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1 bes for biomedical research and diagnostics, emphasizing the needs and opportunities that have been u
2 remodeling beyond a mere structural role and emphasize the need for a better understanding of this mo
3 fication associated with MGP dysfunction and emphasize the need for a comprehensive approach to this
4                          These findings also emphasize the need for a different management approach f
5                                These results emphasize the need for a holistic view on biochar use in
6                                  The results emphasize the need for a new classification for selectin
7                              To this end, we emphasize the need for a paradigm shift towards integrat
8 In this review, we summarize recent work and emphasize the need for a solid theoretical framing to gu
9                           These observations emphasize the need for accurate and rapid molecular test
10                         These considerations emphasize the need for alternative therapies.
11                           These results also emphasize the need for care when building coarse-grained
12 clinical relevance of the molecular data and emphasize the need for careful parental assessments and
13                               These findings emphasize the need for careful scheduling of treatment w
14 ve dichotomous effects on TLR4 signaling and emphasize the need for caution in interpreting the resul
15                               These findings emphasize the need for caution when ascribing variants a
16                                  We strongly emphasize the need for caution when using SDMs to predic
17 ajor adverse cardiac events in the long term emphasize the need for close follow-up.
18                                           We emphasize the need for combined chemical and biological
19                                These results emphasize the need for consideration of all exposure rou
20                                 Our findings emphasize the need for considering context-specific effe
21  H1N1 viruses with avian influenza virus and emphasize the need for continued surveillance of influen
22 t can both directly or indirectly damage DNA emphasize the need for developing facile methods to asse
23 -term implications of active coeliac disease emphasize the need for early detection and strict adhere
24 f sampling effort as an explanatory variable emphasize the need for effective monitoring and risk ass
25                                  Such models emphasize the need for existing connectivity to form vis
26 raphic differences in these associations and emphasize the need for further investigation of eating d
27 he essential role of RAD21 in eukaryotes and emphasize the need for further understanding of the role
28                             Our results thus emphasize the need for greater access to high quality Ce
29                               These analyses emphasize the need for improved annotation of disease al
30 however, current relapse and mortality rates emphasize the need for improved therapeutic strategies.
31  of CR6261 and CR9114 against H2 viruses and emphasize the need for in vivo evaluation of bNAbs.IMPOR
32  the crucial importance of female choice and emphasize the need for incorporating between-individual
33                                  Our results emphasize the need for long-term, range-wide measurement
34                     The results of the study emphasize the need for model inputs relative to SCR perf
35                    The results of this study emphasize the need for more frequent and higher-quality
36                                These results emphasize the need for more mechanistic attention to bas
37                                These results emphasize the need for more studies regarding the effica
38                                 We therefore emphasize the need for more theoretical and empirical wo
39 e use of higher-order reasoning schemes that emphasize the need for multiple perspectives, allow for
40 mple of the antibiotic-resistance crisis and emphasize the need for new approaches to treat and preve
41                                 Our findings emphasize the need for new strategies that not only redu
42 ic study of the human inner ear continues to emphasize the need for non- or minimally invasive clinic
43 malaria and insecticide-resistant mosquitoes emphasize the need for novel methods of disease control.
44                                These results emphasize the need for oncologists to endorse and facili
45 rspective, it is important for clinicians to emphasize the need for parental adherence to a child's t
46                            Also, our results emphasize the need for performing more studies with T1D
47  vitamin E treatment in the SELECT trial and emphasize the need for preclinical studies using accurat
48 rities in the occurrence of DM, CKD, and HTN emphasize the need for prevention and treatment options
49 es, not simply reflecting greater adiposity, emphasize the need for prevention strategies starting in
50                                           We emphasize the need for regular and long-term follow-up a
51 ulted specifically from exome sequencing and emphasize the need for rigorous statistical evaluation o
52 incidence in these North American cities and emphasize the need for scale-up of opioid agonist therap
53                               These findings emphasize the need for screening for multiple nutrient d
54                  In addition, the guidelines emphasize the need for studies that focus on multicompon
55                                   These data emphasize the need for study of familial CNV risk factor
56 n the geomechanical responses of these sites emphasize the need for systematic geomechanical appraisa
57 rtance for decision making, and, as such, we emphasize the need for the functioning of an endocarditi
58 valid in vitro models of malignant cells and emphasize the need for validation of primary tumor cultu
59                  Discussion: The PPA results emphasized the need for a differentiated approach to tub
60  rapid growth of candidate novel markers has emphasized the need for a systematic approach to their e
61 tion of OPV (starting with Sabin type 2) and emphasized the need for affordable IPV options.
