ライフサイエンスコーパス: embryonic lethal

1 ockout mice for PCNA (Pcna(-/-)), which were embryonic lethal.

2 ental animals because perlecan disruption is embryonic lethal.

3 nockout of FAK in endothelial cells (ECs) is embryonic lethal.

4 e been hampered because BRG1 inactivation is embryonic lethal.

5 nd knockdown of smn-1 by RNA interference is embryonic lethal.

6 imal, suggesting that the latter genotype is embryonic lethal.

7 selves, double mutants missing both are also embryonic lethal.

8 rotein null phenotype is severely anemic and embryonic lethal.

9 ce homozygous knockout mice (ubc13(-/-)) are embryonic lethal.

10 asts and the Rb null phenotype is anemic and embryonic lethal.

11 k the diphthamide modification on eEF-2, are embryonic lethal.

12 hrough either the PDGFRalpha or PDGFRbeta is embryonic lethal.

13 Homozygous Pax3(Cre/Cre) embryos are embryonic lethal.

14 in mice on a predominantly B6 background is embryonic lethal.

15 pporting the suggestion that the mutation is embryonic lethal.

16 ved and after several generations, became an embryonic lethal.

17 rast, homozygous deletion of the NRC gene is embryonic lethal.

18 us knockout of the single murine Smn gene is embryonic lethal.

19 of function of this tumor suppressor gene is embryonic lethal.

20 stem because homozygous disruption of Hex is embryonic lethal.

21 ring defects, whereas homozygous mutants are embryonic lethal.

22 Loss of UTX in female mice is embryonic lethal.

23 ased four-fold over normal levels, were also embryonic lethal.

24 The deletion when homozygous is embryonic lethal.

25 ert syndrome, while the mouse null allele is embryonic lethal.

26 ine transmission of an inactive Piga gene is embryonic lethal.

27 that the mutation of the TRalpha gene is not embryonic lethal.

28 omozygous 7901delG mutation in humans is not embryonic lethal.

29 ival motor neuron gene ( Smn ) whose loss is embryonic lethal.

30 any of the PDGF ligand and receptor genes is embryonic lethal.

31 distal colon, Dom/Dom homozygous animals are embryonic lethal.

32 ote is viable whereas Knobbly is a recessive embryonic lethal.

33 onserved protein whose germ line deletion is embryonic lethal.

34 hat homozygous Setd1a knockout (KO) mice are embryonic lethal.

35 ngle-copy gene whose insertional alleles are embryonic lethal.

36 ormal lifespan, while homozygotes were early embryonic lethal.

37 report that claimed TSPO knock-out mice were embryonic lethal.

38 undly alters mitochondrial morphology and is embryonic lethal.

39 Homozygosity for H is embryonic lethal.

40 Homozygous Sptlc2-deficient mice are embryonic lethal.

41 Null alleles of SIEL are embryonic lethal.

42 at the mice homozygous mutant for SEL1L were embryonic lethal.

43 y compatible with life, Rela(-/-) mice being embryonic lethal.

44 Most mutant alleles of pAbp are embryonic lethal.

45 Mice totally lacking in SPT are embryonic lethal.

46 e because germ-line deletion of GSK-3beta is embryonic-lethal.

47 However, URO-synthase null mice were early embryonic lethals.

48 ne identified during screens for conditional embryonic lethals.

49 gosity, which led to the identification of 1 embryonic lethal, 1 larval lethal, and 1 adult recessive

50 Although Ini1-null mice are embryonic lethal, 15-30% of mice heterozygous for Ini1 p

51 Because Mpi ablation is embryonic lethal, a murine CDG-Ib model will require hyp

52 HuR, a ubiquitously expressed member of the embryonic lethal abnormal vision (ELAV) family of RNA-bi

53 Among these proteins, embryonic lethal abnormal vision (ELAV) proteins are amo

54 ng study, we identify p40 as a member of the embryonic lethal abnormal vision (ELAV)-like family of R

55 The embryonic lethal abnormal vision (ELAV)-like RNA-binding

56 or RNA-binding proteins (RBPs) including the embryonic lethal abnormal vision (ELAV)/Hu family protei

57 By using cloned promoter fragments of the embryonic lethal abnormal vision gene or the myosin heav

58 We show here that the RBP embryonic lethal abnormal vision like 1 (ELAVL1, also kn

59 a ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding

60 Previously, we reported that an embryonic lethal abnormal vision-like (ELAV) protein bin

61 The four Hu [embryonic lethal abnormal vision-like (ELAVL)] protein f

62 nylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human a

63 e RNA-binding proteins: CUG-binding protein, embryonic lethal abnormal vision-type RNA-binding protei

