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1 state leading to the formation of the minor enantiomer.
2 nding allylic amines using the same catalyst enantiomer.
3 trate, with an observed preference for the S enantiomer.
4 hed DNA, in the absence of the other, Lambda enantiomer.
5 tartaric acid derivative to isolate a single enantiomer.
6 tural information about binding of the Delta enantiomer.
7 emic starting material into a single product enantiomer.
8 preference is shown by the host for the (R)-enantiomer.
9 AP sites with higher affinity than the Delta-enantiomer.
10 evant pathway in the production of the major enantiomer.
11 quantification of each E and Z isomer of the enantiomer.
12 erence for the experimentally observed major enantiomer.
13 ted at semipreparative level into their pure enantiomers.
14 -tetrapetalones A and C and their respective enantiomers.
15 served if the two states consist of opposite enantiomers.
16 -alanine, and L-cysteine, as well as their D-enantiomers.
17 of the active and inactive H4R state by the enantiomers.
18 nthesis also enables the preparation of both enantiomers.
19 s and pressures to separate over 60 pairs of enantiomers.
20 YP26A1 depleted 18-OH-atRA and the 4-OH-atRA enantiomers.
21 e amenable to resolution into optically pure enantiomers.
22 CdTe QDs led to chiral recognition of these enantiomers.
23 ino sugars, 18 amino acids, and 4 amino acid enantiomers.
24 inactive state of D3R in complex with these enantiomers.
25 he first to generate these targets as single enantiomers.
26 kably more potent than the corresponding (R)-enantiomers.
27 exhibited similar turnover rates as their l-enantiomers.
29 wo enantiomers were synthesized: the (1S,2R) enantiomer 15 showed higher activity than its (1R,2S) an
31 racemic mixture and ascertained that the two enantiomers (30a and 30b) are equiactive inhibitors for
34 lective microbial processes favoring the (R)-enantiomer, a pronounced enantioselectivity favoring (S)
36 as generally the derivative of the (R)-amine enantiomer across the series that was studied, indicatin
37 ifferent magnitude on left- and right-handed enantiomers, an effect that could be exploited for chira
39 tures are available, most include the Lambda enantiomer and there is very little structural informati
40 the similarity between recognition sites of enantiomers and common conformational lability, high fid
42 monomers reveal interesting base pairing of enantiomers and packing arrangements directed by the chi
44 on that occurs between photoexcited D-/L-Trp enantiomers and rGO/gamma-CD giving rise to an enantiose
46 e products are resolvable into atropisomeric enantiomers, and are the first simple diarylamines to di
48 nded' (clockwise) morphology is induced by D-enantiomers, and sequentially switching between amino-ac
51 hat differ considerably in efficacy: the (R)-enantiomers are antagonists/weak partial agonists, where
56 V subtypes establishes the non-natural toxin enantiomer as a reversible antagonist of channel functio
58 f Z-1, i.e., more strongly bound carboxylate enantiomer as well as higher enantiomer concentration ca
59 linked to preferential binding of one of the enantiomers as a result of either stronger or additional
60 actions produced 50:50 (racemic) mixtures of enantiomers, as evidenced by common abiotic laboratory s
70 ciparum 80S ribosome with the (+)-mefloquine enantiomer bound to the ribosome GTPase-associated centr
71 the first X-ray crystal structure of a Delta enantiomer bound to well-matched DNA, in the absence of
72 ligand binding site induced by the bound (S)-enantiomers, but not by the (R)-enantiomers, that are fe
73 pene could be enhanced relative to the other enantiomer by the application of a sequence of microwave
74 16b, Ki = 24.3 nM] was resolved into its two enantiomers by chiral HPLC, and the absolute configurati
75 The ability to stabilize and differentiate enantiomers by DECS opens up a vast window of opportunit
78 raphic literature and propose that the Delta enantiomer can bind with five different binding modes, o
79 han enantiopure compounds, and the mixing of enantiomers can enhance the aggregation propensity of pe
82 y technologies used to achieve separation of enantiomers, chiral selectors are designed to display di
83 rsors may have played an ancient role in the enantiomer composition of life's carbohydrate-related bi
84 und carboxylate enantiomer as well as higher enantiomer concentration caused faster relaxation to E-1
85 scale reactions revealed that the titled API enantiomers could be successfully obtained with excellen
88 From the peptides designed, RR4 and its D-enantiomer, D-RR4, emerged as the most potent analogues