62 the global outbreak of an influenza pandemic emphasized the need for an effective vaccine adjuvant.
63 e and formidable immune evasion arsenal have emphasized the need for more effective antimicrobial app
64 zing radiation (IR) to large populations has emphasized the need for rapid and reliable methods of bi
65               Taken together, these findings emphasized the need for surveillance of pikR1/pikR2-base
66 s for the current gene therapy strategy that emphasizes the need for a combinatorial therapy to both
67 everity of disease, morbidity, and mortality emphasizes the need for a culture method that permits si
68  multiple renal, hepatic and splenic lesions emphasizes the need for a high index of clinical suspici
69                                    This work emphasizes the need for a high-resolution structure to g
70 en across the different developmental stages emphasizes the need for a holistic life-cycle approach t
71                                 This finding emphasizes the need for better understanding of the fact
72 ally limited to surgery and radiation, which emphasizes the need for better understanding of this dis
73 a recent Q fever outbreak in the Netherlands emphasizes the need for better understanding this unique
74 ive biology of mechanosensitive channels and emphasizes the need for care in analysing protein comple
75                   More generally, this study emphasizes the need for careful consideration of human s
76                                    Our study emphasizes the need for classifying membrane proteins in
77 and Ag NPs and enhance their toxic potential emphasizes the need for conducting future toxicity studi
78 rising in Hg(II) bioassays with cysteine and emphasizes the need for considering changes in chemical
79                                         This emphasizes the need for continued adherence support amon
80 valence of depression in all three disorders emphasizes the need for effective therapies.
81 g the current published recommendations, and emphasizes the need for evidence-based guidelines and un
82                                  This result emphasizes the need for experiments that constrain the c
83 al mus-scale transitions in the loops, which emphasizes the need for extended simulations in studies
84 in the presence of sequence polymorphism and emphasizes the need for extreme caution and thorough pri
85                                  This result emphasizes the need for functional confirmation of annot
86 imits its added value to early diagnosis and emphasizes the need for further biomarker research.
87 er, the existence of alternative conclusions emphasizes the need for future research.
88  for chronic musculoskeletal manifestations, emphasizes the need for identification of genetic determ
89  and nurse-patient interaction of nurses and emphasizes the need for implementing institutional polic
90                                         This emphasizes the need for improved prevention and early de
91          This improvement in life expectancy emphasizes the need for insurance companies to update an
92 on of attrition and nonignorable missingness emphasizes the need for longitudinal diagnostics and for
93                                   This paper emphasizes the need for methods to manage the N cycle th
94                                   This study emphasizes the need for molecular stratification in leio
95  into the pathogenic mechanisms involved and emphasizes the need for more complex yet tractable exper
96                                         This emphasizes the need for more coordinated in situ and rem
97                                         This emphasizes the need for much improved implementation of
98 trains of Mycobacterium tuberculosis (M. tb) emphasizes the need for new antitubercular drugs.
99  domains that are conformationally flexible, emphasizes the need for new approaches for modeling RNA
100                                         This emphasizes the need for new biomarkers for the evaluatio
101 ancy even in the most recent calendar period emphasizes the need for new treatment options for these
102 of then nonresectable or metastasized tumors emphasizes the need for novel imaging approaches.
