ライフサイエンスコーパス: endomembrane

1 f phosphatidylserine from plasma membrane to endomembrane.

2 th independently localized to the same yeast endomembrane.

3 t) was also constructed with markers for the endomembrane.

4 o recruitment and phosphorylation of eNOS at endomembranes.

5 nal and morphological integrity of the plant endomembranes.

6 ccumulates in the nucleus, chloroplasts, and endomembranes.

7 ne tubules emanating from these disorganized endomembranes.

8 rounded by a reservoir of the recruited host endomembranes.

9 contributes to dynactin's interactions with endomembranes.

10 e place of SNARE assembly and thus fusion at endomembranes.

11 dy complex and dynamic systems such as plant endomembranes.

12 d; however, less is known about transport at endomembranes.

13 uttling, G proteins constitutively reside in endomembranes.

14 mily translocate specifically from the PM to endomembranes.

15 h direct communication between receptors and endomembranes.

16 g distributions of D1R and NR1 occurred near endomembranes.

17 more rarely were associated with cytoplasmic endomembranes.

18 of Cu(+) across both the plasma membrane and endomembranes.

19 1, ULK1, and Beclin 1 in response to damaged endomembranes.

20 4,5)P2 hydrolysis with carrier biogenesis on endomembranes.

21 ein associated with both plasma membrane and endomembranes.

22 ylate mislocalized palmitoylated proteins on endomembranes.

23 t virus viability depends on functional host endomembranes.

24 targeting sequence resulted in enhanced RalB endomembrane accumulation and decreased RalB association

25 d plants expressing a PIN2GFP fusion exhibit endomembrane accumulation of PIN2GFP, but no changes in

26 we analyzed Cdc42, which concentrates in the endomembrane and has been shown to act downstream of Ras

27 and K-Ras4B from the plasma membrane to the endomembrane and inhibits their nanoclustering.

28 Microtubule-based endomembrane and organelle motility utilizing the motor

29 n each region, many neuronal profiles showed endomembrane and plasmalemmal distributions of one or bo

30 s Ras proteins to interact with Cdc42 on the endomembrane and that in order for a given Ras protein t

31 e danger receptor galectin-8 detects damaged endomembranes and activates autophagy through recruitmen

32 ains of the plasma membrane as well as other endomembranes and are capable of generating distinct sig

33 Sphingolipids are structural components of endomembranes and function through their metabolites as

34 ecific manner, underscoring the link between endomembranes and gravitropism.

35 that these pollen grains contained aberrant endomembranes and lacked an intine layer.

36 ated with cytoplasmic organelles, especially endomembranes and mitochondria, and with plasma membrane

37 eins traffic between the plasma membrane and endomembranes and signal from the cytosolic face of a va

38 ary and sufficient to remodel host actin and endomembranes and to recruit TGB2/3 to the X-body, thus

39 the combined activities of the cytoskeleton, endomembrane, and cell wall biosynthetic systems organiz

40 er, H-Ras formed a complex with Cdc42 on the endomembrane, and this interaction was enhanced when H-R

41 ylation leads to defective Ras activation on endomembranes, and may help account for impaired Erk act

42 ajor component of plant plasma membranes and endomembranes, and mediate a diverse range of biological

43 r trafficking of organelles, organization of endomembranes, and mitosis.

44 localize to the plasma membrane rather than endomembranes, and rather than hydrolyzing PPi to create

45 ER and did not cause obvious changes in the endomembrane architecture, suggesting that the vesicles

46 lying the organization and dynamics of plant endomembranes are largely unknown.

47 hing techniques, we demonstrate that fusomal endomembranes are part of a single continuous endoplasmi

48 ecruited on LC3B-positive 'autophagy-related endomembranes' (ARE).

49 h tumor necrosis factor-alpha activated only endomembrane-associated Chp.

50 ein, Rain, that may serve as an effector for endomembrane-associated Ras.

51 1) receptors localized in close proximity to endomembrane-associated trimeric G protein and adenylyl

52 ne were sufficient to promote Chp plasma and endomembrane association.

