ライフサイエンスコーパス: endodermal

1 sing a novel transgenic line that labels the endodermal actin cytoskeleton, we found that these stage

2 er is involved in Fe influx into vacuoles of endodermal and bundle sheath cells.

3 tion, the Wnt(high) hESCs predominantly form endodermal and cardiac cells, whereas the Wnt(low) hESCs

4 In endodermal and cortical cells, the noa1 mutant acts syne

5 The fact that both endodermal and ectodermal beta-catenin knockout animals

6 tor signaling and causes ectopic mesodermal, endodermal and epidermal fate commitment in the embryo.

7 lar growth and differentiation especially in endodermal and germ cell lineages.

8 adenosine induces the expression of some key endodermal and hepatocyte-specific genes in mouse and hu

9 Metabolic switching during endodermal and mesodermal differentiation coincides with

10 ssion of transcription factors driving early endodermal and mesodermal differentiation, partially ove

11 The control system initiates non-interacting endodermal and mesodermal gene regulatory networks in ve

12 neighboring cell populations of ectodermal, endodermal and mesodermal origin.

13 es, with the supporting cell types from both endodermal and mesodermal origins in a hexagonal lobule

14 wever, hhex and prox1 expression in adjacent endodermal and mesodermal tissues appeared unaffected by

15 of hPGC-like fate, whereas BLIMP1 represses endodermal and other somatic genes during specification

16 ALT2 was expressed specifically in root endodermal and peridermal cells as well as in stem later

17 spiral cleavage program in which ectodermal, endodermal, and mesodermal origins are known from intrac

18 derivatives of each germ layer, ectodermal, endodermal, and mesodermal.

19 ate decisions and outgrowth of the embryonic endodermal anlagen.

20 ledge on the formation of these two distinct endodermal barriers and their regulatory role in nutrien

21 xpression shifts in the neural tube, and the endodermal boundary between AmphiXlox and AmphiCdx shift

22 In the vertebrate head, endodermal branches, called pharyngeal pouches, form thr

23 , Sox2 was identified as an oncogene in many endodermal cancers, including colon cancer.

24 e conversion of human fibroblasts towards an endodermal cell fate by employing non-integrative episom

25 o an adjacent cell layer, where it specifies endodermal cell fate; it is also essential for apical me

26 plication along the cortical, epidermal, and endodermal cell files, suggested to be daughters, grandd

27 root tip of Arabidopsis, where it specifies endodermal cell identity and stem cell function, respect

28 pagation is channeled through the cortex and endodermal cell layers and this movement is dependent on

29 red mouse embryonic stem (ES) cells with the endodermal cell line End2 by co-aggregation or End2-cond

30 rom ES cells, including the commitment to an endodermal cell lineage, with the temporal profile chara

31 ias the differentiation toward mesodermal or endodermal cell lineage.

32 Conversely, endodermal cell migration defects are dependent on a Cxc

33 am of Nodal signaling and indirectly affects endodermal cell migration via Cxcr4a-signaling.

34 ivities of spatially and temporally distinct endodermal cell populations in the early mouse embryo re

35 Detailed characterization of ES cell-derived endodermal cell types by gene expression analysis in vit

36 onal network, hypermethylation of pancreatic endodermal cell-fate determining genes and have a poor p

37 ers and determined the number of cortex, not endodermal, cell layers formed in the root.

38 rane movement of apoplastic solutes into the endodermal cells [7, 8].

39 mation in which, upon N-cadherin expression, endodermal cells actively migrate away from their epibla

40 Cdx2-negative endodermal cells also fail to express Sox2, a marker of

41 the middle of anticlinal cell walls between endodermal cells and fill the gap between them [4-6].

