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3 ion (tES) with a time course that mimics the endogenous activity of its target is capable of altering
5 ion of calpain increases the localization of endogenous adhesion signaling to growth cone filopodia.
8 that this method can be used to silence the endogenous allele of ataxin 7 and replace it with an exo
9 our hypothesis that visual flicker entrained endogenous alpha-band networks, which in turn impaired t
10 conjunction with CRISPR/Cas9 knockout of the endogenous alphabeta TCR resulted in more efficient redi
11 terminus was also observed in activation of endogenous alphaIIbbeta3 in human erythroleukemia (HEL)
12 hat transgenic BAR indeed converts two plant endogenous amino acids, aminoadipate and tryptophan, to
15 cells from the tissue, while utilizing both endogenous and ectopic cellular behaviours to dismantle
16 nts on the one hand, and for defence against endogenous and environmental stresses on the other hand.
17 f all organisms, are continuously exposed to endogenous and exogenous damaging agents, representing a
23 provided rapid annotation of a diversity of endogenous and gut microbially derived metabolites affec
25 (GPCRs), which are modulated by a variety of endogenous and synthetic ligands, represent the largest
26 xed dimers, formed by mispairing between the endogenous and transgenic TCRs, may harbor autoreactive
30 n of delivery strategies that exploits these endogenous approaches promises to provide better solutio
31 This ensured that pupil responses reflected endogenous arousal fluctuations opposed to differences i
32 c increase in plasma membrane recruitment of endogenous arrestin 3 following alpha2AAR activation.
33 than the control condition were found under endogenous attention but not under exogenous attention.
34 ry, we have shown the apoplastic presence of endogenous auxin epitopes recognised by an anti-IAA anti
35 ere we demonstrate that the expression of an endogenous Braf(D631A) kinase-inactive isoform in mice (
36 dence suggests that flicker may also entrain endogenous brain oscillations, thereby modulating cognit
37 ws predominant cytoplasmic localization, but endogenous C3G is a component of nuclear fractions in a
38 This paper reports that the abundances of endogenous cardiolipin and phosphatidylethanolamine halv
39 , to know whether these rescue mice maintain endogenous CB1 receptor expression level, detailed anato
40 l4 -mediated liver injury in WT mice induced endogenous CcnE1 expression and proliferation of survivi
41 We have developed a strategy to rewire the endogenous cellular regulatory network of yeast to enhan
42 ates exposed to in utero inflammation via an endogenous cerebral cholinergic anti-inflammatory pathwa
43 ocking channels into a closed state and that endogenous CFTR in HBEs is affected by SMase activity.
45 HbF concentrations and concentrations of the endogenous chelators haptoglobin, hemopexin, and alpha1-
46 on of incoming bacteriophage/plasmid DNA and endogenous chromosomal DNA within Escherichia coli at 37
47 ification of a sequence-specific single-copy endogenous chromosomal locus containing a DNA double-str
48 of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metr
49 ural processes of animals are governed by an endogenous circadian clock, which is dependent on transc
50 y let-7 was found enriched after pulldown of endogenous CircPVT1, suggesting that CircPVT1 might sele
51 and Pamudurti et al. (2017) demonstrate that endogenous circular RNAs may generate proteins, thereby
52 These results demonstrate that enhancing endogenous clearance of tumor cell debris is a new thera
53 chromatin immunoprecipitation sequencing for endogenous CLOCK in adult neocortices and RNA sequencing
54 selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpens
55 rofibrotic responses of uremic leukocytes to endogenous components present in the PDE of noninfected
56 s very close to linear, allowing the unknown endogenous concentration to be estimated using a numeric
57 ategies activated by Nrf2, we also highlight endogenous coping responses that might be therapeuticall
59 ber responds to a suite of environmental and endogenous cues that regulate flowering time in C. hirsu
61 ceptor dimer pairings that are not formed by endogenous cytokines and that are not found in nature, a
63 and islet cell function, we analyzed how an endogenous deletion mutant affected Pdx1 expression embr
64 contribution of dynein to the motility of an endogenous dendritic cargo and found that dynein inhibit
65 ibitory controls (DNIC) are a unique form of endogenous descending inhibitory pathway since they can
67 e, and light, provide an excellent source of endogenous DNA (15-46%) of sufficient quality for whole-
71 ancer cells promotes survival by suppressing endogenous DNA damage, and may control cell fate through
72 or abasic sites, which are a common type of endogenous DNA damage, can forge interstrand DNA-DNA cro
76 serum desmosine, which is a linked marker of endogenous elastin degradation, are possible biomarkers
81 Such proteolysis is carried out either by endogenous enzymes in ripened foods or by the combined a
82 ulture, both Nanobodies were able to inhibit endogenous EphA4-mediated growth-cone collapse induced b
88 ompared with the amount of adducts formed by endogenous FA, raising the possibility that epigenetic m
