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1 ied, rendering embolic protection approaches empiric.
2 and June, 2010, we did a randomised trial of empiric 14-day triple, 5-day concomitant, and 10-day seq
3 : 2 methods using only clinical information (empiric 5 mg/day dosing and a formal clinical algorithm)
4                                           An empiric 6-food elimination diet effectively induced remi
5                                  Notably, an empiric 6-food elimination diet is as effective as a ski
6                                           An empiric 6-food elimination diet or removal of positive f
7                                  Group 2 had empiric ablation with the same 3.7-GBq (131)I dosage, bu
8                                           An empiric administered activity of 7.4 GBq (200 mCi) would
9                    Three new models based on empiric AIS injury severities were developed.
10 signed (1:1) eligible participants to either empiric albendazole every 3 months plus praziquantel ann
11                                              Empiric and compartmental model times to peak aortic enh
12 we compared beta-lactams with vancomycin for empiric and definitive therapy of MSSA bloodstream infec
13 t is unclear if this association is true for empiric and definitive therapy.
14 n this population, treatment remains largely empiric and focused on optimizing myocardial performance
15 gin revising methods to reflect the emerging empiric and mechanistic knowledge.
16  correct diagnosis and to choose appropriate empiric and specific agents and maximize the likelihood
17 ailable provides opportunities for effective empiric and specific therapy.
18 d early because they influence prophylactic, empiric, and specific therapy strategies.
19                                     Limiting empiric anti-gram-positive therapy to neutropenic patien
20 ard MTB diagnostic testing (24%) or received empiric anti-tuberculosis therapy (15%).
21                      Determining when to use empiric anti-VRE antibiotic therapy in this population r
22  promising method of guiding rational use of empiric anti-VRE antimicrobial therapy in patients with
23 This study sought to examine the efficacy of empiric antiarrhythmic drugs in a rigorously characteriz
24 o define if severity should be used to guide empiric antibiotic choices.
25 fluoroquinolones were the most commonly used empiric antibiotic for ASB [245/691 (35%)].
26                                              Empiric antibiotic monotherapy is considered the standar
27 could be considered as one of the first-line empiric antibiotic therapies.
28                                    Delays in empiric antibiotic therapy are associated with increased
29 llow, and </= one single intravenous dose of empiric antibiotic therapy before study drug treatment i
30                                              Empiric antibiotic therapy can be narrowly targeted at G
31  cultures are often considered when choosing empiric antibiotic therapy for a suspected urinary tract
32 ons, should be understood both when choosing empiric antibiotic therapy for infectious keratitis and
33  study is to determine the rate of prolonged empiric antibiotic therapy in adult ICUs in the United S
34 amine the relationship between the prolonged empiric antibiotic therapy rate and certain ICU characte
35 of factors associated with the ICU prolonged empiric antibiotic therapy rate was conducted using Stud
36                                    Prolonged empiric antibiotic therapy rate was determined as the ra
37  was significantly associated with prolonged empiric antibiotic therapy rate.
38 iated pneumonia had lower rates of prolonged empiric antibiotic therapy than those that did not, 45.1
39                                    Prolonged empiric antibiotic therapy was defined as empiric antibi
40 ed peritonitis treatment guidelines in which empiric antibiotic therapy was stratified by disease sev
41 ial treatment failure, but not inappropriate empiric antibiotic therapy, was a mortality risk factor
42 sistance is important in making decisions of empiric antibiotic therapy.
43 phylactic, definitive, empiric, or prolonged empiric antibiotic therapy.
44                     To prevent inappropriate empiric antibiotic treatment in patients with bacteremia
45 or threshold values result in evaluation and empiric antibiotic treatment of large numbers of uninfec
46 pneumonia accounted for approximately 60% of empiric antibiotic use.
47  FUBC, unless bacteria were not sensitive to empiric antibiotic.
48 .0 degrees C 72 to 96 hours after receipt of empiric antibiotics (NBL group: 22.7% vs BL group: 13.9%
49 termined as the ratio of the total number of empiric antibiotics continued for at least 72 hours divi
50 for particulate aspiration, consideration of empiric antibiotics for pneumonia treatment, and lower r
51                                The choice of empiric antibiotics for the treatment of gram-negative b
52 comycin and ceftazidime seem to be excellent empiric antibiotics for treating endophthalmitis.