53 es the rate of phospholipid biosynthesis and endomembrane biogenesis to cell cycle progression in Ara

54 Coordination of endomembrane biogenesis with cell cycle progression is c

55 rees of altered movement of RAB2:GFP-labeled endomembrane bodies were used to generate a training set

56 way, can associate with the next enzyme, the endomembrane-bound cinnamate 4-hydroxylase (C4H), to fac

57 ven by myosin motors dragging organelles and endomembrane-bounded cargo along actin filament bundles.

58 pids and acyl chains resemble those of other endomembranes, bundle ceramide and sphingomyelin nearly

59 genic H-Ras mutant that is restricted to the endomembrane can still transform cells.

60 which myosin XI-K attaches to its principal endomembrane cargo, a yeast two-hybrid library of Arabid

61 bidopsis (Arabidopsis thaliana), a family of endomembrane cation exchangers (CAXs) transports Ca(2+)

62 ity can be controlled solely by manipulating endomembrane cation flux capacities.

63 ression enhanced recruitment of alsin to the endomembrane compartment in glial cells, suggesting that

64 st a panel of plasma membrane (PM) and other endomembrane compartment markers to identify molecules t

65 veral nucleated cells possessing an abundant endomembrane compartment.

66 e to membrane-associated functions; however, endomembrane compartmentalization and endocytosis/exocyt

67 TFL1 localizes to endomembrane compartments and colocalizes with the putat

68 s define a trafficking pathway with specific endomembrane compartments and polar auxin transport prot

69 t uncovered this link between small RNAs and endomembrane compartments and present an overview of the

70 dopsis thaliana, are associated with diverse endomembrane compartments and tissues in plants, althoug

71 ansporters that alter the environment across endomembrane compartments are thought to be important pl

72 brassinosteroid receptor BRI1 into distinct endomembrane compartments termed "endosidin bodies"; how

73 to redistribute from the plasma membrane to endomembrane compartments, dissociated R7BP-bound R7 RGS

74 e activity are avirulent and fail to acidify endomembrane compartments, exhibiting pleiotropic defect

75 eciation that G proteins are also present at endomembrane compartments, where they can potentially in

76 y plasma membrane (PM)-localized PEN3-GFP in endomembrane compartments.

77 hat both Vnx1 and Cax1 proteins are found in endomembrane compartments.

78 endocytosis followed by trafficking to deep endomembrane compartments.

79 free of significant contamination from other endomembrane compartments.

80 oplasmic, nuclear, nucleolar, organellar and endomembrane compartments.

81 ssing, sorting and trafficking to subsequent endomembrane compartments.

82 that operate from both the cell surface and endomembrane compartments.

83 ter is required to sustain metallation of an endomembrane cuproenzyme, providing a mechanism for exqu

84 Endomembrane cuproproteins are thought to incorporate co

85 It can be loaded onto secreted and endomembrane cuproproteins by translocation from the cyt

86 We demonstrate for the first time that endomembrane-delimited H-Ras mediates VEGF-induced activ

87 ully restored by modest overexpression of an endomembrane-delimited H-Ras palmitoylation mutant.

88 achieved using combinations of heterologous endomembrane desaturases and elongases expressed in mode

89 s the palmitoylation cycle controlling GAD65 endomembrane distribution, resulting in aberrant accumul

90 r contributions to H-Ras plasma membrane and endomembrane distribution.

91 dicating that autophagy triggered by damaged endomembranes during the entry of assembled tau seeds pr

92 esolved to scaffold Rab GTPases and regulate endomembrane dynamics in an isoform-specific manner.

93 Phox (PX) domain-containing protein Mdm1 in endomembrane dynamics.

94 a global fluorescence-based screen to reveal endomembrane effector genes.

95 sion structure, by remodeling host actin and endomembranes (endoplasmic reticulum and Golgi).

96 in inhibition of proliferation and defective endomembrane expansion and reduced expression of CD138 a

97 ous PtdInsP kinase activity increased in the endomembrane fraction of hyperosmotically stressed cells

98 from the plasma membrane to a lower phase or endomembrane fraction.

