ライフサイエンスコーパス: endometriosis

1 n process occurs along the pain neuroaxis in endometriosis.

2 -beta1 through the ID1 pathway in women with endometriosis.

3 between macrophages and nerves in peritoneal endometriosis.

4 or nonsteroidal targets for the treatment of endometriosis.

5 ts in oncology and women's health, including endometriosis.

6 eased clinical pregnancy rates in women with endometriosis.

7 Rbeta function stimulated the progression of endometriosis.

8 um, GLI1 expression is reduced in women with endometriosis.

9 ian tube, gastrointestinal tract, cervix and endometriosis.

10 ial implants, contributing to development of endometriosis.

11 ontribute to the development and severity of endometriosis.

12 dulatory role of IL-10 in the development of endometriosis.

13 lation may be involved in the development of endometriosis.

14 y foods were associated with a lower risk of endometriosis.

15 rrier to the identification and treatment of endometriosis.

16 pelvic pain (CPP) who are suspected to have endometriosis.

17 une factors, which are altered in women with endometriosis.

18 on factor KLF11/Klf11 in the pathogenesis of endometriosis.

19 se and hindlimb vibration) and in a model of endometriosis.

20 nd the scope and capability for treatment of endometriosis.

21 oods are associated with a decreased risk of endometriosis.

22 t a subset of clear cell cancers evolve from endometriosis.

23 nd cell migration in the invasive disease of endometriosis.

24 CH and mirex were positively associated with endometriosis.

25 g of the genetic factors that play a role in endometriosis.

26 bjects with and without the invasive disease endometriosis.

27 25(OH)D level was inversely associated with endometriosis.

28 nting de novo disease-associated fibrosis in endometriosis.

29 ysis, and 168 of these reported a history of endometriosis.

30 effective therapeutic approach in women with endometriosis.

31 sions and the peritoneal fluid in women with endometriosis.

32 a considerable impact on the development of endometriosis.

33 vated 2,4OH-BP levels may be associated with endometriosis.

34 nd central hyperalgesia in mice with induced endometriosis.

35 and 738, respectively, reported a history of endometriosis.

36 r IL-1 receptor type 2 (IL1R2) in women with endometriosis.

37 may play a major role in the pathogenesis of endometriosis.

38 rial cells that are hallmarks of progressive endometriosis.

39 nd likely participate in the pathogenesis of endometriosis.

40 onal axis promotes pathogenic progression of endometriosis.

41 fic subtypes of ovarian cancer in women with endometriosis.

42 lead to surgery, such as uterine fibroids or endometriosis.

43 rotein axis in regulation of inflammation in endometriosis.

44 cells in a mouse model of surgically induced endometriosis.

45 lity-preserving, and effective treatment for endometriosis.

46 as a clinical compound for the treatment of endometriosis.

47 ophilin cochaperone in the etiology of human endometriosis.

48 of pelvic pain, one of the core symptoms of endometriosis.

49 down-regulation of FKBP52 in cases of human endometriosis.

50 tudy the unique aspects of P(4) signaling in endometriosis.

51 possibility that DCs may also play a role in endometriosis.

52 on and rectum and evaluation of rectosigmoid endometriosis.

53 somatic stimulation in treating symptoms of endometriosis.

54 together explain up to 5.19% of variance in endometriosis.

55 ng their contribution to the pathogenesis of endometriosis.

56 se and the reduced fertility associated with endometriosis.

57 entified 19 independent common risk loci for endometriosis.

58 mechanism to the complex pathophysiology of endometriosis.

59 ressed the estrogen-dependent progression of endometriosis.

60 ding protein 3 (IGFBP-3) was associated with endometriosis.

61 term nonestrogen or nonsteroidal therapy for endometriosis.

62 matched eutopic endometrium from women with endometriosis.

63 A in the pathogenesis and pathophysiology of endometriosis.

64 ts in the lesion survival and progression of endometriosis.

65 on are associated with relief of pain due to endometriosis.

66 e information is available in the context of endometriosis.

67 reased in the peritoneal fluid of women with endometriosis.

68 lay an essential role in the pathogenesis of endometriosis.

69 ciated with improved outcomes for women with endometriosis?

70 es, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the ab

71 howed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84).