53          These findings impact the choice of empiric antibiotics in critically ill burn patients.
54 widespread practice of a prolonged course of empiric antibiotics in patients with presumed CRS.
55 h infectious diseases, limiting the need for empiric antibiotics in this age group.
56          Early administration of appropriate empiric antibiotics is essential for achieving the best
57                                  Half of all empiric antibiotics ordered in critically ill patients a
58  classified as BL or NBL groups based on the empiric antibiotics received.
59 ed empiric antibiotic therapy was defined as empiric antibiotics that continued for at least 72 hours
60                                              Empiric antibiotics upon development of hematoma did not
61               The most frequently prescribed empiric antibiotics were vancomycin and piperacillin/taz
62 lance the need for administering appropriate empiric antibiotics while also minimizing the use of cli
63 ng management (modification and cessation of empiric antibiotics), and empiric antifungal treatment (
64                                       Of the empiric antibiotics, 333 of 660 (50%) were continued for
65                                              Empiric antibiotics, antivirals, and antifungals were ad
66 ibiotic resistance is important in selecting empiric antibiotics.
67  assessed 72 to 96 hours after initiation of empiric antibiotics.
68 east 72 hours divided by the total number of empiric antibiotics.
69                                              Empiric antifibrinolytics for children should be questio
70 IA) has the potential to decrease the use of empiric antifungal agents.
71 ctions (9 vs 17; P = .09), and less frequent empiric antifungal therapy (24.1% vs 30.2%, P = .11) wit
72 ntext of intensive monitoring and structured empiric antifungal therapy, 6-month FFS and overall surv
73 nitial presentation, ongoing management, and empiric antifungal therapy.
74 n and cessation of empiric antibiotics), and empiric antifungal treatment (risk stratification, evalu
75 for diagnosis, laboratory investigation, and empiric antimicrobial and adjunctive therapy were develo
76                                              Empiric antimicrobial choices should be modified in area
77  recent antibiotic exposure when formulating empiric antimicrobial regimens for suspected Gram-negati
78            We examined the impact of initial empiric antimicrobial therapeutic variables on the hospi
79 orm clinicians regarding the best choice for empiric antimicrobial therapy against this multidrug-res
80  the relationship between aspects of initial empiric antimicrobial therapy and mortality in patients
81 e process of selection and implementation of empiric antimicrobial therapy in this high-risk group sh
82 nappropriate and delayed appropriate initial empiric antimicrobial therapy is associated with increas
83  Practices for antimicrobial prophylaxis and empiric antimicrobial therapy should be regularly assess
84                        Inappropriate initial empiric antimicrobial therapy was administered in 155 (2
85                  Symptoms progressed despite empiric antimicrobial therapy, and the patient died afte
86 s, should be taken into account in selecting empiric antimicrobial treatment.
87  analyses suggest that improved targeting of empiric antimicrobials for multidrug-resistant bacteria,
88 gan failures, bacteremia, appropriateness of empiric antimicrobials, or adjunct therapies.
89                                              Empiric antimycotic prophylaxis initiated at the time of
90                                        Early empiric antiviral treatment is recommended for those wit
91 on holds the promise of rational rather than empiric approaches for the treatment of cancer patients.
92 irst all-cause shock was non-inferior in the EMPIRIC arm (hazard ratio = 0.95, 90% confidence interva
93 n a shock were non-inferior and lower in the EMPIRIC arm compared to the TAILORED arm.
94  significantly less often (p = 0.001) in the EMPIRIC arm.
95 environment interactions were examined using empiric Bayes-mediated linear models.
96 Compared with the "Do Nothing" strategy, the empiric beta-blocker strategy cost an incremental $12,40
97                            Compared with the empiric beta-blocker strategy, in turn, both the EGD-->B
98 e more expensive and less effective than the empiric beta-blocker strategy.