103                      However, this work also emphasizes the need for pharmaceutical or behavioral int
104 oacrylate generated by metabolic enzymes and emphasizes the need for RidA to quench this reactive met
105 ch as the zwitterionic Fos-choline-12, which emphasizes the need for simple validation assays like th
106 etween traditional prognostic markers and RS emphasizes the need for standardized assessment and supp
107                                         This emphasizes the need for taking exposure levels into acco
108                                     Our work emphasizes the need for the examination of learning in n
109  oxidation byproducts as NDMA precursors and emphasizes the need for their consideration when evaluat
110 on of the 2009 pandemic H1N1 influenza virus emphasizes the need for universal influenza vaccines tha
111 -arterial treatment of acute ischemic stroke emphasizes the need for well designed prospective studie
112                                 This finding emphasizes the need for well-designed prospective studie
113                               We conclude by emphasizing the need for a comprehensive definition of s
114 ance the treatment of rectal cancer, further emphasizing the need for a multidisciplinary approach to
115 r, the risk of severe HT rises considerably, emphasizing the need for a readily available assay of DE
116 he true heritability is bounded away from 0, emphasizing the need for accurate confidence intervals.
117 ndations for future miRNA biomarker studies, emphasizing the need for accurate interpretation within
118 are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eli
119 likely larger than that for the State total, emphasizing the need for additional measurements in unde
120 ine inactivation of Cryptosporidium oocysts, emphasizing the need for additional pool remediation opt
121 ere not reproducible using the HMA approach, emphasizing the need for additional study.
122  combined with a low treatment satisfaction, emphasizing the need for adequate treatment, especially
123 est and most widespread in recorded history, emphasizing the need for an effective vaccine.
124 fficient to reduce mortality in endotoxemia, emphasizing the need for APC's cytoprotective actions, b
125 inics, and neurovascular emergency services, emphasizing the need for appropriate blood-sensitive mag
126      Significant Hawthorne effects occurred, emphasizing the need for appropriately designed studies
127 mmentary highlights the article by Ng et al, emphasizing the need for autopsies to better model infec
128 d model compared with the LeuBAT structures, emphasizing the need for careful experimental verificati
129                               We conclude by emphasizing the need for collaborative research that lin
130 ained by the variation of single parameters, emphasizing the need for comprehensive sensitivity analy
131 een computational and experimental chemists, emphasizing the need for computation to predict experime
132 ip between vitamin D and asthma and allergy, emphasizing the need for controlled, prospective studies
133 l, community, and agricultural settings; and emphasizing the need for establishing regional active su
134 fe style factor affecting human health, thus emphasizing the need for evidence-based dietary guidelin
135  mass fractions of Na less than 4 mg kg(-1), emphasizing the need for exact matching of matrix compos
136 entified using traditional linkage analysis, emphasizing the need for exome sequencing of complex lip
137 chondrial disorders is currently inadequate, emphasizing the need for experimental models.
138 atterns were encountered in 31% of patients, emphasizing the need for further evaluation in larger se
139 gnificant spatial variability in subsidence, emphasizing the need for further measurement, which coul
140 e cause of this structure remains equivocal, emphasizing the need for further molecular characterizat
141 patially and temporally resolved (13)C MRSI, emphasizing the need for further MR methodologic develop
142  directions for isoform function prediction, emphasizing the need for heterogeneous genomic data inte
143 y recipient tumor cells were not detectable, emphasizing the need for improved additive MiHA-specific
144 ng other countries in the region and beyond, emphasizing the need for improved EV-A71 surveillance an
145 fects on lung function and disease severity, emphasizing the need for improved pediatric asthma contr
146  of the burden of these diseases on society, emphasizing the need for increased attention toward adva
147  from these large collaborative initiatives, emphasizing the need for life-long follow-up of survivor
148 phase-locking is disturbed in schizophrenia, emphasizing the need for more studies of oscillatory syn
149 r from interobserver diagnostic variability, emphasizing the need for new diagnostic modalities.
