ライフサイエンスコーパス: end joining

1 tion, which typically arise by nonhomologous end joining.

2 ion, with a repair bias toward nonhomologous end joining.

3 poor substrates for classical non-homologous end joining.

4 levels, and altered levels of non-homologous end joining.

5 to the role of ARTEMIS in nonhomologous DNA end joining.

6 ial use of microhomologous DNA sequences for end joining.

7 letions (indels) via mutagenic nonhomologous end joining.

8 icated DNA repair via microhomology-mediated end joining.

9 ns in base excision repair and nonhomologous end joining.

10 akpoints resembling repair by non-homologous end joining.

11 MSI1 reduces the frequency of nonhomologous end-joining.

12 arising from the loss of ligase 4-dependent end-joining.

13 teins that promote error-prone nonhomologous end-joining.

14 sive mechanisms, homologous recombination or end-joining.

15 ould be reversed by inhibiting nonhomologous end-joining.

16 and-break creation followed by nonhomologous end-joining.

17 via the mutagenic alternative non-homologous end joining (A-NHEJ) pathway.

18 the use of microhomology-based, alternative end-joining (A-EJ) and increased frequencies of intra-S

19 duced level) by a poorly defined alternative end-joining (A-EJ) pathway.

20 Importantly, NHEJ instead of alternative end-joining (A-EJ) was revealed as the predominant mecha

21 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which relies on PARP1 and LIG3.

22 s associated with a defect in non-homologous end joining, a major pathway for DNA double-strand break

23 n error-free mechanism, or by non-homologous end joining, a process susceptible to introducing errors

24 homologous recombination and non-homologous end-joining activities were significantly decreased in M

25 ritical role during terminal transferase and end-joining activities: it acts as a pseudo-template whe

26 Moreover, Red1 exhibited nonhomologous DNA end-joining activity, thus revealing an unexpected role

27 mologous end joining (C-NHEJ) or alternative end joining (ALT-EJ)], which cause distinct rearrangemen

28 now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, LIG3, and PARP1

29 Alternative non-homologous end joining (alt-NHEJ) was originally identified as a ba

30 motes insertion mutations during alternative end-joining (alt-EJ) by an unknown mechanism.

31 polymerase that is essential for alternative end-joining (alt-EJ) of double-strand breaks (DSBs) and

32 Alternative end-joining (alt-EJ) repair of DNA double-strand breaks

33 DNA repair pathways, such as non-homologous end joining and homologous recombination, may be importa

34 replication and repair by both nonhomologous end joining and homologous repair is misregulated when l

35 pes of solid tumors, in which non-homologous end joining and microhomology end joining are the predom

36 model of DNA damage repair by non-homologous end joining and of gamma irradiation-induced cellular se

37 NONO and XLF are both required for efficient end joining and radioresistance in cell-based assays.

38 fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-stra

39 cies of accurate or mutagenic non-homologous end-joining and gene correction by homologous recombinat

40 occurred via both alternative nonhomologous end-joining and homologous recombination pathways.

41 two major DSB repair pathways-nonhomologous end-joining and homologous recombination repair (HRR).

42 ge, which suppresses repair by nonhomologous end-joining and homologous recombination.

43 pleted cells display increased nonhomologous end-joining and reduced homologous recombination for DSB

44 cluding Tel1 (ATM) activation, nonhomologous end joining, and DNA double-strand break end resection w

45 logous recombination, microhomology-mediated end joining, and single strand annealing.

46 ibute to efficient resection, non-homologous end joining, and tolerance to DNA-damaging agents when o

47 endent protein kinase-mediated nonhomologous end-joining, and, when combined with olaparib, caused ab

48 non-homologous end joining and microhomology end joining are the predominant mechanisms.

49 gene conversion and classical nonhomologous end-joining are the most physiologically predominant for

50 SET is required for efficient non-homologous end joining as well as homologous recombination.

51 re sensitive than the typical non-homologous end joining assay.

52 ibe an improved SFPQ*NONO-dependent in vitro end joining assay.

