ライフサイエンスコーパス: embryonic stem cell

1 Foxa2+ population during differentiation of embryonic stem cells.

2 ndodermal differentiation of mouse and human embryonic stem cells.

3 dynamics of respective chromosomes in mouse embryonic stem cells.

4 tion of bivalent gene transcription in mouse embryonic stem cells.

5 he expression of inflammatory genes in mouse embryonic stem cells.

6 to CpG island-containing promoters in mouse embryonic stem cells.

7 eted from select subsets of ribosomes within embryonic stem cells.

8 ng, and regulatory element function in mouse embryonic stem cells.

9 ible for genome-wide H3K27me3 deposition, in embryonic stem cells.

10 12 different mRNAs from mouse fibroblast and embryonic stem cells.

11 associated virus integration site 1 in human embryonic stem cells.

12 e global chromatin affinity of BRG1 in mouse embryonic stem cells.

13 ptional changes accompanying differentiating embryonic stem cells.

14 plasmic, and nuclear proteins in T cells and embryonic stem cells.

15 s, and on MGE-like cells differentiated from embryonic stem cells.

16 e its binding to intractable genomic loci in embryonic stem cells.

17 is required for the differentiation of mouse embryonic stem cells.

18 mesoderm formation in frog embryos and human embryonic stem cells.

19 Similar results were obtained in human embryonic stem cells.

20 ed to fluctuate stochastically in individual embryonic stem cells.

21 ays that had alphaKG-sensitive expression in embryonic stem cells.

22 sociated with chromatin state in the initial embryonic stem cells.

23 wise microRNA-deficient Dgcr8 knockout mouse embryonic stem cells.

24 DNA elements during differentiation of mouse embryonic stem cells.

25 lopmental and pluripotent potential of human embryonic stem cells.

26 x that contributes to epigenetic programs in embryonic stem cells.

27 and rescues the lethality of Brca2-deficient embryonic stem cells.

28 des to genomes directly within live H1 human embryonic stem cells.

29 nd endogenous retrovirus silencing in murine embryonic stem cells.

30 oduces its targeted constructs into C57BL/6N embryonic stem cells.

31 gulatory landscape of human naive and primed embryonic stem cells.

32 rate our approach on Oct4 and Nanog in mouse embryonic stem cells.

33 nd by Polycomb repressive complex 2 in human embryonic stem cells.

34 th chromatin domain boundaries in testes and embryonic stem cells.

35 methylation and hydroxymethylation in murine embryonic stem cells.

36 as "preborder"; its transcriptome resembles embryonic stem cells.

37 ctive RAS protein normally expressed only in embryonic stem cells.

38 dy marked as potential regulatory domains in embryonic stem cells.

39 printed genes in Naa10p-knockout embryos and embryonic stem cells.

40 th methylated DNA, as we illustrate in mouse embryonic stem cells.

41 velopmental identities of mouse versus human embryonic stem cells.

42 ploidy in human HAP1 cells and haploid mouse embryonic stem cells.

43 cer of mesendoderm in vertebrate embryos and embryonic stem cells.

44 man pre-implantation embryos and naive human embryonic stem cells.

45 , we show that human astrocytes derived from embryonic stem cells actively transfer aggregated alpha-

46 olycomb repressive complex 2-deficient mouse embryonic stem cells also release Bmp4 but retain their

47 Pseudotemporal ordering of human embryonic stem cell and induced pluripotent stem cell-de

48 nsive methods of homologous recombination in embryonic stem cells and are available for only 25% of

49 ion distinguish transcripts modified in both embryonic stem cells and brain from those methylated in

50 evelopment, applications of IDP-ASE to human embryonic stem cells and breast cancer cells indicate th

51 s (DF), hiPSc present the same properties as embryonic stem cells and can generate any cell type afte

52 HMGA2 expresses at high levels in both embryonic stem cells and cancer cells, where it interact

53 and proteins at the transition between naive embryonic stem cells and cells primed to differentiate.

