ライフサイエンスコーパス: enamel matrix

1 s the major protein component of the forming enamel matrix.

2 ntrolled changes to the pH of the developing enamel matrix.

3 sported from ameloblasts into the developing enamel matrix.

4 ses) and to the newly secreted extracellular enamel matrix.

5 se in EMSP1 activity in the transition-stage enamel matrix.

6 proteins constituting most of the developing enamel matrix.

7 est amounts of ameloblastin were detected in enamel matrix.

8 hanges in the constituents of the developing enamel matrix.

9 this is also when MMP20 is secreted into the enamel matrix.

10 y disrupting normal protein removal from the enamel matrix.

11 ndary revealed the "fish net" pattern of the enamel matrix.

12 results in acidification of the mineralizing enamel matrix.

13 ay serve several functional roles within the enamel matrix.

14 nsists of the amelogenin fraction of porcine enamel matrix (AMEL) suspended in a vehicle of propylene

15 lasts and activated promoter activity of the enamel matrix ameloblastin gene.

16 the proteinase from porcine transition-stage enamel matrix and characterized it by partial protein se

17 ss amelogenin properly, possesses an altered enamel matrix and rod pattern, has hypoplastic enamel th

18 le proteinases are present in the developing enamel matrix, and the precise role of enamelysin in the

19 transcripts containing exon4 (AMG+4) in the enamel matrix, and the relative binding of recombinant A

20 The components of the developing enamel matrix are generally specific for that matrix.

21 ese findings constrain the emerging model of enamel matrix assembly by helping to define the limits o

22 d that AMG+4 proteins were secreted into the enamel matrix at the early maturation stage.

23 racterised by near-normal volumes of organic enamel matrix but with weak, creamy-brown opaque enamel

24 aturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel form

25 ion results in a release of protons into the enamel matrix, causing an acidification of the local mic

26 ally substitute for C/EBPalpha to produce an enamel matrix competent to direct biomineralization.

27 This may suggest that either another enamel matrix component in EMD may be responsible for so

28 t requires a combined interaction with other enamel matrix components of EMD to direct the regenerati

29 ible for the transportation and secretion of enamel matrix components, and proteases processing ename

30 x serine proteinase 1, an enzyme involved in enamel matrix degradation and with a putative role in th

31 d bone allograft (DFDBA) in combination with enamel matrix derivative (EMD + DFDBA) compared to ename

32 matrix derivative (EMD + DFDBA) compared to enamel matrix derivative (EMD) alone in the treatment of

33 Enamel matrix derivative (EMD) and autologous fibrinogen

34 Enamel matrix derivative (EMD) and collagen membranes (C

35 The use of various combinations of enamel matrix derivative (EMD) and grafting materials ha

36 periodontal surgery using the combination of enamel matrix derivative (EMD) and natural bone mineral

37 Enamel matrix derivative (EMD) and recombinant human pla

38 The mechanisms of action of enamel matrix derivative (EMD) are poorly understood, an

39 In this study, we compare the effects of enamel matrix derivative (EMD) associated with a hydroxy

40 this study, we compare the effectiveness of enamel matrix derivative (EMD) associated with a simplif

41 sidering xenogeneic collagen matrix (CM) and enamel matrix derivative (EMD) characteristics, it is su

42 s study was to evaluate the effectiveness of enamel matrix derivative (EMD) combined with a bovine-de

43 ctice reports on the clinical efficacy of an enamel matrix derivative (EMD) combined with either demi

44 Enamel matrix derivative (EMD) contains a variety of hyd

45 The enamel matrix derivative (EMD) contains hundreds of pept

46 Porcine enamel matrix derivative (EMD) has a clinical use in fac

47 Enamel matrix derivative (EMD) has an extensive document

48 Enamel matrix derivative (EMD) has been developed as a s

49 The enamel matrix derivative (EMD) has been recently introdu

50 The use of an enamel matrix derivative (EMD) has been shown to enhance

51 Enamel matrix derivative (EMD) has been shown to promote

52 Enamel matrix derivative (EMD) has been shown to promote

53 The clinical use of an enamel matrix derivative (EMD) has been shown to promote

54 In periodontal therapy enamel matrix derivative (EMD) has been successfully use

55 Recently, enamel matrix derivative (EMD) has been the subject of s

56 Enamel matrix derivative (EMD) has been used in periodon

57 Although enamel matrix derivative (EMD) has been used to promote

58 Although enamel matrix derivative (EMD) has demonstrated the abil

59 Previous studies have demonstrated that enamel matrix derivative (EMD) has the ability to improv

60 Previous studies have demonstrated that enamel matrix derivative (EMD) has the ability to improv

61 ized freeze-dried bone allograft (DFDBA) and enamel matrix derivative (EMD) have been used with varyi