53 ation sequencing into a highly sensitive DSB end-joining assay and apply it to endogenous AID-initiat

54 Here, we evaluate the effect of ssO on end-joining at DSB sites both in vitro and in cells.

55 53BP1 recruitment involved in non-homologous end joining but not BRCA1 recruitment for homologous rec

56 Here we show that DNA capping precludes end joining by classic ATP-dependent and NAD(+)-dependen

57 the toxicity associated with non-homologous end joining by promoting the use of homologous recombina

58 ) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ).

59 hereas Ku-dependent classical non-homologous end joining (C-NHEJ) has a minimal role to repair rerepl

60 Classical nonhomologous end joining (C-NHEJ) is a major mammalian DNA double-str

61 EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end joining (ALT-EJ)

62 break repair via the canonical nonhomologous end joining (c-NHEJ) pathway.

63 Canonical non-homologous end joining (c-NHEJ) repairs DNA double-strand breaks (D

64 facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recombination (HR) p

65 letions occur during classical nonhomologous end joining (C-NHEJ).

66 within S regions by classical nonhomologous end joining (C-NHEJ).

67 Classical non-homologous end-joining (C-NHEJ) is the dominant pathway for DSB rep

68 require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on Ku70/80 and LI

69 The classic nonhomologous end-joining (c-NHEJ) pathway is largely responsible for

70 the main process is classical non-homologous end-joining (C-NHEJ) which relies on Ku binding to DNA e

71 in wild-type versus classical nonhomologous end-joining (C-NHEJ)-deficient NSPCs reveals that both C

72 le in ICL repair was seen for non-homologous end-joining (cku-80) or base excision repair (nth-1, exo

73 Classical non-homologous end joining (cNHEJ) and homologous recombination compete

74 tion for LRF in the classical non-homologous end joining (cNHEJ) pathway of double-strand break (DSB)

75 (XLF) functions in classical non-homologous end-joining (cNHEJ) but is dispensable for the repair of

76 Tel1/ATM kinase signaling and non-homologous end joining, consistent with the role of Xrs2 as a chape

77 ing proteins required for the non-homologous end joining DNA repair pathway, increases the efficiency

78 S-S junctions are joined via a nonhomologous end joining DNA repair process.

79 s in the PGBD5 transposase domain as well as end-joining DNA repair and induced structural rearrangem

80 identified recently as a novel nonhomologous end-joining DNA repair factor in human cells.

81 s plays a critical role in the nonhomologous end-joining DNA repair pathway and provides prosurvival

82 s found to be involved in the non-homologous end-joining DNA repair process and in poly ADP-ribose po

83 and play a functional role in nonhomologous end-joining DNA repair.

84 subsequent wrongful recombination and end-to-end joining during cell division.

85 ocks DSB resection to promote non-homologous end-joining during immunoglobulin class switch recombina

86 e same time, thereby reducing non-homologous end joining efficiency.

87 ting in gene conversion events as well as an end joining (EJ) pathway for repair of DSBs when no homo

88 uld potentially be mediated by either of two end-joining (EJ) repair pathways [canonical nonhomologou

89 that inversion depends on the non-homologous end-joining enzyme LIG4.

90 f H4 regulates binding of the non-homologous end joining factor 53BP1, which engages chromatin throug

91 part through antagonism of the nonhomologous end-joining factor 53BP1.

92 major DSBs repair pathways is nonhomologous end joining for which Ku70/80 is essential for repair.

93 Hypomorphic mutations in the non-homologous end-joining gene DCLRE1C (encoding ARTEMIS) have been de

94 tem was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in opium poppy (Pa

95 ining, is developed and solved, showing that end-joining has a distinct effect on the growth of fibri

96 repair, base excision repair, nonhomologous end joining, homologous recombination, and methylguanine

97 n pathway, and seems to block HR and promote end joining in addition to its regulatory role in DNA da

98 d antagonizes 53BP1-dependent non-homologous end joining in S/G2 phase.