99 Biochemical characterization of endomembrane fractions from vnx1 mutant cells and zebraf

100 Endomembrane fractions from yeast cells were used to mea

101 es genetic evidence to support an unexpected endomembrane function for a member of the plasma membran

102 ere annotated in three broad categories: (1) endomembrane function, containing p.Phe508del processing

103 f actin filaments that controls a variety of endomembrane functions including the endocytic internali

104 into the role of Asna1/TRC40 in maintaining endomembrane homeostasis and beta-cell function, we inac

105 eby regulating PtdIns(3,5)P(2) synthesis and endomembrane homeostasis in mammalian cells.

106 e PIKfyve has been implicated in maintaining endomembrane homeostasis in mammalian cells.

107 inly associated with the plasma membrane and endomembranes, implying a potential involvement of vitam

108 The M2R was localized to endomembranes in DAT-containing somatodendritic profiles

109 suggests that TRPV1 receptors also reside on endomembranes in neurons and can mediate Ca(2+) release

110 ged AtCCX3 fusion proteins were localized to endomembranes in plants and yeast.

111 owth factor receptor alpha to LAMP2-positive endomembranes in the absence of ligand, suggesting that

112 Dynamic intracellular of endomembranes, in combination with increased velocity an

113 ectrin-based cytoskeleton is associated with endomembranes, including the Golgi complex and cytoplasm

114 dings reveal an essential role for the plant endomembrane, independent of secretion, in the intercell

115 Our results reveal that by monitoring endomembrane integrity, cells reduce entry of tau seeds

116 In a proteomic screen for endomembrane interactants of the RING-domain E3 ligase,

117 ependent endocytosis and escape from damaged endomembranes into the cytosol, where they seed the aggr

118 The pH homeostasis of endomembranes is essential for cellular functions.

119 Intracellular membrane (endomembrane) is thought to play a central role in the r

120 cant increase in p47(phox) immunolabeling on endomembranes just beneath the plasmalemmal surface (+42

121 2-mediated lysine defatty-acylation promotes endomembrane localization of K-Ras4a, enhances its inter

122 ma membrane (PM) targeting and increases the endomembrane localization of lipidated proteins that are

123 ynein IC fragments have different effects on endomembrane localization, suggesting that different end

124 in experiments aimed at defining nuclear or endomembrane localization.

125 subunit1) or ALIS5, leading to differential endomembrane localizations of the interacting proteins,

126 ry, these findings suggest that AtCCX3 is an endomembrane-localized H(+)-dependent K(+) transporter w

127 e studies define a newly recognized role for endomembrane-localized H-Ras in mediating nitric oxide-d

128 eaving the function of the large majority of endomembrane-localized H-Ras unexplained.

129 partments and mediates the ubiquitination of endomembrane-localized PHT1;1.

130 vel protein that can serve as an effector of endomembrane-localized Ras.

131 rotrimeric G proteins signal at a variety of endomembrane locations, in addition to their canonical f

132 e importance of NHX5 and NHX6 in maintaining endomembrane luminal pH and supports the notion that pro

133 the plasma membrane are tightly regulated by endomembrane machinery, especially the endocytic and rec

134 Similarly, crosses with other endomembrane marker fusions identified mislocalization t

135 Co-expression analyses of AtPIP2;1 with endomembrane markers revealed that H2O2 triggers AtPIP2;

136 th NEV-specific antiserum and a set of plant endomembrane markers revealed that NEV localizes to the

137 rane localization, suggesting that different endomembranes may bind dynein via distinct mechanisms.

138 These findings also suggest that endomembranes may provide an obstacle to colocated trans

139 he 34 compounds were found to cause aberrant endomembrane morphologies.

140 r the application of GFP technology in plant endomembranes, namely optical tweezers and forward genet

141 ssary for proliferation and expansion of the endomembrane network in response to LPS.

142 trand RNA viruses are known to rearrange the endomembrane network to make it more conducive for repli

143 Most RNA viruses remodel the endomembrane network to promote virus replication, matur

144 of a strategy to quantitatively dissect the endomembrane network.

145 Endomembranes of eukaryotic cells are dynamic structures

146 about the topology and dynamics of PS in the endomembranes of normal cells.

147 of the plasma membrane, tonoplast, and other endomembranes of plant cells.

148 bolite that has been suggested to target the endomembranes of yeast.