42 ellae are glycerolipid polymers covering the endodermal cells and likely function as a barrier to lim

43 sis was associated with dedifferentiation of endodermal cells as documented by a decrease in key tran

44 Reducing Rac1 activity in endodermal cells caused them to bypass the random migrat

45 In contrast, endodermal cells closer to the midline give rise to panc

46 Rather, we observe that endodermal cells constrict their apices, adopting bottle

47 d, conversely, that the presence of anterior endodermal cells defective for S1pr2 or Galpha(13) in wi

48 e GA-regulated rate of expansion of dividing endodermal cells dictates the equivalent rate in other r

49 How endodermal cells differentiate into distinct cell types

50 ive feedback loop stimulated in a select few endodermal cells early during lateral root development,

51 Here, we show that endodermal cells efficiently promote the emergence of me

52 n gene expression, Nodal and Activin-derived endodermal cells exhibit a distinct difference in functi

53 Instead, the endodermal cells exhibit cell-autonomous expression of g

54 During gut development, endodermal cells express Sonic hedgehog (Shh), which is

55 Because of inherent difficulties in deriving endodermal cells from undifferentiated cell cultures, ap

56 eals that the presence of wild-type anterior endodermal cells in Galpha(13)-deficient embryos is suff

57 strip, a diffusion barrier deposited between endodermal cells in plant roots.

58 The endodermal cells in the distal tips of the developing lu

59 we show that TAEL is able to induce ectopic endodermal cells in the presumptive ectoderm via targete

60 itis elegans shows that during embryogenesis endodermal cells interact with and regulate primordial g

61 evealed that the ectopic suberization at the endodermal cells limits Ca transport through the transme

62 At early somite stages, endodermal cells located at least two cells away from th

63 Based on our in-vivo observation that early endodermal cells maintain contact with nascent pre-cardi

64 ion of the ventral pancreas, differentiating endodermal cells need to be protected from exposure to B

65 fully differentiated, highly specialized non-endodermal cells of the pharynx into fully differentiate

66 labeled GAs specifically accumulated in the endodermal cells of the root elongation zone.

67 These data provide in vivo evidence that endodermal cells outside the liver-forming region retain

68 trongly, specifically and transiently in the endodermal cells overlying early lateral root primordia

69 maging and functional analyses revealed that endodermal cells reach their characteristic innermost po

70 for hepatic specification, and suggest that endodermal cells remain competent to differentiate into

71 Endodermal cells retain cell-cell junctions while invagi

72 During zebrafish gastrulation, endodermal cells sequentially exhibit first random, nonp

73 roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberi

74 The molecular program that instructs endodermal cells to adopt the respiratory fate is not fu

75 ate mesoderm, signals through Alk8 to induce endodermal cells to become liver.

76 ignaling regulates the ability of individual endodermal cells to differentiate into beta-cells.

77 parian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks ex

78 y be important in pulling the ectodermal and endodermal cells together.

79 d pharyngeal mesoderm, as well as pharyngeal endodermal cells underlying the second heart field.

80 Endodermal cells utilize proteins linked to endocytosis

81 Importantly, inhibiting Bmp signaling within endodermal cells via genetic means increased the number

82 Moreover, expressing gai in dividing endodermal cells was sufficient to block root meristem e

83 ansion of more than a million-fold for human endodermal cells with full retention of their developmen

84 Si was localized in the cell walls of the endodermal cells with little apparent effect of the Lsi2

85 Fbeta reduced the proliferation of wild-type endodermal cells within the explants as assessed by BrdU

86 cing was completely restricted to the QC and endodermal cells within which the dsRNA transgenes were

87 ed Casparian strips, ectopic suberization of endodermal cells, and low accumulation of shoot calcium

88 en Bmp2b was overexpressed, medially located endodermal cells, fated to become pancreas and intestine

89 he transmembrane pathway through unsuberized endodermal cells, rather than the sites of lateral root

90 The epithelium derived from endodermal cells, which surrounds the auditory tube and

91 ns PGCs internalize by attaching to internal endodermal cells, which undergo morphogenetic movements

92 ting gene expression in the adjacent CEI and endodermal cells.

93 Notch-dependent expression in mesodermal and endodermal cells.

94 step along the way: PGCs get cut in half by endodermal cells.

95 ound that defects in S1pr2/Galpha13-mediated endodermal convergence affected all three modes of myoca

96 dissolution between cells in the overlaying endodermal, cortical, and epidermal tissues.

97 the parental root and have to emerge through endodermal, cortical, and epidermal tissues.