99 ct effect of the repression of nonhomologous end joining in Sir(-) mutants and that the apparent recr

100 a high level of precision by non-homologous end-joining in mammalian cells.

101 importance of TDP2-dependent non-homologous end-joining in protecting both gene transcription and ge

102 itivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the strongest effect.

103 ouble-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brai

104 tein kinase (DNA-PK)-mediated non-homologous end joining is inhibited.

105 Non-homologous end joining is initiated by the association of Ku with D

106 Specifically, nonhomologous end joining is the predominant mechanism used in the G1

107 odel of fibril formation kinetics, including end-joining, is developed and solved, showing that end-j

108 repair of stalled replication forks and DNA end joining-it fills a unique niche in restoring genomic

109 In nonhomologous end joining, Ku loads onto broken DNA via a channel cons

110 suggested fundamental role of nonhomologous end joining mechanism during eccDNA formation.

111 by homologous recombination or nonhomologous end joining mechanisms can lead to the introduction of s

112 Translocation-formation requires DNA end-joining mechanisms and incompletely characterized, p

113 Among end-joining mechanisms, the main process is classical no

114 Micro-homology-mediated non-homologous end joining (MMEJ) can also be used but to a lesser exte

115 Of interest, robust microhomology-mediated end joining (MMEJ) was observed with DNA substrates bear

116 Microhomology-mediated end joining (MMEJ), an error-prone pathway for DNA doubl

117 rnative NHEJ pathway, microhomology-mediated end joining (MMEJ), can also be deployed.

118 null mutation in the microhomology-mediated end-joining (MMEJ) component, polymerase theta/mutagen-s

119 to as the error-prone microhomology-mediated end-joining (MMEJ) pathway.

120 d with a promotion of microhomology-mediated end-joining (MMEJ), a subtype of alt-NHEJ, in G1-phase.

121 d-joining (NHEJ), and microhomology-mediated end-joining (MMEJ).

122 for repair, known as microhomology-mediated end-joining (MMEJ).

123 is indicative of activation of nonhomologous end joining (NHEJ) and homologous recombination (HR) rep

124 wo major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR).

125 air that buttresses canonical non-homologous end joining (NHEJ) and is manifest in NHEJ-defective can

126 ration of knockout alleles via nonhomologous end joining (NHEJ) and knock-in alleles via homology-dir

127 Homology-directed repair and non-homologous end joining (NHEJ) are the two major DSB repair pathways

128 ir DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family X DNA polymera

129 Nonhomologous end joining (NHEJ) can effectively resolve chromosome br

130 cal (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-strand break (DSB)

131 found that COH29 could inhibit nonhomologous end joining (NHEJ) efficiency and that no HR activity wa

132 of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair.

133 -strand break (DSB) repair by non-homologous end joining (NHEJ) in human cells is initiated by Ku het

134 Non-homologous end joining (NHEJ) involves limited processing, but homo

135 Non-homologous end joining (NHEJ) is a key cellular process ensuring ge

136 Non-homologous end joining (NHEJ) is a major DNA double-strand break (D

137 Non-homologous end joining (NHEJ) is a major pathway to repair DNA doub

138 Non-homologous end joining (NHEJ) is the main repair pathway for DNA do

139 Non-homologous end joining (NHEJ) is the major model proposed for Agrob

140 however, the preponderance of non-homologous end joining (NHEJ) mediated repair events over homology

141 e hypothesize that inhibiting non-homologous end joining (NHEJ) or enhancing homology-directed repair

142 s) are repaired by either the non-homologous end joining (NHEJ) or homologous recombination (HR) path

143 breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombination (HR).

144 ks followed by repair through non-homologous end joining (NHEJ) or stalled fork repair.

145 The non-homologous end joining (NHEJ) pathway is used in diverse species to

146 nappropriate activation of the nonhomologous end joining (NHEJ) pathway.

147 ing repair by the error-prone non-homologous end joining (NHEJ) pathway.

