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1 ied, rendering embolic protection approaches empiric.
2 and June, 2010, we did a randomised trial of empiric 14-day triple, 5-day concomitant, and 10-day seq
3 : 2 methods using only clinical information (empiric 5 mg/day dosing and a formal clinical algorithm)
10 signed (1:1) eligible participants to either empiric albendazole every 3 months plus praziquantel ann
12 we compared beta-lactams with vancomycin for empiric and definitive therapy of MSSA bloodstream infec
14 n this population, treatment remains largely empiric and focused on optimizing myocardial performance
16 correct diagnosis and to choose appropriate empiric and specific agents and maximize the likelihood
22 promising method of guiding rational use of empiric anti-VRE antimicrobial therapy in patients with
23 This study sought to examine the efficacy of empiric antiarrhythmic drugs in a rigorously characteriz
29 llow, and </= one single intravenous dose of empiric antibiotic therapy before study drug treatment i
31 cultures are often considered when choosing empiric antibiotic therapy for a suspected urinary tract
32 ons, should be understood both when choosing empiric antibiotic therapy for infectious keratitis and
33 study is to determine the rate of prolonged empiric antibiotic therapy in adult ICUs in the United S
34 amine the relationship between the prolonged empiric antibiotic therapy rate and certain ICU characte
35 of factors associated with the ICU prolonged empiric antibiotic therapy rate was conducted using Stud
38 iated pneumonia had lower rates of prolonged empiric antibiotic therapy than those that did not, 45.1
40 ed peritonitis treatment guidelines in which empiric antibiotic therapy was stratified by disease sev
41 ial treatment failure, but not inappropriate empiric antibiotic therapy, was a mortality risk factor
45 or threshold values result in evaluation and empiric antibiotic treatment of large numbers of uninfec
48 .0 degrees C 72 to 96 hours after receipt of empiric antibiotics (NBL group: 22.7% vs BL group: 13.9%
49 termined as the ratio of the total number of empiric antibiotics continued for at least 72 hours divi
50 for particulate aspiration, consideration of empiric antibiotics for pneumonia treatment, and lower r
59 ed empiric antibiotic therapy was defined as empiric antibiotics that continued for at least 72 hours
62 lance the need for administering appropriate empiric antibiotics while also minimizing the use of cli
63 ng management (modification and cessation of empiric antibiotics), and empiric antifungal treatment (
71 ctions (9 vs 17; P = .09), and less frequent empiric antifungal therapy (24.1% vs 30.2%, P = .11) wit
72 ntext of intensive monitoring and structured empiric antifungal therapy, 6-month FFS and overall surv
74 n and cessation of empiric antibiotics), and empiric antifungal treatment (risk stratification, evalu
75 for diagnosis, laboratory investigation, and empiric antimicrobial and adjunctive therapy were develo
77 recent antibiotic exposure when formulating empiric antimicrobial regimens for suspected Gram-negati
79 orm clinicians regarding the best choice for empiric antimicrobial therapy against this multidrug-res
80 the relationship between aspects of initial empiric antimicrobial therapy and mortality in patients
81 e process of selection and implementation of empiric antimicrobial therapy in this high-risk group sh
82 nappropriate and delayed appropriate initial empiric antimicrobial therapy is associated with increas
83 Practices for antimicrobial prophylaxis and empiric antimicrobial therapy should be regularly assess
87 analyses suggest that improved targeting of empiric antimicrobials for multidrug-resistant bacteria,
91 on holds the promise of rational rather than empiric approaches for the treatment of cancer patients.
92 irst all-cause shock was non-inferior in the EMPIRIC arm (hazard ratio = 0.95, 90% confidence interva
96 Compared with the "Do Nothing" strategy, the empiric beta-blocker strategy cost an incremental $12,40
100 EBL (sEGD-->EBL) if varices are present, (5) empiric beta-blocker therapy in all patients, and (6) no
104 patients receiving empiric PTZ compared with empiric carbapenem therapy (95% confidence interval, 1.0
106 sease where systemic therapy has relied upon empiric chemotherapy despite the presence of genomic alt
108 opulation at high risk for relapse following empiric chemotherapy, although such models do not accoun
109 erapy sensitivity and resistance assays with empiric chemotherapy, emphasizing survival outcomes.