98 erm convergence during segmentation, and the endodermal defects correlate with the extent of cardia b

99 emarkably, genetic loss of Tfeb also yielded endodermal defects, while AMPK-null ESCs overexpressing

100 that heart development appeared normal after endodermal deletion of Nkx2.5 whereas mesodermal deletio

101 ty and the patterning of both ectodermal and endodermal derivatives along the primary body axis.

102 o steer ES cells towards developing specific endodermal derived urothelium.

103 ation and offer a potentially safe source of endodermal-derived tissues for transplantation therapies

104 olesterol homeostasis and cell plasticity in endodermal-derived tissues.

105 7alpha(1) is a direct target of the maternal endodermal determinant VegT and of Sox17 itself.

106 ple pathways regulate the complex process of endodermal development, including the Bone morphogenetic

107 indicator, the presence of free Cu increased endodermal development, while amendments prevented this

108 y by influencing both membrane integrity and endodermal development.

109 me endoderm, and is important in controlling endodermal development.

110 at these sites as a biomarker when assessing endodermal differentiation capacity as a readout.

111 non-CG methylation that correctly identifies endodermal differentiation capacity in 23 out of 25 (92%

112 3%, P<9.1 x 10(-6)) and correctly identifies endodermal differentiation capacity in nine out of ten p

113 Transcripts for parietal endodermal differentiation markers, including laminin, J

114 n of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells.

115 AD2,3 signaling pathways synergize to induce endodermal differentiation of human embryonic stem cells

116 Wnt/beta-catenin transcription and promotes endodermal differentiation.

117 ranscriptional network of core regulators of endodermal differentiation.

118 critical for proper lung bud initiation and endodermal differentiation.

119 ptional networks underlying Arabidopsis root endodermal differentiation.

120 Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages.

121 sion, and increased interactions between the endodermal enhancer and IGF2 promoter.

122 at transcriptionally active genes, i.e. the endodermal enhancers contact the maternal H19 and the pa

123 ly pure endodermal populations revealed that endodermal enhancers existed in a surprising diversity o

124 rescue experiments further demonstrate that endodermal Eph-ephrin signaling promotes pouch integrity

125 duced the expression of genes found in other endodermal epithelia but not normally associated with th

126 sion of Shh in the cloaca and cloaca-derived endodermal epithelia.

127 s in the area vasculosa follow the migrating endodermal epithelial cell (EEC) layer in the area vitel

128 quirements of Wnt signaling in two phases of endodermal epithelial transitions.

129 stive tract requires interactions between an endodermal epithelium and mesenchymal cells derived from

130 we dissect the distinct roles of YAP/TAZ in endodermal epithelium and mesenchyme and find that, alth

131 Initially, Wnt11r and Rac1 destabilize the endodermal epithelium to promote the lateral movement of

132 germ cells (PGCs), which migrate through the endodermal epithelium.

133 embryoid bodies (EBs) or into extraembryonic endodermal (ExE) cells as a model for cellular different

134 ramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.

135 Endodermal explants from conditional TGFbeta receptor II

136 udding by TGFbeta was partially abrogated in endodermal explants from Smad3(-/-) or conditional endod

137 the Hh signaling components ptc1 and smo in endodermal explants, indicating a possible molecular mec

138 ing, which inhibited Nkx2.1 in cultured lung endodermal explants.

139 strula stage, while module 24 generates late endodermal expression at gastrula and pluteus stages.

140 ver, given the considerable overlap in their endodermal expression domains, a functional redundancy b

141 These elements individually drive transgenic endodermal expression in the blastula and gastrula.

142 We show that endodermal expression involves the GATA transcription fa

143 at Nkx2.5 in the mesoderm is essential while endodermal expression is dispensable for early heart for

144 Taken together with our finding that endodermal expression of cyp26 genes is subject to posit

145 defects are partially due to a reduction in endodermal expression of the hairy/enhancer of split-rel

146 o regions co-operate in regulating the early endodermal expression of the Xsox17alpha(1) gene.

147 transcription factors that are required for endodermal expression.

148 e intermediate steps downstream of the early endodermal factor Gata5, which progressively lead to the

149 nesis; later, increased wnt activity altered endodermal fate by enhancing liver growth at the expense

150 be prostaglandin E2 (PGE2) as a regulator of endodermal fate specification during development.