148 rotein kinase (DNA-PK) and the nonhomologous end joining (NHEJ) repair pathway are intrinsically anti

149 lication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplification of vira

150 logous recombination (HR) and non-homologous end joining (NHEJ) repair systems, leading to genomic in

151 enzyme, which are involved in nonhomologous end joining (NHEJ) repair, enhance amplification of vira

152 rom a moderate attenuation of non-homologous end joining (NHEJ) repair, the role of DEK in DNA repair

153 Nonhomologous end joining (NHEJ) repairs chromosome breaks and must re

154 Non-homologous end joining (NHEJ) repairs DNA double strand breaks in n

155 we suggest a role of LKB1 in non-homologous end joining (NHEJ), a major DNA double-strand break (DSB

156 plays a key role in mediating non-homologous end joining (NHEJ), a major repair pathway for DNA doubl

157 of these methods is limited by nonhomologous end joining (NHEJ), an alternative DNA repair pathway th

158 homologous recombination (HR), nonhomologous end joining (NHEJ), and single-strand annealing (SSA).

159 pecific gene knockout through non-homologous end joining (NHEJ), but it remains inefficient for preci

160 and organisms via error-prone nonhomologous end joining (NHEJ), but the efficiency of precise sequen

161 particular those required for non-homologous end joining (NHEJ), do not form discrete foci in respons

162 ologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and template switching

163 (NER), mismatch repair (MMR), non-homologous end joining (NHEJ), homologous recombination (HR) and in

164 nce changes through inaccurate nonhomologous end joining (NHEJ), often leading to gene inactivation.

165 Rap1 protects telomeres from non-homologous end joining (NHEJ), plays important roles in telomere le

166 air mechanism in human cells, non-homologous end joining (NHEJ), rejoins broken DNA ends by direct li

167 Kcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-strand breaks t

168 ologous recombination (HR) and nonhomologous end joining (NHEJ), the two major DSB repair pathways.

169 In contrast to non-homologous end joining (NHEJ), TMEJ efficiently repairs end structu

170 rescued by the inactivation of nonhomologous end joining (NHEJ).

171 classical, versus alternative, nonhomologous end joining (NHEJ).

172 logous recombination (HR) and non-homologous end joining (NHEJ).

173 ous recombination (HR) and the nonhomologous end joining (NHEJ).

174 ogy directed repair (HDR) and non-homologous end joining (NHEJ).

175 mologous recombination (HR) or nonhomologous end joining (NHEJ).

176 protecting telomeres against non-homologous end joining (NHEJ).

177 influencing the efficiency of non-homologous end joining (NHEJ).

178 s for DSB factors involved in non-homologous end joining (NHEJ).

179 nation (CSR), are repaired by non-homologous end joining (NHEJ).

180 ected recombination (HDR) and non-homologous end joining (NHEJ).

181 a repair defect that involves non-homologous end joining (NHEJ).

182 are predominantly repaired by non-homologous end joining (NHEJ).

183 ingle-strand break repair and non-homologous end joining (NHEJ).

184 Non-homologous end-joining (NHEJ) and homologous recombination (HR) are

185 two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is

186 double-strand breaks (DSBs): non-homologous end-joining (NHEJ) and homologous recombination (HR).

187 re rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppress

188 TRADD facilitates non-homologous end-joining (NHEJ) by recruiting NHEJ repair factors 53B

189 ed with the components of the non-homologous end-joining (NHEJ) complex and participated in the NHEJ-

190 d that it is not suppressed by nonhomologous end-joining (NHEJ) components, arguing that nick process

191 ned inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently i

192 ic gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatme

193 NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway result in radiatio

194 Hypomorphic mutations in the nonhomologous end-joining (NHEJ) DNA repair protein DNA ligase IV (LIG

195 alleles result presumably from nonhomologous end-joining (NHEJ) events before the segregation of soma