72 vs. 1.5+/-0.5 mm(2), n=4 and 4, P<0.0001 for endometriosis; 67.6+/-15.1 vs. 22.7+/-14.6 mm(2), n=5 an

73 Endometriosis, a major reproductive pathology affecting

74 nsecutive patients suspected of having bowel endometriosis above the rectosigmoid junction underwent

75 longer than 6 months without or with minimal endometriosis, adhesions, or pelvic inflammatory disease

76 Endometriosis affects 10-15% of women and is associated

77 Endometriosis affects 10-20% of women of reproductive ag

78 Endometriosis affects approximately 10% of young, reprod

79 Many women with endometriosis also suffer from other chronic pain condit

80 0.01) with moderate or large effect sizes in endometriosis, although these variants may exist in non-

81 ted with incident laparoscopically confirmed endometriosis among 70,556 US women in Nurses' Health St

82 s17561 has also been associated with risk of endometriosis, an epidemiologic risk factor for ovarian

83 tained 310 premenopausal women with incident endometriosis and 615 matched controls.

84 nd evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, exce

85 and cellular aspects of the pathogenesis of endometriosis and associated clinical symptoms.

86 , no genetic enrichment was observed between endometriosis and BMI (P = 0.79).

87 reatment of estrogen-dependent diseases like endometriosis and breast cancer.

88 ferative diseases of the endometrium such as endometriosis and cancer are common and E2 dependent.

89 udies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer,

90 percentage of 42 of the association between endometriosis and CHD could be explained by greater freq

91 ld partially explain the association between endometriosis and CHD.

92 or translational application, for example in endometriosis and contraception.

93 ic estrogens such as tamoxifen, in promoting endometriosis and endometrial cancers.

94 lay an important role in the pathogenesis of endometriosis and endometriosis-associated angiogenesis,

95 nome-wide significantly associated with both endometriosis and fat distribution (waist-to-hip ratio a

96 de transcriptional profiling to characterize endometriosis and found that it exhibits a gene expressi

97 tive study to assess the association between endometriosis and histological subtypes of ovarian cance

98 atistically significant associations between endometriosis and IGF-1 (incidence rate ratio (IRR) = 0.

99 iotic tissue of mice with surgically induced endometriosis and in endometriotic stromal cells biopsie

100 ogenesis and promoting lesion growth both in endometriosis and in tumors.

101 intervention is needed to reduce the risk of endometriosis and infertility.

102 ncreased in peritoneal fluid from women with endometriosis and levels correlated with TGF-beta1 conce

103 pressed in eutopic endometrium of women with endometriosis and likely participate in the pathogenesis

104 h placebo in women with surgically diagnosed endometriosis and moderate or severe endometriosis-assoc

105 se P(4) resistance is favorably indicated in endometriosis and other gynecological diseases.

106 that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attribut

107 rge number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combine

108 No association was noted between endometriosis and risk of mucinous (31 [6.0%] of 516 cas

109 assess the association between self-reported endometriosis and risk of ovarian cancer.

110 sociation between laparoscopically confirmed endometriosis and subsequent CHD among 116 430 women in

111 ved endothelial cells in the pathogenesis of endometriosis and support the potential clinical use of

112 was increased in peritoneum from women with endometriosis and TGF-beta1 increased concentrations of

113 significant evidence of involvement in both endometriosis and WHRadjBMI (in/near KIFAP3, CAB39L, WNT

114 female healthcare: contraception, fibroids, endometriosis, and certain breast cancers.

115 een shown to support angiogenesis in tumors, endometriosis, and lymph nodes.

116 reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer.

117 Only follicular fluid from patients with endometriosis, and not controls, produced ROS and damage

118 se, insulin resistance, lupus erythematosus, endometriosis, and obesity.

119 orders, including advanced prostatic cancer, endometriosis, and precocious puberty.

120 diabetic retinopathy, rheumatoid arthritis, endometriosis, and psoriasis.

121 taglandin E2 (PGE2) are higher in women with endometriosis, and this increased PGE2 plays important r

122 Severe pelvic pain is often associated with endometriosis, and this pain can be diminished with ther

123 Similarly, age at menopause, endometriosis, and tubal ligation were only associated w

124 Two major clinical symptoms of endometriosis are chronic intolerable pelvic pain and su

125 pose one-tenth of reproductive-aged women to endometriosis are poorly understood.

126 ports role for ID1 in the pathophysiology of endometriosis, as an effector of TGFbeta1 dependent upre

127 ole in the pathogenesis of endometriosis and endometriosis-associated angiogenesis, and the angiogene

128 helial growth factor (VEGF), a key player in endometriosis-associated angiogenesis.

129 ed controlled trial; 67 patients with severe endometriosis-associated pain (maximum pain: 7.6 +/- 2.0

130 phages into lesions, plays a pivotal role in endometriosis-associated pain.

131 c pain during a 6-month period in women with endometriosis-associated pain.

132 agnosed endometriosis and moderate or severe endometriosis-associated pain.