151 ion is further required for consolidation of endodermal fate via upregulation of Sox17, highlighting

152 in E than MS, and SYS-1 is critical for the endodermal fate.

153 -beta converted all or nearly all cells into endodermal fates expressing gut-specific esterase.

154 ning pancreas identity by regulating foregut endodermal fates.

155 of Fgfr2 results in two distinct phenotypes: endodermal Fgfr2 deletion causes mild hypospadias and in

156 ive positions in a process largely driven by endodermal folding and other large-scale tissue deformat

157 tionally, we show that the broadly expressed endodermal forkhead factors Foxa1 and Foxa2 can cooperat

158 interchangeable and interact with different endodermal GATA factors with only modest differences in

159 Targeted repression of endodermal GATAa function disrupts endoderm morphogenesi

160 s in veg2-derived cells and extinguishes the endodermal gene regulatory network in mesodermal precurs

161 ic movements and differentiation events, the endodermal germ layer gives rise to the epithelial linin

162 ates the specification of the mesodermal and endodermal germ layers during gastrulation.

163 yonic specification: the broad activation of endodermal GRNs, the regional specification of the immed

164 rmal ABCC (MRP) transporter is necessary for endodermal gut morphogenesis in sea urchin embryos.

165 ed to actively migrate away from the forming endodermal gut tube, and subsequently underwent characte

166 e embryonic liver, Gata4 is expressed in the endodermal hepatic bud and in the adjacent mesenchyme of

167 absence of Hh signaling, we postulated that endodermal Hh restrains mesenchymal Notch pathway activi

168 orally with this step was Sox17, encoding an endodermal HMG-box transcription factor.

169 e those reported for mutations in labial, an endodermal homeotic gene required for copper cell specif

170 in embryonic progenitor cell lines and early endodermal hPS cell derivatives.

171 appropriate ECM could itself induce anterior endodermal identity in the absence of PI3K signalling.

172 that Fn1 dose was key to specifying anterior endodermal identity in vivo and in vitro.

173 ls and repressed Cdx2, a master regulator of endodermal identity.

174 This occurs because the endodermal induction step allows for more efficient and

175 red to when HGF is absent (14.2%) during the endodermal induction step.

176 ntiation protocols (embryoid body formation, endodermal induction, directed differentiation) commonly

177 ring gastrulation, to allow subsequent intra-endodermal interactions.

178 oised enhancer state predicts the ability of endodermal intermediates to respond to inductive signals

179 thelial transition to insert into the outer, endodermal layer of the embryo.

180 450 7A1 (Cyp7A1), demonstrating a definitive endodermal lineage differentiation.

181 rs signifies developmental competence during endodermal lineage diversification.

182 onstrate the efficient generation of hepatic endodermal lineage from human iPSCs that exhibits key at

183 and in hESCs differentiated into definitive endodermal lineage.

184 Thus far, derivation of endodermal lineages has focused predominantly on hepatoc

185 whether iPS cells could generate autologous endodermal lineages in vitro.

186 derived EP cells differentiate into numerous endodermal lineages, including monohormonal glucose-resp

187 CL in hESCs promoted differentiation to meso-endodermal lineages, the emergence of haematopoietic and

188 pecific to the interstitial, ectodermal, and endodermal lineages, we found that the targeting of tran

189 types, including hematopoietic, cardiac, and endodermal lineages.

190 opulation segregated into the mesodermal and endodermal lineages.

191 le to differentiate along the mesodermal and endodermal lineages.

192 with impaired differentiation capacity into endodermal lineages.

193 The endodermal lining of the adult gastro-intestinal tract h

194 A and Wnt3a, elevates the expression of the endodermal marker Foxa2 (forkhead box a2) by 39.3% compa

195 Finally, in differentiating human ES cells, endodermal markers were more efficiently induced by Noda

196 gulating this pathway restored expression of endodermal markers.

197 responses, pointing to a pivotal role of the endodermal membrane in nutrient homeostasis.

198 of morphogenetic events involving reciprocal endodermal-mesodermal interactions.

199 to a specialized transition zone between the endodermal midgut and ectodermal hindgut that shares mol

200 e Drosophila intestinal tract, including the endodermal midgut and ectodermal hindgut/Malpighian tubu

201 nd migration behavior, which are crucial for endodermal morphogenesis and cell fate decisions.

