ライフサイエンスコーパス: emetine

1 gene when protein synthesis is inhibited by emetine.

2 by the translation inhibitors anisomycin and emetine.

3 he CTLs with the protein synthesis inhibitor emetine.

4 In contrast, application of emetine 1 hr after LTP induction at the commissural-asso

5 eatment with the protein synthesis inhibitor emetine (1 microM) totally prevented the expression of g

6 al CSF, 44 +/- 10%; methysergide, 40 +/- 5%; emetine, 35 +/- 9%; and cycloheximide, 57 +/- 29%; all p

7 Bath application of emetine, a protein synthesis inhibitor, blocked eCB-LTD

8 opmentally down-regulated-8, suggesting that emetine accesses a previously undescribed cullin-indepen

9 Unfortunately, emetine also induces a stress response that results in u

10 of serotonin (5-HT), the local perfusion of emetine, an inhibitor of protein synthesis, or a TAT-AS

11 In contrast, emetine, an inhibitor of the ribotoxic stress response,

12 Also, injection of emetine and 5,6-dichlorobenzimidazole into Aplysia preve

13 eptide, and the protein synthesis inhibitors emetine and anisomycin.

14 dicinal plant Psychotria ipecacuanha such as emetine and cephaeline possess a monoterpenoid-tetrahydr

15 monoterpenoid-isoquinoline alkaloids such as emetine and cephaeline, whose biosynthesis derives from

16 A synthesis, while the other two inhibitors, emetine and cycloheximide, blocked cell cycle progressio

17 An intermediate response was observed to emetine and cycloheximide, weak activators of JNK.

18 R-triggered FasL/Fas killing is inhibited by emetine and cyclosporin A, whereas IL-2-induced FasL/Fas

19 ets also emerged, among them that methadone, emetine and loperamide (Imodium) may antagonize muscarin

20 because 5,6-dichlorobenzimidazole riboside, emetine, and brefeldin A inhibited the increase in Glu u

21 Surprisingly, cycloheximide (CHX), emetine, and verrucarin A were able to induce transcript

22 s method, we identify the bioactive alkaloid emetine as a selective inhibitor of the uncharacterized

23 Using this cell line, we have identified emetine as a specific inhibitor of HIF-2alpha protein st

24 site, Plasmodium falciparum, in complex with emetine at 3.2 A resolution.

25 eased 12-83% of emetine at pH 6.5 and 41-95% emetine at pH 5.5.

26 These prodrugs released 12-83% of emetine at pH 6.5 and 41-95% emetine at pH 5.5.

27 atic properties of the IpeGlu1 revealed that emetine biosynthesis branches off from N-deacetylisoipec

28 considered to be a part of the reactions for emetine biosynthesis, whereas its 1 beta(R)-epimer N-dea

29 hich was supposed to be the intermediate for emetine biosynthesis.

30 L-2-induced FasL/Fas killing is inhibited by emetine, but not by cyclosporin A.

31 ine), whereas a protein synthesis inhibitor (emetine) decreased it by only 24%.

32 Experiments using the irreversible inhibitor emetine demonstrated that AKR.H-2(b) cells had to be met

33 Moreover, emetine dissolves preformed SGs as it promotes the assem

34 ated decay is inhibited by cycloheximide and emetine, drugs that stabilize polysomes, but is unaffect

35 lls were treated with cycloheximide (CHX) or emetine, expression levels were restored to those observ

36 Hygromycin B and emetine failed to elevate ceramide levels or induce apop

37 hibitors, such as anisomycin, cycloheximide, emetine, harringtonine, and puromycin, unlike several tr

38 The N-2' position of the natural product emetine has been derivatized to thiourea, urea, sulfonam

39 ge IC(50) ranging from 0.079 to 10 muM) than emetine (IC(50) ranging from 0.0237 to 0.0329 muM).

40 Emetine-induced HIF-2alpha down-regulation was confirmed

41 trand template blocked the time-dependent or emetine-induced instability but did not eliminate aphidi

42 Drugs that stabilize polysomes (emetine) inhibit the assembly of SGs, whereas drugs that

43 Prolonged cell culture, emetine inhibition of lagging-strand synthesis, or slowi

44 Emetine interacts with the E-site of the ribosomal small

45 Selective injection of DRB or emetine into the presynaptic or postsynaptic neuron befo

46 Emetine is an anti-protozoan drug used in the treatment

47 In this approach, inhibition of NMD with emetine is complemented with inhibiting NMD by blocking

48 -yohimbenone and a formal synthesis of (+/-)-emetine is described.

49 composed of two copies of the P-gp substrate emetine, linked by tethers of varied composition.

50 An optimum distance between the emetine molecules of approximately 10 A was found to be

51 plication of the protein synthesis inhibitor emetine or cycloheximide 1 hr after MF LTP induction in

52 thysergide) or protein synthesis inhibitors (emetine or cycloheximide) were injected intrathecally in

53 These data support the use of emetine or structurally related compounds as useful lead

54 Administration of emetine or the RNA synthesis inhibitor actinomycin-D bef

55 Pretreatment with methysergide, emetine, or cycloheximide attenuated or abolished phreni

56 rlay at neutral pH containing 1 microgram of emetine per ml and 20 micrograms of NaF per ml, resulted

57 Anisomycin, cycloheximide, emetine, puromycin, and puromycin aminonucleoside, a neg

58 Without altering HIF-2alpha mRNA level, emetine rapidly and dramatically down-regulated HIF-2alp

59 The emetine-resistant protein, rpS14-EmRR, which contains tw

60 y IpeOMT2 and IpeOMT1 to form cephaeline and emetine, respectively.

61 NAC treated with emetine retained approximately 40% of their capacity to

62 long isoform, which could be ameliorated by emetine, suggesting that the mutation induces nonsense-m

63 otein synthesis inhibitors cycloheximide and emetine to acute rat hippocampal slices have no effect o

64 ast to the pattern of initiation detected in emetine-treated cells, analysis of the short nascent str

65 ear the initiation region (IR) identified in emetine-treated cells.

66 osine phosphorylation and PI3K binding after emetine treatment to raise intracellular amino acids and

67 To overcome this, we have combined the emetine treatment with actinomycin D, which effectively