62 ith a xenogenous collagen matrix (CM) and/or enamel matrix derivative (EMD) in combination with a cor

63 Acellular dermal matrix graft (ADMG) or enamel matrix derivative (EMD) in conjunction with a cor

64 Enamel matrix derivative (EMD) is a composite of protein

65 Enamel matrix derivative (EMD) is commonly used in perio

66 Enamel matrix derivative (EMD) is suggested to stimulate

67 Enamel matrix derivative (EMD) is used during periodonta

68 this study was to determine the effect of an enamel matrix derivative (EMD) on cementoblast behavior

69 of this study is to determine the impact of enamel matrix derivative (EMD) on superoxide (O(2)(-)) g

70 ellular dermal matrix (ADM) with and without enamel matrix derivative (EMD) on the percentage of root

71 have been demonstrated with the addition of enamel matrix derivative (EMD) to demineralized freeze-d

72 Porcine fetal enamel matrix derivative (EMD) was implanted bilaterally

73 After surgical debridement, enamel matrix derivative (EMD) was placed into the bony

74 Enamel matrix derivative (EMD) was shown to enhance soft

75 neutral ethylene diamine tetracetic acid and enamel matrix derivative (EMD) were first used to treat

76 Use of enamel matrix derivative (EMD) when dealing with non-con

77 milarly, in guided tissue regeneration (GTR)/enamel matrix derivative (EMD) with and without laser tr

78 inical studies suggest that a combination of enamel matrix derivative (EMD) with demineralized freeze

79 have also demonstrated the efficacy of using enamel matrix derivative (EMD) with demineralized freeze

80 of periodontal regeneration treatments with enamel matrix derivative (EMD), a commercial formulation

81 ontaining different concentrations of either enamel matrix derivative (EMD), amelogenin, platelet-der

82 m of this study is to evaluate the effect of enamel matrix derivative (EMD), tyrosine-rich amelogenin

83 onally advanced flaps (CAF) with and without enamel matrix derivative (EMD).

84 ward regeneration in infrabony defects using enamel matrix derivative (EMD).

85 e graft and the coronally advanced flap with enamel matrix derivative (EMD).

86 es of osteogenic maturation to porcine fetal enamel matrix derivative (EMD).

87 resolution in intrabony defects treated with enamel matrix derivative (EMD).

88 good outcomes have also been obtained using enamel matrix derivative (EMD).

89 logenin fraction of porcine enamel matrix in enamel matrix derivative (i.e., AMEL) is not antibacteri

90 enic (bone morphogenetic protein [BMP]-2 and enamel matrix derivative [EMD]) were compared to a contr

91 In summary, the combination of enamel matrix derivative and autogenous bone represents

92 1) Biologics (enamel matrix derivative and recombinant human platelet-

93 xenograft used alone and in combination with enamel matrix derivative are effective for the treatment

94 h >/= 4 mm) was treated regeneratively using enamel matrix derivative at two centers (Frankfurt am Ma

95 from the same surgical site was treated with enamel matrix derivative in a dampen dish and then added

96 n enhancement of hard tissue parameters when enamel matrix derivative is added to demineralized freez

97 ort the concept that clinical application of enamel matrix derivative may enhance periodontal wound r

98 tudy was to compare the clinical efficacy of enamel matrix derivative placed under a coronally advanc

99 The combination of enamel matrix derivative plus autogenous bone graft stim

100 ve tissue grafts (SCTGs), matrix grafts, and enamel matrix derivative protein (EMD) procedures were s

101 A recent study suggests that the addition of enamel matrix derivative to demineralized freeze-dried b

102 he results of this study, the application of enamel matrix derivative to denuded root surfaces receiv

103 of a commercially prepared embryonic porcine enamel matrix derivative to induce new bone formation in

104 Enamel matrix derivative was reconstituted and applied t

105 ized freeze-dried bone allograft (DFDBA), or enamel matrix derivative with or without DFDBA.