64 g protein 3, and the CUG-binding protein and embryonic lethal abnormal vision-type RNA-binding protei

65 The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu protein family, play

66 Here we demonstrate a role for the embryonic lethal abnormal visual (ELAV) RNA-binding prot

67 Hu proteins are homologs of the Drosophila embryonic lethal abnormal visual protein and contain thr

68 The Drosophila locus embryonic lethal abnormal visual system (elav) encodes a

69 The embryonic lethal abnormal visual system (ELAV) is a gene

70 The product of the Drosophila embryonic lethal abnormal visual system is a conserved p

71 the RNA-binding protein encoded by the elav (embryonic lethal abnormal visual system) gene is a candi

72 Mammalian neuron-specific embryonic lethal abnormal visual-like Hu proteins (HuB,

73 enes, Jagged-1, a Notch-receptor ligand, and embryonic-lethal abnormal vision, Drosophila-like 2 (ELA

74 We show that ELAV (embryonic-lethal abnormal visual system) is a key mediat

75 lso dominant maternal enhancers of recessive embryonic lethal alleles of dpp and screw.

76 that act as maternal enhancers of recessive embryonic lethal alleles of dpp.

77 Embryonic lethal alleles of ed reveal a role of Ed in re

78 m intercrosses between F0 animals that carry embryonic lethal alleles recapitulate loss-of-function p

79 C8 has been defined by temperature-sensitive embryonic lethal alleles that strongly affect germline m

80 Rae1-null and Bub3-null mice are embryonic lethal, although cells from these mice did not

81 ted deletion of the murine Acf gene is early embryonic lethal and Acf(-/-) blastocysts fail to implan

82 Null mutations in this gene are embryonic lethal and can be rescued by expression in the

83 s MLL4 enzyme-dead KI (Mll4(KI/KI)) mice are embryonic lethal and die around E10.5, which phenocopies

84 TEL-/- mice are embryonic lethal and die between E10.5-11.5 with defecti

85 Mice with mWh knockout are early embryonic lethal and display DNA damage.

86 in null alpha- and beta-spectrin mutants are embryonic lethal and display severely disrupted neurotra

87 The syx(4) mutant animals are embryonic lethal and display severely impaired neuronal

88 MDKOs were embryonic lethal and displayed a variety of defects in c

89 PS1 null mice are embryonic lethal and exhibit axial skeleton malformation

90 However, FADD-deficient mice are embryonic lethal and FADD(-/-) T cells developed from FA

91 und mutants lacking Jnk1 and Jnk2 genes were embryonic lethal and had severe dysregulation of apoptos

92 ShcA knockout mice are embryonic lethal and have clearly suggested an important

93 probably explains why loss of Ezh2 is early embryonic lethal and obligatory for the derivation of pl

94 -receptor (PDGFR beta) deficiency in mice is embryonic lethal and results in cardiovascular, renal, p

95 Mice lacking Mdm2 in the heart were embryonic lethal and showed defects at the time recombin

96 Homozygous mutants were embryonic lethal and showed impaired neural tube closure

97 onstrated that ablation of FKRP functions is embryonic lethal and that the homozygous-null embryos di

98 notypes than OVCA1(-/-) mice (which are 100% embryonic lethal) and a small fraction survived to adult

99 the SHR-binding protein SIEL (SHR-INTERACING EMBRYONIC LETHAL) and localizes to both microtubules and

100 e that germline deletion of Ada3 in mouse is embryonic lethal, and adenovirus-Cre mediated conditiona

101 Plk1 homozygous null mice were embryonic lethal, and early Plk1(-/-) embryos failed to

102 Homozygous knock-in TRalpha1(PV/PV) mice are embryonic lethal, and heterozygous TRalpha1(PV/+) mice d

103 t enhancer of Bar (B), oro is also recessive embryonic lethal, and homozygous oro embryos show variab

104 FADD-null mutations in mice are embryonic-lethal, and analysis of FADD(-)/- T cells from

105 complete knock-out of Cdc42 in the mouse is embryonic-lethal, and its targeted deletion in various t

106 and found that systemic Snx13-null mice were embryonic lethal around midgestation.

