ライフサイエンスコーパス: encoded protein

1 t motif located in the central domain of the encoded protein.

2 and results in an E102D substitution in the encoded protein.

3 or cassette or the resulting activity of the encoded protein.

4 tructural features of the MG192 gene and its encoded protein.

5 uman cancers are immunoreactive for a LINE-1-encoded protein.

6 o a change to the amino acid sequence of the encoded protein.

7 of gene23 and the potential function of its encoded protein.

8 n the NDE1 gene that cause truncation of the encoded protein.

9 nd were predicted to functionally impact the encoded protein.

10 don substitutions that impair folding of the encoded protein.

11 ular structural or folding properties of the encoded protein.

12 ysis predicted that the mutation damages the encoded protein.

13 with increased expression of HIBCH mRNA and encoded protein.

14 d coordinate co-translational folding of the encoded protein.

15 n PPMS patients and loss of function for the encoded protein.

16 netics at the level of both the mRNA and the encoded protein.

17 f RNAs that correlate with properties of the encoded proteins.

18 ectly coupled to a reduced production of the encoded proteins.

19 them into an outer shell or capsid of virus-encoded proteins.

20 s the functional analysis of influenza virus-encoded proteins.

21 hout affecting the abundance of the mRNAs or encoded proteins.

22 pecific characteristics in their genomes and encoded proteins.

23 tion of methionines in the N-terminus of the encoded proteins.

24 them into an outer shell or capsid of virus-encoded proteins.

25 mutations within the binding sites of their encoded proteins.

26 uses requires efficient translation of viral-encoded proteins.

27 ch less is known about the properties of the encoded proteins.

28 demonstrated functional conservation of the encoded proteins.

29 ent side chains corresponding to genetically encoded proteins.

30 oth in mutation type and location within the encoded proteins.

31 reservation of structure and function of the encoded proteins.

32 ccurately reflect changes in levels of their encoded proteins.

33 esis and import of a large number of nuclear-encoded proteins.

34 subtilis cells independently of other phage-encoded proteins.

35 majority of lincRNAs do not function through encoded proteins.

36 eptides from vaccinia- and influenza A virus-encoded proteins.

37 n and experimental characterization of their encoded proteins.

38 s comprised of at least 33 different virally encoded proteins.

39 s in revealing new biochemical properties of encoded proteins.

40 teract with GCK, and kinetic activity of the encoded proteins.

41 processes and functional constraints on the encoded proteins.

42 process that is largely dependent on nuclear-encoded proteins.

43 consequently increases accumulation of their encoded proteins.

44 variants suggests deleterious effects to the encoded proteins.

45 d concomitant differential expression of the encoded proteins.

46 volutionary functional divergence of homolog-encoded proteins.

47 the optimal functional range of genetically encoded proteins.

48 y of chloroplast transcripts and chloroplast-encoded proteins.

49 roteins and diminished expression of plastid encoded proteins.

50 e transcripts associate independent of their encoded proteins.

51 that serve to increase or decrease levels of encoded proteins.

52 A ratios, and both nuclear and mitochondrial encoded proteins.

53 Biochemical analysis of the encoded proteins, a cobalamin (Cbl)-dependent S-adenosyl

54 nsert stability and consistency of transgene encoded protein accumulation through commercially releva

55 A large number of host-encoded proteins affect the replication of plus-stranded

56 A world, before the evolution of genetically encoded proteins, ancestral organisms contained RNA gene

57 n populations, we resurrected the originally encoded proteins and examined their functions.

58 fl, and the levels of transcripts and their encoded proteins and phosphoproteins were highly congrue

59 and reduces the steady-state levels of mtDNA-encoded proteins and respiration, apparently because of

60 eader sequences, the functional landscape of encoded proteins and the impact of light on gene express

61 in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interfer

62 n of chloroplast transcripts and chloroplast-encoded proteins, and defective processing of chloroplas

63 a membrane and mitochondria-associated Abcc9-encoded proteins, and found that the myocardium failed t

64 DIRS-1 transcripts, the expression of DIRS-1-encoded proteins, and the loss of most DIRS-1-derived se

65 duced the expression of immediate-early gene-encoded protein Arc/Arg3.1, effectors that are critical

66 ructural reactivity and the structure of the encoded protein are related.