106 se histologic sections strongly suggest that enamel matrix derivative works in a biomimetic fashion b

107 h a bone replacement graft [combination], or enamel matrix derivative), according to predefined crite

108 utilizing collagen membrane, with or without enamel matrix derivative, can be successfully used in ob

109 ed flap plus acellular dermal matrix grafts, enamel matrix derivative, or collagen matrix led to the

110 and were not directly related to the use of enamel matrix derivative.

111 Enamel matrix derivatives (EMDs) have been used in perio

112 Enamel matrix derivatives (EMDs) have demonstrated proof

113 ins, known to be present in some mixtures of enamel matrix derivatives.

114 cle cells and to determine the effects of an enamel matrix-derived protein (EMD) on these cells.

115 n the pH range that occurs in the developing enamel matrix during amelogenesis.

116 f ameloblastin in the ameloblasts and in the enamel matrix during different postnatal (PN) days (days

117 (37, 55, and 66 kDa) in both ameloblasts and enamel matrix during PN development.

118 enting unwanted mineral formation within the enamel matrix during the secretory stage of amelogenesis

119 in parallel to their role in the developing enamel matrix, ERPs have retained an evolutionary conser

120 ecific gene product that may be important in enamel matrix formation and mineralization.

121 Mutations in genes critical to enamel matrix formation have been documented, but curren

122 ovide novel strategies for the regulation of enamel matrix formation.

123 ger isoforms (55 and 66 kDa) appeared in the enamel matrix from day 3 onward.

124 8.9 +/- 11.5); and the 10 sites treated with enamel matrix gained on average 5.9 +/- 1.5 mm of CAL (C

125 asts secrete amelogenins on the pre-existing enamel matrix glycoproteins at the dentine-enamel juncti

126 ypothesis that amelogenins may interact with enamel matrix glycoproteins is tested by hemagglutinatio

127 The amelogenin fraction of porcine enamel matrix in enamel matrix derivative (i.e., AMEL) i

128 The developing enamel matrix is a highly dynamic system mainly composed

129 ed, hypomineralized, and protein-rich if the enamel matrix is not completely removed.

130 -length amelogenin protein in the developing enamel matrix, loss of ameloblast phenotype, increased a

131 y stage and can readily be isolated from the enamel matrix of developing teeth.

132 Enamelin is the largest protein in the enamel matrix of developing teeth.

133 most abundant non-amelogenin proteins in the enamel matrix of developing teeth.

134 hesize that abnormal extracellular pH in the enamel matrix of mice with the cystic fibrosis gene knoc

135 reveal that enamelin is essential for proper enamel matrix organization and mineralization.

136 The enamel matrix pH during amelogenesis was studied in 10 n

137 The normal mouse enamel matrix pH was generally higher and modulated diff

138 determine their relationship with endogenous enamel matrix protein (amelogenin).

139 The correct spatiotemporal patterning of enamel matrix protein (EMP) expression is fundamental to

140 Enamel matrix protein derivative (EMD) and particulate a

141 eatment of intrabony defects treated with an enamel matrix protein derivative (EMD) combined with eit

142 Multiple exposures to enamel matrix protein derivative (EMD) during periodonta

143 ine bone mineral (DBBM) combined with either enamel matrix protein derivative (EMD) or collagen membr

144 Enamel matrix protein derived from embryonic porcine too

145 loblastin (AMBN) is the second most abundant enamel matrix protein expressed during amelogenesis.

146 In general, enamel matrix protein treatment resulted in greater tiss

147 mm defects, the height of new cementum with enamel matrix protein treatment was 45% greater than the

148 Recently, a cDNA clone for an enamel matrix protein, ameloblastin (AMBN), has been iso

149 Ameloblastin, an enamel matrix protein, is expressed by differentiating a

150 Amelogenin, the major extracellular enamel matrix protein, plays critical roles in controlli

151 assembly by helping to define the limits of enamel matrix protein-protein interactions that are beli

152 , new tissue height was more similar between enamel matrix protein-treated defects and control defect

153 and function of amelogenin, the predominant enamel matrix protein.

