ライフサイエンスコーパス: endoglin

1 ounding endocardium (Cx40(-), VEGFR2(-), and endoglin(+)).

2 nase 14 (MMP-14) as the cleavage protease of endoglin.

3 is an essential receptor in angiogenesis, or endoglin.

4 signaling can compensate for the absence of endoglin.

5 tor studies showed no involvement of ALK5 or endoglin.

6 Z binding motif in the cytoplasmic domain of endoglin.

7 ith GIPC-promoting cell surface retention of endoglin.

8 evel for accessory molecules beta-glycan and endoglin.

9 l specific TGF-beta superfamily co-receptor, endoglin.

10 roduced similar effects to the inhibition of endoglin.

11 marker expression similar to that seen with endoglin.

12 in hemangioblast frequency in the absence of endoglin.

13 ugh the direct transcriptional regulation of Endoglin.

14 ants was clearly enhanced in the presence of endoglin.

15 interact, and that each also interacts with endoglin.

16 increased motility was inhibited by soluble endoglin.

17 Interestingly, Src phosphorylation of endoglin-(612)YIY(614) was also an important process for

18 ngineering multiple tumor models deprived of endoglin, a co-receptor for TGF-beta in endothelial cell

19 factor beta (TGF-beta) type I receptor, and endoglin, a TGF-beta co-receptor, play an essential role

20 -like tyrosine kinase receptor 1 and soluble endoglin, a TGF-beta signaling inhibitor, we investigate

21 cyte migration by regulating the function of endoglin, a TGF-beta1 accessory receptor.

22 Endoglin, a transforming growth factor-beta co-receptor,

23 We previously demonstrated that endoglin, a type III transforming growth factor beta (TG

24 Here we demonstrate that endoglin abrogates TGFbeta-mediated cell motility, but d

25 TRC105, along with several other endoglin Abs tested, enhance endoglin shedding through d

26 avage substrates tissue transglutaminase and endoglin accompanied MMP-14 suppression.

27 merous vascular conditions, the mechanism of endoglin action remains poorly understood.

28 ncer progression; furthermore, they show how endoglin acts to support the viability of tumor-infiltra

29 The importance of endoglin, ALK-1, and ALK-5 in endothelial biology is und

30 ar diseases both support essential roles for endoglin, ALK-1, and ALK-5 in the vasculature.

31 Blocking of endoglin-ALK1-SMAD1/5 might be a good candidate for ther

32 n increase Smad1/5/8 signalling by promoting endoglin/ALK1 cell surface complex formation.

33 Here, we report that endoglin also plays an important role early in developme

34 Here we identified endoglin, an EC-specific TGF-beta co-receptor essential

35 Mutations in endoglin and activin-like kinase receptor 1 (ALK1) cause

36 ation via the TGF-beta superfamily receptors endoglin and activin-like kinase-1 (ALK1).

37 RNA knockdown of endoglin and ALK1 impaired SDF1/CXCR4 regulation by BMP9

38 remodeling, acting via the HHT target genes, endoglin and ALK1.

39 Although prior studies indicated that endoglin and Alk5 were not directly involved in epitheli

40 ition of pericyte migration was dependent on endoglin and alphaV integrin.

41 l therapeutics to reduce circulating soluble endoglin and ameliorate the clinical features of severe

42 oglin internalization and co-accumulation of endoglin and beta-arrestin2 in endocytic vesicles.

43 demonstrate the specific interaction between endoglin and beta-arrestin2 in endothelial cells, enhanc

44 ities of biologically active STBM associated endoglin and Flt-1/sFlt-1 could contribute to the increa

45 missing for the endothelial cell coreceptor endoglin and for the ALK1 type I receptor, which enables

46 Here we report a novel mechanism in which endoglin and Galpha-interacting protein C-terminus-inter

47 h demonstrate a specific interaction between endoglin and GIPC in endothelial cells, mediated by a cl

48 studies define a novel non-Smad function for endoglin and GIPC in regulating endothelial cell functio

49 Here we describe a novel interaction between endoglin and GIPC, a scaffolding protein known to regula

50 hing mammosphere-initiating cells, including endoglin and prion protein, will facilitate the elucidat

51 SPARC interacted directly with endoglin and reduced endoglin interaction with alphaV in

52 Placental growth factor increased, whereas endoglin and soluble vascular endothelial growth factor

53 endoglin shedding through direct coupling of endoglin and the membrane-type 1 matrix metalloproteinas

54 Here we define a novel interaction between endoglin and the scaffolding protein beta-arrestin2.

55 We established that endoglin and type II receptors bind to overlapping sites

56 In this project, the redundancy between endoglin and vascular endothelial growth factor (VEGF) s

57 Moreover, combined targeting of the endoglin and VEGF pathway, with the VEGF receptor kinase

58 These studies define a novel function for endoglin, and further expand the roles mediated by the u

59 ncluding VE-cadherin, von Willebrand factor, endoglin, and intercellular adhesion molecule-2.