107 This model was proved embryonic lethal as a result of severe anemia by embryon

108 Col5a2(-/-) homozygosity is embryonic lethal at approximately 12 days post conceptio

109 In contrast, the Polg2(-/-) is embryonic lethal at day 8.0-8.5 p.c. with concomitant lo

110 Meckel syndrome (MKS) is an embryonic lethal, autosomal recessive disorder character

111 As the mouse Gata-4 knock-out is early embryonic lethal because of a defect in ventral morphoge

112 e, we previously showed that TEL-/- mice are embryonic lethal because of a yolk sac angiogenic defect

113 Disruption of the gene encoding Cited2 is embryonic lethal because of defects in the development o

114 Homozygosity for the genetrap allele was embryonic lethal before embryonic day E10.5, whereas the

115 A null mutation in the Fpn1 gene is embryonic lethal before gastrulation, hypomorphic Fpn1(f

116 Germ line disruption of the TAF7 gene is embryonic lethal between 3.5 and 5.5 days postcoitus.

117 In mice, Adar1 mutations are embryonic lethal but are rescued by mutation of the Mda5

118 Mice lacking the mTLL-1 gene Tll1 are embryonic lethal but have pCP activity levels similar to

119 Ablation of the exchanger is embryonic lethal, but contractility can be studied in em

120 gat1 gene responsible for their synthesis is embryonic lethal, but homozygous mutant blastocysts are

121 Smg1 homozygous KO mice were early embryonic lethal, but Smg1 heterozygous mice showed a pr

122 The homozygous mutation is embryonic lethal by 13.5 days post coitum, demonstrating

123 developmentally retarded, disorganized, and embryonic lethal by day 9.5 of embryonic development (E9

124 is, we studied Tmod3(-/-) embryos, which are embryonic lethal by E18.5.

125 Loss of Hand2 is embryonic lethal by E9.5, obviating a genetic analysis o

126 ce and found that the homozygous mutation is embryonic lethal by embryonic day (E) 12.5 and associate

127 out mice and found that Hrpt2(-/-) mice were embryonic lethal by embryonic day 6.5 (E6.5).

128 present study shows that P3H2-null mice are embryonic-lethal by embryonic day 8.5.

129 d two temperature-sensitive and semidominant embryonic-lethal Caenorhabditis elegans mutants, each wi

130 he cardiac-specific NCX1 (NCX1h) gene causes embryonic lethal cardiac arrhythmia in zebrafish tremblo

131 t studies by us and others have demonstrated embryonic lethal cardiovascular phenotypes in SRF-null a

132 Loss of NFAR function, which was embryonic-lethal, caused an increase in protein synthesi

133 talpid3 is an embryonic-lethal chicken mutation in a molecularly un-ch

134 Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in

135 hh is sufficient to rescue most of the early embryonic lethal defects in a Disp1-null mutant backgrou

136 Knockout of Palladin in mice is embryonic lethal, demonstrating the importance of Pallad

137 es of two members of the Halloween family of embryonic lethals, disembodied (dib) and shadow (sad), c

138 Targeted alpha(v) or beta8 deletion is embryonic lethal due to defective placenta and brain ang

139 wever, because Runx1 knockout mice are early embryonic lethal due to failure of hematopoiesis, the ro

140 we show that loss of Prmt5 function is early embryonic-lethal due to the abrogation of pluripotent ce

141 Homozygous alpha-TM null mice are embryonic lethal, dying between 8 and 11.5 days post coi

142 The homozygous Dab2-deficient mutant is embryonic lethal (earlier than E6.5) due to defective ce

143 The TSK/TSK mutation is embryonic lethal; embryos have been reported to die at 7

144 the other hand, blocked all locomotion, was embryonic lethal even in syt I heterozygotes, and result

145 /-) mice were not viable because of an early embryonic lethal event.

146 ror in meiotic segregation, is invariably an embryonic lethal event.

147 Mutant embryos (designated G1G3ki), though embryonic lethal, exhibit partial rescue, characterized

148 ion can rescue multilineage hematopoiesis in embryonic lethal gata1-/- mutants for over 6 months.

149 The paternal-effect embryonic-lethal gene, spe-11, is required for normal de

150 nal phenotypes after RNA interference of 147 embryonic lethal genes previously identified in a system

151 ouse genome contains approximately 3479-4825 embryonic lethal genes, or about 13.7%-19% of all genes.

152 Interestingly, embryonic lethal genes, the most essential genes in mous

153 ns in 2-3 years, identifying perhaps 250-350 embryonic lethal genes.