99                               In conclusion, empiric beta-blocker therapy for the primary prophylaxis
100 EBL (sEGD-->EBL) if varices are present, (5) empiric beta-blocker therapy in all patients, and (6) no
101                RMD platforms can help inform empiric beta-lactam therapy in cases where bla genes are
102                              With widespread empiric broad-spectrum beta-lactam use creating selectiv
103  estimated collision cross sections using an empiric calibration method.
104 patients receiving empiric PTZ compared with empiric carbapenem therapy (95% confidence interval, 1.0
105 ll, 335 patients were included; 249 received empiric carbapenems and 86 OADs.
106 sease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alt
107                                              Empiric chemotherapy with albendazole was instituted and
108 opulation at high risk for relapse following empiric chemotherapy, although such models do not accoun
109 erapy sensitivity and resistance assays with empiric chemotherapy, emphasizing survival outcomes.
110                   Despite recent advances in empiric chemotherapy, including interval reduction of CH
111                                              Empiric circumferential pulmonary vein isolation (CPVI)
112 res associated with unfavorable responses to empiric combination chemotherapy, and defining robust su
113 ge drug development and mitigate against the empiric combination of such drugs outside of a clinical
114  of 689 primary prevention patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Pro
115  against the use of stimulant medications or empiric continuous positive airway pressure to reduce dr
116 ildren with NS are typically treated with an empiric course of glucocorticoid (Gc) therapy; a class o
117                          The map will enable empiric coverage estimates and multipoint linkage analys
118 ated to locations in the visual field, using empiric cross-sectional patient data.
119 mpares favorably with previous results using empiric CUP regimens.
120 n cancer-specific therapies than they did to empiric CUP therapy with taxane/platinum regimens.
121                                           An empiric cutoff of more than 20% of PR-positive tumor cel
122                                              Empiric data and expert opinion suggest that use of feed
123                                           No empiric data exist regarding predictors of risk after no
124 e the effect of transmission dynamics on the empiric data from molecular epidemiologic studies.
125                                              Empiric data on recruitment of minorities into clinical
126 yperendemic communities, but there are scant empiric data on the number of rounds of treatment that a
127 pecially the phonological theory, and review empiric data suggesting genetic and neurobiological infl
128 timal because these definitions are based on empiric description of occurrences that are merely assoc
129 ces and the (18)F-FDG sources allowed for an empiric determination of the relative response for these
130     Our findings do not suggest an effect of empiric deworming in the delaying of HIV disease progres
131           We aimed to assess the efficacy of empiric deworming of adults with HIV in delaying HIV dis
132 tification of a majority of responders to an empiric diet with few food triggers, avoiding unnecessar
133 nalysis of five cancer genomes and performed empiric distribution fitting to examine the true distrib
134  may be useful in determining the utility of empiric donor pretreatment with low-dose dopamine.
135                      In a clinical trial, an empiric dose of octreotide treatment prolonged time to t
136 by 59% and 50%, respectively, supporting the empiric dose reductions in the PSC-MEC arm designed in a
137 algorithm (52%) than with all other methods: empiric dosing (37%; odds ratio [OR]: 2.2), clinical alg
138                At most institutions, a fixed empiric dosing strategy is often used, with administered
139 e with dosimetry, we have observed that this empiric dosing strategy often results in administered RA
140 c tables predicted warfarin dose better than empiric dosing, formal pharmacogenetic algorithms were t
141 rgy testing-directed elimination diet and an empiric elimination diet based on common food allergens.
142  and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic
143 -directed elimination diets, and nondirected empiric elimination diets.
144 ared with either allergy testing-directed or empiric elimination diets.
145 emoval of foods identified on SPTs/APTs plus empiric elimination of milk leads to resolution in 77% o
146 red carefully because there was only limited empiric evidence for several input parameters.
147 ically in the treatment of ICDs, there is no empiric evidence supporting their use in PD.
148 ed by class I vs the human proteome provides empiric evidence that the range of proteins sampled by c
149                                     Although empiric exclusion from the diet of the 6 food groups mos
150 second-stage spatial filters can account for empiric findings of linear relations between perimetric
151                                              Empiric first and second-line triple treatments have una
152 d pretreatment and after 3, 6, and 9 days of empiric first-line therapy.