60 ptor type 2, activin receptor-like kinase 1, endoglin, and mothers against decapentaplegic 9.

61 rmed expression of alpha(v)beta(3) integrin, endoglin, and VEGFR2 on tumor vascular endothelial cells

62 pression levels of alpha(v)beta(3) integrin, endoglin, and VEGFR2, which vary during tumor growth in

63 l EC-restricted genes including VE-cadherin, endoglin, and von Willebrand factor, and a negative regu

64 on either Smad 2/3 or Smad 1/5/8 activation, endoglin antagonized TGF-beta-mediated ERK signaling, al

65 detect angiogenesis using anti-VEGF and anti-endoglin (anti-CD105) and activated glial cells (anti-gl

66 of action of TRC105, an anti-angiogenic anti-Endoglin antibody currently evaluated in clinical trials

67 These data show that both Alk5 and endoglin are directly involved in the process of EMT, th

68 Our results identify endoglin as a critical component of TGFbeta1 signaling i

69 Taken together, these results establish endoglin as a critical mediator of autophagy and demonst

70 h factor, placenta growth factor, or soluble endoglin as assessed by ELISA.

71 luble fms-like tyrosine kinase-1 and soluble endoglin, as assessed by enzyme-linked immunosorbent ass

72 It does so by activating ALK2-Smad1 endoglin-associated signaling.

73 ng platform detects as few as 1000 copies of endoglin at concentrations as low as 83 fM with high det

74 e cardiac fibroblast and show that targeting endoglin attenuates cardiac fibrosis, thereby providing

75 The endoglin/beta-arrestin2 interaction results in endoglin

76 Alk5 and endoglin both mediate endothelial cell proliferation in

77 mapping analysis of the different domains of endoglin by examining their contributions to the selecti

78 have shown that the extracellular domain of endoglin can be cleaved and released into the circulatio

79 profiles demonstrated that low expression of endoglin (CD105) correlated with a subgroup of adipose-d

80 Endoglin (CD105) is an endothelial-specific transforming

81 Our array data suggested that endoglin (CD105) mRNA is significantly upregulated in HC

82 Endoglin (CD105), a receptor of the transforming growth

83 Endoglin (CD105), a transmembrane protein of the transfo

84 ing is modulated by the TGF-beta co-receptor endoglin (CD105).

85 nvolved in inflammation, strongly adhered to endoglin-coated plates and to endoglin-expressing endoth

86 was localized to the orphan domain of human endoglin composed of the amino acid sequence 26-359.

87 ese findings provide the first evidence that endoglin decreases PCa cell motility through activation

88 Moreover, the data suggest that endoglin deficiency impaired SDF1 expression in endothel

89 cient to restore a low-motility phenotype in endoglin deficient cells.

90 , genistein was shown to induce reversion of endoglin-deficient cells to a low motility, endoglin-rep

91 Tumors from endoglin-deficient mice adapted to the weakened angiogen

92 during the response to hindlimb ischemia, in endoglin-deficient mice.

93 on to a low-motility phenotype in aggressive endoglin-deficient PCa cells.

94 teins (IGFBP) in the conditioned medium from endoglin-deficient PrSCs and that endoglin-dependent reg

95 This endoglin-dependent adhesion was abolished by soluble end

96 nalling to focal adhesion kinase (FAK) in an endoglin-dependent manner.

97 d increased endothelial cell migration in an endoglin-dependent manner.

98 addressed this question by investigation of endoglin-dependent prostate cancer progression in a TRAM

99 edium from endoglin-deficient PrSCs and that endoglin-dependent regulation of IGFBP-4 secretion was c

100 Whereas endoglin did not have a direct impact on either Smad 2/3

101 ymerizing ZP proteins such as betaglycan and endoglin do not contain this cleavage site.

102 Other ZP proteins (namely, betaglycan and endoglin) do not polymerize but serve as important membr

103 Unlike endothelial cells, endoglin does not modulate Smad-mediated TGF-beta signal

104 in physiology and disease, the mechanism of endoglin down-regulation remains unknown.