67 identical on the nucleotide level, and their encoded proteins are 79% identical to each other.

68 Finally, we found that all RNA1-encoded proteins are cis-acting relative to RNA1.

69 genes between these gene cassettes and their encoded proteins are distinguished by %G + C and protein

70 conditional knockdowns to determine that the encoded proteins are essential and to identify their sta

71 s are not common, and in some cases, the two encoded proteins are functionally related.

72 Nuclear-encoded proteins are imported into the organelle, and th

73 plicated in inherited retinal dystrophy; the encoded proteins are involved in a broad spectrum of pat

74 nes are somatically mutated in CMM, or their encoded proteins are involved in melanomagenesis.

75 Importantly, the encoded proteins are linked to neuronal processes shared

76 Whereas the encoded proteins are most homologous to Dicistrovirus po

77 as to determine whether mitochondrial genome-encoded proteins are regulated by microRNAs inside the m

78 cted hepatoma cells to define viral and host-encoded proteins associated with mature virions.

79 ed, these analyses revealed 148 unique virus-encoded proteins associated with the virion (about 35% o

80 We show that the encoded protein associates with rRNA and plays a highly

81 The encoded proteins (AtTAD2 and AtTAD3, for tRNA-specific a

82 ecules due to the development of genetically encoded, protein-based sensors.

83 om the population, that is, the gene and its encoded protein become harmful after a mutation occurred

84 The encoded protein belonged to a huge family of glutamine a

85 s from cone-setting acrocona plants, and the encoded protein belongs to the MADS box gene family of t

86 y demonstrated to inhibit degradation of the encoded protein (beta-catenin) by E3 ubiquitin ligases.

87 onstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (also known

88 pt ATP production and translation of nuclear encoded proteins--both of which are shown to disrupt mit

89 catae in the tick versus the mammal, and the encoded protein (BTA121) is predicted to be surface loca

90 ral selection favors efficient expression of encoded proteins, but the causes, mechanisms, and fitnes

91 may influence structure and function of the encoded proteins by co-translational effects, we sought

92 ssed in platelets and neutrophils, where its encoded protein CalDAG-GEFI facilitates the activation o

93 d herpesvirus (KSHV; or human herpesvirus-8)-encoded protein called K-bZIP (also named K8) was found

94 he 'reverse' reaction requires another phage-encoded protein called the recombination directionality

95 EBV-induced gene 3 (EBI3)-encoded protein can form heterodimers with IL-27P28 and

96 previously described RIP family member, the encoded protein carries an RNA recognition motif (RRM) a

97 mapping to the extended ATPase domain of the encoded protein cause BAMS in all 14 cases studied.

98 lative increase in the synthesis of TOP mRNA-encoded proteins compared to other proteins.

99 Two of these FPI-encoded proteins constitute effectors, whereas the other

100 Fifteen FA genes are known, and the encoded proteins cooperate in a common DNA repair pathwa

101 ng these peaks are eight meiosis genes whose encoded proteins coordinate a specific subset of early m

102 To ascertain if phage encoded proteins could form the basis of a gonococcal va

103 Three mitochondrial DNA-encoded proteins, Cox1, Cox2, and Cox3, comprise the cor

104 Cowpox virus encoded protein CPXV203 blocks MHCI surface expression b

105 Expression of the mitochondrially encoded proteins Cytochrome oxidase subunit 1, Apocytoch

106 do not determine amino acid sequences of the encoded proteins, define mRNA secondary structure and st

107 5% of its phylogenetically tractable nucleus-encoded proteins deriving from green algae.

108 SpyCatcher is a genetically-encoded protein designed to spontaneously form a covalen

109 between an X-encoded RNA and an autosomally encoded protein dictates Xist induction.

110 acid (acidic amino acid) substitution in the encoded protein domain that defines GST substrate specif

111 ifferential nuclear levels of L1ORF1p, an L1-encoded protein essential for L1 ribonucleoprotein parti

112 ns are members of one of the largest nucleus-encoded protein families in plants.