54 tulate PGC specification in vitro from naive embryonic stem cells and characterize the early events o

55 CORE to map the chromatin landscape in mouse embryonic stem cells and differentiated neural cells.

56 also applied SingleSplice to data from mouse embryonic stem cells and discovered a set of genes that

57 A previous study using embryonic stem cells and embryonic stem cell-derived neu

58 Comparison of enhancer regions between embryonic stem cells and female germline stem cells iden

59 ed Geminin-associated chromatin locations in embryonic stem cells and Geminin- and Zic1-associated lo

60 We test our approach on H1 human embryonic stem cells and H1-derived neural progenitor ce

61 undamental to kidney development, from mouse embryonic stem cells and human induced pluripotent stem

62 We apply GAM to mouse embryonic stem cells and identify enrichment for specifi

63 transient G1 phase of rapidly dividing mouse embryonic stem cells and identifying a window for UV-irr

64 nto postmitotic neurons of NPCs derived from embryonic stem cells and in Emx1-cre conditional mutant

65 rs show that ablation of PRC2 genes in human embryonic stem cells and in mice results in changes in p

66 es epitopes SSEA4 and globo-H in stem cells (embryonic stem cells and induced pluripotent stem cells)

67 and mouse DNA methylomes from brain neurons, embryonic stem cells and induced pluripotent stem cells,

68 en the transcriptome and epigenome in single embryonic stem cells and induced pluripotent stem cells.

69 astomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells.

70 ing the earliest stages of X inactivation in embryonic stem cells and is dependent on the C-terminal

71 s DSBs in low-input samples of cancer cells, embryonic stem cells and liver tissue.

72 gation to the inflammatory response in mouse embryonic stem cells and mouse embryonic stem cell-diffe

73 5C in total and nuclear poly(A) RNA of mouse embryonic stem cells and murine brain.

74 By measuring transcriptional output in embryonic stem cells and neural precursor cells, we show

75 eracts with and phosphorylates PCNA in human embryonic stem cells and other cell lines.

76 entiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, wit

77 solution (6-hourly) in differentiating mouse embryonic stem cells and report new insight into molecul

78 uman neuronal progenitor cells (derived from embryonic stem cells) and fetal muscle samples by includ

79 ethylation genome-wide in human cells, mouse embryonic stem cells, and Drosophila Biochemical analysi

80 network that maintains pluripotency in mouse embryonic stem cells, and find an incoherent feedforward

81 o interrogate the 2-Mb POU5F1 locus in human embryonic stem cells, and identified 45 cis-regulatory e

82 ry response mechanism is not active in mouse embryonic stem cells, and in vitro differentiation promo

83 RNA molecules in the embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells

84 remain associated with chromosomes in mouse embryonic stem cells, and that the exclusion previously

85 2 is dispensable for pluripotency when human embryonic stem cells are converted into the naive state.

86 s described in this article demonstrate that embryonic stem cells are fundamentally different from di

87 r 3-bp substitutions in MMR-proficient mouse embryonic stem cells as effectively as in MMR-deficient

88 e established synchronized cultures of mouse embryonic stem cells as they exit the ground state of pl

89 ns in developmental biology, immunology, and embryonic stem cell-based regenerative medicine.

90 targeting guide RNA using an inducible human embryonic stem cell-based system and microinjection of m

91 nitor cells were biallelically accessible in embryonic stem cells but premarked with bivalent histone

92 yst2/Kat7/Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to

93 Here we report that human embryonic stem cells can be induced to differentiate int

94 (2016) show that a confined colony of human embryonic stem cells can spontaneously sense its boundar

95 -)" or "Casp1(-/-)" mice generated using 129 embryonic stem cells carry a 129-associated inactivating

96 polycomb repressive complex 2 genes in human embryonic stem cells causes pluripotency loss and sponta

97 e specific markers, such as SOX2 and ZIC3 in embryonic stem cells, CDK5R1 and REST in neurons and CD8

98 Embryonic stem cells co-express Oct4 and Oct1, a related

99 e in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting

100 ir work on gene targeting, which showed that embryonic stem cells could be modified by homologous rec

101 leukemia (KBM7 and HAP1), as well as haploid embryonic stem cells derived from several organisms.

102 Mouse embryonic stem cells derived from the epiblast contribut

103 l RNAs in VZV-infected fibroblasts and human embryonic stem cell-derived (hESC) neurons.

104 of engineered cardiac tissues made of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs).