105 ontrast, in the presence of activated ErbB2, endoglin downregulation in MCF10A cells leads to enhance

106 Endoglin downregulation in non-tumorigenic MCF10A breast

107 Although endoglin dysfunction contributes to numerous vascular co

108 ndings indicate an important role of soluble endoglin ECD in the regulation of angiogenesis and highl

109 Finally, murine endoglin ECD-Fc acted as an anti-angiogenic factor that

110 ane assay, the mouse and the truncated human endoglin ECD-Fc both significantly reduced VEGF-induced

111 We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with h

112 A number of endoglin ectodomain-targeting antibodies (Abs) can effec

113 lts show, for the first time, that targeting endoglin, either with neutralizing antibodies or a ligan

114 determine vesicle size, purity and Flt-1 and endoglin (Eng) expression.

115 d specific promoter/enhancer combinations of Endoglin (ENG) have been shown to target blood and endot

116 Endoglin (ENG), a co-receptor for several TGFbeta-family

117 Here, we show that endoglin (Eng), a receptor for the TGFbeta superfamily,

118 Endoglin (Eng), an accessory receptor for the transformi

119 Endoglin (ENG), an ancillary receptor for several member

120 matrix metalloproteinase-2 (MMP-2), MMP-14, endoglin (ENG), and superoxide dismutase 3 in ascending

121 amily, activin-like kinase-type 1 (ALK1) and endoglin (ENG), which are associated with hereditary hem

122 Wnt signalling pathways are integrated in an endoglin (Eng)-dependent manner in cardiac and haematopo

123 strate that the TGFbeta auxiliary coreceptor endoglin (eng, CD105) is expressed in a subset of neural

124 h the RGD-containing extracellular domain of endoglin, enhanced leukocyte transmigration, and this in

125 Endoglin enhances ALK1-SMAD1/5 signaling in different ce

126 Nevertheless, tumors deprived of endoglin exhibited a delayed onset of resistance to anti

127 gly adhered to endoglin-coated plates and to endoglin-expressing endothelial cells.

128 support the notion that individuals with low endoglin-expressing PCa will benefit from genistein trea

129 We further identified that reduced endoglin expression attenuates cardiac fibrosis, preserv

130 omal cells (PrSC) confirmed that suppressing endoglin expression decreased cell proliferation, the ab

131 e cohort of invasive breast cancers, lack of endoglin expression in the tumor cell compartment correl

132 We first report that endoglin expression is increased in the left ventricle o

133 We hypothesized that reduced endoglin expression may limit cardiac fibrosis in heart

134 We here show that loss of endoglin expression mediated by either antisense DNA or

135 In this study, we have observed increased endoglin expression on the cell surface of an HCV core-e

136 We have observed endoglin expression on the HCV core-expressing cell surf

137 We identified endoglin expression on the majority of blasts from patie

138 emonstrated significantly (P </= .04) higher endoglin expression than both alpha(v)beta(3) integrin a

139 and tumor induced angiogenesis (by means of Endoglin expression).

140 nfirm these data, we assessed the effects of endoglin-Fc (an endoglin ligand trap) on metastasis form

141 on of angiogenesis and highlight efficacy of endoglin-Fc as a potential anti-angiogenesis therapeutic

142 reatment with TRC105 in the resection model, endoglin-Fc-expressing tumors showed strong inhibition o

143 ressed on endothelial cells were identified: endoglin, Fms-like tyrosine kinase-3 ligand, EGF-like re

144 alpha5beta1 integrin and endoglin form a complex on the cell surface and co-inter

145 al-specific TGF-beta superfamily coreceptor, endoglin, form a heteromeric complex and bind similar TG

146 er photobleaching (FRAP) to demonstrate that endoglin forms stable homodimers that function as a scaf

147 trasensitive detection and quantification of endoglin from unprocessed human urine samples using a gi

148 le-1 (PECAM-1), CD144/VE-cadherin, and CD106/Endoglin, from vascular endothelial cells.

149 Several agents that interfere with ALK1 and endoglin function are currently in clinical trials for a

150 nstrate that GIPC is a critical component of endoglin function during developmental angiogenesis in v

151 However the mechanism by which endoglin functions at this early developmental stage is

152 xtracellular domain (ECD) of mouse and human endoglin fused to an immunoglobulin Fc domain.