113 criptional silencing of FMR1 and loss of the encoded protein, FMRP (fragile X mental retardation prot

114 The encoded proteins form multiple homo- and hetero-interact

115 we describe the application of a genetically encoded Protein-fragment Complementation Assay (PCA) bas

116 IMPORTANCE HBZ, the antisense transcript-encoded protein from HTLV-1, is now well recognized as a

117 The encoded proteins from 2-3 billion years (Gyr)-old beta-l

118 revealed that these virulence-related genes encoded proteins from almost all functional classes, whi

119 epends on the import of thousands of nucleus-encoded proteins from the cytosol.

120 insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane

121 result in a complete loss of function of the encoded protein, Galphaolf, an adenylyl-cyclase-stimulat

122 Arabidopsis (Arabidopsis thaliana) GTs whose encoded proteins glucosylate a diversity of terpenes.

123 ost RNA polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity f

124 of non-locus of enterocyte effacement (LEE)-encoded protein H, designated NleH1 and NleH2, both of w

125 t IgG allo-antibodies recognize Y chromosome-encoded proteins (H-Y) and a dominant H-Y epitope, DEAD

126 riboflavin transporters, although the rft-1 encoded protein had greater transport activity.

127 histiocytosis (LCH) and demonstrate that the encoded protein has strong gain-of-function properties.

128 The encoded protein has two conserved domains with homology

129 ree-dimensional spatial relationships in the encoded protein have yet to be systematically explored.

130 und in the genomes of higher plants, and the encoded proteins have been found localized both to the n

131 duce PrgB, even independently of other pCF10-encoded proteins, have severely compromised cell envelop

132 In this study, we found that the HTLV-1-encoded protein HBZ activates expression of BDNF, and co

133 s (RNPs) formed by these RNAs with the virus-encoded protein hepatitis delta antigen (HDAg) perform e

134 is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1

135 mitochondrial genome and additional nuclear-encoded proteins imported from the cytosol.

136 beta-lyase activity has been assigned to the encoded protein in the genome data bank, is a CCBL2 (syn

137 folding can alter the folded structure of an encoded protein in vivo, versus the structure formed whe

138 tly enhanced, suggesting a role of both host-encoded proteins in a defense response against TMV.

139 reflect the functional relationships of the encoded proteins in DNA repair.

140 can translationally regulate mitochondrially encoded proteins in spatially distinct mitochondrial sub

141 ting proper folding of a subset of F-plasmid-encoded proteins in the periplasm.

142 on were analysed and involvement of selected encoded proteins in the tick midgut physiology discussed

143 rologous viruses to express individual virus-encoded proteins in wheat.

144 d an essential role for P58, one of the RNA2-encoded proteins, in the process of RNA2 replication.

145 have uncovered new mechanisms by which virus-encoded proteins inhibit Ub and Ub-like (Ubl) modificati

146 in severe reduction in the expression of its encoded protein, inhibitor of kappaB kinase complex-asso

147 ision in vivo of CTnDOT utilizes four CTnDOT-encoded proteins, IntDOT, Xis2c, Xis2d, and Exc, and a h

148 gulated by the microRNA miR164 Moreover, the encoded proteins interacted physically with the chloropl

149 complicated process, involving five element-encoded proteins (IntN1, Orf2, Orf2x, Orf3, and PrmN1) a

150 trate that modulating the sorting of nuclear-encoded proteins into mitochondria, mediated by the TIM2

151 he main entry gate for the import of nuclear-encoded proteins into mitochondria.

152 specifically evolved to deliver bacterially encoded proteins into target eukaryotic cells.

153 the extrinsic arm from 23 additional nuclear-encoded proteins, iron-sulfur clusters, and flavin monon

154 The ORF54-encoded protein is a dUTPase; however, dUTPase activity

155 press different permuted variants of the ORF-encoded protein is created by: (i) using bacteria to sel

156 to be able to support this activity when the encoded protein is expressed in HEK293T cells.

157 The encoded protein is highly conserved in many vertebrates

158 Although the encoded protein is integral to the host membrane, its pr

159 eveloping transplant recipients and that the encoded protein is localized within mitochondria.