202 by which TGFbeta inhibits FGF10-induced lung endodermal morphogenesis may entail both inhibition of c

203 data uncover a novel mechanism through which endodermal-myocardial communication can guide the cell m

204 However, the molecular underpinnings of this endodermal-myocardial relationship remain unclear.

205 f the lung epithelium derive from embryonic, endodermal, NK2 homeobox 1-expressing (NKX2-1+) precurso

206 forward genetic screen for genes regulating endodermal organ development, we identified mutations at

207 wo forward genetic screens for regulators of endodermal organ development.

208 l repressor Histone deacetylase 1 (Hdac1) in endodermal organogenesis in zebrafish.

209 ing gene expression programmes in vertebrate endodermal organogenesis.

210 is crucial for regulating distinct steps in endodermal organogenesis.

211 se defects in the development of a number of endodermal organs including the liver and pancreas.

212 Endodermal organs such as the lung, liver and pancreas e

213 or injury-induced epithelial regeneration in endodermal organs, and may provide a basis for understan

214 mportant functions in several mesodermal and endodermal organs, including heart, liver and pancreas.

215 nce between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to

216 the nervous system, chordamesoderm, limb and endodermal organs.

217 would, resulting in bilateral duplication of endodermal organs.

218 all three germ layers, including tissues of endodermal origin (i.e., liver).

219 neurenteric cysts are rare cystic masses of endodermal origin lined with mucin producing low columna

220 rprisingly, the lineage map also revealed an endodermal origin of the perineum, which is the first de

221 ved, but endoderm-derived, like PNECs, whose endodermal origin we confirm.

222 GRP-LE in the midgut, the central section of endodermal origin where PGRP-LE is enriched.

223 cific patterns of remodelling (ectodermal or endodermal origin).

224 In bladder, another organ of endodermal origin, we find that despite its initial pres

225 igh frequency of Kras mutations in tumors of endodermal origin.

226 ed against many carcinomas of ectodermal and endodermal origin; however, sarcomas, arising from mesod

227 ted with other cancer types of epithelial or endodermal origins such as lung cancer, head and neck ca

228 med biphasic consequences of wnt activation: endodermal pattern formation and gene expression require

229 e Ptf1a(EDD) rapidly expanded the endogenous endodermal Pdx1-positive domain and recruited other panc

230 knocking down her5 recapitulates some of the endodermal phenotypes of shiri mutants, further revealin

231 t is involved in the influx of Cd across the endodermal plasma membrane and thus may play a key role

232 ptional and chromatin mapping of highly pure endodermal populations revealed that endodermal enhancer

233 dermal potential and possible ectodermal and endodermal potentials also, the ASC could conceivably be

234 death within the pharyngeal arches, aberrant endodermal pouch morphogenesis, and hypoplastic cranial

235 The endodermal pouches are a series of reiterated structures

236 wing two origins: delayed differentiation of endodermal precursors and transdifferentiation of parath

237 PC+ alveolar progenitors as they emerge from endodermal precursors in response to stimulation of Wnt

238 line, we show that her5 is expressed in the endodermal precursors that populate the pharyngeal regio

239 ulation begins with the migration of the two endodermal precursors, Ea and Ep, from the surface of th

240 Gastrulation movements place endodermal precursors, mesodermal precursors and primord

241 cify these cells efficiently from definitive endodermal precursors.

242 s and parathyroid glands arise from a shared endodermal primordium in the third pharyngeal pouch (3rd

243 n in mouse embryonic stem cells and involved endodermal production of fibronectin.

244 To address these issues, we established endodermal progenitor (EP) cell lines from human embryon

245 On initial culture, converted definitive endodermal progenitor cells (cDE cells) are specified in

246 cPF cells and their derivatives, pancreatic endodermal progenitor cells (cPE cells), can be greatly

247 Here we describe derivation of human induced endodermal progenitor cells (hiEndoPCs) from gastrointes

248 nt manner to regulate the differentiation of endodermal progenitor cells of the tongue into taste bud

249 eurog3 (Neurogenin3 or Ngn3) actively drives endodermal progenitor cells towards endocrine islet cell

250 suggesting that activated Kras may affect an endodermal progenitor to initiate oncogenesis.