154 Ameloblasts synthesize and secrete the enamel matrix proteins (amelogenin, ameloblastin, and en

155 Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix

156 Enamel matrix proteins (EMP) have been shown to enhance

157 aluate the effectiveness of a combination of enamel matrix proteins (EMP), bovine porous bone mineral

158 -X-Y motif, the molecular mechanism by which enamel matrix proteins (EMPs) assemble into the organic

159 ntal defects can be achieved with the use of enamel matrix proteins (EMPs) or by grafting with bovine

160 Enamel matrix proteins (EMPs) play a role in enamel form

161 ate, gene expression profiles of major tooth enamel matrix proteins (EMPs), amelogenin (AMELX), ename

162 have identified evidence that the genes for enamel matrix proteins (EMPs), milk caseins, and salivar

163 The enamel matrix proteins amelogenin, ameloblastin, and ena

164 ve analysis may suggest a positive effect of enamel matrix proteins and a negative effect of DG used

165 ns constitute the major portion of secretory enamel matrix proteins and are known to be highly altern

166 various sizes treated with a combination of enamel matrix proteins and autogenous bone graft.

167 tive (EMD) contains a variety of hydrophobic enamel matrix proteins and is extracted from developing

168 Differentiated ameloblasts synthesizing enamel matrix proteins and odontoblasts expressed the ge

169 ects, one using extracellular matrix such as enamel matrix proteins and the other using growth factor

170 i.e., self-assembly, associations with other enamel matrix proteins and with calcium phosphate biomin

171 Embryonic enamel matrix proteins are hypothesized to be involved i

172 Embryonic enamel matrix proteins are involved in the formation of

173 h enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone

174 Matrix metalloproteinase 20 cleaves enamel matrix proteins during the secretory stage, and K

175 To date, three distinct classes of enamel matrix proteins have been cloned.

176 t data that support cooperative functions of enamel matrix proteins in mediating the structural hiera

177 Several studies have examined the role of enamel matrix proteins in root formation and periodontal

178 arding the potential role of the assembly of enamel matrix proteins in the regulation of crystal grow

179 activity and promotes the phosphorylation of enamel matrix proteins in vitro and in cells.

180 Studies suggest that enamel matrix proteins induce differentiation and minera

181 work is needed to further incorporate other enamel matrix proteins into the system, this study bring

182 Although delayed removal of the enamel matrix proteins may play a role in the hypominera

183 d this technique to determine the effects of enamel matrix proteins on the gene activities of periodo

184 fect of DG used alone or in combination with enamel matrix proteins on the regeneration of Class III

185 nt of various sized periodontal defects with enamel matrix proteins stimulated substantial periodonta

186 to investigate the adsorption properties of enamel matrix proteins to bone grafts after surface coat

187 into immature enamel and removal of cleaved enamel matrix proteins via endocytosis.

188 Although the expression of multiple enamel matrix proteins was down-regulated in the mutant

189 the surface of bone grafting materials when enamel matrix proteins were delivered in either a liquid

190 neutral ethylene diamine tetracetic acid and enamel matrix proteins were used to treat the defects.

191 Amelogenins are a group of extracellular enamel matrix proteins which are believed to be involved

192 Amelogenin and ameloblastin, the major enamel matrix proteins, are important for enamel mineral

193 eviously reported that genes for three major enamel matrix proteins, five proteins necessary for dent

194 est that in addition to its role of cleaving enamel matrix proteins, MMP20 also cleaves junctional co

195 ta (AI) can be caused by the deficiencies of enamel matrix proteins, molecules responsible for the tr

196 matrix components, and proteases processing enamel matrix proteins.

197 rabony defects of various sizes treated with enamel matrix proteins.

198 Amelogenins bind to GlcNAc of the dentine-enamel matrix proteins.

199 enamel, as well as the expression pattern of enamel matrix proteins.

200 ole for cathepsin K in degrading re-absorbed enamel matrix proteins.

201 dues in the Ser-x-Glu/pSer motifs in several enamel matrix proteins.

202 One hypothesis is that enamel matrix proteins/peptides secreted by ameloblasts

203 miR-exon4, with no changes in expression of enamel matrix-related genes.

204 re-secretory ameloblasts to the beginning of enamel matrix secretion.

205 Enamel matrix serine proteinase 1 (EMSP1) is a proteolyt

206 ine proteases, has been variously designated enamel matrix serine proteinase 1 (EMSP1), prostase, KLK

207 We designate this protein enamel matrix serine proteinase 1 or EMSP1.

208 igen (PSA) and 78% identity with the porcine enamel matrix serine proteinase 1, an enzyme involved in

209 omineralized, the protein composition of the enamel matrix was unaltered.

210 ion of proteins secreted into the developing enamel matrix, we have constructed a porcine enamel orga

211 the most superficial layer of the developing enamel matrix, while other enamelin cleavage products ar