91 ype II E) are possible, leading to different enantiomers depending on the imine configuration (E- or
94 urate binding sites on GABAA Rs underlie the enantiomers' different pharmacological activities in mic
95 ther, our work demonstrates highly efficient enantiomer differentiation by DNA and offers a first com
96 of side effects resulting from the undesired enantiomer (distomer) and/or its metabolites, which at t
98 depressant effects, and that the (2R,6R)-HNK enantiomer exerts behavioural, electroencephalographic,
100 e configurationally stable, but the resolved enantiomers exhibit no optical activity at the alphaD-li
104 tablished model for interpreting isotope and enantiomer fractionation patterns showed potential for a
108 d host molecules for discrimination of guest enantiomers has been largely overlooked, which is surpri
110 larial activity, was synthesized as a single enantiomer in 13 steps from simple building blocks (17 l
112 was identified, capable of producing either enantiomer in high enantioselectivity (77% (R)-2 to 92%
113 we determined that D-2HG is the predominant enantiomer in human breast tumors and show that the D-2H
115 e separation and determination of malic acid enantiomers in apple juice by open-tubular capillary ele
116 identification and precise quantification of enantiomers in chiral mixtures is crucial for enantiomer
117 t method for the determination of naringenin enantiomers in fruit juices after salting-out-assisted l
118 H4 allowed isolation of the individual thiol enantiomers in good yield ( approximately 40%) and high
119 concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of h
121 nstrate >80% enrichment level of counterpart enantiomers in solution without using chiral selectors o
122 d there are distinct differences between the enantiomers in terms of the emission behaviour when boun
123 ring between the inherently chiral AuNPs and enantiomers in the first filter holder, which results in
124 ents implicate a shared binding side for the enantiomers in the inner pore cavity of NaV These findin
125 e was demonstrated by the analysis of ATNL's enantiomers in the range of 1.88 x 10(-7)-1.88 x 10(-5)
127 a free energy penalty per "incorrect" amine enantiomer incorporated, and a free energy of coupling b
132 in the transition state leading to the minor enantiomer is only possible at the expense of reactant d
133 , the colorimetric discrimination of alanine enantiomers is examined and, more importantly, AuNPs-emb
134 fferent combinations of ligand and substrate enantiomers, it is now possible to access all four stere
136 strategy to interface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality
138 two different states (A and B) from the same enantiomer, leading to a conversion of the kinetically t
139 antiopure compounds, we determined that both enantiomers make equivalent pseudosymmetric interactions
142 mechanism for how biomineralization-related enantiomers might exert hierarchical control to form ext
143 is of both (-)-mitragynine and its unnatural enantiomer, (+)-mitragynine, employing a proline-catalyz
144 of TETROL and the carbonyl group of the (R)-enantiomer (O...O 2.621(2) A) compared with a significan
149 rams of drug discovery generally exploit one enantiomer of a chiral compound for lead development fol
150 Specifically, the population of a specific enantiomer of a chiral terpene could be enhanced relativ
151 has been prepared on a multigram scale, the enantiomer of a selective oestrogen has been synthesized
152 ereoselective transformations to afford each enantiomer of a set of P-stereogenic compounds such as s
153 y sets of conditions enable access to either enantiomer of allylboronate product from a single enanti
154 n of alpha-magnesiated benzoates with either enantiomer of Andersen's readily available menthol-deriv
157 preparation of the 10-epi derivative and the enantiomer of depudecin, which represent interesting ste
161 orted d-allo-ShK was in fact d-ShK, the true enantiomer of natural l-ShK toxin, and that the apparent
162 noroxomaritidine to normaritidine, with the enantiomer of noroxomaritidine dictating whether the der
163 The enzyme was shown to hydrolyze the RP-enantiomer of O-methyl O-cyclohexyl p-nitrophenyl thioph
164 itoes displaying selectivity towards the (R)-enantiomer of octenol and susceptibility to the insect r
165 iomer of allylboronate product from a single enantiomer of readily prepared allylic pivalate substrat
166 and one stepwise, for the production of each enantiomer of the desymmetrized product using the comple
169 folds, and notably (-)-ent-quiannulatene, an enantiomer of the fungal metabolite (+)-quiannulatene.