154 The mutation, designated dek38-Dsg, is embryonic lethal, has a defective basal endosperm transf

155 ein isoforms (EcR-A, EcR-B1, and EcR-B2) are embryonic lethal, hindering analysis of EcR function dur

156 Whereas homozygous KO mice were embryonic lethals, homozygous KI and compound heterozygo

157 Deletion of APE-1 activity is embryonic lethal in animals and is lethal in cells.

158 bservations that loss of function of FLNA is embryonic lethal in males but manifests in females as a

159 iency of the C3 convertase regulator Crry is embryonic lethal in mice unless C3 also is absent.

160 Usp16 knockout is embryonic lethal in mice, but does not affect ESC viabil

161 tations of GINS component-encoding genes are embryonic lethal in mice.

162 zyme in repairing abasic sites in DNA, is an embryonic lethal in mice.

163 ransfer protein large subunit (lMTP) gene is embryonic lethal in the homozygous state in mice.

164 Several participants are embryonic lethals in knockout mice.

165 The RyR2-V2475F mutation appears embryonic-lethal in homozygous mice, but heterozygous mi

166 LRP1 gene deletion is embryonic-lethal in mice.

167 Ticrr deficiency is embryonic-lethal in the absence of exogenous DNA damage

168 However, only Vdac2(-/-) (V2(-/-)) mice are embryonic lethal, indicating a unique and fundamental fu

169 Here, we find by positional cloning that the embryonic lethal island beat (isl) mutation in zebrafish

170 These findings contrast with those in the embryonic-lethal knockout mouse, highlighting difference

171 lities in embryo and placental structures of embryonic lethal lines.

172 es for dosage-sensitive phenotypes and mouse embryonic lethals mapped to the vicinity.

173 ns for temperature-sensitive maternal effect embryonic lethal (Mel) mutants, we have identified 32 mu

174 t Rb-/- prostatic tissue can be rescued from embryonic lethal mice and used to test its susceptibilit

175 Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were ge

176 Moreover, while PinX1-null mice were embryonic lethal, most PinX1+/- mice spontaneously devel

177 nder the strongest selection are enriched in embryonic lethal mouse knockouts, Mendelian disease-asso

178 is for each modifier using four unrelated ts embryonic lethal mutants.

179 ormation, we have identified a collection of embryonic-lethal mutants in which cell divisions are del

180 Finally, we characterize an embryonic lethal mutation caused by endogenous splicing

181 ong loss-of-function, temperature-sensitive, embryonic lethal mutation in the maternally required gen

182 Somatic homozygous clones of an embryonic lethal mutation in this gene (stru1A122) cause

183 ur insertional alleles of foxi one (foo), an embryonic lethal mutation in zebrafish that displays def

184 d with this type of insertional mutagen is 1 embryonic lethal mutation per 70-100 proviral insertions

185 nionless (amn) mouse, which has a recessive, embryonic lethal mutation that interferes specifically w

186 A recessive embryonic lethal mutation was obtained.

187 We have isolated an embryonic lethal mutation, SBU2, that causes somite form

188 ross revealed that Mom2R encodes a recessive embryonic lethal mutation.

189 Embryonic lethal mutations (total of 34) were overwhelmi

190 We have screened for zygotic embryonic lethal mutations affecting cuticular morpholog

191 Exquisite embryonic lethal mutations have been isolated in hundred

192 In a large-scale mutagenesis screen for embryonic lethal mutations in zebrafish Danio rerio we h

193 rge-scale genetic screen for zygotic effect, embryonic lethal mutations in zebrafish we have identifi

194 that are expressed in mast cells, including embryonic lethal mutations, in vitro or in vivo.

195 n of loci that influence the effect of early embryonic lethal mutations, thus furthering knowledge of

196 rtially ventralized phenotype similar to dpp embryonic lethal mutations.

197 om 92 F(2) families and obtained 9 recessive embryonic lethal mutations.

198 utagenesis screens been conducted to isolate embryonic lethal mutations.

