ライフサイエンスコーパス: endolysosomal

1 ated protein aggregates, lipofuscinosis, and endolysosomal abnormalities.

2 urodegenerative disorder characterized by an endolysosomal accumulation of cholesterol and other lipi

3 Endolysosomal acidification and the endosomal transporte

4 betaA3/A1-crystallin is essential for normal endolysosomal acidification, and thereby, normal activat

5 ocytes restored V-ATPase activity and normal endolysosomal acidification, thereby increasing the leve

6 The resulting endolysosomal alkalization impedes macrophage antigen pr

7 ing brain homeostasis, as dysfunction of the endolysosomal and autophagic pathways has been associate

8 gnized early neuropathologic features in the endolysosomal and autophagy systems of neurons, includin

9 associated defects in RAB7L1 or LRRK2 led to endolysosomal and Golgi apparatus sorting defects and de

10 d in pigment cells, localizes exclusively to endolysosomal and melanosomal membranes unlike most G pr

11 resentation on MHC-II involve both classical endolysosomal and nonclassical cytosolic pathways.

12 is degraded by acidic thiol-proteases in the endolysosomal apparatus and then metabolized, as in mamm

13 Here, we identify an endolysosomal ATP-sensitive Na(+) channel (lysoNa(ATP)).

14 n mutations in the ATP13A2 gene encoding the endolysosomal ATPase ATP13A2.

15 ts underscore the importance of misregulated endolysosomal biogenesis in Wnt signaling and cancer.

16 us to examine the relationship between MITF, endolysosomal biogenesis, and Wnt signaling.

17 nal delivery, microvillus morphogenesis, and endolysosomal biogenesis.

18 -1-induced Ca(2+) response is abolished upon endolysosomal but not Golgi disruption.

19 omal membrane fusion involving P2X4-mediated endolysosomal Ca(2+) release and subsequent CaM activati

20 However, the molecular mechanisms for intra-endolysosomal Ca(2+) release and the downstream Ca(2+) t

21 Intra-endolysosomal Ca(2+) release is required for endolysosom

22 We propose that NAADP regulates endolysosomal Ca(2+) storage and release via TPCs and co

23 here that NAADP-mediated Ca(2+) release from endolysosomal Ca(2+) stores activates inward membrane cu

24 in A1, indicating Ca(2+) release from acidic endolysosomal Ca(2+) stores.

25 ly releases Ca(2+) from acidic intracellular endolysosomal Ca(2+) stores.

26 cellular sphingosine and subsequently caused endolysosomal calcium accumulation, which in turn led to

27 ilic drugs (CADs), this mechanism led to the endolysosomal calcium as a critical target for developme

28 s and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second me

29 radation of Ags is performed by pH-dependent endolysosomal cathepsins.

30 protein (TbMLP) orthologous to the mammalian endolysosomal cation channel Mucolipin 1.

31 colipin TRP (TRPML) proteins are a family of endolysosomal cation channels with genetically establish

32 Two-pore channels (TPCs) are endolysosomal cation channels.

33 have identified two-pore channels (TPCs) as endolysosomal channels that are regulated by NAADP; howe

34 We conclude that the endolysosomal channels TPC1 and TPC2 are essential for a

35 es, lysosomal dysfunction due to loss of the endolysosomal Cl(-) transporter ClC-b/CLCN7 delayed degr

36 hat HSP70 release involves transit though an endolysosomal compartment and is inhibited by lysosomotr

37 Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late en

38 ion and exocytosis, as well as regulation of endolysosomal compartment identity.

39 The host endolysosomal compartment is often manipulated by intrac

40 oparticles are rapidly internalized into the endolysosomal compartment of cancer cells, and exhibit a

41 artment that fuses with lysosome to form the endolysosomal compartment.

42 embrane and associated components within the endolysosomal compartment.

43 s to the Toll-like Receptor (TLR) containing endolysosomal compartment.

44 c acids by TLR9 requires its cleavage in the endolysosomal compartment.

45 MP3) and LAMP1 indicating enhancement of the endolysosomal compartment.

46 rafficking from the endoplasmic reticulum to endolysosomal compartments and its subsequent proteolyti

47 strategy to restrict receptor activation to endolysosomal compartments and prevent TLRs from respond

48 ospholipase C inhibition and alkalization of endolysosomal compartments blocked its activation by TNF

49 imiting membrane and, to a lesser extent, to endolysosomal compartments by confocal fluorescence and

50 which then prevents the acidification of the endolysosomal compartments by inhibiting vacuolar ATPase

51 ion or block the fusion of autophagosomes to endolysosomal compartments caused an increase in C99 lev

52 ring proteolytic cleavage and trafficking to endolysosomal compartments for ligand-induced signaling.

