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1 trix proteins (amelogenin, ameloblastin, and enamelin).
2 ecies show evidence of positive selection on enamelin.
3 re correlated with the adaptive evolution of enamelin.
4 monstrated ameloblast-specific expression of enamelin.
5 es that encode ameloblastin, amelogenin, and enamelin.
6 on of mRNA encoding a fourth enamel protein: enamelin.
7 bservations strongly suggest that the 32-kDa enamelin and amelogenins cooperate to promote nucleation
8                                       Intact enamelin and proteolytic cleavage products containing it
9 emonstrate ameloblast-specific expression of enamelin and reveal that enamelin is essential for prope
10 tations to the secreted proteins amelogenin, enamelin, and enamelysin result in visibly, structurally
11 atrix proteins amelogenin, ameloblastin, and enamelin are also expressed during this same approximate
12 rter assays revealed increased expression of enamelin but decreased expression of kallikrein 4 (prote
13 e density was not affected in the absence of enamelin, but its volume was, which is likely a conseque
14 rified antipeptide antibody specific for the enamelin carboxyl terminus demonstrate that enamelin is
15 cloned and characterized a full-length human enamelin cDNA and determined by radiation hybrid mapping
16                          The longest porcine enamelin cDNA clone has 3907 nucleotides, exclusive of t
17     Polymerase chain-reaction phenotyping of enamelin cDNA suggests that porcine enamelin transcripts
18 hosphorylated serine (p.S216L) in the 32-kDa enamelin cleavage product.
19 of the developing enamel matrix, while other enamelin cleavage products are observed in deeper enamel
20 on/exon junctions within the mouse and human enamelin coding regions are between codons, so there are
21                  Patterns of polymorphism in enamelin correspond with population-level differences in
22 e a knock-in mouse carrying a null allele of enamelin (Enam) that has a lacZ reporter gene replacing
23  matrix proteins (EMPs), amelogenin (AMELX), enamelin (ENAM), ameloblastin (AMBN), amelotin (AMTN), t
24 ction on enamel thickness may drive adaptive enamelin evolution in human populations.
25       Our work shows that bursts of adaptive enamelin evolution occur on primate lineages with inferr
26                    The restricted pattern of enamelin expression makes the human enamelin gene a prim
27 ucine, suggesting that the allele may affect enamelin function.
28                               Defects in the enamelin gene (ENAM) cause amelogenesis imperfecta (AI).
29                            To date, 4 unique enamelin gene (ENAM) defects have been identified in kin
30 ttern of enamelin expression makes the human enamelin gene a prime candidate in the etiology of amelo
31  To gain information on the structure of the enamelin gene and to facilitate the future assessment of
32 l enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis impe
33           In general, mutations in the human enamelin gene cause hypoplastic enamel, often with horiz
34                                          The enamelin gene has 10 exons interrupted by 9 introns.
35 ate the search for specific mutations in the enamelin gene in kindreds suffering from amelogenesis im
36 cloned and characterized the mouse and human enamelin genes.
37 , addition of 18 and 80 micro g/mL of 32-kDa enamelin in gels containing 1.5% amelogenin accelerated
38 ilitate the future assessment of the role of enamelin in normal and diseased enamel formation, we hav
39 To improve our understanding of the roles of enamelin in normal enamel formation, and to gain informa
40                Here we report the results of enamelin in situ hybridization in a day 1 mouse developi
41           We propose that phosphorylation of enamelin is critical for its function.
42                                              Enamelin is critical for proper dental enamel formation,
43 cific expression of enamelin and reveal that enamelin is essential for proper enamel matrix organizat
44 y 1 mouse developing incisor that shows that enamelin is expressed by ameloblasts, but not by odontob
45 ing the secretory stage of enamel formation, enamelin is found among the crystallites in the rod and
46                                              Enamelin is likely to be essential for proper dental ena
47                      The gene encoding human enamelin is located on the long arm of chromosome 4, in
48                                  In the pig, enamelin is secreted as 186-kDa phosphorylated glycoprot
49  enamelin carboxyl terminus demonstrate that enamelin is synthesized and secreted by secretory-phase
50                                              Enamelin is the largest protein in the enamel matrix of
51                     Although the function of enamelin is unknown, it is thought to participate in ena
52                                              Enamelin-null (ENAM(-/-)) mice have no enamel.
53 ing AI in mice carrying a p.S55I mutation in enamelin; one of the most commonly mutated proteins unde
54                                           No enamelin protein could be detected by Western blotting i
55 evelop a deeper understanding of the role of enamelin protein during formation with regard to crystal
56 s of mutations in the ENAM gene encoding the enamelin protein, results in enamel hypoplasia.
57     The effects of amelogenin and the 32-kDa enamelin proteins on apatite nucleation were investigate
58 Ser(216) is one of two serines on the 32-kDa enamelin that is phosphorylated by Golgi casein kinase a
59          Addition of 18 micro g/mL of 32-kDa enamelin to 10% gelatin also caused inhibition of nuclea
60 yping of enamelin cDNA suggests that porcine enamelin transcripts are not alternatively spliced and u
61 he gene encoding the enamel-specific protein enamelin underlies the phenotype observed in this family
62 oblast markers amelogenin, ameloblastin, and enamelin was down-regulated, as was expression of Msx2 a
63   We present analyses of one such candidate, enamelin, whose protein product operates in tooth enamel

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