153 ereas bone morphogenetic protein-9 enhances, endoglin/GIPC-mediated membrane scaffolding of PI3K and

154 Endoglin has been identified as an important suppressor

155 This function was tested in endoglin heterozygous mice (Eng(+/-)) and their wild-typ

156 enetic protein receptor genes, ENG, encoding endoglin (HHT1), or ACVRL1 encoding ALK1 (HHT2), and con

157 aryocytic maturation, and the CD150(+)CD9(lo)endoglin(hi) fraction, which contains erythroid lineage-

158 Additionally, we observed upregulation of endoglin/ID1 mRNA expression in chronic HCV patient live

159 , an increase in alphaV integrins present in endoglin immunoprecipitates, and enhanced alphaV integri

160 s and point to a role for BMP9 signaling via endoglin in a switch from an SDF1-responsive autocrine p

161 together, these findings point to a role for endoglin in both hemangioblast specification and hematop

162 a activity and identify a novel function for endoglin in controlling pericyte behavior.

163 time points, further supports a function for endoglin in early hematopoiesis.

164 pericyte migration, aberrant association of endoglin in focal complexes, an increase in alphaV integ

165 used recruitment of ALK1 into a complex with endoglin in human umbilical vein endothelial cells (HUVE

166 stent with these data, ectopic expression of endoglin in MDA-MB-231 cells blocks TGF-beta-enhanced ce

167 Expression of endoglin in NCSCs declined with age, coinciding with a r

168 stablish the pathophysiologic involvement of endoglin in prostate cancer progression; furthermore, th

169 dings demonstrate a cell autonomous role for endoglin in smooth muscle cell specification contributin

170 Overexpression of endoglin in the neural crest caused pericardial hemorrha

171 at MMP-14 is the likely cleavage protease of endoglin in the setting of preeclampsia.

172 ine CXCL12, suggesting a regulatory role for endoglin in transendothelial leukocyte trafficking.

173 The mechanism by which endoglin inhibits PCa cell motility is unknown.

174 transforming growth factor-beta co-receptor Endoglin inhibits the migration of prostate and breast c

175 nteracted directly with endoglin and reduced endoglin interaction with alphaV integrin.

176 onstrate for the first time that endothelial endoglin interacts with leukocyte integrin alpha5beta1 v

177 We demonstrate that endoglin interacts with the PI3K subunits p110alpha and

178 doglin/beta-arrestin2 interaction results in endoglin internalization and co-accumulation of endoglin

179 directly phosphorylates this motif to induce endoglin internalization and degradation via the lysosom

180 ed BMP9-dependent recruitment of co-receptor endoglin into this angiogenesis-mediating signaling comp

181 Endoglin is a co-receptor predominantly expressed in end

182 Membrane-associated endoglin is a coreceptor for TGFbeta1 signaling and has

183 Endoglin is a transforming growth factor beta (TGF-beta)

184 Endoglin is a transforming growth factor beta (TGF-beta)

185 Endoglin is a transforming growth factor beta (TGFbeta)

186 Endoglin is an accessory receptor for TGF-beta that has

187 Endoglin is an accessory receptor for TGFbeta and can as

188 Soluble endoglin is an anti-angiogenic protein that is released

189 Human endoglin is an RGD-containing transmembrane glycoprotein

190 Therefore, targeting endoglin is currently being explored in clinical trials

191 Although endoglin is essential for angiogenesis and its expressio

192 Here we demonstrate that endoglin is expressed in a subset of invasive breast can

193 However, the mechanism of action of endoglin is not well defined.

194 Endoglin is part of the TGF-beta receptor complex and ha

195 The mechanism through which soluble endoglin is released from the placenta is currently unkn

196 jects with heart failure and determined that endoglin is required for TGFbeta1 signaling in human car

197 Furthermore, the S-endoglin/L-endoglin mRNA expression ratio was significan

198 and eng(+/+) ES cells revealed that lack of endoglin leads to profound reductions in the levels of k

199 luble fms-like tyrosine kinase-1 and soluble endoglin levels and restored fetal growth in mice that w

200 ts with GM6001 decreased circulating soluble endoglin levels in mouse serum (P </= 0.05).

201 The results reveal that endoglin levels in urine have the potential to predict f

202 weeks through 20 weeks of gestation, soluble endoglin levels were significantly higher in women in wh

203 , we assessed the effects of endoglin-Fc (an endoglin ligand trap) on metastasis formation.