196 Ku70, a known nonhomologous end-joining (NHEJ) factor, also functions in tumor suppr

197 As the non-homologous end-joining (NHEJ) factor, Ku70/80 (Ku), is quickly recr

198 in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chromatin in cells

199 Nonhomologous end-joining (NHEJ) is a key pathway for efficient repair

200 Nonhomologous end-joining (NHEJ) is a major DNA double-strand break re

201 Nonhomologous end-joining (NHEJ) is a major repair pathway for DNA dou

202 Nonhomologous end-joining (NHEJ) is the major DNA double-strand break

203 In humans, nonhomologous DNA end-joining (NHEJ) is the major pathway by which DNA dou

204 Non-homologous end-joining (NHEJ) is the most prominent DNA double stra

205 Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand brea

206 The alternative non-homologous end-joining (NHEJ) machinery facilitates several genomic

207 Furthermore, coexpression the nonhomologous end-joining (NHEJ) machinery from the closely related ar

208 The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repair

209 The nonhomologous end-joining (NHEJ) pathway is essential for the preserva

210 The nonhomologous end-joining (NHEJ) pathway is the primary repair pathway

211 that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair to fix DNA brea

212 The non homologous end-joining (NHEJ) pathway of double-strand break (DSB)

213 rnunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-strand DNA break re

214 The non-homologous end-joining (NHEJ) pathway repairs DNA double-strand bre

215 which are not repaired by the non-homologous end-joining (NHEJ) pathway.

216 and abnormal regulation of the nonhomologous end-joining (NHEJ) pathway.

217 ogous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways.

218 rate genome rearrangements by non-homologous end-joining (NHEJ) processes in specialized subnuclear r

219 by genetically eliminating Ku nonhomologous end-joining (NHEJ) protein, indicating that Ctp1-depende

220 we show that FBXW7 facilitates nonhomologous end-joining (NHEJ) repair and that FBXW7 depletion cause

221 e (DNA-PK) phosphorylation and nonhomologous end-joining (NHEJ) repair efficiency and fidelity.

222 contrast, alleles created by non-homologous end-joining (NHEJ) repair of double-stranded DNA breaks

223 ologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways, with defective local

224 ed repair (HDR) and decreased non-homologous end-joining (NHEJ) repair, suggesting that Wwox contribu

225 ich are typically repaired by non-homologous end-joining (NHEJ) resulting in nonspecific insertions,

226 se activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recombination (HR)

227 o 58% of reads as repaired via nonhomologous end-joining (NHEJ) with deletions and/or small (1 to 3 b

228 ith a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the improvement in ce

229 However, nonhomologous end-joining (NHEJ), an error-prone repair, acts concurre

230 homologous recombination (HR), nonhomologous end-joining (NHEJ), and microhomology-mediated end-joini

231 mage checkpoint components and nonhomologous end-joining (NHEJ), but not homologous recombination.

232 diesterase 2 (TDP2)-dependent non-homologous end-joining (NHEJ), but whether this process suppresses

233 ologous recombination (HR) and nonhomologous end-joining (NHEJ), causes accumulation of spontaneous D

234 cond major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial.

235 channelled through repair by non-homologous end-joining (NHEJ).

236 logous-recombination (HR) and non-homologous-end-joining (NHEJ).

237 n cancers display hallmarks of nonhomologous end-joining (NHEJ).

238 B) repair pathways, including non-homologous end-joining (NHEJ).

239 itulate DSB repair via MMEJ or nonhomologous end-joining (NHEJ).

240 ile counteracting error-prone non-homologous end joining of DNA double-strand breaks.

241 rs impairs Ku80 removal after non-homologous end joining of DSBs.

242 e that the excursions promote non-homologous end joining of dysfunctional telomeres and implicated Ne

243 where successful deletion and non-homologous end joining of up to 725 kb reframed the DMD gene.

244 both acting in end resection, also promotes end-joining of uncapped telomeres.

245 The dependence of some end joining on only Ku and XRCC4.DNA ligase IV allows us

246 ation restart-bypass mechanism terminated by end joining or by microhomology-mediated template switch

247 breaks can be eliminated via non-homologous end joining or homologous recombination.

248 are generally repaired through nonhomologous end joining or homologous recombination.

249 oved to allow repair by either nonhomologous end joining or homology-directed repair.