133 treatments for the control or elimination of endometriosis-associated pain.

134 Finally, treatment of endometriosis-bearing mice with the angiogenesis inhibit

135 e measured in sera from surgically confirmed endometriosis cases (n = 248) first diagnosed between 19

136 cohort including 2,019 surgically confirmed endometriosis cases and 14,471 controls.

137 ion case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls.

138 typing large numbers of surgically-confirmed endometriosis cases and controls, and/or sequencing high

139 ase severity (P=0.0046) when moderate/severe endometriosis cases are tested against minimal/mild case

140 nistered into the peritoneum of baboons with endometriosis, cells in lesions selectively underwent ap

141 evere (n = 136) endometriosis (rAFS: revised endometriosis classification of the American Fertility S

142 ic stromal cells biopsied from patients with endometriosis compared to normal endometrium.

143 ted levels of EPCs in the blood of mice with endometriosis compared with control subject that underwe

144 dy, a population-based case-control study of endometriosis conducted among 18- to 49-year-old female

145 To address this, we used two endometriosis datasets genotyped on common arrays with f

146 growth-promoting effects, may contribute to endometriosis development.

147 ncer, rheumatoid arthritis, atherosclerosis, endometriosis, diabetic retinopathy, and age-related mac

148 association between POPs and the odds of an endometriosis diagnosis and the consistency of findings

149 ved only between 2,4OH-BP and the odds of an endometriosis diagnosis in the operative cohort (OR = 1.

150 tervals (CIs) for each POP in relation to an endometriosis diagnosis, with separate models run for ea

151 ophorectomy and earlier age at surgery after endometriosis diagnosis.

152 rations of BP derivatives and the odds of an endometriosis diagnosis; ORs increased across quartiles

153 Endometriosis (ENDO) is a disorder in which vascularized

154 re pelvic pains are symptoms associated with endometriosis (ENDO), a common condition among women tha

155 grade serous ovarian cancers (HGSOCs) and in endometriosis epithelial cells (EECs), the likely precur

156 ently conditioned with serum from women with endometriosis exhibited a tolerogenic phenotype, includi

157 iosis, women with laparoscopically confirmed endometriosis had a higher risk of myocardial infarction

158 or coactivators (SRCs) in the progression of endometriosis has not been elucidated.

159 nds and estrogen-dependent diseases (such as endometriosis) have not been examined previously.

160 ged after adjustment for uterine fibroids or endometriosis history.

161 , randomized, 6-month phase 3 trials (Elaris Endometriosis I and II [EM-I and EM-II]) to evaluate the

162 In a syngeneic mouse model of endometriosis, IL-33 injections caused systemic inflamma

163 yl levels to classify women with and without endometriosis illustrates the potential benefits of thes

164 hat KLF11 expression was diminished in human endometriosis implants and further investigated its path

165 believed that these nascent nerve fibers in endometriosis implants influence dorsal root neurons wit

166 We induced endometriosis in 8-wk-old female C57BL/6 mice by implant

167 1 and IGFBP-3 and laparoscopically confirmed endometriosis in a case-control study nested within the

168 egy that could be useful to treat peritoneal endometriosis in humans.

169 , PM10), and timing of exposure with risk of endometriosis in the Nurses' Health Study II.

170 adulthood were not associated with incident endometriosis in this cohort of women.

171 sistent organochlorine pollutants (POPs) and endometriosis in women, with differences attributed to m

172 Endometriosis is a chronic inflammatory condition in wom

173 Endometriosis is a chronic, estrogen-dependent condition

174 Endometriosis is a chronic, inflammatory disease charact

175 Endometriosis is a common cause of both cyclic and chron

176 Endometriosis is a common cause of CPP in adolescents wh

177 Endometriosis is a common cause of pelvic pain and infer

178 Endometriosis is a common cause of pelvic pain and infer

179 Endometriosis is a common gynaecological disease associa

180 Endometriosis is a common gynecological condition with c

181 Endometriosis is a common gynecological disease that aff

182 Endometriosis is a debilitating condition that is catego

183 Endometriosis is a debilitating disease characterized by

184 Endometriosis is a debilitating, estrogen-dependent, pro

185 Endometriosis is a disease defined by the presence of en

186 Endometriosis is a gynecological disorder affecting 6%-1

187 Endometriosis is a heritable hormone-dependent gynecolog

188 Endometriosis is a major cause of chronic pain, infertil

189 Endometriosis is a prevalent gynecologic disease associa

190 Endometriosis is a relatively common condition in women

191 Endometriosis is a risk factor for epithelial ovarian ca

192 Endometriosis is an estrogen-dependent inflammatory diso

193 interactions, providing novel evidence that endometriosis is an estrogen-dependent neuroinflammatory

194 Endometriosis is an incurable gynecological disorder cha

195 Endometriosis is an inflammatory condition that is assoc

196 ver, the role of TGFB1 in the development of endometriosis is as yet undefined.