199 In screening for embryonic-lethal mutations in Caenorhabditis elegans, we

200 c to EcR-B1 that uncouple metamorphosis, and embryonic-lethal mutations that map to common sequences

201 interactions, both partners show overlapping embryonic lethal or high incidence of males RNAi phenoty

202 Unlike PAK4-null mice, which are embryonic lethal, PAK5-null mice develop normally and ar

203 Homozygous brec mutants are embryonic lethal, paralyzed, and show no detectable syna

204 ene) during murine development results in an embryonic lethal phenotype characterized by a complete l

205 orphogen Indian hedgehog (IHH) results in an embryonic lethal phenotype characterized by the conspicu

206 mTOR was recently knocked out in mice; the embryonic lethal phenotype demonstrates a critical role

207 d deletion of Foxm1 gene in mice produces an embryonic lethal phenotype due to severe abnormalities i

208 and found that hemizygous deletion led to an embryonic lethal phenotype due to severe anemia resultin

209 k1 gene in mice and zebrafish resulted in an embryonic lethal phenotype due to severe dilation of blo

210 for a MTAP null allele (Mtap(lacZ)) have an embryonic lethal phenotype dying around day 8 postconcep

211 In contrast to recent observations of an embryonic lethal phenotype for TRF2 inactivation in Caen

212 of the Shh signaling pathway or to the early embryonic lethal phenotype in Ptc null mutants.

213 e belly spot and intercrossing results in an embryonic lethal phenotype in the homozygous state.

214 Analysis of the embryonic lethal phenotype indicates that mutant alleles

215 The DDK syndrome is an early embryonic lethal phenotype observed in crosses between f

216 . remanei homologs, can fully complement the embryonic lethal phenotype of a C. elegans med-1,2(-) st

217 The embryonic lethal phenotype of knock-out mice because of

218 The early embryonic lethal phenotype of mice lacking metaxin demon

219 This study aimed to characterize the embryonic lethal phenotype of the Apj-/- mice and to def

220 In contrast to the embryonic lethal phenotype of the homozygous betaARK1 kn

221 tive function of TRAP220 is evidenced by the embryonic lethal phenotype of Trap220(-)(/)(-) mice and

222 Crry(-/-) is an embryonic lethal phenotype secondary to the maternal com

223 or a null mutation in Rad51 display an early embryonic lethal phenotype that can be partly rescued by

224 ymes to blastoderm-stage embryos leads to an embryonic lethal phenotype that results from the failure

225 Through the use of a chimeric approach, the embryonic lethal phenotype was circumvented and a role f

226 Among the double mutants, an embryonic lethal phenotype was observed for mice that we

227 combination results in a partially penetrant embryonic lethal phenotype with severe developmental car

228 In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di

229 on of CeWwp1 via RNA interference yielded an embryonic lethal phenotype, despite the presence of at l

230 ption of the murine RAD51 gene results in an embryonic lethal phenotype, indicating that Rad51 protei

231 whole-body deletion of the p32 results in an embryonic lethal phenotype, mice heterozygous for p32 ar

232 e, ptcIN is a dominant suppressor of the oro embryonic lethal phenotype, suggesting a close and dose-

233 he single gene that encodes AtUBP14 cause an embryonic lethal phenotype, with the homozygous embryos

234 at the mutant allele (Tsc1-) has a recessive embryonic lethal phenotype.

235 ge, edema, and developmental delay, and late embryonic lethal phenotype.

236 al models in which HAS2 null animals have an embryonic lethal phenotype.

237 ypoplasia and 3 days before the onset of the embryonic lethal phenotype.

238 hibit skin and skeletal abnormalities and an embryonic lethal phenotype.

239 m line and is tightly linked to a recessive, embryonic lethal phenotype.

240 it maps to a mutation in this region with an embryonic lethal phenotype.

241 a reduced APC function background caused an embryonic lethal phenotype.

242 r target genes and might contribute to their embryonic lethal phenotype.

243 In contrast to the embryonic-lethal phenotype of alpha4 integrin-null mice,

244 ull allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype.

245 ified that, when hemizygous, caused specific embryonic lethal phenotypes (exencephaly and edema) in m

246 ncluding excess D-glucose) that give rise to embryonic lethal phenotypes during organogenesis are ass

247 Among them are 121 genes that have embryonic lethal phenotypes in mice, cause defects in tr

248 Genetic tests on the embryonic lethal phenotypes indicated that for 13 genes,

249 in endothelial biology is underscored by the embryonic lethal phenotypes of knock-outs in mice due to

250 notypes in PPS patients are less severe than embryonic lethal phenotypes of Pofut2-null mice.

251 In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely rescued

252 s were identified as null mutants with early embryonic lethal phenotypes that could be rescued by GRX

253 , we obtained three insertional mutants with embryonic lethal phenotypes, and identified two of the d

254 in BCKDH function manifest larval arrest and embryonic lethal phenotypes, and mmBCFA supplementation

255 ca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a ho

256 However, embryonic-lethal phenotypes and systemic, indirect dysfu

257 day 13 (e13) fetal liver of mice exhibiting embryonic-lethal phenotypes.