105 We found that suppression of PRRX1 in human embryonic stem cell-derived cardiomyocytes and embryonic

106 Additionally, in human embryonic stem cell-derived cardiomyocytes challenged wi

107 nction and loss-of-function approaches in an embryonic stem cell-derived cortical differentiation mod

108 Using human embryonic stem cell-derived intestinal organoids, we dem

109 Here, we analyze the transcriptomes of human embryonic stem cell-derived lineage-specific progenitors

110 neural progenitor cells in vivo and on human embryonic stem cell-derived neural progenitors.

111 cally activated following infection of human embryonic stem cell-derived neurons and that this activa

112 revious study using embryonic stem cells and embryonic stem cell-derived neurons indicated that Nf1 R

113 6 cells by scRNA-seq covering distinct human embryonic stem cell-derived progenitor states.

114 We show that Lmo2-/- mouse embryonic stem cells differentiated to Flk-1+ haemangiob

115 transcriptome of distal projections of human embryonic stem cells differentiated using a protocol whi

116 onse in mouse embryonic stem cells and mouse embryonic stem cell-differentiated cells.

117 ction, but not to LPS, was observed in mouse embryonic stem cell-differentiated fibroblasts.

118 variant, macroH2A1, has an important role in embryonic stem cell differentiation and tumor progressio

119 The enhancer landscape during embryonic stem cell differentiation has been well charac

120 We find that during embryonic stem cell differentiation loss of HMGNs leads

121 nducible gain-of-function experiments during embryonic stem cell differentiation, we found that Mesp2

122 ortant role for DNA replication during mouse embryonic stem cell differentiation, which could shed li

123 resisting the gene activation signals during embryonic stem cell differentiation.

124 y-state and nascent RNA levels and perturbed embryonic stem cell differentiation.

125 ssion of neural differentiation genes during embryonic stem cell differentiation.

126 We reported previously that mouse embryonic stem cells do not have a functional IFN-based

127 pping to predicted fetal brain promoters and embryonic stem cell enhancers.

128 DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing

129 mide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting

130 , we document an essential role for FGFRs in embryonic stem cell (ESC) differentiation, with FGFR1 ag

131 K9 demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity.

132 studies suggest that only a minority of the embryonic stem cell (ESC) inoculum contributes to the ad

133 model X-SCID in vitro, we generated a mouse embryonic stem cell (ESC) line in which a disease-causin

134 understand this, we employed a novel murine embryonic stem cell (ESC) line that, like mouse embryos,

135 To study TERT regulation, we generated mouse embryonic stem cell (ESC) lines containing single-copy b

136 ng (ChIP-Seq) of 104 DNA binding proteins in embryonic stem cell (ESC) lines.

137 Embryonic stem cell (ESC) pluripotency, defined as the a

138 embryonic development and the maintenance of embryonic stem cell (ESC) self-renewal.

139 sing the self-organizing properties of mouse embryonic stem cell (ESC), we report that ESC-derived ne

140 microenvironment, we injected murine YFP(+) embryonic stem cells (ESC) into the amniotic fluid of E1

141 3, which is known to control self-renewal of embryonic stem cells (ESC).

142 colonies of trophoblast differentiated from embryonic stem cells (ESC).

143 pluripotency genes drives differentiation of embryonic stem cells (ESC).

144 lf-renewal and pluripotency - shared between embryonic stem cells (ESCs) and adult aggressive tumours

145 e binding sites for SOX2 and POU5F1 in mouse embryonic stem cells (ESCs) and EpiSCs are divergent, re

146 Here, we combined mouse embryonic stem cells (ESCs) and extraembryonic trophobla

147 Blastocyst-derived embryonic stem cells (ESCs) and gonad-derived embryonic

148 oduced RNA-genome interaction maps for human embryonic stem cells (ESCs) and human embryonic kidney (

149 sion, we carried out an RNAi screen in mouse embryonic stem cells (ESCs) and identified a list of nov

150 Embryonic stem cells (ESCs) and induced pluripotent stem

151 TET1ALT is repressed in embryonic stem cells (ESCs) but becomes activated in emb

152 Mammalian embryonic stem cells (ESCs) can self-organize in vitro,

153 Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on t

154 Mouse embryonic stem cells (ESCs) cultured in serum are charac

155 Chromatin in embryonic stem cells (ESCs) differs markedly from that i

156 of chimeras created by injecting tetraploid embryonic stem cells (ESCs) expressing green fluorescent

157 of LIF, WNT and MAPK-ERK to stabilize mouse embryonic stem cells (ESCs) in their naive state has bee

158 d that 30% of the genome in interphase mouse embryonic stem cells (ESCs) is marked with H3S10ph.