153 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,
154 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,
155                                    Use of an empiric fixed dose of 750 mg of daptomycin is predicted
156  provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid
157  provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid
158 lso made conditional recommendations against empiric food avoidance, upper gastrointestinal radiograp
159  sizes on system resolution and extended the empiric formula for reconstructed image resolution of co
160  least partially affected by the adequacy of empiric gram-negative antimicrobial therapy.
161                                       Basing empiric HCAP therapy on its severity and the presence of
162 nditions, testing for CS instead of starting empiric IBS therapy cost an incremental $11,000 to achie
163                                 Standardized empiric ICD programming for VT/VF settings is at least a
164 ents with SLE have been managed largely with empiric immunosuppressive therapies, which are associate
165 epidemiologic shift has implications for the empiric management of community-associated infection whe
166 ty percent of the data was used to derive an empiric measure of severity of each of the 1322 injuries
167                                              Empiric measures of injury severity for each of the trau
168 ng endoscopy is cost-effective compared with empiric medical management in patients with compensated
169 o extract how biomolecules interact.The text empirics method that was investigated, though arising fr
170 egion was examined, as estimated by using an empiric model and baseline occupation and leisure activi
171                                           An empiric model based on the data presented (and the liter
172 n the basis of these individual doses and on empiric models of radiation-induced cell death (i.e., re
173 c to Physician-Tailored Programming of ICDs [EMPIRIC], Multicenter Automatic Defibrillator Implantati
174 is and effective management of tuberculosis, empiric multidrug treatment is initiated in almost all s
175 ents were randomly assigned to standardized (EMPIRIC, n = 445) or physician-tailored (TAILORED, n = 4
176 ients to surgery or imaging surveillance and empiric nephron-sparing surgery.
177 ains equally as interesting is the idea that empiric observations of novel targeted drugs in select s
178 ere categorized as prophylactic, definitive, empiric, or prolonged empiric antibiotic therapy.
179 th an LOD score of 2.95 (nominal P = 0.0001; empiric P = 0.0003).
180 dds (LOD) score of 2.50 (nominal P = 0.0003; empiric P = 0.0004) and on chromosome 14 (14q22) with an
181 also found of linkage to refraction on 7q36 (empiric P = 2.32 x 10(-3)), a region previously linked t
182  to 22q11 of adjusted refraction and myopia (empiric P = 4.43 x 10(-3) and 1.48 x 10(-3), respectivel
183 d for hyperopia on chromosome 3, region q26 (empiric P = 5.34 x 10(-4)), a region that had shown sign
184 3), respectively) and to 7p15 of refraction (empiric P = 9.43 x 10(-4)).
185 S 3.30; empiric P=.024) and 17p11 (MLS 3.63; empiric P=.015), as well as suggestive evidence on 5p13
186 icant evidence of linkage on 6q12 (MLS 3.30; empiric P=.024) and 17p11 (MLS 3.63; empiric P=.015), as
187 ll as suggestive evidence on 5p13 (MLS 2.55; empiric P=.091).
188 7300539; P(nominal) [P(n)] = 2.6 x 10(-8); P(empiric) [P(e)] = 0.0005 and rs822387; P(n) = 3.8 x 10(-
189                                           An empiric perspective on what epidemiology has studied ove
190 and should be considered as new policies for empiric pneumonia management are developed.
191 ance, did not significantly reduce excessive empiric prescription of MRSA-active antibiotics despite
192 abnormal test locations with total deviation empiric probability plots in glaucoma patients, we compa
193 was 1.92 times higher for patients receiving empiric PTZ compared with empiric carbapenem therapy (95
194                                              Empiric quantification of human mobility patterns is par
195                                However, many empiric questions about how best to structure and implem
196 ical evaluations included (a) calculation of empiric receiver operating characteristic curves to dete
197 8% of patients were treated with an inactive empiric regimen.
198 hilia in a similar proportion of patients as empiric removal of foods but required that fewer foods b
199 s that affords protection and the support of empiric research is critical.