150 fectiveness for risk stratification, further emphasizing the need for optimal patient selection for c
151 ly from published sets and between patients, emphasizing the need for patient-specific adjustment.
152 flect interplay between alcohol and smoking, emphasizing the need for preventive measures.
153 d in the United States over the past decade, emphasizing the need for rapid and accurate tests for CD
154 that BPVT responds to vitamin K antagonists, emphasizing the need for reliable diagnosis.
155 ity is generally determined by liver biopsy, emphasizing the need for simple noninvasive methods for
156  are crucial for cell-to-cell communication, emphasizing the need for spatially resolved data on cyto
157 y responses required T cell help to develop, emphasizing the need for T-B collaboration for long-term
158 rvival in survivors who develop CVD is poor, emphasizing the need for targeted prevention strategies
159  measured in infancy persist into childhood, emphasizing the need for targeted therapeutic interventi
160 tion with corresponding lung volume changes, emphasizing the need for tight control over lung volume
161 8 of 1231] vs 3.7% [121 of 3311]; P < .001), emphasizing the need for timely advanced treatment.
162 th photoreceptor degeneration in the Tg rats emphasizes the need in behavioral therapeutic studies fo
163                                These results emphasize the need of careful prosthesis selection in ea
164 ing liver growth with its energy demands and emphasize the need of lipids for regeneration.
165 of nephrocalcinosis and that our case series emphasizes the need of a well-organized retrospective st
166 ss preclinical tests fail in these patients, emphasizing the need of improved preclinical models to t
167                        Together, our results emphasize the need to account for the complex history of
168                               These findings emphasize the need to address challenges in personalized
169                         Together our results emphasize the need to analyze kinetics of protein intera
170 biased degradation among genomic regions and emphasize the need to assess sample integrity immediatel
171                                  The authors emphasize the need to be innovative and not bound by the
172 -induced disease exacerbation in rodents and emphasize the need to better understand the basic mechan
173 entions for preventing or curing the disease emphasize the need to better understand the genes involv
174  calculators to tropical farming systems and emphasize the need to broaden the scope of the underlyin
175                                  Our results emphasize the need to carefully account for population s
176 ease patients with early visual symptoms and emphasize the need to clarify the pathophysiological cha
177                                  Our results emphasize the need to closely monitor this vulnerable po
178  assumes negative effects of nonnatives, and emphasize the need to consider context-dependence and in
179                                 They also re-emphasize the need to consider factors beyond the kinesi
180                      Together, these results emphasize the need to consider mutualists as potential i
181                                 Our findings emphasize the need to continue and expand such surveilla
182 grees of visual impairment in these patients emphasize the need to continue refining our understandin
183                             These statistics emphasize the need to develop and implement more effecti
184 nderestimate AZT resistance levels, and they emphasize the need to develop subtype-specific genotypic
185  processes from degeneration, these findings emphasize the need to develop therapeutics aimed at axon
186                               These findings emphasize the need to devise a mechanism that allows dat
187                                  Our results emphasize the need to enhance our understanding of the r
188                                           We emphasize the need to enhance translational efforts and
189                                   These data emphasize the need to evaluate the neurocognitive and pa
190                        These inconsistencies emphasize the need to evaluate the role of hormones in p
191 n as a function of juvenile density and time emphasize the need to evaluate their roles through later
192 t into how a small molecule binds an IDP and emphasize the need to examine motions on the low microse
193 on in the development of the human tumor and emphasize the need to experimentally determine the signi
194                                           We emphasize the need to explore proposed retinal connectiv
195 transmissibility of influenza viruses and we emphasize the need to find better predictors of both sea
196 ct of initial conditions and seasonality and emphasize the need to focus on appropriate characterizat
197                    These discordant findings emphasize the need to focus on oncology-specific measure
198                                These results emphasize the need to further investigate the possible r
199                                      We also emphasize the need to further understand the functional
200                                These results emphasize the need to identify interventions beyond effe