53 Membranes of endolysosomal compartments in macrophages are often dama

54 ath), that localizes to the cell surface and endolysosomal compartments in neurons.

55 Traffic through late endolysosomal compartments is regulated by sequential si

56 Dietary fat accumulates in lipid droplets or endolysosomal compartments that undergo selective expans

57 a molecular connection between the Golgi and endolysosomal compartments to enhance proliferative mTOR

58 nd monocytes, but not basophils, traffics to endolysosomal compartments under steady-state conditions

59 9 traffics from the endoplasmic reticulum to endolysosomal compartments where it is cleaved by reside

60 dly traffic these soluble peptides into late endolysosomal compartments where they are subject to deg

61 y, thereby compromising acidification of the endolysosomal compartments, leading to reduced gamma-sec

62 ke receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of

63 ran, a bulk-endocytosis marker, and with the endolysosomal compartments.

64 eceptor 9 (TLR9) recognizes microbial DNA in endolysosomal compartments.

65 ent cells, leading to GLUT1 mis-sorting into endolysosomal compartments.

66 fective exocytosis and impaired integrity of endolysosomal compartments.

67 implement a manual patch-clamp technique for endolysosomal compartments.

68 by increasing the APP/BACE-1 convergence in endolysosomal compartments.

69 rts TLRs from the early endosome to the late endolysosomal compartments.

70 e degradation of APP C-terminal fragments in endolysosomal compartments.

71 heckpoints that restrict their activation to endolysosomal compartments.

72 en 1), indicating a lack of integrity in the endolysosomal compartments.

73 asitophorous vacuole (PV) that acquires host endolysosomal components.

74 wever, the biological significance of excess endolysosomal Cu accumulation has not been assessed.

75 HIV PIs modified endolysosomal degradation and epitope production of prot

76 ecessary for their efficient endocytosis and endolysosomal degradation and present three lines of evi

77 inding and internalization as well as faster endolysosomal degradation compared with Bet v 1.

78 Endolysosomal degradation of Bet v 1 and Mal d 1 resulte

79 rface binding and the kinetics of uptake and endolysosomal degradation of Bet v 1, Api g 1, and Mal d

80 strate a novel mechanism for endocytosis and endolysosomal degradation of class I, which may be appli

81 Beclin 2 is required for ligand-induced endolysosomal degradation of several G protein-coupled r

82 al proteases (cathepsins) mitigates the fast endolysosomal degradation of the MOG40-48 core epitope.

83 lts from enhanced endocytosis and subsequent endolysosomal degradation of the target proteins.

84 aluate the possible relationship between the endolysosomal degradation pathway and autophagy on the p

85 bial virulence factors; however, the role of endolysosomal degradation pathways in these processes is

86 ays, supporting the hypothesis that impaired endolysosomal degradation underlies the pathogenesis of

87 Endolysosomal degradation was simulated in vitro by usin

88 ell-activating region, low susceptibility to endolysosomal degradation, and induction of a Bet v 1-in

89 2, interacts with KSHV GPCR, facilitates its endolysosomal degradation, and inhibits vGPCR-driven onc

90 Resulting from perturbed endolysosomal degradation, Plaa mutant neurons accumulat

91 h Dau c 1 was still detectable after 48 h of endolysosomal degradation.

92 nic effects of KSHV GPCR by facilitating its endolysosomal degradation.

93 of activated cell surface receptors via the endolysosomal degradative pathway.

94 ospholipid vesicles and gastrointestinal and endolysosomal digestions in the presence or absence of l

95 t can be turned on by redox activation after endolysosomal disruption and delivery into the cytosol,

96 nown, however, about the role of DNase II in endolysosomal DNA sensing by TLR9.

97 To identify genes governing endolysosomal dynamics, we conducted a global fluorescen

98 Our findings indicate that endolysosomal dysfunction and abnormalities of alpha-syn

99 tools to study aberrant lipid metabolism of endolysosomal dysfunction associated with AD.

100 To further explore how endolysosomal dysfunction causes PD-related neurodegener

101 st common PD-causing LRRK2 mutation, linking endolysosomal dysfunction to the pathogenesis of LRRK2-m

102 lein-independent neurotoxicity consequent to endolysosomal dysfunction.

103 lic consequences of Complex I inhibition and endolysosomal effects of imiquimod might also contribute

104 ways on" reporter and subcellular imaging of endolysosomal escape by confocal microscopy.