200 at appropriateness is a logical extension of empiric research, which has revealed substantial variati
201  over the past one half century largely from empiric science and consensus opinions and recommendatio
202 on is required if we hope to transition from empiric selection of therapeutics to risk-based, biology
203 ult eosinophilic oesophagitis (EoE), whereas empiric six-food elimination diet (SFED) achieves an eff
204 utively demonstrated to trigger EoE after an empiric six-food elimination diet-based study protocol a
205                   We recommend the following empiric sorafenib starting doses by cohort: cohort 1, 40
206                                However, this empiric strategy is not always successful.
207         This observation is supported by the empiric studies in pathophysiology and controlled labora
208 y-adjusted life expectancy (4 days) than did empiric surgery at a lower lifetime cost ($3466), domina
209 use of insufficient powering, differences in empiric TB treatment rates, and disease severity between
210  accuracy of standard algorithms for initial empiric TB treatment, contact investigation, and housing
211                    Fifty-nine (38%) received empiric TB treatment.
212 perative randomized clinical trials based on empiric therapeutic strategies.
213                    Diagnostic approaches and empiric therapies can be guided by these destination-spe
214  compared with that in patients who received empiric therapy (hazard ratio [HR] 3.24, p=0.0051 [95% C
215 er azoles or amphotericin B as first-line or empiric therapy for fungal infections.
216 d extragenital contact after sexual assault; empiric therapy for gonorrhea, chlamydia, and trichomoni
217 t or 10-day sequential four-drug regimens as empiric therapy for H pylori infection in diverse Latin
218                                      Optimal empiric therapy for hospitalized patients with healthcar
219 bials can no longer be relied on as the sole empiric therapy for severely ill outpatients whose infec
220 ed 14-day mortality of PTZ vs carbapenems as empiric therapy in a cohort of patients with ESBL bacter
221 etermine the risks and benefits of prolonged empiric therapy in the critically ill.
222                              The choices for empiric therapy include combination regimens and monothe
223 nic therapy in those unresponsive to initial empiric therapy is discouraged.
224 within DLBCL will likely improve the current empiric therapy of DLBCL by identifying rational therape
225 coverage and, as such, may be considered for empiric therapy of endophthalmitis caused by yeast or mo
226                                       Prompt empiric therapy that focuses on the most likely infectio
227 of 660 unique antibiotics were prescribed as empiric therapy to 364 patients.
228                              Modification of empiric therapy to include aminoglycosides should be con
229                                Inappropriate empiric therapy was associated with an increased risk of
230                                              Empiric therapy was defined as starting treatment 2 days
231  assumed by the guidelines nor the choice of empiric therapy was predictive of either the early treat
232                        Patients who received empiric therapy with a beta-lactam had similar mortality
233 ermine the cost-effectiveness of appropriate empiric therapy with broad-spectrum agents active agains
234 ion in whom blood cultures were obtained and empiric therapy with broad-spectrum beta-lactams and/or
235                                              Empiric therapy with OADs was not associated with mortal
236 patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OAD
237  immunoglobulins (IVIG) have been used as an empiric therapy without proof of effectiveness.
238                                          For empiric therapy, 474 (94%) IDC and 297 (87%) NIDC patien
239 ion allows more options to be considered for empiric therapy, at least for some patients, depending o
240                                           In empiric therapy, ciprofloxacin was the first choice of d
241                     The primary exposure was empiric therapy, defined as antibiotic therapy administe
242 in if penicillin allergic) is recommended as empiric therapy, unless fluoroquinolone prophylaxis was
243 ithm, with only 53% receiving broad-spectrum empiric therapy, yet 92.9% received appropriate therapy
244 ophylaxis and diagnostic-based preemptive or empiric therapy.
245 loss of renal function and poor responses to empiric therapy.
246 poraneously by assay-guided chemotherapy and empiric therapy.