159 Here, we report that depleting Spt6 in embryonic stem cells (ESCs) reduced expression of plurip

160 Naive pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation

161 n from the naive status represented by mouse embryonic stem cells (ESCs) to a state capacitated for l

162 t non-mammary cells including testicular and embryonic stem cells (ESCs) to adopt a mammary epithelia

163 Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-bas

164 ene promoters upon differentiation of murine embryonic stem cells (ESCs) to neural progenitor cells (

165 K3beta can be selectively inhibited in mouse embryonic stem cells (ESCs) using a chemical-genetic app

166 Although AMPK-deficient embryonic stem cells (ESCs) were normal in the pluripote

167 treated EpiSCs exhibiting features of naive embryonic stem cells (ESCs) within 3 days.

168 of induction of differentiation of mammalian embryonic stem cells (ESCs), accumulation of the repress

169 In mouse embryonic stem cells (ESCs), CBX6 and CBX7 are the most

170 959-972) report that, in naive mouse embryonic stem cells (ESCs), p53 controls DNA methylatio

171 eriments reveal VPE-promoter interactions in embryonic stem cells (ESCs), prior to gene activation.

172 of GSK-3-dependent phosphorylation in mouse embryonic stem cells (ESCs), we found that approximately

173 ng transcripts (lincRNAs) expressed in mouse embryonic stem cells (ESCs), which might be incomplete w

174 ich reflect aberrant differences relative to embryonic stem cells (ESCs).

175 and the murine leukemia virus (MLV) in mouse embryonic stem cells (ESCs).

176 superior chromosomal stability compared with embryonic stem cells (ESCs).

177 encode a module of TF-binding sites in mouse embryonic stem cells (ESCs).

178 human fibroblasts as well as mesenchymal and embryonic stem cells for both two- and three-dimensional

179 ion of human imaging reporter genes in human embryonic stem cells for long-term molecular imaging.

180 available Prnp(-/-) lines were generated in embryonic stem cells from the 129 strain of the laborato

181 In mouse embryonic stem cells, genomic deletion of the 11-bp NREs

182 Mammalian haploid embryonic stem cells (haESCs) provide new possibilities

183 , which is crucial for functional studies of embryonic stem cells, has not been exploited to date in

184 Setd5-deficient embryonic stem cells have impaired cellular proliferatio

185 ding genes (exomes) of 140 independent human embryonic stem cell (hES cell) lines, including 26 lines

186 chanisms which govern the formation of human embryonic stem cell (hESC) colonies.

187 icing (epi)genetic code, DeepCode, for human embryonic stem cell (hESC) differentiation by integratin

188 blished several human stem cell lines: human embryonic stem cell (hESC) line carrying the common T158

189 wing perivascular progenitors from the human embryonic stem cell (hESC), line ESI-017.

190 ion analysis of >30 batches of grafted human embryonic stem cell (hESC)-derived progenitors.

191 Using neurons derived from human embryonic stem cells (hESC) and cell-free wild-type (WT)

192 Here, we evaluated the survival of human embryonic stem cells (hESC) constitutively expressing GF

193 Differentiated human embryonic stem cells (hESC) continue to provide a model

194 (3D) neuronal cell models derived from human embryonic stem cells (hESC) provide an excellent tool fo

195 the monoclonal antibody mAb-A4 against human embryonic stem cells (hESC), which also bound specifical

196 We then found CX45 was expressed in human embryonic stem cells (hESCs) and human dermal fibroblast

197 Pancreatic progenitors derived from human embryonic stem cells (hESCs) are a potential source of t

198 Human embryonic stem cells (hESCs) are used as platforms for d

199 Naive human embryonic stem cells (hESCs) can be derived from primed

200 er defined differentiation conditions, human embryonic stem cells (hESCs) can be directed toward a me

201 Activin/SMAD signaling in human embryonic stem cells (hESCs) ensures NANOG expression an

202 1, TET2 and TET3 triple-knockout (TKO) human embryonic stem cells (hESCs) exhibit prominent bivalent

