populations evolving most quickly and int

243 Transcriptomes recovered from these embryonic cell populations revealed striking, early diff

244 e witnessed renewed interest in defining the embryonic cell populations that directly contribute to t

245 sensory nervous system are derived from two embryonic cell populations, the neural crest and cranial

246 efore arise in germ cells and in pluripotent embryonic cells, prior to germline specification, yet th

247 occur on multiple chromosomes in very early embryonic cells, prior to their allocation to the germli

248 emaining differences between naive hESCs and embryonic cells related to mono-allelic XIST expression

249 To generate POP-1 asymmetry, most early embryonic cells require contact with signaling cells tha

250 pha-synuclein over-expressed in human neural embryonic cells results in patterns of degeneration that

251 Studies with cultured cell lines and primary embryonic cells showed that miR-665 represses the expres

252 lications for transcriptional regulation and embryonic cell sorting and suggesting a putative mechano

253 or bioengineering new teeth if suitable, non-embryonic cell sources can be identified.

254 ical and legal complications associated with embryonic cell sources, investigators have proposed the

255 el strategy for identification of genes with embryonic cell-specific functionality.

256 estigate dynamic mechanisms that pattern the embryonic cell surface.

257 , most likely for its function in sustaining embryonic-cell survival, which requires its association

258 ect a fundamental structural property of the embryonic cell that is essential to Hh signaling.

259 l neural crest (CNC) consists of multipotent embryonic cells that contribute to craniofacial structur

260 ve in spite of the fact that many cancer and embryonic cells that have gone through EMT still coopera

261 In contrast, slightly older embryonic cells that have no apparent prior exposure to

262 such marks occur in descendant, multipotent embryonic cells that have restricted cell fate choices.

263 ural crest cells (NCCs) are highly patterned embryonic cells that migrate along stereotyped routes to

264 Embryonic cells that migrate long distances must critica

265 ers from embryonic cells, yet it is only for embryonic cells that we have a quantitative understandin

266 ansition from the G2 phase to the M phase in embryonic cells, the trigger for mitotic entry in somati

267 itro expansion, and at ratios >1:3 postnatal:embryonic cells, they inhibit the ability of embryonic d

268 h animal, demonstrating the contributions of embryonic cells to adult tissues.

269 This function relies on the ability of embryonic cells to couple their autonomous random motili

270 Using early embryonic cells to determine the functional relationship

271 ore, our findings reveal that the ability of embryonic cells to differentially reset their intrinsic

272 Ventx2 knockdown restored the competence of embryonic cells to differentiate.

273 the mesenchymal characteristics of FAK-null embryonic cells to generate committed mouse embryonic fi

274 mouse 17 clone 1 fibroblast cells and mouse embryonic cells to the same extent as the parental wild-

275 vestigate the role of Utf1 (Undifferentiated embryonic cell transcription factor 1) in mouse germ cel

276 derm cell fate and that the loss of this key embryonic cell type in mutant embryos results in pattern

277 The radial glial cell, a transient embryonic cell type known for its crucial role in neuron

278 as a result of inductive signaling from one embryonic cell type to another.

279 The neural crest, a multipotent embryonic cell type, originates at the border between ne

280 Six1 is expressed in multiple embryonic cell types and plays important roles in prolif

281 strate that TACC3 acts as a +TIP in multiple embryonic cell types and that this requires the conserve

282 d Sage and Fkh cannot alter the fate of most embryonic cell types even when expressed early and conti

283 romatin structure and organisation over many embryonic cell types for both human and mouse that, for

284 ology," a strategy of using in-vitro-derived embryonic cell types to elucidate both fundamental and e

285 imb and hindlimb, and between limb and other embryonic cell types, are correlated with tissue-specifi

286 Somites give rise to a number of different embryonic cell types, including the precursors of skelet

287 dysfusion gene is expressed in a variety of embryonic cell types, including tracheal-fusion, leading

288 ycle regulatory components between these two embryonic cell types.

289 overlapping with TACC1 and TACC3 in multiple embryonic cell types.

290 ll spectrum of gene expression from discrete embryonic cell types.

291 r time in the oocyte and between ovarian and embryonic cell types.

292 f the mouse CV nerve with respect to the two embryonic cells types that produce it, specifically, the

293 e show that RLIM levels are downregulated in embryonic cells undergoing rXCI.

294 assays revealed that Ihh is up-regulated in embryonic cells upon BMP treatment.

295 Here, using time-lapse imaging of live embryonic cells, we show that chemical or mutational dis

296 Using nuclear extract from 293 (human embryonic) cells, we mapped a second (non-canonical) Sp1

297 , unlike X-chromosome inactivation in female embryonic cells, where 25-30% of X-linked structural gen

298 niotic primordium also serves as a source of embryonic cells, which may contribute to cardiovascular

299 ison of cyt c-deficient HeLa cells and mouse embryonic cells with those expressing a full complement

300 mitotic entry in somatic cells differs from embryonic cells, yet it is only for embryonic cells that