112 res associated with unfavorable responses to empiric combination chemotherapy, and defining robust su
113 ge drug development and mitigate against the empiric combination of such drugs outside of a clinical
114 of 689 primary prevention patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Pro
115 against the use of stimulant medications or empiric continuous positive airway pressure to reduce dr
116 ildren with NS are typically treated with an empiric course of glucocorticoid (Gc) therapy; a class o
126 yperendemic communities, but there are scant empiric data on the number of rounds of treatment that a
127 pecially the phonological theory, and review empiric data suggesting genetic and neurobiological infl
128 timal because these definitions are based on empiric description of occurrences that are merely assoc
129 ces and the (18)F-FDG sources allowed for an empiric determination of the relative response for these
130 Our findings do not suggest an effect of empiric deworming in the delaying of HIV disease progres
132 tification of a majority of responders to an empiric diet with few food triggers, avoiding unnecessar
133 nalysis of five cancer genomes and performed empiric distribution fitting to examine the true distrib
136 by 59% and 50%, respectively, supporting the empiric dose reductions in the PSC-MEC arm designed in a
137 algorithm (52%) than with all other methods: empiric dosing (37%; odds ratio [OR]: 2.2), clinical alg
139 e with dosimetry, we have observed that this empiric dosing strategy often results in administered RA
140 c tables predicted warfarin dose better than empiric dosing, formal pharmacogenetic algorithms were t
141 rgy testing-directed elimination diet and an empiric elimination diet based on common food allergens.
142 and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic
145 emoval of foods identified on SPTs/APTs plus empiric elimination of milk leads to resolution in 77% o
148 ed by class I vs the human proteome provides empiric evidence that the range of proteins sampled by c
150 second-stage spatial filters can account for empiric findings of linear relations between perimetric
153 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,
154 -differentiated TC treated with (131)I by an empiric fixed activity of 3.7 GBq at Gustave Roussy (GR,
156 provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid
157 provided no OS advantage when compared with empiric fixed RAI activity in the management of thyroid
158 lso made conditional recommendations against empiric food avoidance, upper gastrointestinal radiograp
159 sizes on system resolution and extended the empiric formula for reconstructed image resolution of co
162 nditions, testing for CS instead of starting empiric IBS therapy cost an incremental $11,000 to achie
164 ents with SLE have been managed largely with empiric immunosuppressive therapies, which are associate
165 epidemiologic shift has implications for the empiric management of community-associated infection whe
166 ty percent of the data was used to derive an empiric measure of severity of each of the 1322 injuries
168 ng endoscopy is cost-effective compared with empiric medical management in patients with compensated
169 o extract how biomolecules interact.The text empirics method that was investigated, though arising fr
170 egion was examined, as estimated by using an empiric model and baseline occupation and leisure activi
172 n the basis of these individual doses and on empiric models of radiation-induced cell death (i.e., re
173 c to Physician-Tailored Programming of ICDs [EMPIRIC], Multicenter Automatic Defibrillator Implantati
174 is and effective management of tuberculosis, empiric multidrug treatment is initiated in almost all s
175 ents were randomly assigned to standardized (EMPIRIC, n = 445) or physician-tailored (TAILORED, n = 4
177 ains equally as interesting is the idea that empiric observations of novel targeted drugs in select s
180 dds (LOD) score of 2.50 (nominal P = 0.0003; empiric P = 0.0004) and on chromosome 14 (14q22) with an
181 also found of linkage to refraction on 7q36 (empiric P = 2.32 x 10(-3)), a region previously linked t
182 to 22q11 of adjusted refraction and myopia (empiric P = 4.43 x 10(-3) and 1.48 x 10(-3), respectivel
183 d for hyperopia on chromosome 3, region q26 (empiric P = 5.34 x 10(-4)), a region that had shown sign
185 S 3.30; empiric P=.024) and 17p11 (MLS 3.63; empiric P=.015), as well as suggestive evidence on 5p13
186 icant evidence of linkage on 6q12 (MLS 3.30; empiric P=.024) and 17p11 (MLS 3.63; empiric P=.015), as
188 7300539; P(nominal) [P(n)] = 2.6 x 10(-8); P(empiric) [P(e)] = 0.0005 and rs822387; P(n) = 3.8 x 10(-
191 ance, did not significantly reduce excessive empiric prescription of MRSA-active antibiotics despite
192 abnormal test locations with total deviation empiric probability plots in glaucoma patients, we compa
193 was 1.92 times higher for patients receiving empiric PTZ compared with empiric carbapenem therapy (95
196 ical evaluations included (a) calculation of empiric receiver operating characteristic curves to dete
198 hilia in a similar proportion of patients as empiric removal of foods but required that fewer foods b
200 at appropriateness is a logical extension of empiric research, which has revealed substantial variati