149 s1 mutants that are restricted to either the endomembrane or the plasma membrane.

150 lasm, or specifically affiliated with either endomembranes or large dense-core vesicles.

151 ockdown of the oxidase Nox4, expressed on ER endomembranes, or expression of ER-targeted catalase blo

152 ted in somata and dendrites, associated with endomembranes, or in dendritic spines.

153 Endomembrane organelle maturation requires cargo deliver

154 d in polysomes engaged in the translation of endomembrane organelle proteins, whereas translocon acce

155 e also able to measure the dynamics of PS in endomembrane organelles.

156 rse genetic analysis of membrane traffic and endomembrane organisation in Arabidopsis.

157 ehiscence, suggesting defects in vacuole and endomembrane organization.

158 lytic processing of storage proteins require endomembrane pH homeostasis.

159 quantitatively evaluate dynamic subcellular endomembrane phenotypes induced by bioactive chemicals,

160 We suggest that changes in endomembrane potential affect JA pathway activity.

161 position 80 to a leucine residue in a small endomembrane protein encoded by the gold36 locus (At1g54

162 AFL1 interacted with the endomembrane proteins protein disulfide isomerase 5 (PDI

163 in the biogenesis of thousands of eukaryotic endomembrane proteins.

164 adioisotopic electrodiffusion flux assays on endomembrane proteoliposomes suggested that *O(2)(-) and

165 To define downstream targets of endomembrane Ras pathways, we analyzed Cdc42, which conc

166 ator of signaling specificity functioning at endomembranes rather than at the plasma membrane.

167 membrane protein, known as 6K2, that induces endomembrane rearrangements for the formation of viral r

168 inhibition of mTORC1 activity abolishes both endomembrane reorganization and IL-8 secretion.

169 Our results indicate that the actin/endomembrane-reorganizing properties of TGB1 function to

170 Membrane fusion at endomembranes requires cross-talk between Rab GTPases an

171 mRNAs encoding endomembrane-resident proteins were bound via direct, ri

172 y, we demonstrated that cells transformed by endomembrane-restricted oncogenic H-Ras formed tumors in

173 ata show that cell transformation induced by endomembrane-restricted oncogenic H-Ras was blocked when

174 However, when examined in ras1 null cells, endomembrane-restricted Ras1 supported morphology but no

175 rane Ca(2+) channels and Ca(2+) release from endomembrane stores coordinately elevate cytosolic free

176 APM1 associates with brefeldin A-sensitive endomembrane structures and the plasma membrane in corti

177 type root tips, although PIN2 accumulates in endomembrane structures in pid-9 roots.

178 Archaea are prokaryotic organisms that lack endomembrane structures.

179 e activated Ras was found to be localized in endomembranes such as the Golgi apparatus instead of pla

180 ts function as a scaffold that positions the endomembrane system and acts as a substrate on which org

181 TMEM127 dynamically associates with the endomembrane system and colocalizes with perinuclear (ac

182 like Rab8 to control trafficking through the endomembrane system and on to the cilium.

183 s that wax components are trafficked via the endomembrane system and packaged in Golgi-derived secret

184 d sphingolipids, are major components of the endomembrane system and plasma membrane in most eukaryot

185 ing evidence reveals connections between the endomembrane system and small RNA activities in plants a

186 s revealed that MYR localized protein to the endomembrane system and that partitioning between this m

187 proteins with well-established roles in the endomembrane system and the process of transcription elo

188 complexes (CSCs), which are assembled in the endomembrane system and trafficked to the plasma membran

189 CTL1/POM1 coincided with CESAs in the endomembrane system and was secreted to the apoplast.

190 This endomembrane system arose and diversified during a perio

191 ed that AtGALT2 is probably localized in the endomembrane system consistent with its function.

192 Fusion of organelles in the endomembrane system depends on Rab GTPases that interact

193 Membrane fusion within the eukaryotic endomembrane system depends on the initial recognition o

194 proteins initiate their journey through the endomembrane system from specific subdomains of the endo

195 ith green fluorescent protein markers of the endomembrane system in Arabidopsis seedlings, we show th

196 the final site of protein deposition in the endomembrane system in developing rice endosperm.