247                  The ongoing transition from empiric to molecular medicine has engendered a need for
248 lusion criteria; 4 randomized (Comparison of Empiric to Physician-Tailored Programming of ICDs [EMPIR
249 ion patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Programming of Implantable
250 ive microbiology resulted in less changes of empiric treatment (33 [40%] vs 112 [60%]; p=0.005) and s
251 s among all isolates with the following: (1) empiric treatment (B and C), and treatment guided by POC
252 nosed with a stepwise approach incorporating empiric treatment and antisecretory therapy, combined MI
253 instructed versus induced patients initiated empiric treatment based on clinical and radiography find
254 se) to guide treatment changes compared with empiric treatment changes, and the benefits and risks of
255 st step in bridging the gap between RMDs and empiric treatment decisions.
256     The patient's condition worsened despite empiric treatment for an infectious etiology.
257                        In patients receiving empiric treatment for sepsis, prior colonization with 3G
258  Therapeutic plasma exchange is an effective empiric treatment for thrombotic thrombocytopenic purpur
259 idime-avibactam was highly effective for the empiric treatment of cUTI (including acute pyelonephriti
260                                          For empiric treatment of febrile dysenteric diarrhea invasiv
261 e to beta-lactam agents commonly used in the empiric treatment of febrile neutropenia was observed on
262 nd/or multidosed antibiotic regimens for the empiric treatment of intraabdominal infections.
263 lness with no laboratory-confirmed etiology, empiric treatment of iNTS disease is a major challenge i
264 tance to 4 beta-lactams commonly used in the empiric treatment of neutropenic fever.
265 cological principles will help guide optimal empiric treatment of outpatient UTIs.
266                                   Successful empiric treatment of patients with the hypereosinophilic
267 nerally is the recommendation as the initial empiric treatment of suspected bacterial endophthalmitis
268 to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all ca
269 prophylaxis regimens, programs should devise empiric treatment regimens that are directed against the
270 s (LBCLs) with inferior responses to current empiric treatment regimens.
271                                              Empiric treatment should be considered for ELBW infants
272 erratically and, instead, clinicians rely on empiric treatment strategies and ignore public health im
273 h to determine the appropriate threshold for empiric treatment when PE is suspected before diagnostic
274                  We were unable to show that empiric treatment with OAD was associated with a worse o
275 patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed
276                                    Continued empiric treatment without POC testing was projected to r
277 tential clinical and public health impact on empiric treatment, contact investigation, and housing in
278 duce the frequency and impact of unnecessary empiric treatment, contact investigation, and housing, p
279                          Even with prompt or empiric treatment, mortality and neurodevelopmental impa
280 ame-day diagnoses, and-because of widespread empiric treatment-may not result in more patients starti
281 of guideline adherence on appropriateness of empiric treatment.
282 e often lacking, leading to the necessity of empiric treatment.
283  effectiveness of assay-guided treatment and empiric treatment.
284 signed patients to assay-guided treatment or empiric treatment.
285 ancomycin for definitive therapy but not for empiric treatment.
286                                          The EMPIRIC trial had a significant reduction of patients wi
287 used by clinicians to tailor therapy, but an empiric trial of a proton pump inhibitor may be an alter
288 eflux disease (GERD) commonly starts with an empiric trial of proton pump inhibitor (PPI) therapy and
289                                              Empiric trial using proton pump inhibitors is still the
290 need to be taken into account when designing empiric trials to determine appropriate blood pressure t
291                                              Empiric triple treatments for Helicobacter pylori (H. py
292 ntibody-mediated rejection (biopsy proven or empiric), two patients (12%) lost their graft by 1 year.
293  elusive, current therapeutic strategies are empiric, unfocused and often unsatisfactory.
294 streptococci (VGS) is a major factor driving empiric use of an anti-gram-positive antimicrobial in pa
295                                              Empiric use of antibiotics not specific for B. pseudomal
296 ion of an intensivist-led model of care, the empiric use of meropenem, and adjunctive treatment with
297  cultures in our series, suggesting that the empiric use of vancomycin in the setting of severe suspe
298 e drugs should undergo clinical trial before empiric use.
299 r vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates dendritic cel
300 re starting thiopurine therapy compared with empiric weight-based dosing and explores the performance

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