203 the human embryo, we used colonies of human embryonic stem cells (hESCs) grown on micropatterned sub

204 While the transcriptional network of human embryonic stem cells (hESCs) has been extensively studie

205 ed pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) have the capacity to partic

206 influence differentiation outcomes in human embryonic stem cells (hESCs) in vitro Systematic investi

207 s in spin embryoid bodies derived from human embryonic stem cells (hESCs) lack HOXA expression compar

208 ic organoids (COs) from differentiated human embryonic stem cells (hESCs) or induced pluripotent stem

209 ional modifications and p53 binding in human embryonic stem cells (hESCs) undergoing differentiation

210 To model hematopoiesis, human embryonic stem cells (hESCs) were allowed to differentia

211 Until recently, human embryonic stem cells (hESCs) were shown to exist in a st

212 reproduced by expressing mutant FUS in human embryonic stem cells (hESCs), whereas knockdown of endog

213 an essential factor in self-renewal of human embryonic stem cells (hESCs).

214 id/hindbrain cell differentiation from human embryonic stem cells (hESCs).

215 uired for self-renewal and survival of human embryonic stem cells (hESCs).

216 ences within the 1-Mbp POU5F1 locus in human embryonic stem cells (hESCs).

217 athway in several cell types including human embryonic stem cells (hESCs).

218 ed pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs).

219 els and L1 mobilization in pluripotent mouse embryonic stem cells, implying that Tex19.1 prevents de

220 levitate neuroprogenitors derived from human embryonic stem cells in 3D multilayered fibrin tissue co

221 the dynamics of the chromatin fiber in mouse embryonic stem cells, in combination with dynamical simu

222 ingle-molecule imaging of CHD4 in live mouse embryonic stem cells, in the presence and absence of one

223 ges of gene editing versus gene targeting in embryonic stem cells, including the breadth of species a

224 We describe the first Niam embryonic stem cell interactome, which includes proteins

225 Here the authors differentiate mouse embryonic stem cells into neurons, and analyze the local

226 ciency in the inflammatory response in mouse embryonic stem cells is also attributed to the lack of f

227 trolled gene regulation in 3D-cultured human embryonic stem cells is developed using hollow gold nano

228 liferation in somatic cells, but its role in embryonic stem cells is unknown.

229 However, the efficiency of HR in embryonic stem cells is unpredictable, depending on the

230 Embryonic stem cells lacking HMGNs show reduced ability

231 aneous deletion of these shadow enhancers in embryonic stem cells leads to impaired activation of Hox

232 Here we used a dual-reporter embryonic stem cell line to generate enriched population

233 FNB2-tdTomato/EPHB4-EGFP dual reporter human embryonic stem cell line to identify factors that regula

234 in dopaminergic neurons derived from a human embryonic stem cell line.

235 In contrast, Slc52a3 -/- embryonic stem cell lines could be readily established a

236 ERT binding across 5 cancer cell lines and 2 embryonic stem cell lines revealed that endogenous TERT,

237 y utilizing Brachyury, Etv2, or Scl reporter embryonic stem cell lines to further understand the mech

238 se (HD) knock-in mouse models and associated embryonic stem cell lines.

239 Embryonic stem cells locked in the naive state are able

240 ce-dependent activation of expression of the embryonic stem cell markers OCT4, NANOG, SOX2 and SSEA1

241 We applied scTDA to the analysis of murine embryonic stem cell (mESC) differentiation in vitro in r

242 r ERbeta influences differentiation of mouse embryonic stem cells (mESC) into neural lineages, we com

243 Murine embryonic stem cells (mESC) were fused with human endoth

244 lism, thereby impacting maintenance of mouse embryonic stem cells (mESCs) and subsequent embryogenesi

245 mongst different developmental stages, mouse embryonic stem cells (mESCs) are resistant to cell fate

246 We have measured mouse embryonic stem cells (mESCs) at different states during

247 gulates the naive pluripotent state of mouse embryonic stem cells (mESCs) by enabling LIF-dependent S

248 Mouse embryonic stem cells (mESCs) deficient for DGCR8, a key

249 a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed p

250 alytic SET domains of MLL3 and MLL4 in mouse embryonic stem cells (mESCs) does not disrupt self-renew

251 erogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-

252 th necessary and sufficient to convert mouse embryonic stem cells (mESCs) into 2-cell-embryo-like ('2

253 mal translocations can be generated in mouse embryonic stem cells (mESCs) via CRISPR/Cas9.

