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1 f DNA replication in the absence of mitosis (endomitosis).
2 through the ectopic induction of premeiotic endomitosis.
3 s arise from mononucleated Hodgkin cells via endomitosis.
4 es are platelet precursor cells that undergo endomitosis.
5 oiesis, but is dispensable for megakaryocyte endomitosis.
6 hly expressed in young MKs, in parallel with endomitosis.
7 division but continued to accumulate DNA by endomitosis.
8 for understanding the molecular basis of MK endomitosis.
9 from polyploid megakaryocytes which undergo endomitosis.
10 er a phase of DNA synthesis, thus leading to endomitosis.
11 totic cell cycle while not detectable during endomitosis.
12 ls undergoing a mitotic cell cycle or during endomitosis.
13 within a single nucleus, a process known as endomitosis.
14 ough the stochastic occurrence of premeiotic endomitosis.
15 Gp1balpha also participates in megakaryocyte endomitosis, a form of controlled and precise whole-geno
16 loidization in megakaryocytes is achieved by endomitosis, a specialized cell cycle in which DNA repli
18 that the pathways leading to megakaryocytic endomitosis and c-Myc-induced tetraploidy are mechanisti
20 ant proportion of these cells do not undergo endomitosis and express markedly lower levels of mRNA of
21 at high levels in megakaryocytes undergoing endomitosis and is markedly upregulated following exposu
24 ow an important role for MAPK in TPO-induced endomitosis and underscore the value of primary cells wh
25 at Polo-like kinase 1 (Plk1) is required for endomitosis, and ablation of the Plk1 gene in megakaryoc
28 ry evaluated; the molecular underpinnings of endomitosis are being increasingly understood; the intra
29 ell fusion of unrelated Hodgkin cells nor to endomitosis, but rather is mediated by re-fusion of daug
30 ntrol polyploidization and the transition to endomitosis by impeding cell cycling and promoting apopt
32 We conclude that mitosis is abrogated during endomitosis due to the absence of cdk1 and the failure t
33 aryocytes (MKs) undergo successive rounds of endomitosis during differentiation, resulting in polyplo
35 cted during the mitotic cell cycle or during endomitosis; however, cyclin B1-dependent Cdc2 kinase ac
37 egulates Tpo-mediated cell proliferation and endomitosis in hematopoietic cell lines and primary hema
38 ctor is distinct from TPO because it induces endomitosis in IL-3-generated megakaryocytes in vitro, w
39 leukins, and SDF1a, that can induce in vitro endomitosis in immature human megakaryocytes in the pres
42 on of c-myc oncogene on megakaryopoiesis and endomitosis in vivo, using transgenic mice carrying c-my
45 study indicates that Fanca expression during endomitosis is crucial for normal megakaryopoiesis and p
47 lls, the extent to which it is necessary for endomitosis of megakaryocytes remains controversial.
48 oles of 2 nonmuscle myosin IIs (NMIIs) on MK endomitosis: only NMII-B (MYH10), but not NMII-A (MYH9),
49 tensions, and reduced phosphorylation of the endomitosis regulators LIM domain kinase 1, cofilin, and
51 telet lineage display a striking increase in endomitosis, similar to changes seen following Mpl ligan
52 with TGCs endocycling rather than undergoing endomitosis, they have low expression of M-phase genes.
53 opmental Cell, Gao et al. trace the basis of endomitosis to sequential downregulation of guanine nucl
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