197 Endometriosis is considered an estrogen-dependent diseas

198 Endometriosis is considered to be an estrogen-dependent

199 A genetic component in endometriosis is now recognized, and several groups have

200 Endometriosis is often associated with a chronic pelvic

201 The etiology of endometriosis is poorly understood, and few modifiable r

202 Diagnosis and treatment of endometriosis is, on average, delayed by 7-10 years from

203 ng autism, breast cancer, colorectal cancer, endometriosis, ischaemic stroke, leukemia, lymphoma and

204 1 or IGFBP-3 plays a role in the etiology of endometriosis, it is minimal and perhaps only among youn

205 have been associated with deep infiltrating endometriosis, its contribution to the disease pathophys

206 w-derived DCs (BMDCs) incorporated into both endometriosis lesions and into B16 melanoma tumors and e

207 Endometriosis lesions are characterized by the presence

208 As both tumors and endometriosis lesions depend on angiogenesis, we investi

209 ing pain and the establishment of innervated endometriosis lesions outside the uterus.

210 aling pathway (including COX-2, EP2, EP4) in endometriosis lesions, dorsal root ganglia (DRG), spinal

211 +) DCs infiltrating sites of angiogenesis in endometriosis lesions.

212 retrograde menstrual tissues to give rise to endometriosis lesions.

213 ought to play a role in the establishment of endometriosis lesions.

214 ays important role in survival and growth of endometriosis lesions.

215 ity for the establishment and maintenance of endometriosis lesions.

216 P2/EP4: (i) decreases growth and survival of endometriosis lesions; (ii) decreases angiogenesis and i

217 i) decreases angiogenesis and innervation of endometriosis lesions; (iii) suppresses proinflammatory

218 molecular environment of the endometrium and endometriosis lesions; and (v) restores endometrial func

219 in transforming growth factor beta1 impairs endometriosis-like lesion growth in mice.

220 hat seminal plasma enhances the formation of endometriosis-like lesion via a direct effect on endomet

221 ndometrial tissue resulted in development of endometriosis-like lesions in 63% of ovariectomized estr

222 radiol significantly inhibited the growth of endometriosis-like lesions in a dose-dependent manner.

223 iosis that transient hypoxia in transplanted endometriosis-like lesions results in the up-regulation

224 considered to be involved in the etiology of endometriosis, neither the extent of their participation

225 Endometriosis occurs in approximately 10% of women and i

226 As most endometriosis occurs on organ surfaces facing the perito

227 Chronic inflammatory events such as endometriosis or mucosal exposure to talc increase the r

228 common variants between fat distribution and endometriosis (P = 3.7 x 10(-3)), which was stronger whe

229 iation of rs519664[T] in TTC39B on 9p22 with endometriosis (P=4.8 x 10(-10); OR=1.29).

230 mparisons to assess how fat distribution and endometriosis pathogenesis research fields can inform ea

231 targeted proteomics of peritoneal fluid from endometriosis patients and find growth-factor-driven ADA

232 RNA binding protein (RNABP) HuR/TTP axis in endometriosis patients compared to menstrual stage match

233 remains unknown, it is well established that endometriosis patients exhibit immune dysfunction.

234 ) protein was found elevated in the serum of endometriosis patients.

235 with a significant positive association with endometriosis [per 1-SD increase in log-transformed gamm

236 he mouse SRC-1 gene has an essential role in endometriosis progression.

237 This novel, noninvasive model of endometriosis provides a means to study early angiogenes

238 xcised moderate (n = 67) or severe (n = 136) endometriosis (rAFS: revised endometriosis classificatio

239 %, and 10%, respectively, and the cumulative endometriosis recurrence rate was 1%, 6%, and 8%, respec

240 Endometriosis-related pain has a marked negative impact

241 divides type I tumors into three groups: i) endometriosis-related tumors that include endometrioid,

242 s the SNP with the strongest association for endometriosis risk (P = 1.84 x 10-5, OR = 1.244 (1.126-1

243 ive novel loci significantly associated with endometriosis risk (P<5 x 10(-8)), implicating genes inv

244 io appeared to be positively associated with endometriosis risk among women aged <40 years at blood d

245 re was no evidence of an association between endometriosis risk and distance to road or exposure to P

246 Our data suggested increased endometriosis risk associated with serum concentrations

247 The involvement of KDR in endometriosis risk highlights the importance of the VEGF

248 We investigated endometriosis risk in relation to environmental exposure

249 er, our results suggest that SNPs increasing endometriosis risk in this region act through CDC42, but

250 on between these air pollution exposures and endometriosis risk.