201 s and the lack of targeted therapies for TSS emphasize the need to identify key players of the storm'
202 n development for alcohol use disorder (AUD) emphasize the need to identify novel molecular targets a
203                                  The results emphasize the need to include any available functional i
204 eformation connections described in our work emphasize the need to include metamorphic and fluid tran
205                                   These data emphasize the need to include time and INa-L in evaluati
206                                These results emphasize the need to integrate individual variation to
207                                 Our findings emphasize the need to interrogate the mutations in codin
208                                These results emphasize the need to investigate a pediatric RSV vaccin
209 GWAS, disease genomics, and gene therapy and emphasize the need to investigate both types of mutation
210 pes can be maintained within populations and emphasize the need to investigate interactions between s
211 are dependent upon the microbial context and emphasize the need to investigate various infection mode
212                               These findings emphasize the need to maximize 6MP regimen adherence and
213                                 Our findings emphasize the need to mitigate emissions from both resid
214                                 Our findings emphasize the need to prepare for potential pandemics ca
215 cts on the exchange of greenhouse gases, and emphasize the need to project future hydrological regime
216                                 Our findings emphasize the need to quantify fluvial carbon losses in
217                          These findings also emphasize the need to quantify the relative contribution
218 iomyelitis infection in Pakistan and further emphasize the need to scale-up clinical and environmenta
219  side effects is rather small, these data do emphasize the need to select patients carefully for RRA
220                                  Besides, we emphasize the need to suspect this syndrome in a female
221 igratory bird breeds throughout its life and emphasize the need to understand how events throughout t
222                   Losses of corals worldwide emphasize the need to understand what drives reef declin
223                                  Finally, we emphasize the need to use adaptive path-based approach i
224                          Recent studies have emphasized the need to combine genetic diversity and dis
225 ed from the Great East Japan Earthquake have emphasized the need to develop strategies to respond to
226 energy costs and environmental concerns have emphasized the need to produce sustainable renewable fue
227               In conclusion, this commentary emphasizes the need to accept the fact that epidemiology
228                                     Our work emphasizes the need to achieve high mobility in combinat
229                                    Our study emphasizes the need to analyze a large number of subject
230 chwann cell function in the adult animal and emphasizes the need to approach potential therapeutic mo
231                                   This study emphasizes the need to assess toxicants together with ot
232 ential for permanent hearing impairment also emphasizes the need to better understand and manage this
233 ed to aged or ovariectomized female mice and emphasizes the need to combine histopathological and fun
234             The resulting structural picture emphasizes the need to combine symmetry-averaged long-ra
235            This large-scale response pattern emphasizes the need to complement established structural
236                                     Our work emphasizes the need to consider absolute levels of diffe
237                                  This report emphasizes the need to consider brucellosis as a part of
238                            This finding also emphasizes the need to consider the full range of social
239  direct and indirect economic effect of ASDs emphasizes the need to continue to search for effective
240 ver, the emergence of drug-resistant mutants emphasizes the need to develop additional agents that ha
241 larly aging, converge on the vessel wall and emphasizes the need to develop effective strategies to i
242 hey will be captured by limited biopsies and emphasizes the need to develop therapies specifically ta
243                   Overall, the present study emphasizes the need to disentangle gut microbiota signat
244  prognosis and lack of efficacious treatment emphasizes the need to elucidate the pathways playing a
245 f the hollow core fibril at physiological pH emphasizes the need to examine toxic effects of minor ol
246                                   This study emphasizes the need to expand our understanding of the r
247 hallenge that prediction algorithms face and emphasizes the need to experimentally validate predicted
248 t part of EU raw material consumption, which emphasizes the need to focus on the full production chai
249                            Finally, our work emphasizes the need to frequently evaluate the integrity
250                    LUAD's high heterogeneity emphasizes the need to further study this tumor type and