250 ut instead form most often via nonhomologous end joining or microhomology-mediated break-induced repl

251 DSBs are repaired by non-homologous end-joining or homology directed repair (HDR).

252 double strand break repair by nonhomologous end joining, particularly in nonreplicating cells contai

253 tion strategies relying on the nonhomologous end joining pathway may induce compensatory fetal hemogl

254 NA break (DSB) repair via the non-homologous end joining pathway, as unrepaired DSBs are the primary

255 Kcs, which is integral to the non-homologous end joining pathway, thus negatively regulates ATM activ

256 e in repair by the alternative nonhomologous end joining pathway.

257 mproved by suppression of the non-homologous end joining pathway.

258 le-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important not only for rep

259 the main nuclease in the non-homologous DNA end-joining pathway (NHEJ).

260 1C gene, is a component of the nonhomologous end-joining pathway and participates in hairpin opening

261 gap-filling synthesis in the non-homologous end-joining pathway of double-strand break repair.

262 The 53BP1-dependent end-joining pathway plays a critical role in double stra

263 We propose that an alternative end-joining pathway rather than C-NHEJ, serves as a prim

264 As a member of the non-homologous end-joining pathway, it is also involved in repairing a

265 Ku70 is a key component of the nonhomologous end-joining pathway, which is the major pathway for DNA

266 ty of the break were due to a non-homologous end-joining pathway, while larger deletions were process

267 strand breaks by the classical nonhomologous end-joining pathway.

268 A double-strand breaks by the non-homologous end-joining pathway.

269 plexes that participate in the nonhomologous end-joining pathway.

270 ial DNA repair proteins in the nonhomologous end-joining pathway.

271 PCs reveals that both C-NHEJ and alternative end-joining pathways can generate translocations by join

272 d in Atad5(+/m) cells, although the types of end-joining pathways were not affected.

273 nd breaks that are repaired by nonhomologous end-joining pathways.

274 tive base excision repair and non-homologous end-joining, pathways required for repair of both DNA si

275 or Lig4-defective conditions, an alternative end-joining process (A-EJ) can operate and exhibits a tr

276 eleterious single-strand annealing (SSA) and end-joining processes that led to the loss of large chro

277 logous recombination and other nonhomologous end-joining processes.

278 on that arose through microhomology-mediated end joining rather than nonallelic homologous recombinat

279 vealing a competition between telomerase and end-joining recombination proteins for access to deprote

280 ates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phos

281 phosphorylation of DNA-PK, a non-homologous end joining repair protein, in Hec-108 cells.

282 uble strand breaks may trigger nonhomologous end joining repair, leading to frameshift mutations, or

283 Wnt signalling enhances non-homologous end-joining repair in CRC, which is mediated by LIG4 tra

284 ently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regenerating the ta

285 timately become substrates for nonhomologous end-joining repair, leading to large-scale genomic rearr

286 DNA break and is required for nonhomologous end-joining repair.

287 epair and, to a lesser extent, nonhomologous end-joining repair.

288 As microhomology-mediated end-joining requires annealing of single-strand DNA ends

289 homologous recombination and non-homologous end joining, respectively, were transcriptionally activa

290 homologous recombination and non-homologous end joining, respectively.

291 70 or lig4, both essential components of the end-joining response, increased recombination-based repa

292 d synthesis-dependent microhomology-mediated end joining (SD-MMEJ), predicts that differences between

293 '-end gap filling is consistent with data on end-joining substrate specificity in cells, and provides

294 ligase activity for classical non-homologous end joining (the predominant DNA double-strand break rep

295 DNA polymerase theta (Pol theta)-mediated end joining (TMEJ) has been implicated in the repair of

296 t MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs in a site-speci

297 ipsis in TCC-UB is mediated by nonhomologous end-joining using kilobase, rather than megabase, fragme

298 one H3 from the genome during non-homologous end joining was promoted by both ATM and the ATP-depende

299 ase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by pol

300 DSBs are resolved to promote long-range DNA end-joining while suppressing genomic instability inhere