160 The encoded protein is responsible for phosphorylation-media

161 Divergence of the two encoded proteins is associated with a loss of similarity

162 Avoiding activation of immunity to vector-encoded proteins is critical to the safe and effective u

163 ALE isoform of which the RNA, rather than an encoded protein, is critical for the eventual recovery o

164 ided by the gene sequence independent of the encoded protein isoform.

165 We generate a novel genetically encoded protein kinase A (PKA) biosensor anchored onto t

166 Mouse gammaherpesvirus 68 (MHV68)-encoded protein kinase orf36 interacted with HDAC1 and 2

167 tion, reflecting the expression of the phage-encoded protein kinase, T7PK.

168 olved in latency, UL133-UL138, and a virally encoded protein kinase, UL97, which plays crucial roles

169 e protein kinases as well as the herpesvirus-encoded protein kinases as an anti-herpesvirus therapeut

170 thylation, can directly interact with the L1-encoded protein L1-ORF1p, stimulate its polyubiquitylati

171 eletion (amino acids 402 to 424 of the ORF1a-encoded protein) largely abolished the inhibitory effect

172 Finally, we found that the EBV-encoded protein latent membrane protein 1 (LMP1) enhance

173 The EBV-encoded protein LMP1 is essential for promoting viral tu

174 broadly expressed in neural tissue, and its encoded protein localizes to the primary cilium in an in

175 This murine cytomegalovirus (MCMV)-encoded protein, m12, restrains NK cell effector functio

176 We observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive

177 The majority of crAssphage-encoded proteins match no known sequences in the databas

178 Tmem79/Matt gene, with no expression of the encoded protein mattrin in the skin of mutant mice.

179 f iron overload, suggesting that the stm3944-encoded protein may mediate iron efflux.

180 ctural relationships between mRNAs and their encoded proteins may have evolved to allow efficient and

181 ular phylogenetic analyses that indicate the encoded proteins may represent Piccolo orthologs.

182 his trend is most likely because the nuclear-encoded proteins mediating these processes eventually le

183 ncreatic islet beta-cells that lack the MEN1-encoded protein menin develop into tumors.

184 Depletion of the nuclear-encoded protein MSH1 causes dramatic and heritable chang

185 yeast Saccharomyces cerevisiae, the nuclear-encoded proteins Mss51 and Pet309 specifically activate

186 esvirus (KSHV) open reading frame 57 (ORF57)-encoded protein (Mta) is a multifunctional regulator of

187 The NF1-encoded protein neurofibromin is a Ras GTPase-activating

188 (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of An

189 se risk by characterizing its effects on the encoded protein, NIPA.

190 the tight junction barrier while the non-LEE-encoded proteins NleH1 and NleH2 possess significant ant

191 r this distinction we designate the gene and encoded protein nonA/NonA.

192 ght reflect the fact that one or both of its encoded proteins (NS1 and NEP) are maladapted for replic

193 unction of NSP4 is balanced by another virus-encoded protein, NSP1, which is implicated in PI3K/AKT a

194 nectria hypovirus 1 was detected in the ORFA-encoded protein of L2-dsRNA/SsMBV1.

195 ed by ycf1, so it would be the first plastid-encoded protein of this apparatus; (2) ycf1 is unique to

196 tment is limited in cases where the genes or encoded proteins of co-infecting strains are functionall

197 re surrounded by only two membranes, nucleus-encoded proteins of complex plastids face additional bar

198 These replicons produce SG RNAs and encoded proteins of interest 10- to 50-fold more efficie

199 DhMRE proteins show similarities to nuclear-encoded proteins of the AMF Rhizophagus irregularis, whi

200 Defects in nuclear-encoded proteins of the mitochondrial translation machin

201 arts, although they do not express a virally encoded protein on their surface, thus distinguishing th

202 is observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, and found

203 focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT proces

204 sid that augment cellular immunity to vector-encoded proteins or those of AAV8 that may induce tolera

205 ngth L1 mRNA and the L1 open reading frame 1-encoded protein (ORF1p) were readily detected in hESCs a

206 A levels and subsequent expression of the L1-encoded proteins (ORF1p and ORF2p).

207 cone-shaped structure, composed of the HIV-1-encoded protein p24(CA), which contains the viral RNA an

208 ic mutations cause a loss of function of the encoded protein Parkin.