197 uxes and possibly pH modulation of an active endomembrane system in guard cells.

198 motor that transports cargo vesicles of the endomembrane system in intracellular recycling pathways.

199 The endomembrane system in plant-microbe interactions 1013 I

200 s, yet little is known about the role of the endomembrane system in this process.

201 resent an overview of the involvement of the endomembrane system in various aspects of RNA silencing.

202 m of PAP is targeted to the cytosol from the endomembrane system in yeast.

203 nt provokes a profound reorganization of the endomembrane system into foci containing double membrane

204 We propose that the endomembrane system is an integral component of RNA sile

205 der to provide direct pH measurements in the endomembrane system lumen, we targeted genetically encod

206 The identity of organelles in the endomembrane system of any eukaryotic cell critically de

207 O](51):GalT activities were localized to the endomembrane system of Arabidopsis suspension-cultured c

208 proton-pumping vacuolar ATPase found in the endomembrane system of eukaryotes.

209 The endomembrane system of eukaryotic cells uses membrane-en

210 ex family involved in protein sorting in the endomembrane system of eukaryotic cells.

211 sm for the transport of proteins through the endomembrane system of plants.

212 cycling pectin methylesterase enzymes in the endomembrane system of seed coat epidermal cells.

213 The endomembrane system plays essential roles in plant devel

214 that, during organogenesis, the Arabidopsis endomembrane system specifies an important additional ce

215 that all of these enzymes are targeted to an endomembrane system such as the Golgi where they may pro

216 Enveloped viruses exploit the endomembrane system to enter host cells.

217 in growing oocytes and traffics through the endomembrane system to the cell surface, where it is rel

218 internalized by activated neutrophils in the endomembrane system via 12(S)-HETE.

219 ancestors, secretion of material through the endomembrane system was the major mechanism for interact

220 mRNAs encoding resident proteins of the endomembrane system were clustered at high ER-enrichment

221 Cs) and nuclear membranes coevolved with the endomembrane system, and that the last eukaryotic common

222 some eukaryotic organelles, for example the endomembrane system, evolved without endosymbiotic input

223 protein even though these organisms have no endomembrane system, suggesting that the Vps4/ESCRT-III

224 dditional insights into the sculpting of the endomembrane system.

225 fission dynamics may be conserved within the endomembrane system.

226 exes are required for membrane fusion in the endomembrane system.

227 lic proteins that tend to associate with the endomembrane system.

228 sses, responses to (a)biotic stress, and the endomembrane system.

229 rt of pistil ECM proteins in the pollen tube endomembrane system.

230 vironment, and predominantly localize to the endomembrane system.

231 trol systems to structure and coordinate the endomembrane system.

232 the channel was sensitive to disrupting the endomembrane system.

233 plicated essentially all compartments of the endomembrane system.

234 thesizes many lipid components of the entire endomembrane system.

235 egradative (i.e., catabolic) branches of the endomembrane system.

236 n on epidermal cells and organization of the endomembrane system.

237 itochondria are indeed integrated within the endomembrane system.

238 s in sorting protein constituents within the endomembrane system.

239 equires proper ion and pH homeostasis of the endomembrane system.

240 ing mutants that trap secretory cargo in the endomembrane system.

241 somes are unique among the organelles of the endomembrane system.

242 Gemmata obscuriglobus possesses an extensive endomembrane system.

243 is enriched for functions related to diverse endomembrane systems and their organization.

244 Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.

245 istributed along cytoplasmic tubulovesicular endomembrane systems in somata and large dendrites, but

246 lein revealed alterations of the presynaptic endomembrane systems similar to our findings in cell cul

247 imarily as fusogens for vesicle transport in endomembrane systems.

248 lutionarily highly conserved and fundamental endomembrane systems.

249 ysosomal fusion capacity and accumulation of endomembranes that accompanies PSEN deficiency.

250 ed transcription and translation, a role for endomembranes that has not been reported previously for

251 the resealing response of a cell that lacks endomembrane, the red blood cell, with that of several n

252 islocalization of GFP-RAB7 and GFP-RAB8 from endomembrane to cytosol, enhanced binding to RABGDI, and

253 energy to pump H(+) across the tonoplast and endomembranes to create proton motive force (pmf).