170 de novo synthesis of l-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) and a preli
172 cute hippocampal slices, (+)-CIQ, the active enantiomer of the positive allosteric modulator CIQ, sig
173 absolute configuration of the major (-)-(R) enantiomer of the product is assigned computationally ac
174 e enantioselective formation of the observed enantiomer of the product with 92% ee, which matches the
175 lobin and generated mutants that form either enantiomer of the products of C-H insertion and catalyse
177 ng stoichiometric amounts of the (+)- or (-)-enantiomer of the scarcely available and expensive diami
178 study sought to determine whether the active enantiomer of the selective and full D1 receptor agonist
181 tion of the outer orbital of configurational enantiomers of 1,3- and 2,3-butanediols has been examine
187 (+) antipodes of batrachotoxin, as well both enantiomers of a C-20 benzoate-modified derivative.
189 guration inferred from CD spectra of the two enantiomers of a diborane complex has been established f
190 ative populations of two otherwise identical enantiomers of a large gas-phase molecule using resonant
194 By switching the achiral proton source, both enantiomers of a series of tertiary alpha-aryl-1-indanon
195 nantiodivergent catalyst pair delivering the enantiomers of alpha-functionalized aldehyde products in
196 kwise) spiralling morphology is induced by L-enantiomers of Asp and Glu, whereas 'left-handed' (clock
198 al framework, it is also able to resolve the enantiomers of chiral analytes, including those of limon
199 methyl group of toluene, we synthesized both enantiomers of chiral toluene with all three H isotopes
201 erotonin transporter (SERT) and the S- and R-enantiomers of citalopram on the single molecule level.
202 rement of the chiroptical properties of both enantiomers of clerobungin A, supporting the scalemic na
204 nd additional oxidation peaks common to both enantiomers of each studied beta-blocker, allowing thus
206 The separation and determination of the enantiomers of malic acid in the apple juice solution di
209 ring using new MDOs self-assembled from both enantiomers of proline and cinchona alkaloid thiourea de
211 tanedimethanol) allows the synthesis of both enantiomers of some chiral aldehydes, whose behavior in
212 This allowed for the preparation of both enantiomers of the bicyclic product with near-identical
213 ferent nucleophiles, allowing access to both enantiomers of the corresponding allylic amines using th
224 the work published on the adsorption of pure enantiomers, of enantiomeric mixtures, and of prochiral
228 ioselective degradation enriched SM in the R-enantiomer over longer periods and may be associated wit
229 ce in both biotic and abiotic samples (seven enantiomer pairs d/l-Ala, -Asp, -Glu, -His, -Leu, -Ser,
231 (PCBs) and enantiomer fractions (EFs) of PCB enantiomers (PCBs 95, 132, 135, and 149) were investigat
232 tures, and this activity is dependent on the enantiomer present, as some pyrethroids are chiral.