204 We now demonstrate that soluble endoglin limits TGFbeta1 signaling and type I collagen s

205 -megakaryocyte progenitor and CD150(+)CD9(hi)endoglin(lo) cells are TPO-responsive and that the latte

206 te progenitor population, the CD150(+)CD9(lo)endoglin(lo) fraction of Lin(-)cKit(+)IL7 receptor alpha

207 fraction is distinct from the CD150(+)CD9(hi)endoglin(lo) fraction, which contains bipotential precur

208 is therefore important to determine whether endoglin loss affects genistein's efficacy and, if so, b

209 luble fms-like tyrosine kinase 1 and soluble endoglin, markers thought to be related to the disease.

210 more, cell-sorting experiments revealed that endoglin marks the hemangioblast on day 3 of EB differen

211 hree types of targeted MBs (MB(Integrin), MB(Endoglin), MB(VEGFR2)) was tested in cell culture under

212 SPARC deficiency resulted in endoglin-mediated blockade of pericyte migration, aberra

213 of ALK2, but not TGFbetaRI (ALK5), abrogated endoglin-mediated decreases in cell motility and constit

214 Functionally, endoglin-mediated fibronectin/alpha5beta1 integrin and T

215 at both BMPRII and ActRIIA are necessary for endoglin-mediated suppression of human PCa cell invasion

216 Endoglin-mediated suppression of invasion was also shown

217 o type II TGFbeta receptors are required for endoglin-mediated suppression of invasion: activin A rec

218 However, the mechanism by which endoglin mediates TGF-beta signaling through ALK-1 and A

219 Endoglin modulates the crucial balance between pro- and

220 Furthermore, the S-endoglin/L-endoglin mRNA expression ratio was significantly lower i

221 ut not a threonine phosphorylation-defective endoglin mutant blocked cell detachment and the antiprol

222 ted that only NCSC expressing high levels of endoglin (NCSC(CD105+)) had myogenic differentiation pot

223 In vitro TRC105, an endoglin-neutralizing antibody, increased VEGF signaling

224 n younger explants but, by stage 16, loss of endoglin no longer alters proliferation rates.

225 tential was deficient in NCSCs obtained from endoglin null embryos.

226 tors, TbetaRII preferentially phosphorylated endoglin on cytosolic domain serine residues Ser(634) an

227 ive (ca)ALK1, but not caALK5, phosphorylated endoglin on cytosolic domain threonine residues.

228 ase 1 (ALK1), type II receptors, co-receptor endoglin, or to mature BMP9 domain targeting antibodies

229 Moreover, we demonstrate that Endoglin overexpression abrogates the increased migratio

230 th treatments produced a decrease in soluble endoglin (P </= 0.05).

231 d lower serum PlGF (P=0.003), higher soluble endoglin (P=0.006), and higher sFlt-1:PlGF ratio (P=0.00

232 Evaluation of the endoglin pathway suggested that enhanced osteogenesis am

233 Finally, administration of an endoglin peptide containing the consensus matrix metallo

234 horylation in HUVECs and indicate a role for endoglin phosphorylation in the regulation of endothelia

235 lation, suggesting a sequential mechanism of endoglin phosphorylation.

236 ic expression of HCV core protein.IMPORTANCE Endoglin plays a crucial role in fibrogenesis and angiog

237 Endoglin plays a key role in angiogenesis by modulating

238 Here we show that PRH can bind to the Endoglin promoter in immortalised prostate and breast ce

239 Overall, endoglin promotes autophagy by impeding Smad2 transcript

240 EMT) in the heart, the expression pattern of endoglin prompted a re-examination.

241 pression in these cells results in increased Endoglin protein expression, whereas PRH knockdown resul

242 , whereas PRH knockdown results in decreased Endoglin protein expression.

243 19, P=0.02); at 18 to 25 weeks, with soluble endoglin (r=0.18, P=0.02); and at 26 to 33 weeks, with s

244 satility index correlated with serum soluble endoglin (r=0.19, P=0.02) and sFlt-1 levels (r=0.17, P=0

245 llular distribution studies demonstrate that endoglin recruits GIPC to the plasma membrane and co-loc

246 We propose that endoglin regulates primitive hematopoiesis by modulating

247 tion of BrdU incorporation shows that, while endoglin regulates proliferation at an early stage, redu

248 s also the mechanism responsible for soluble endoglin release in preeclampsia, we investigated the ex

249 and the effects of its inhibition on soluble endoglin release.

250 endoglin-deficient cells to a low motility, endoglin-replete phenotype.