254 in a shift of fluorescence localization from endomembranes to cytosol in C4H overexpressing plants, w

255 oplasmic surfaces of the plasma membrane and endomembranes to maintain G protein pools in intracellul

256 HO2 modulates the degradation of PHO1 in the endomembranes to maintain Pi homeostasis in plants.

257 ctors, auxin transport and response factors, endomembrane traffic components and other signaling path

258 e and membrane stability, cell polarity, and endomembrane traffic.

259 During polarized growth of pollen tubes, endomembrane trafficking and actin polymerization are tw

260 hored receptors (MyoB) that, together, drive endomembrane trafficking and cytoplasmic streaming in th

261 1/TRC40, is implicated in the maintenance of endomembrane trafficking and ER homeostasis.

262 ese reagents will be valuable for dissecting endomembrane trafficking and gravitropism and for cognat

263 ecently, a link has been established between endomembrane trafficking and gravitropism.

264 sults provide evidence of cross talk between endomembrane trafficking and the actin cytoskeleton in p

265 Disrupting endomembrane trafficking by BFA or wortmannin perturbed

266 tion during cytokinesis that does not affect endomembrane trafficking during interphase or cytoskelet

267 ) function as the central junction for major endomembrane trafficking events, including endocytosis a

268 rapidly elongating cells require tip-focused endomembrane trafficking for the deposition and recyclin

269 ved in various instances of clathrin-related endomembrane trafficking in plants.

270 screen to discover small molecules targeting endomembrane trafficking in vivo in a complex eukaryote,

271 n indirect effect, possibly due to perturbed endomembrane trafficking of certain membrane-localized s

272 trastructural evidence suggestive of somatic endomembrane trafficking of M2Rs, whose activation serve

273 trations of drugs that interfere with either endomembrane trafficking or the actin cytoskeleton, then

274 with markers of cellular compartments of the endomembrane trafficking pathway.

275 es auxin-mediated tissue differentiation and endomembrane trafficking pathways downstream of ribosoma

276 Endomembrane trafficking relies on the coordination of a

277 of a palmitoylation-dependent, nonclassical endomembrane trafficking system for the plasma membrane

278 ins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-

279 :H7 type III effector EspG as a regulator of endomembrane trafficking using a functional screen, and

280 EACH-domain-containing protein implicated in endomembrane trafficking, is required for both electrica

281 anisms are thought to involve alterations in endomembrane trafficking, mitochondrial function, and li

282 lays a conserved role in organizing cellular endomembrane trafficking, required for delivery of defen

283 (GTPase)-a protein previously implicated in endomembrane trafficking-as a regulator of the phosphati

284 nds that altered pollen tube development and endomembrane trafficking.

285 cytoskeleton was critical for some steps in endomembrane trafficking.

286 gies to dissect biological processes such as endomembrane trafficking.

287 blished as biochemically distinct domains by endomembrane trafficking.

288 e latent oncogenic potential in dysregulated endomembrane trafficking.

289 g cells is shown to match an interruption in endomembrane transport.

290 One endomembrane-type Ca-ATPase from Arabidopsis (Arabidopsi

291 d away from the growing bud, possibly to the endomembrane/vacuolar system.

292 wax export requires GNL1- and ECH-dependent endomembrane vesicle trafficking to deliver cargo to pla

293 N associated with PI3K-C2beta on a subset of endomembrane vesicles and enhanced both basal and growth

294 tition between the cytosolic pools of motile endomembrane vesicles that colocalize with myosin XI-K a

295 The BBN-conjugate partially localized in endomembrane vesicles that were associated with Rab7 or

296 s actin polymerization-dependent movement of endomembrane vesicles, and Las17 (a yeast WASp homolog)

297 les, including endoplasmic reticulum, Golgi, endomembrane vesicles, peroxisomes, and mitochondria.

298 Rheb is targeted to endomembranes via its C-terminal CAAX (C=cysteine, A=ali

299 y colocalized and physically interact in the endomembranes, where the ubiquitin conjugase activity of

300 The sphingolipid content varies among endomembranes with pre- and post-Golgi compartments bein