201 over the past one half century largely from empiric science and consensus opinions and recommendatio
202 on is required if we hope to transition from empiric selection of therapeutics to risk-based, biology
203 ult eosinophilic oesophagitis (EoE), whereas empiric six-food elimination diet (SFED) achieves an eff
204 utively demonstrated to trigger EoE after an empiric six-food elimination diet-based study protocol a
208 y-adjusted life expectancy (4 days) than did empiric surgery at a lower lifetime cost ($3466), domina
209 use of insufficient powering, differences in empiric TB treatment rates, and disease severity between
210 accuracy of standard algorithms for initial empiric TB treatment, contact investigation, and housing
214 compared with that in patients who received empiric therapy (hazard ratio [HR] 3.24, p=0.0051 [95% C
216 d extragenital contact after sexual assault; empiric therapy for gonorrhea, chlamydia, and trichomoni
217 t or 10-day sequential four-drug regimens as empiric therapy for H pylori infection in diverse Latin
219 bials can no longer be relied on as the sole empiric therapy for severely ill outpatients whose infec
220 ed 14-day mortality of PTZ vs carbapenems as empiric therapy in a cohort of patients with ESBL bacter
224 within DLBCL will likely improve the current empiric therapy of DLBCL by identifying rational therape
225 coverage and, as such, may be considered for empiric therapy of endophthalmitis caused by yeast or mo
231 assumed by the guidelines nor the choice of empiric therapy was predictive of either the early treat
233 ermine the cost-effectiveness of appropriate empiric therapy with broad-spectrum agents active agains
234 ion in whom blood cultures were obtained and empiric therapy with broad-spectrum beta-lactams and/or
236 patients with BSI due to ESBL-E who received empiric therapy with such drugs (other active drugs [OAD
239 ion allows more options to be considered for empiric therapy, at least for some patients, depending o
242 in if penicillin allergic) is recommended as empiric therapy, unless fluoroquinolone prophylaxis was
243 ithm, with only 53% receiving broad-spectrum empiric therapy, yet 92.9% received appropriate therapy
248 lusion criteria; 4 randomized (Comparison of Empiric to Physician-Tailored Programming of ICDs [EMPIR
249 ion patients from the EMPIRIC (Comparison of Empiric to Physician-Tailored Programming of Implantable
250 ive microbiology resulted in less changes of empiric treatment (33 [40%] vs 112 [60%]; p=0.005) and s
251 s among all isolates with the following: (1) empiric treatment (B and C), and treatment guided by POC
252 nosed with a stepwise approach incorporating empiric treatment and antisecretory therapy, combined MI
253 instructed versus induced patients initiated empiric treatment based on clinical and radiography find
254 se) to guide treatment changes compared with empiric treatment changes, and the benefits and risks of
258 Therapeutic plasma exchange is an effective empiric treatment for thrombotic thrombocytopenic purpur
259 idime-avibactam was highly effective for the empiric treatment of cUTI (including acute pyelonephriti
261 e to beta-lactam agents commonly used in the empiric treatment of febrile neutropenia was observed on
263 lness with no laboratory-confirmed etiology, empiric treatment of iNTS disease is a major challenge i
267 nerally is the recommendation as the initial empiric treatment of suspected bacterial endophthalmitis
268 to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all ca
269 prophylaxis regimens, programs should devise empiric treatment regimens that are directed against the
272 erratically and, instead, clinicians rely on empiric treatment strategies and ignore public health im
273 h to determine the appropriate threshold for empiric treatment when PE is suspected before diagnostic
275 patients with BSI due to ESBL-E who received empiric treatment with OADs or carbapenems was performed
277 tential clinical and public health impact on empiric treatment, contact investigation, and housing in
278 duce the frequency and impact of unnecessary empiric treatment, contact investigation, and housing, p
280 ame-day diagnoses, and-because of widespread empiric treatment-may not result in more patients starti
287 used by clinicians to tailor therapy, but an empiric trial of a proton pump inhibitor may be an alter
288 eflux disease (GERD) commonly starts with an empiric trial of proton pump inhibitor (PPI) therapy and
290 need to be taken into account when designing empiric trials to determine appropriate blood pressure t
292 ntibody-mediated rejection (biopsy proven or empiric), two patients (12%) lost their graft by 1 year.
294 streptococci (VGS) is a major factor driving empiric use of an anti-gram-positive antimicrobial in pa
296 ion of an intensivist-led model of care, the empiric use of meropenem, and adjunctive treatment with
297 cultures in our series, suggesting that the empiric use of vancomycin in the setting of severe suspe
299 r vaccine YF-17D, one of the most successful empiric vaccines ever developed, activates dendritic cel
300 re starting thiopurine therapy compared with empiric weight-based dosing and explores the performance
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