251 heir higher mortality and progressive course emphasizes the need to identify AR-HIES patients early,
252                                         This emphasizes the need to identify individuals with this su
253 factors that regulate gene expression, which emphasizes the need to include chromatin structural para
254                          Moreover, this work emphasizes the need to incorporate both microcomponents
255 ing processes in functionally important ways-emphasizes the need to integrate multiple mechanisms of
256                                    Our study emphasizes the need to interpret transcriptomic data set
257                                   This study emphasizes the need to investigate a periodic estrogen r
258 ange may lead to more variable food quality, emphasizes the need to maintain and strengthen existing
259 for MSC-derived resistance to forodesine and emphasizes the need to move toward combinations with age
260 an outperform their natural counterparts and emphasizes the need to optimize donor-acceptor distance
261 POLG2 mutations in mitochondrial disease and emphasizes the need to quantitatively characterize the b
262 the dwarfed phenotype of the mutant and thus emphasizes the need to re-address the proposed role of P
263                                 This finding emphasizes the need to screen for cardiovascular disease
264 artifacts in cancer genomics data, our study emphasizes the need to survey the diversity of normal as
265 in cancer cells that prevents apoptosis, and emphasizes the need to synergize nanoparticle design wit
266                                This approach emphasizes the need to take into account defect interact
267 or regulating histone demethylase levels and emphasizes the need to tightly regulate chromatin modifi
268                         This finding further emphasizes the need to understand how brain reward netwo
269 d protein in mice versus human patients, and emphasizes the need to understand species-specific prote
270 n shaping geographic diversity patterns, and emphasizes the need to understand the mechanisms underpi
271 quent use of macaques in biomedical research emphasizes the need to understand the molecular basis of
272                     The present work further emphasizes the need to use well-defined energy landscape
273 % of infections were identified on days 0-3, emphasizing the need to address maternal and environment
274  ALAN can broadly effect migratory behavior, emphasizing the need to better understand the implicatio
275 regulating commercial sex are also reviewed, emphasizing the need to carefully consider the medical a
276 h significantly increased risk for bleeding, emphasizing the need to carefully determine if and when
277 and effector functions, with the differences emphasizing the need to carefully interpret preclinical
278 d significantly below the theoretical yield, emphasizing the need to computationally investigate and
279 e relative richness of these three families, emphasizing the need to consider the incomplete nature o
280 pposed to warm summers on a signaling trait, emphasizing the need to consider year-round influences o
281                We outline future directions, emphasizing the need to couple next-generation sequencin
282  female and male heart is currently unknown, emphasizing the need to define human myocardial biology.
283  irreversible EGFR kinase inhibitors further emphasizing the need to develop more potent therapies ag
284 ly associated with platinum drug resistance, emphasizing the need to directly measure the intratumor
285 atory and cytoskeletal remodelling pathways, emphasizing the need to explore biochemical alterations
286 for patients with CAPS and residual disease, emphasizing the need to explore other NLRP3-mediated pat
287 nt predators on prey metacommunity assembly, emphasizing the need to explore the role of predator die
288 xicities that are unique to immunotherapies, emphasizing the need to familiarize the oncology practit
289 e >70 affected individuals reported to date, emphasizing the need to identify the underlying genetic
290 ate C.albicans-mediated mucosal inflammation emphasizing the need to optimize the applied antifungal
291                               We conclude by emphasizing the need to place the 30-day COPD readmissio
292 trum to that found in the adult counterpart, emphasizing the need to promote sun protection practices
293  stimulate T cell responses in vivo, further emphasizing the need to regulate both pathways to induce
294 inst a backdrop of nutrient over-enrichment, emphasizing the need to separate these effects to gauge
295  traditional stoves with clean technologies, emphasizing the need to shift in the long term to near e
296 and quality of life (QOL) they have enabled, emphasizing the need to sustain our national investment
297 f diversity and eutrophication on stability, emphasizing the need to understand how drivers of global
298  altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells
299 set by natural disasters are also presented, emphasizing the need to understand the magnitude frequen
300  resistance have proven to be heterogeneous, emphasizing the need to use broad therapeutic approaches

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