105 for the investigation of new strategies for endolysosomal escape of biomacromolecules to facilitate

106 render targeted in vivo delivery, efficient endolysosomal escape, and dynamic control over activatio

107 capsids before and after pH shift exhibited endolysosomal escape.

108 me that intracellular endothelin-1 activates endolysosomal ET(B) receptors and increase cytosolic Ca(

109 ndothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitric oxide formation, th

110 Both proteins were digested by endolysosomal extracts of mdDC.

111 All proteins were digested with endolysosomal extracts, and the resulting peptides were

112 y that couples the cell's metabolic state to endolysosomal function and are crucial for physical endu

113 eins involved in translation, secretion, and endolysosomal function.

114 egulator of lysosomes, leading to diminished endolysosomal function.

115 nsient, and after resealing of the membrane, endolysosomal fusion continued.

116 Secretory and endolysosomal fusion events are driven by SNAREs and cof

117 intracellular Na(+) channels able to control endolysosomal fusion, a key process in autophagic flux.

118 re not synonymous, even in the context of an endolysosomal genetic defect linked to Parkinsonism, and

119 l PI(3)P pool has separable consequences for endolysosomal homeostasis and cortical remodeling.

120 embrane influx, promote efflux, and maintain endolysosomal homeostasis.

121 Similar to TLR11, TLR12 is an endolysosomal innate immune receptor that colocalizes an

122 es and intact lysosomes and thereby preserve endolysosomal integrity.

123 Moreover, the primary endolysosomal ion is Na(+), not K(+), as had been previo

124 t exhibited rapid release in the presence of endolysosomal lipases.

125 Earlier work demonstrated that the endolysosomal lipid PI(3,5)P2 activates V-ATPases contai

126 ned from these studies that perturbations in endolysosomal, lipid metabolism, and immune response pat

127 Endolysosomal localization and cleavage of intracellular

128 the sequential recruitment of early and late endolysosomal markers to the elongating tPCs.

129 l phagocytes, macrophages are susceptible to endolysosomal membrane damage inflicted by the pathogens

130 lly control PI conversion in endocytosis and endolysosomal membrane dynamics during endosome maturati

131 te [PtdIns(3,5)P2] and for the regulation of endolysosomal membrane dynamics in mammals.

132 a thus suggest a new molecular mechanism for endolysosomal membrane fusion involving P2X4-mediated en

133 endolysosomal Ca(2+) release is required for endolysosomal membrane fusion with intracellular organel

134 ignaling through the actin cytoskeleton with endolysosomal membrane trafficking events.

135 by the CUE domain promotes Vps9 function in endolysosomal membrane trafficking via promotion of loca

136 P2X4 and calmodulin (CaM) form a complex at endolysosomal membrane where P2X4 activation recruits Ca

137 , measurement of channel currents across the endolysosomal membrane), including control experiments,

138 this paper, by direct patch-clamping of the endolysosomal membrane, we report that PI(3,5)P(2), an e

139 ciated with impaired activation of mTORC1 at endolysosomal membranes, the accumulation of the mannose

140 cies-mediated rupture of the photosensitised endolysosomal membranes, the spatio-temporal selectivity

141 Found in vacuolar or endolysosomal membranes, they regulate the conductance o

142 y the long Irgm1 isoforms can be detected on endolysosomal membranes.

143 that maintains or restores the integrity of endolysosomal membranes.

144 ivities at both the plasma membrane (PM) and endolysosomal membranes.

145 T) using a photosensitiser that localises in endolysosomal membranes.

146 o compromised retromer-mediated recycling of endolysosomal membranes.

147 lease from acidic-like Ca(2+) stores via the endolysosomal NAADP-sensitive two-pore channels.

148 on mast cells, a cell type unusually rich in endolysosomal organelles (secretory granules).

149 ught to take place at the cell surface or in endolysosomal organelles.

150 bilizing messenger that releases Ca(2+) from endolysosomal organelles.

151 l activities and characteristics in isolated endolysosomal organelles.

152 t lysosomal trafficking regulator Lyst links endolysosomal organization to the selective control of t

153 verexpression of P2X4, as well as increasing endolysosomal P2X4 activity by alkalinization of endolys

154 Previously, we demonstrated that endolysosomal P2X4 forms channels activated by luminal a

155 from WT and polymorphic variant carriers for endolysosomal patch-clamp experimentation to confirm key

156 In contrast to the alternatively used planar endolysosomal patch-clamp technique, this method is a vi

157 The development of endolysosomal patch-clamp techniques has made it possibl

158 olyubiquitination leads to degradation by an endolysosomal pathway and demonstrate a novel mechanism

159 mmals has been considered to function in the endolysosomal pathway and in the biosynthetic pathway on

160 lar NTHI avoids, escapes, or neutralizes the endolysosomal pathway and persists within human respirat

161 Chlamydial inclusions are uncoupled from the endolysosomal pathway and undergo fusion with cellular o

162 ae that regulate membrane trafficking in the endolysosomal pathway by activating Rab5 GTPases.