258 ial for angiogenesis, as demonstrated by the embryonic lethal phentoype when targeted for deletion in

259 Phenotype genes were further divided into 'embryonic lethal', 'postnatal lethal', and 'non-lethal p

260 While Wls-EKO was embryonic lethal precluding further analysis in adult he

261 Mice with deletions of fgfr1 or fgfr2 are embryonic lethal prior to the onset of kidney developmen

262 Embryonic lethal ptip-null mutants and conditional mutan

263 Male mutant monkeys were embryonic lethal, reiterating that RTT is a disease of f

264 Although most genes with sterile or embryonic lethal RNAi phenotypes are involved in basal c

265 D), and interaction with the SHR INTERACTING EMBRYONIC LETHAL (SIEL) protein, little information is k

266 s in mis-localization of the SHR-INTERACTING EMBRYONIC LETHAL (SIEL) protein, which has been shown to

267 fied a novel protein, SHORT-ROOT INTERACTING EMBRYONIC LETHAL (SIEL), that interacts with SHR, CAPRIC

268 ally screened EMS-mutagenized Drosophila for embryonic lethal strains with defects in glutamatergic s

269 cinerea, whereas T-DNA insertion alleles are embryonic lethal, suggesting an essential role for MED21

270 PIGA-null mutations are thought to be embryonic lethal, suggesting that p.Arg412( *) PIGA has

271 s with wild-type pollen result in occasional embryonic lethals that also stain for GUS activity.

272 Because the c-jun-null mutation is early embryonic lethal, thereby hindering a genetic analysis,

273 etic deletion of c-Jun in transgenic mice is embryonic lethal; therefore, transgenic mice encoding a

274 Because global loss of both pRb alleles is embryonic lethal, this hypothesis has not been tested in

275 t displayed a range in disease severity from embryonic lethal to viable with mild neuromuscular defic

276 While loss of mouse Smn is embryonic lethal, two copies of SMN2 prevents this embry

277 ontaining T-DNA insertions in both genes are embryonic lethal, under ideal laboratory growth conditio

278 ECs and hematopoietic cells and resulted in embryonic lethal vascular defects by e11.5.

279 Because mTOR knock-outs are embryonic lethal, we generated a viable hypomorphic mous

280 Given that HDAC3 null mice are embryonic lethal, we used for our analyses a combination

281 to be allelic, and at least two of these are embryonic lethal when homozygous.

282 highly similar, but Erk2 deletion in mice is embryonic lethal whereas Erk1 deletion is not.

283 ation had critical functions (knockouts were embryonic lethal), whereas the knockouts of 5 less criti

284 null for the alpha2(V) gene Col5a2 are early embryonic lethal, whereas haploinsufficiency caused aber

285 When homozygous, the D61G mutant is embryonic lethal, whereas heterozygotes have decreased v

286 T (e.g., Tg737 or the IFT kinesin Kif3a) are embryonic lethal, whereas kidney-specific disruption of

287 SART1(-/-) mice were embryonic lethal, whereas male SART1(+/-) mice spontaneo

288 ous Erg(DeltaEx4/DeltaEx4) knockout mice are embryonic lethal, which is associated with a marked redu

289 Caspase-8-deficient mice are embryonic lethal, which makes study of caspase-8 in prim

290 etic knockout of RuvBL1 in a murine model is embryonic lethal while conditional inactivation in the h

291 Its germ line deletion is embryonic lethal with abnormal cardiovascular system for

292 Rnf4 deficiency is embryonic lethal with higher levels of methylation in ge

293 Both mutations are embryonic lethal with overlapping defects, but the defec

294 Germ-line deletion of either HIF subunit is embryonic lethal with unique features suggesting importa

295 AE2 and the SUMO-conjugating enzyme SCE1 are embryonic lethal, with arrest occurring early in embryo

296 Homozygous mutants were embryonic lethal, with death at mid-gestation from cardi

297 ut mice and determined that the phenotype is embryonic lethal, with embryos and the few stillborn pup

298 disturbed the developing vasculature and was embryonic lethal within days of the heart beating.

299 ular lesion that is responsible for a severe embryonic lethal zipper allele.

300 le for zipIIF107, one of the original severe embryonic lethal zipper alleles.