209 ven mRNA is unlikely to generate more of the encoded protein, particularly at low ribosome availabili

210 tin-like polypeptides (ELPs) are genetically encoded protein polymers that reversibly phase separate

211 ever, the biochemical characteristics of its encoded protein product (MtRecD) remain largely unknown.

212 MCPH1, the encoded protein product, has been implicated in various

213 ly as functional RNAs rather than through an encoded protein product.

214 f mutations relative to the structure of the encoded protein products.

215 The UL33-encoded protein (pUL33) interacts with pUL28, but its pr

216 The virus-encoded protein pUS9 promotes axonal dissemination by so

217 ble in the host cell membrane from the virus-encoded protein PVAP and open at the end of the infectio

218 Genetic evidence has suggested that pLS20-encoded protein RcoLS20 represses expression of a large

219 Mutants deficient in GlgA, a chromosome-encoded protein regulated by pGP4, also consistently col

220 ole of the hCD79b secondary promoter and its encoded protein remain unclear, the current data suggest

221 d the causative gene but the function of the encoded protein remains unknown.

222 ue-specific and subcellular locations of the encoded proteins require further investigation, our stud

223 they may be under immune selection, and the encoded proteins require investigation.

224 how that the Ltr proteins are the only phage-encoded proteins required for the activation of the pack

225 New work in aphids shows that a nuclear-encoded protein resulting from a horizontal gene transfe

226 We previously reported that the adenovirus-encoded protein RIDalpha rescues the cholesterol storage

227 ional splicing system in which a genetically encoded protein scaffold induces the splicing and activa

228 five transcripts in S. moellendorffii whose encoded proteins share homology with BBI inhibitory loop

229 The encoded proteins share ~85% amino acid sequence identity

230 Plastid-encoded proteins showed a comparable distribution of N-t

231 reflected in a significant decrement of its encoded protein SNAT2.

232 The encoded proteins, SP-A1 and SP-A2, differ quantitatively

233 suggests a loss-of-function mechanism of the encoded protein, spatacsin.

234 The encoded protein SRRM2 (also called SRm300) is part of th

235 assembly of nucleus-encoded and chloroplast-encoded protein subunits as well as the insertion of hun

236 ynthesis of all 13 mitochondrial DNA (mtDNA)-encoded protein subunits of the human oxidative phosphor

237 of conserved positions in mitochondrial DNA-encoded proteins suggest that CUU and CUA codons corresp

238 tochondria leads to defects in mitochondrial-encoded protein synthesis and abnormal mitochondrial dyn

239 decreases IRE-mRNA/IRP1 binding, increasing encoded protein synthesis.

240 We have identified a virus-encoded protein termed gp37/Dip, which directly binds an

241 the bacteriophage microcosm, involves a SaPI-encoded protein that directly and specifically interfere

242 We have identified the first host cell-encoded protein that inhibits cell fusion in mammals.

243 antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellula

244 cterial F plasmids relies on TraM, a plasmid-encoded protein that recognizes multiple DNA sites to re

245 l design and implementation of a genetically encoded protein that specifically inhibits GBA motifs: G

246 was activated in cells expressing a plasmid-encoded protein that was targeted to the twin-arginine t

247 viruses is greatly affected by numerous host-encoded proteins that act as restriction factors.