163 rnover of synaptic membrane proteins via the endolysosomal pathway is essential for synaptic function

164 Maturation of organelles in the endolysosomal pathway requires exchange of the early end

165 otein-(APP) cleaving enzyme (BACE1) from the endolysosomal pathway to recycling endosomes represents

166 nscriptional level by trafficking within the endolysosomal pathway where MARCH1 is proteolyzed.

167 e membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtub

168 t manner, is subsequently trafficked via the endolysosomal pathway, and is killed in lysosomes after

169 hila phagosome exists completely outside the endolysosomal pathway, and the M. tuberculosis phagosome

170 n a trafficking defect of two cargoes of the endolysosomal pathway, influenza A virus (IAV) and epide

171 its of the retromer, Rh1 is processed in the endolysosomal pathway, leading to a dramatic increase in

172 d that pffs are rapidly trafficked along the endolysosomal pathway, where most of the material remain

173 TrCP ubiquitin E3 ligase and occurred via an endolysosomal pathway.

174 pool size by enhancing SV trafficking to the endolysosomal pathway.

175 in targeted HIV-1 Gag for degradation by the endolysosomal pathway.

176 radation by lysosomes and trafficking in the endolysosomal pathway.

177 the degradation of endocytic cargoes by the endolysosomal pathway.

178 in-modified cargoes are sequestered into the endolysosomal pathway.

179 quired for trafficking and tubulation in the endolysosomal pathway.

180 digestive PVs that fully mature through the endolysosomal pathway.

181 that regulates membrane transport along the endolysosomal pathway.

182 (MHC-I) from the trans-Golgi network to the endolysosomal pathway.

183 regulate postinternalization steps along the endolysosomal pathway.

184 gned to localize within organelles along the endolysosomal pathway.

185 data identify Vps34 as a major regulator of endolysosomal pathways in podocytes and underline the fu

186 ellular protein complex implicated in TGN to endolysosomal pathways.

187 mport through transmembrane transporters and endolysosomal pathways.

188 fundamental question: are SVs sorted toward endolysosomal pathways?

189 Here we show that endolysosomal pH is critical for receptor sorting and tu

190 lls a carbohydrate epitope is generated upon endolysosomal processing of group B streptococcal type I

191 RNase-L also regulated the expression of the endolysosomal protease, cathepsin-E, and endosome-associ

192 It was also shown that altered expression of endolysosomal proteases (cathepsins) mitigates the fast

193 Here, we identify the cathepsin L/B endolysosomal proteases functioning in a direct and rate

194 Dau c 1 was incubated with endolysosomal proteases, and the resulting fragments wer

195 binding cassette transporter 2 (ABCA2) is an endolysosomal protein most highly expressed in the centr

196 These findings demonstrate that sorting of endolysosomal proteins begins at an earlier stage and in

197 r a different mechanism in which two sets of endolysosomal proteins undergo early segregation to dist

198 human two-pore channels (TPC1 and TPC2) are endolysosomal proteins, that NAADP-mediated calcium sign

199 fusion and protein transport) interact with endolysosomal Rabs to coordinate their signaling activit

200 impeding binding of the C-loop of NPC1, the endolysosomal receptor for EBOV.

201 2) ubiquitination, which leads to Galpha(i2) endolysosomal sequestration and destruction.

202 ected against proteolytic degradation by the endolysosomal serine protease cathepsin G.

203 This protection requires the vacuolar/endolysosomal signaling lipid PI3,5P2 We show that Pho85

204 eutrophil extracellular trap production, and endolysosomal signaling.

205 Endocytosis, but not endolysosomal size, contributes to cortical remodeling b

206 e used snapin mutants as tools to assess how endolysosomal sorting and trafficking impact presynaptic

207 containing protein 1 (UBXD1) cofactor during endolysosomal sorting of caveolin-1.

208 : the biogenesis of multivesicular bodies in endolysosomal sorting; the budding of HIV-1 and other vi

209 sensitive, presumably arising from different endolysosomal sources.

210 common pathogenic mechanisms associated with endolysosomal storage disorders.