251 organochlorine pesticides (OCPs), may affect endometriosis risk.

252 stent and strong association with increasing endometriosis risk.

253 oci in our meta-analysis that associate with endometriosis:, RNF144B-ID4 on 6p22.3 (rs6907340; P = 2.

254 Endometriosis (RR = 1.27, 95% CI: 0.70, 2.31; P = 0.43)

255 ars and confirm a strong correlation between endometriosis severity and infertility (n = 1182, P<0.00

256 and Mmp9(-)/(-) mice with surgically induced endometriosis showed that activation of tumor necrosis f

257 a C57BL/6 mouse model of surgically induced endometriosis significantly decreased the size of endome

258 at might lead to malignant transformation of endometriosis so as to help identify subsets of women at

259 Here we report the discovery of a new endometriosis susceptibility locus on 4q12 (rs17773813[G

260 descent to examine the mechanism underlying endometriosis susceptibility.

261 Here we identify an endometriosis-targeting peptide that is internalized by

262 ay were 18% less likely to be diagnosed with endometriosis than those reporting 2 servings per day (r

263 cted vitamin D level had a 24% lower risk of endometriosis than women in the lowest quintile (rate ra

264 In summary, we developed a mouse model of endometriosis that exhibits similarities to human perito

265 demonstrate in an established mouse model of endometriosis that transient hypoxia in transplanted end

266 Endometriosis, the presence of ectopic endometrial tissu

267 Endometriosis, the presence of ectopic endometrial tissu

268 tant recurrent miscarriages and remission of endometriosis, these findings have clinical implications

269 yses restricting cases to those with ovarian endometriosis (third vs. lowest quartile: OR = 2.5; 95%

270 , in the eutopic endometrium from women with endometriosis throughout the menstrual cycle.

271 pared between women with deeply infiltrative endometriosis undergoing CO2 laser ablative surgery with

272 al-medium-specific POPs were associated with endometriosis, underscoring the importance of methodolog

273 ted a genome-wide association scan (GWAS) of endometriosis using 25.5 million sequence variants detec

274 ential role of protein-modifying variants in endometriosis using exome-array genotyping in 7164 cases

275 igated the role of IL-33 in the pathology of endometriosis using patient samples, cell lines and a sy

276 we developed and validated a mouse model of endometriosis using syngeneic menstrual endometrial tiss

277 To determine phenotype-specificity, endometriosis was also generated in Klf9-/- animals.

278 Self-reported endometriosis was associated with a significantly increa

279 ospective cohort, laparoscopically confirmed endometriosis was associated with increased risk of CHD.

280 ser laparoscopic excision of moderate-severe endometriosis was comparable in women with or without bo

281 This GWAS of endometriosis was conducted with high diagnostic certain

282 Endometriosis was defined as visualized disease in the o

283 th an increase in the odds of a diagnosis of endometriosis was examined in 600 women who underwent la

284 Endometriosis was induced in BALB/c-Rag2(-/-)Il2rg(-/-)

285 at the serum level of IL-10 in patients with endometriosis was significantly higher than that in heal

286 on between serum beta-HCH concentrations and endometriosis was stronger in analyses restricting cases

287 identify genetic factors that contribute to endometriosis we conducted a two-stage genome-wide assoc

288 In a preclinical mouse model of endometriosis we demonstrated overexpression of the PGE2

289 By using human tissues and a mouse model of endometriosis, we demonstrate that macrophages in lesion

290 Using an athymic mouse model of endometriosis, we now report that Icon largely destroys

291 2,486 incident cases of surgically confirmed endometriosis were identified over 710,230 person-years

292 cases of incident laparoscopically confirmed endometriosis were reported.

293 e, 17-45 years) who were suspected of having endometriosis were reviewed.

294 vations suggest a model for the pathology of endometriosis where BLyS-responsive plasma cells interac

295 licular fluid from patients with the disease endometriosis, which affects 10% of women and is associa

296 olymorphisms (SNPs) robustly associated with endometriosis, which together explain up to 5.19% of var

297 genetic variants underlying the aetiology of endometriosis, WHRadjBMI and BMI using GWAS data.

298 berrant molecular and cellular mechanisms in endometriosis with the intention of providing much-neede

299 When compared with women without endometriosis, women with laparoscopically confirmed end

300 analyses using data from the Women's Risk of Endometriosis (WREN) study, a population-based case-cont