248 anterograde control by a battery of nucleus-encoded proteins that are imported in the chloroplast, w

249 showed a systematic decrease of chloroplast-encoded proteins that are part of the photosynthetic app

250 rs, such as NKG2D, which recognize host cell-encoded proteins that can only be found on diseased cell

251 is accomplished by spanins, which are phage-encoded proteins that connect the cytoplasmic membrane (

252 mitochondrial import of hundreds of nuclear-encoded proteins that control genome maintenance, replic

253 The other subset of miR-519 target mRNAs encoded proteins that control intracellular calcium leve

254 ivery and removal challenges, or genetically encoded proteins that form or bind a native photosensiti

255 aracterized four different families of phage-encoded proteins that function as activators required fo

256 Cht11, Uck2, Echs1, whd, Ccdc58, and Apop1) encoded proteins that had mitochondrial functions or cou

257 tions (2) , DNA modifications (3) , or phage-encoded proteins that interfere with the CRISPR-Cas syst

258 al for the prodigious translation of plastid-encoded proteins that is required during the installatio

259 Potato virus X (PVX) requires three virally encoded proteins, the triple gene block (TGB), for movem

260 Virally encoded proteins therefore exist to limit, inhibit or ta

261 It contains the Tn7-encoded proteins TnsB, which binds specifically to the t

262 to actively replicating DNA with the element-encoded protein TnsE.

263 unction manner and impair the ability of the encoded protein to mediate substrate ubiquitination, alt

264 : brain gene expression atlases, genetically encoded proteins to monitor and manipulate neuronal acti

265 aE') removes a single glutamic acid from the encoded protein, torsinA.

266 (DSB) repair pathway disrupt binding of the encoded proteins, transport into the nucleus and initiat

267 The Escherichia coli F element-encoded protein TraR is a distant homolog of the chromos

268 evance of UMOD for CKD is clear, because the encoded protein, uromodulin (Tamm-Horsfall protein), is

269 The soluble poxvirus-encoded protein viral CC chemokine inhibitor (vCCI), a C

270 The encoded protein was functionally characterized and is as

271 Additionally, the FTS_1680-encoded protein was identified as a membrane-associated

272 mitochondrial localization of the AT3G11470-encoded proteins was validated by the ability of their N

273 In addition, DSY3157, an adjacently encoded protein, was shown to be a methylcobalamin:tetra

274 he characterization of these genes and their encoded proteins we present a model of the subcellular o

275 ng transcript abundance and the level of the encoded protein, we integrate genome-wide experimental d

276 By analyzing the encoded proteins, we discovered concurrent amino acid ch

277 genome-wide bioinformatics analysis of ISKNV-encoded proteins, we found that ISKNV open reading frame

278 e-cell imaging of viral RNA (vRNA) and virus-encoded proteins, we show that the TGB proteins have dis

279 Expression and functional studies of the encoded protein were performed and included measurement

280 were isolated from five cultivars, and their encoded proteins were biochemically analyzed.

281 Mitochondrially encoded proteins were differentially affected, with near

282 Its major encoded proteins were distantly similar to those of T7.

283 The functions of the encoded proteins were investigated by complementation ex

284 Encoded proteins were investigated in skin biopsy specim

285 rse transcription (RT)-PCR analyses, and the encoded proteins were predicted to specify premature sto

286 In total, six novel plasmid-encoded proteins were translocated into macrophage-like

287 esulting in gain or loss of function for the encoded protein, whereas most fall in noncoding regions

288 ria, TOM and TIM complexes transport nuclear-encoded proteins, whereas the Oxa1 is required for the i

289 Importantly, we describe novel non-esx1-encoded proteins, which affect ESX-1 activity, which col

290 Two of the five encoded proteins, which we named E. histolytica ILWEQ (E

291 pesvirus late genes depends on several virus-encoded proteins whose function is not completely unders

292 confirming the reduction in abundance of the encoded protein will often aid the link between genotype

293 a-localized inhibitor of apoptosis), a virus-encoded protein with a unique, albeit poorly understood

294 ssed upon GlcNAc accumulation, many of which encoded proteins with an extracellular Domain of Unknown

295 The 12 genes controlled by NrrF encoded proteins with biological functions including ene

296 More than half encoded proteins with known enzymatic activity, and six

297 tosynthetic apparatus but not of chloroplast-encoded proteins with other functions.

298 identify two previously unannotated prophage-encoded proteins with tertiary structures similar to gpF

299 s and studied electrogenic properties of the encoded proteins with whole-cell patch-clamp recording.

300 DsRed2 and tTAV gene products (e.g. mRNA and encoded proteins) would have a negligible impact on on-t