211 sion has dramatic and contrasting effects on endolysosomal structures and dynamics, implicating a rol

212 PC2, but not TPC1, caused a proliferation of endolysosomal structures, dysregulating intracellular tr

213 significantly enriched for components of the endolysosomal system (>60%, P < 0.001) and included many

214 fied the two-pore channels (TPCs) within the endolysosomal system as NAADP-regulated Ca(2+) channels

215 t work has further dissected the role of the endolysosomal system in both bone formation by osteoblas

216 oles of PIs in different compartments of the endolysosomal system in mammalian cells and discuss the

217 g of plasma membrane-derived MAG through the endolysosomal system in primary cells and brain tissue.

218 In addition, Notch trafficking across the endolysosomal system is critical in its regulation.

219 tive Ca(2+)-permeable cation channels in the endolysosomal system of cells, as candidate targets for

220 Transport along the endolysosomal system requires multiple fusion events at

221 The compromised endolysosomal system resulting from AMPK or Tfeb inactiv

222 Organelles of the endolysosomal system undergo multiple fission and fusion

223 cretory compartments, catabolic steps of the endolysosomal system, and intracellular trafficking.

224 jor mechanism for mobilizing Ca(2+) from the endolysosomal system, resulting in localized Ca(2+) sign

225 hich are required for their targeting to the endolysosomal system.

226 cytes had defects in the organization of the endolysosomal system.

227 tive phenotypes of mutations that affect the endolysosomal system.

228 intracellular ion channels expressed in the endolysosomal system.

229 ficiency of downstream sorting events in the endolysosomal system.

230 +)-permeable ion channels present within the endolysosomal system.

231 release channels, which are localized on the endolysosomal system.

232 cuole is rendered nonfusogenic with the host endolysosomal system.

233 kaging into coated vesicles destined for the endolysosomal system.

234 cal roles as Ca(2+) -release channels of the endolysosomal system.

235 ce between pathogenic infection and the host endolysosomal system.

236 membrane fusion events in the secretory and endolysosomal systems, and all SNARE-mediated fusion pro

237 Here, we report a novel function of the endolysosomal T. gondii sortilin-like receptor (TgSORTLR

238 e, a class III lipid kinase, is required for endolysosomal TLR-induced expression of type I IFN in mo

239 evoked Ca(2+) release or genetic ablation of endolysosomal TPC1 or TPC2 channels attenuates glucose-

240 activity in a manner that is independent of endolysosomal trafficking and parallel to the Scribble m

241 artite regulation of presynaptic activity by endolysosomal trafficking and sorting: LE transport regu

242 tablish the importance of ubiquitin-mediated endolysosomal trafficking at the synapse.

243 Our data suggest that impaired endolysosomal trafficking in both motor neurons and Schw

244 Moreover, Fig4-regulated endolysosomal trafficking in Schwann cells is essential

245 Although endolysosomal trafficking is well defined, how it is reg

246 Pyk2 depletion resulted in altered endolysosomal trafficking of HPV16 and accelerated unfol

247 ate photoreceptor homeostasis by influencing endolysosomal trafficking of Rhodopsin and TRP.

248 role of Cul3 in regulating late steps in the endolysosomal trafficking pathway.

249 re broadly, our data suggest a role for host endolysosomal trafficking pathways in regulating viral p

250 rsity of Beclin family members in autophagy, endolysosomal trafficking, and metabolism.

251 5-bisphosphate, and plays a critical role in endolysosomal trafficking.

252 olae-mediated pathway, bypassing degradative endolysosomal trafficking.

253 IRG1, RIN3, and RUFY1 all may be involved in endolysosomal transport-a process known to be important

254 dule mutants show intact internalization and endolysosomal transport.

255 yzed and shown to have distinct functions in endolysosomal transport.

256 HC molecules themselves is not necessary for endolysosomal tubule formation.

257 Endolysosomal tubules can be stained with acidotropic dy

258 dition to its association with microtubules, endolysosomal tubules follow the plus ends of microtubul

259 Endolysosomal tubules in DCs exhibit dynamic and saltato

260 he cell surface via long tubular structures (endolysosomal tubules).

261 DCs lacking MyD88 can also form endolysosomal tubules, demonstrating that MyD88-dependen

262 Indeed, nocodazole causes the collapse of endolysosomal tubules.

263 The endolysosomal two-pore channels (TPCs), TPC1 and TPC2, h

264 lumenal pH (approximately 5) and fusion with endolysosomal vesicles, the PV is considered phagolysoso

265 internalized class I chains are delivered to endolysosomal vesicles, where they undergo degradation.

266 gs, TRPM2 expression in DCs is restricted to endolysosomal vesicles, whereas in neutrophils, the chan

267 omplex and/or localization of the complex to endolysosomal vesicles.