254 ynthase kinase-3 (GSK-3) substrates in mouse embryonic stem cells (mESCs), providing a broad profile

255 In mouse embryonic stem cells (mESCs), the transcriptional networ

256 neuralized embryoid bodies (nEBs) from mouse embryonic stem cells (mESCs).

257 ogen molecule enhances self-renewal of mouse embryonic stem cells (mESCs).

258 ve transcription in S. cerevisiae and murine embryonic stem cells (mESCs).

259 Both HeLa and mouse embryonic stem cell mRNAs harboring m(6)As have shorter

260 This study confirms that in embryonic stem cells Myst2 is part of H3 and H4 histone

261 y relevant sets of human iPSCs, SCNT-derived embryonic stem cells (nt-ESCs), as well as in vitro fert

262 e we examine the ability of nuclear transfer embryonic stem cells (NT-ESs) derived from a patient wit

263 tocols for directed differentiation of human embryonic stem cells, obtaining efficient, accelerated p

264 y, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells t

265 ablation or reduction of DNA methylation in embryonic stem cells or cardiac myocytes, respectively,

266 plantable insulin-producing cells from human embryonic stem cells or induced pluripotent stem cells i

267 sing 2D methods or MLOs generated from mouse embryonic stem cells, our human MLOs produced neuromelan

268 oute of hemangiogenic progenitors from mouse embryonic stem cells, perform genome-wide CRISPR screeni

269 Human embryonic stem cells progress through multiple stages in

270 ature beta cells that are derived from human embryonic stem cells (referred to as SC-beta cells), whi

271 This allowed us to use the RUNX1C-GFP human embryonic stem cell reporter cell line to monitor gene a

272 ro assays confirmed their functionality, and embryonic stem cells retained differentiation capacity.

273 The network also controls embryonic stem cell self-renewal but is associated with

274 directly determines the efficiency of mouse embryonic stem cell self-renewal.

275 r, chromatin immunoprecipitation analysis in embryonic stem cells showed extensive binding of Smad2/3

276 The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated i

277 built with cardiomyocytes derived from human embryonic stem cells, simultaneous optical and electric

278 self-renewal but is associated with distinct embryonic stem cell-specific enhancers.

279 ry elements necessary for expression of four embryonic stem cell-specific genes.

280 We find that embryonic stem cell-specific miRNAs mir-93b and mir-427/

281 Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute

282 ed differentiation of myeloid precursors and embryonic stem cells, suggesting a broader role for Nudt

283 ,4-disubstituted pyrimidine known to promote embryonic stem cells survival, is robustly adipogenic an

284 owed inference of the dynamic rates at which embryonic stem cells switch between two gene expression

285 e segment that were generated by traditional embryonic stem cell technology, but these animals contai

286 With this approach, we show in mouse embryonic stem cells that endogenous Dnmt1 gene transcri

287 sive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primit

288 ilitates conversion of inactive enhancers in embryonic stem cells to an active (H3K4me1(+)/H3K27ac(+)

289 prior to differentiation, the propensity of embryonic stem cells to change their epigenetic status i

290 as a proof of principle, we engineered mouse embryonic stem cells to contain multiple scratchpads and

291 The capacity of pluripotent embryonic stem cells to differentiate into any cell type

292 in C57BL/6 NJ (B6N) and 129S1/SvImJ (129S1) embryonic stem cells to engineer mouse strains with reci

293 Sal-like protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-exp

294 Using neurons differentiated from mouse embryonic stem cells, we analyze protein and RNA express

295 g the auxin-inducible degron system in mouse embryonic stem cells, we show that CTCF is absolutely an

296 regulating FLK1+ mesoderm formation in mouse embryonic stem cells, which in turn specifies hemangioge

297 Gain-of-function experiments in human embryonic stem cells, which normally lack lncRHOXF1 RNA,

298 a targeted autosome loss in aneuploid mouse embryonic stem cells with an extra human chromosome and

299 Moreover, human embryonic stem cells with deletion of EZH1 or EZH2 fail

300 adult parenchyma, are frequently compared to embryonic stem cells yet their developmental origin rema