251 Mutations in endoglin result in the vascular defect known as heredita

252 odels of cancer revealed that deficiency for endoglin resulted in a tumor vasculature that displayed

253 -dependent adhesion was abolished by soluble endoglin, RGD peptides, the anti-integrin alpha5beta1 in

254 wn of Smad1 increased motility and abrogated endoglin's effects.

255 Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the

256 wth factor receptor-1 [VEGFR-1]) and soluble endoglin (sEng) are elevated in preeclampsia, and their

257 A soluble form of endoglin (sEng) has been shown to cause endothelial dysf

258 pregnancy-specific syndrome in which soluble endoglin (sEng) is a prognostic marker and plays a patho

259 of this study was to compare plasma soluble endoglin (sEng) levels with standard clinical evaluation

260 e circulating antiangiogenic factor, soluble endoglin (sEng), is elevated in the blood circulation of

261 o release the antiangiogenic factor, soluble endoglin (sEng).

262 Collectively, our study defines endoglin shedding and deregulated TGF-beta signaling dur

263 In addition to this coupling process, endoglin shedding is further amplified by increased MMP-

264 h several other endoglin Abs tested, enhance endoglin shedding through direct coupling of endoglin an

265 In patient samples, increased endoglin signaling after VEGF inhibition was observed.

266 fine a novel mechanism for the regulation of endoglin signaling and function in endothelial cells and

267 ion by HCV core protein was dependent on the endoglin signaling pathway using activin receptor-like k

268 c response, and refractoriness to diminished endoglin signaling was accompanied by increased metastat

269 oding activin receptor-like kinase 1 (ALK1), endoglin, Smad4, and bone morphogenetic protein 9 (BMP9)

270 like kinase 1 (ALK1) Fc blocking peptide and endoglin small interfering RNA (siRNA).

271 Endoglin specifically enhanced TGF-beta1-induced phospho

272 angiogenic mitogens as critical mediators of endoglin stability and function.

273 Because endoglin suppresses PCa cell motility in an activin-like

274 on Smad activation, but were associated with endoglin suppression and accentuated expression of bone

275 or down-regulation by TRACON105 (TRC105), an endoglin-targeting antibody currently in clinical trials

276 1 is a preferred TGFbeta receptor kinase for endoglin threonine phosphorylation in HUVECs and indicat

277 of cell surface markers, including CD105 (or endoglin), Thy1 [or CD90 (cluster of differentiation 90)

278 loy the first transgenic zebrafish model for endoglin to demonstrate that GIPC is a critical componen

279 tion in a manner dependent on the ability of endoglin to interact with beta-arrestin2.

280 tion in a manner dependent on the ability of endoglin to interact with GIPC.

281 dothelial phenotype (Cx40(+), VEGFR2(+), and endoglin(-)) to the surrounding endocardium (Cx40(-), VE

282 te transmigration through cell monolayers of endoglin transfectants was clearly enhanced in the prese

283 ac fibroblasts and further show that soluble endoglin treatment attenuates cardiac fibrosis in an in

284 factor (VEGF) as Src-activators that induce endoglin turnover following (612)YIY(614) phosphorylatio

285 ogical activity of STBM associated Flt-1 and endoglin was assessed by the ability of VEGF, PlGF and T

286 ocarcinoma mouse prostate) mouse model where endoglin was genetically deleted.

287 In this model, endoglin was haploinsufficient such that its allelic del

288 ation and Smad-responsive promoter activity, endoglin was shown to constitutively activate Smad1, wit

289 Soluble endoglin was strongly correlated with sFlt1 and PlGF lev

290 The soluble form of endoglin was suggested to contribute to the pathogenesis

291 An increased level of soluble endoglin was usually accompanied by an increased ratio o

292 trate that this interaction produces soluble endoglin, we treated trophoblastic BeWo cells with eithe

293 As Alk5 interacts with endoglin, we utilized siRNA and a specific inhibitor, HT

294 like tyrosine kinase 1 (sFlt-1), and soluble endoglin were prospectively measured in 159 women from 1

295 NFalpha) and myeloid differentiation factor (Endoglin) were increased in myeloid cells from p65 KO tu

296 and released into the circulation as soluble endoglin, which disrupts TGFbeta1 signaling in endotheli

297 directly to the TGF-beta accessory receptor endoglin, which, in the presence of TGF-beta1, results i

298 ALK1 and ALK5 bind to endoglin with differential dependence on TbetaRII, which

299 owever, the pathophysiologic significance of endoglin with respect to prostate tumorigenesis has yet

300 n interactions between endogenous MMP-14 and endoglin within the preeclamptic placenta.