92 enerate a strain with hTau inserted into the endogenous fly tau locus and expressed under the control
93 locus and expressed under the control of the endogenous fly tau promoter, thus avoiding potential tox
94 and myeloperoxidation, it is unclear whether endogenous formaldehyde can initiate and/or promote dise
95 n of two mature TrkC-miR2 isomiRs, and their endogenous forms were detected in human cell lines as we
96 opoiesis-specific Fh1 deletion (resulting in endogenous fumarate accumulation and a genetic TCA cycle
97 to demonstrate that expression of either the endogenous fusion protein or a chimeric cDNA leads to th
100 Collectively, these results suggest that endogenous GDNF plays an important role in regulating th
101 dies illustrate the genetic influence of the endogenous gene and HLA haplotype on the outcome of gene
102 chnology is, in principle, applicable to any endogenous gene, allowing direct determination of both e
103 Integration of a transgene can disrupt an endogenous gene, potentially interfering with interpreta
110 rrent study determined whether disruption of endogenous glucocorticoid signaling in chondrocytes also
112 n that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more se
114 vestigated glucose-6-phosphatase-independent endogenous glucose production in hepatocytes isolated fr
118 we reversed MA preference/taking by lowering endogenous glutamate and/or Homer2 expression within thi
120 ing phenotype was recapitulated by elevating endogenous glutamate within the NAC shell of mice and we
123 uced and delivered VirE2 protein can use the endogenous host ER/actin network for movement inside hos
124 stion, including microbial interactions with endogenous host glycans and the importance of microbial
127 e thioredoxin system that increase levels of endogenous hydrogen peroxide in the yeast Saccharomyces
134 tigens in a fashion that potently stimulates endogenous immune responses against those antigens.
137 emonstrate the use of CRISPR-Cas9 to edit an endogenous insect cell gene and alter protein glycosylat
138 file in CT-induced intestinal Th17 cells and endogenous intestinal Th17 cells at homeostasis, with up
139 OE) rice plants grown on soil contain higher endogenous iron concentration than wild-type plants in b
140 ific recruitment of an approximately 600-kDa endogenous isoform of Nesprin1 (Nes1(600kDa)) and of Sun
141 JH receptor function, we have recapitulated endogenous JH receptor expression with single cell resol
143 probe 2 (XO44) covalently modified up to 133 endogenous kinases, efficiently competing with high intr
144 white and brown preadipocytes, we show that endogenous KLF4 and Krox20 are dispensable for adipogene
145 However, it has remained unclear whether endogenous KLF4 and Krox20 are required for adipogenesis
146 n this study, we analyzed the requirement of endogenous Kras to maintain survival of murine PDAC cell
147 ever, extrapolation of the transgene data to endogenous L1s suggests that it is unlikely insertional
150 Recently, we demonstrated that enhancing endogenous levels of kynurenic acid (KYNA, a neuroinhibi
151 increase in puncta of LC3(+) autophagosomes, endogenous levels of LC3-II, and ultrastructural charact
152 viors, ovarian cancer cells that express low endogenous levels of MT1-MMP were engineered to express
153 We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset
154 ne mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay imp
155 er the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydro
158 r (UT) and differentiates the effects of the endogenous ligands urotensin II (UII) and urotensin II-r
161 lve the induction of double-strand breaks at endogenous loci followed by the identification of breakp
162 mutation in the heterozygous state from its endogenous locus, we here report that mutant Pik3ca indu
163 tent HIV-1 promoter phenotypically resembles endogenous long terminal repeat (LTR) sequences, pointin
165 ght the importance of choosing cells lacking endogenous MA channels to assay the mechanotransduction
166 nisms of functional interactions between the endogenous mammalian prototoxin, lynx1, and alpha3- and
167 ptor C-type 1 (MR), which functions to clear endogenous mannosylated proteins, a principle used to en
168 the nucleus, decreased co-localization with endogenous Matrin 3 and increased co-localization with s
171 c compounds and might thus have a role as an endogenous mediator in the resolution of inflammation.
172 tors (SPMs), identified in recent years, are endogenous mediators that include the n-3-derived famili
173 partially restored by inhibiting cep-1/p53, endogenous meiotic double strand breaks, or the expressi
176 have shown that sphingosine 1-phosphate, an endogenous microglial signaling mediator that inhibits H
178 rough production of "alarmins." Alarmins are endogenous molecules secreted from cells undergoing nonp
179 knowledge, this is the first report showing endogenous monitoring of alpha-SYN transcription, thus m
184 d a host mechanism of protection by inducing endogenous neuraminidase activity, which accelerated the
186 ed 146 competitive OCT1 ligands, of which an endogenous neurotoxin, 1-benzyl-1,2,3,4-tetrahydroisoqui
189 nt contextual cues by what is necessarily an endogenous, not yet well understood, neural process.