234 e good tumor imaging properties with the (S)-enantiomer providing higher tumor uptake and tumor to br
235 count for the identity of the observed major enantiomers, providing a rationale for the differences i
237 ith agonist activity led to the finding that enantiomers (R,R)-68 and (S,S)-68 have differential effe
239 vedilol and the non-beta-blocking carvedilol enantiomer, (R)-carvedilol, suppressed spontaneous Ca(2+
241 ead development following the principle that enantiomer recognition is central to biological specific
244 o distinct folds on a pair of (6,5) nanotube enantiomers, rendering them large differences in fluores
245 face and the targeted synthesis of a desired enantiomer requires the implantation of chiral informati
246 cific recognition at A2BAR, with the (S)-16b enantiomer retaining all the affinity (Ki = 15.1 nM), as
247 158 muM; CVX, IC50 = 11 muM) than any of its enantiomers S (6c) (collagen, IC50 = 25.3 muM; CRP-XL, I
249 with fluorescently labeled analogues of the enantiomers showed their colocalization in racemic fibri
250 nantiomers in chiral mixtures is crucial for enantiomer specific synthesis as well as chemical analys
252 were unresolvable in a mixture, whereas the enantiomers studied did not exhibit statistically differ
253 mical outcome of the cyclization of a single enantiomer substrate--regardless of its inherent prefere
254 00:1) and enantioselective (92% to 98% major enantiomer) synthesis of such compounds bearing a vinyl
256 he bound (S)-enantiomers, but not by the (R)-enantiomers, that are features of partially activated re
257 Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effective cell ki
258 iral inorganic compounds to be resolved into enantiomers, the absolute configurations of which are de
260 of different KREDs allowed either the M or P enantiomer to be synthesized in excellent enantiopurity.
262 e a sequential polymerization of the lactide enantiomers to afford stereoblock copolymers with predet
263 hat mirror-image packing can enable opposite enantiomers to be accommodated in an enzyme's active sit
264 ence quenching due to the tendency of chiral enantiomers to form complexes with gamma-CD in different
265 indicate that the potential toxicity of PCB enantiomers to newborn chicks may be different from that
268 baseline separated into their corresponding enantiomers under reversed-phase, polar organic and norm
269 -oxazolidine-2-one, was resolved into single enantiomers using a chiral auxiliary to access enantio-e
270 hetic route for preparation of proxyphylline enantiomers using a kinetic resolution (KR) procedure as
271 nsferring information between orthogonal DNA enantiomers via an achiral intermediary, opening the doo
272 llenging to obtain these compounds as single enantiomers via the established synthetic procedures due
275 reference of the CAL-B active site for the R-enantiomer was rationalized by in sillico docking studie
278 heromone of Pseudococcus longispinus and its enantiomer were prepared from the corresponding bornyl a
279 the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction ana
280 ion products (TPs, i.e., MESA and MOXA), and enantiomers were combined to determine SM degradation at
281 Hyperpolarized (13)C-labeled dl-methionine enantiomers were differently observed with a single-scan
287 tuted aryl boronic acids resulted in the (S)-enantiomer when used in combination with certain (R)-pho
288 acids) contain significant excesses of the d enantiomer, whereas other (comparable) sugar acids and s
290 exposure is dramatically increased for each enantiomer while they retain similar pharmacokinetics.
291 ral representatives were resolved into their enantiomers, whose absolute configurations were determin
292 bstituted aryl boronic acids favored the (R)-enantiomer with most of the studied catalysts, meta-alko
293 iomeric composition and discriminate between enantiomers with chiral centers several carbons away fro
294 ge, this is the first example of one pair of enantiomers with contrasting selectivity for human telom
295 erials, yielding both the (R)- and (S)-amine enantiomers with high selectivity (91-99% ee) depending
296 to the different dimensional interaction of enantiomers with hybrid material, a discrepancy occurs i
299 ermined by comparison of the distribution of enantiomers with the experimental variation distribution
300 namically isomerize, interconverting between enantiomers without cleavage of a constituent bond, nor
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