251 oforms exert profoundly different effects on endodermal progenitors and that mutant Kras may initiate

252 Key endodermal progenitors can be derived from patients and

253 Nodal signals induce mesodermal and endodermal progenitors during vertebrate development.

254 Furthermore, KrasV12-expressing endodermal progenitors fail to differentiate upon RA tre

255 pathways cooperate to restrict the number of endodermal progenitors induced in response to Nodal sign

256 third pharyngeal pouch primordia containing endodermal progenitors of both thymus and parathyroid gl

257 transcription factor expressed by embryonic endodermal progenitors that form the lining of the gastr

258 s differentiation and growth arrest in these endodermal progenitors, KrasV12 promotes their prolifera

259 astic and in serum-free medium, tailored for endodermal progenitors, remaining phenotypically stable

260 tem (iPS) cells into beta-like-cells through endodermal progenitors, we have shown that gut endocrine

261 nt stem cell that gives rise to cortical and endodermal progenitors.

262 The liver and pancreas arise from common endodermal progenitors.

263 cation in zebrafish embryos as well as mouse endodermal progenitors.

264 The consequences of disrupted mesodermal and endodermal RA signaling were restricted to the 4th and 6

265 d that as embryos develop, the extent of the endodermal region retaining hepatic competence is gradua

266 consists of the cis-regulatory apparatus of endodermal regulatory genes, which determine the relatio

267 lated by the medio-lateral patterning of the endodermal sheet, a process controlled by Bmp2b.

268 rn the endoderm, but the pathway controlling endodermal shh expression is unclear.

269 We also find that meis3 is required for endodermal shh expression, indicating that meis3 acts up

270 Finally, endodermal SHH signaling is required in an autocrine man

271 bel-tracking experiments suggest that active endodermal shortening around the AIP accounts for most o

272 At the same time, loss of endodermal Sin3a also disrupted cell differentiation of

273 Conditional, endodermal-specific deletion of Pten overcame TGFbeta's

274 rmal explants from Smad3(-/-) or conditional endodermal-specific Smad4(Delta/Delta) embryonic lungs.

275 long with examination of mutants affected in endodermal specification, indicate that GA accumulation

276 , impacting hepatic differentiation, but not endodermal specification: loss of cannabinoid receptor 1

277 , provides robust evidence for expression of endodermal stem cell traits.

278 tes transcriptional program specifying early endodermal stem cells.

279 Endodermal stem/progenitor cells have diverse potential

280 edium (KM), a serum-free medium designed for endodermal stem/progenitor cells.

281 ere found to be incorporated into definitive endodermal structures, such as stomach and intestine.

282 Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeo

283 ing cell movement and the activation of some endodermal target genes.

284 However, endodermal tissue along the secondary axis originated fr

285 The endodermal tissue layer is found in the roots of vascula

286 n we demonstrate that PGCs take advantage of endodermal tissue remodeling to gain access to the gonad

287 to 50% resulted in developmental defects in endodermal tissue, cardiac function, and swimming behavi

288 class of tumors composed of ecto-, meso- and endodermal tissues, all foreign to the site of origin.

289 r gene expression was not evident when other endodermal tissues, such as the lung bud or stomach, wer

290 on of otherwise inaccessible progenitors for endodermal tissues.

291 contributed in a region-specific fashion to endodermal tissues.

292 ell, Kim et al. demonstrate in mice that the endodermal transcription factor Sox17 is required for th

293 They express endodermal transcription factors (e.g., Sox9, SOX17, FOX

294 rized by examining the induction of specific endodermal transcription factors (Foxa1 and Foxa2).

295 NT-beta-catenin signaling is required in the endodermal urethra to activate and maintain Fgf8 express

296 ally derived mesenchyme and extension of the endodermal urethra within an ectodermal epithelial capsu

297 utant showed stronger As accumulation in the endodermal vacuoles, where the Lsi2 transporter is locat

298 lopment and the role of Barx1 in suppressing endodermal Wnt activity.

299 of secreted Wnt antagonists, which suppress endodermal Wnt signaling, to enable stomach epithelial d

300 A detailed examination showed that endodermal Wnt5 functions as a short-range signal that a