190 1 circuit function through the impairment of endogenous NPY release, potentially contributing to heig
191 injected into the NTS to examine the role of endogenous NTS GLP-1R signaling in energy balance contro
192 45 residues of FOG1 to dCas9 to recruit the endogenous nucleosome remodeling and deacetylase complex
194 hat is a physiologically relevant target for endogenous opioid neurotransmitters and analgesics, has
199 rticularly suited to probe the metabolism of endogenous or exogenous secondary metabolites and facili
203 sal breast cancer cell lines with pronounced endogenous overexpression of TRPV4, MDA-MB-468 and HCC15
205 XT concentrations, suggesting that increased endogenous OXT secretion may underlie this improvement.
207 gene therapy combining complete knockdown of endogenous PABPN1 and its replacement by a wild-type PAB
208 rter system and performed glycoproteomics on endogenous parasite glycoproteins using sequential endog
209 ods, we discovered a previously unrecognized endogenous pathway in HEK-293 cells whereby beta2AR acti
211 on potential-gated technology is amenable to endogenous peptides and has been successfully demonstrat
212 e class I, DP(84Gly) constitutively presents endogenous peptides processed by the proteasome and tran
215 y phosphorylated by LRRK2, with evidence for endogenous phosphorylation for ten of them (Rab3A/B/C/D,
222 e site, thus impeding its proteolysis of the endogenous protein substrate, synaptosomal-associated pr
223 s unclear precisely how macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) ac
224 reveal a unique molecular code that defines endogenous proteins as inflammatory stimuli by marking t
226 es the skin barrier integrity by stimulating endogenous proteolytic activity and defines a previously
227 motivation, and food-seeking, while blocking endogenous PVT GLP-1R signaling increased meal size and
229 ad a significant inhibitory influence on the endogenous rate of aerobic or anaerobic microbial respir
230 d after MWCNT exposure, and mice lacking the endogenous receptor CD36 were protected from the neuroin
232 ociated SNP rs12142375-and demonstrate their endogenous regulatory activities on expression of ATF7IP
237 from the LTR retrotransposons of ERV-9 human endogenous retrovirus activated transcription of key ery
238 Our study reveals that upregulation of the endogenous retrovirus HERV-K could both initiate and sus
240 ow they do, and/or did, replicate.IMPORTANCE Endogenous retroviruses are relics of ancestral virus in
242 AXX-SETDB1-KAP1-HDAC1 complex that represses endogenous retroviruses independently of ATRX and H3.3 i
243 retroviruses on HIV-1 replication.IMPORTANCE Endogenous retroviruses inhabit big portions of our geno
244 find that the repression of specific murine endogenous retroviruses is dependent on DAXX, but not on
245 way for further studies on the influence of endogenous retroviruses on HIV-1 replication.IMPORTANCE
248 C for high-contrast and real-time imaging of endogenous RNA molecules in living mammalian cells.
251 her, our study provides direct evidence that endogenous Rspo2 and Rspo3 chromosome rearrangements can
253 rticle carriers by leveraging the long-lived endogenous serum protein albumin as an siRNA carrier.
256 in capillary isoelectric focusing to resolve endogenous signaling transducers and isoforms along vasc
257 1 (PDR1 OE) to investigate whether increased endogenous SL transport is sufficient to improve plant n
258 ed that AtlsiRNA-1, a bacteria-induced plant endogenous small interfering RNA, silences the AtRAP gen
260 terstrand crosslinks (ICLs) are generated by endogenous sources and chemotherapeutics, and pose a thr
261 we review recent studies that shed light on endogenous sources of mutation and epigenomic features t
263 Our findings provide evidence that targeting endogenous spatiotemporal dynamics is a potential therap
265 e underway to engineer viruses to respond to endogenous stimuli in new ways as well as to exogenous s
267 logical advancement enables determination of endogenous SUMOylated proteins under completely native c
268 r alpha-induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activation, and we found t
269 her, these findings identify CIB2 as a novel endogenous suppressor of SK1 signaling and potential pro
272 e, we report that silencing or inhibition of endogenous TAK1 in hepatoma cell lines leads to an upreg
273 ignificantly reduced expression of Axin2, an endogenous target of canonical Wnt signaling, in the dev
275 cific cytotoxicity and near-complete lack of endogenous TCR Vbeta expression, consistent with allelic
277 es, we observed the C35S TRX mutant bound to endogenous TG2 as its principal protein partner in the s
280 both alpha- and beta-cells become targets of endogenous TH signaling during the larval-to-juvenile tr
281 ravascular thrombosis by exhibiting a strong endogenous thrombin-generation capacity that relied on t
282 alpha-synuclein in neuroblastoma cells, and endogenous THSer(P)-31 was detected in VMAT2- and alpha-
289 hat it was possible to enrich the body's own endogenous Tregs by locally delivering a specific combin
290 stigate whether such a mechanism could be an endogenous trigger for autoimmunity, we examined the imp
292 ich the substitution of 2 amino acids of the endogenous TTP protein renders it constitutively active
294 lular tryptophan, FICZ represents a de facto endogenous UVA photosensitiser in sun-exposed skin.
297 but owing to the discovery of their ancient endogenous viral counterparts, their early history is be
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