ライフサイエンスコーパス: endonucleolytic

1 n this tRNA were tested for their effects on endonucleolytic 3'-end processing and CCA addition at th

2 y inactive mutant of the enzyme showing that endonucleolytic ability of the protein is dispensable fo

3 Endonucleolytic action by AtCPSF30 leaves RNA 3' ends wi

4 ubstitutions at Lys301, which is part of the endonucleolytic active site, eliminate binding to the cl

5 The PI-SceI protein splicing and endonucleolytic active sites are separately located in e

6 At the putative endonucleolytic active sites, the superposition reveals

7 The data reveal that sequence-specific endonucleolytic activities cleave the transforming DNA a

8 We show that WH is able to modulate FEN1's endonucleolytic activities depending on the substrate DN

9 n that tethering of the termini enhances the endonucleolytic activities of integrase.

10 presence of both 5'-to-3' exonucleolytic and endonucleolytic activities on the Bacillus subtilis thrS

11 a negative regulatory effect on the Artemis endonucleolytic activities, and phosphorylation by DNA-P

12 lation sites still retain DNA-PKcs-dependent endonucleolytic activities, indicating that basal phosph

13 city enzyme, with both 5' exonucleolytic and endonucleolytic activities.

14 In addition to known disparities in their endonucleolytic activity [13, 14], the four Ago proteins

15 sequence that can act as a substrate for Rep endonucleolytic activity [terminal resolution site (TRS)

16 e the presence of cysteine proteases for its endonucleolytic activity and that the cysteine proteases

17 sociates with human FEN-1 and stimulates its endonucleolytic activity at branched DNA structures and

18 n generates a mutant RNase III with impaired endonucleolytic activity but without blocking its abilit

19 Exo III's apurinic endonucleolytic activity differentially processes hybrid

20 apoptotic nuclear collapse requires a 3'-OH endonucleolytic activity even though the internucleosoma

21 virus terminase complex, pUL89, provides the endonucleolytic activity for genome cleavage, and the do

22 ally associated with the upregulation of the endonucleolytic activity herein described.

23 etely inactive in vitro, whereas it exhibits endonucleolytic activity in the context of FL-L-terminas

24 was used to confirm the existence of a weak endonucleolytic activity in the enzyme.

25 and 3'-DNA overhangs of duplex DNA, and this endonucleolytic activity is dependent upon DNA-PKcs.

26 The endonucleolytic activity is inhibited by the nuclease A

27 ucleolytic activity of FEN-1 in terms of its endonucleolytic activity is proposed based on these obse

28 The endonucleolytic activity of human apurinic/apyrimidinic

29 Gre factors enhance the intrinsic endonucleolytic activity of RNA polymerase to rescue arr

30 otein composition of the degradosome and the endonucleolytic activity of RNase E.

31 In eukaryotes, the endonucleolytic activity of the calf RTH-1 class 5'- to

32 ibly through activation or regulation of the endonucleolytic activity of the N-terminal domain of XPF

33 dent of RelE, and has been proposed to be an endonucleolytic activity of the ribosome.

34 phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs, as well

35 -->3'exodeoxyribonuclease that also exhibits endonucleolytic activity on flap structures (branched du

36 nated with 5' monophosphorylated thrS, while endonucleolytic activity predominated with 5' triphospho

37 Endonucleolytic activity that cleaved HBV RNA at positio

38 extracts prepared from MEL cells contain an endonucleolytic activity that generates decay products c

39 d1 complex, was recently found to possess an endonucleolytic activity that incises on the 5' side of

40 This protein possesses an unexpected endonucleolytic activity that is apparent as an ability

41 , correlating with the predominance of hFEN1 endonucleolytic activity versus hEXO1 exonucleolytic act

42 In soluble extracts, most (80 to 90%) of the endonucleolytic activity was due to RNases I and I*, sin

43 This endonucleolytic activity was inhibited by Zn2+, aurintri

44 The chimeric protein possessed endonucleolytic activity, cleaving both strands of the T

45 Cyclophilins also display endonucleolytic activity, demonstrated by their ability

46 ase activity or the ability to promote Mre11 endonucleolytic activity.

47 ctivity of Argonaute itself, which often has endonucleolytic activity.

48 nce by binding to RNase E and regulating its endonucleolytic activity.

49 g that XBP-1 mRNA is a direct target of IRE1 endonucleolytic activity.

50 roducts indicates that they are generated by endonucleolytic activity.

51 cessing is splicing-independent and requires endonucleolytic activity.

52 o 3' exonucleolytic and a structure-specific endonucleolytic activity.

53 essing of polycistronic pre-snoRNAs involves endonucleolytic activity.

54 an retroposons is mediated by an enzyme with endonucleolytic activity.

55 ent replication, by virtue of intron-encoded endonucleolytic activity.

56 cation, DNA strand separation, and intrinsic endonucleolytic activity.

57 inimal effect on RNase H activity, retaining endonucleolytic and directed cleavage of an RNA/DNA hybr

58 nd repair flap endonucleases (FENs) catalyze endonucleolytic and exonucleolytic (EXO) DNA hydrolyses.

59 Here we show that hMRN catalyzes sequential endonucleolytic and exonucleolytic activities on both 5'

60 ats in the course of replication, relying on endonucleolytic and exonucleolytic activities, respectiv

61 BLM protein stimulates both the endonucleolytic and exonucleolytic cleavage activity of

62 ism for the coordination of the proteolytic, endonucleolytic, and morphogenetic aspects of apoptosis.

63 hen bound to the mRNA, shields the mRNA from endonucleolytic attack and thereby prolongs the mRNA hal

64 that normally protects chromosomal DNA from endonucleolytic attack.

65 es to a single subnuclear focus following an endonucleolytic break.

66 rate anti-RNase E monoclonal antibodies; the endonucleolytic cleavage activity co-purified with the i

67 oth strand and sequence specificities on the endonucleolytic cleavage activity of Orf20.

68 The starvation-induced endonucleolytic cleavage activity targets tRNAs that hav

69 acterial RNA polymerase exhibit an intrinsic endonucleolytic cleavage activity that restores the hybr

70 orts the idea that topo IIIbeta possesses an endonucleolytic cleavage activity.

71 This modulation likely involves endonucleolytic cleavage and a competing interaction wit

72 (A) tail of a mammalian mRNA is generated by endonucleolytic cleavage and poly(A) addition.

73 mRNA fragments generated by endonucleolytic cleavage are most likely removed by exon

74 protein demonstrated a high selectivity for endonucleolytic cleavage at abasic sites in DNA, a prope

75 otein-free and Argonaute 2-loaded miRNAs via endonucleolytic cleavage at CA and UA dinucleotides, pre

76 here that the degradation petD mRNA involves endonucleolytic cleavage at specific sites upstream of t

77 II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a sec

78 whereby the downstream products of RNase J1 endonucleolytic cleavage become substrates for the 5' to

79 or residues were removed from the 3' end by endonucleolytic cleavage before polymerization began.

80 Although the initial endonucleolytic cleavage by definition generates two pro

81 s in translation elongation are targeted for endonucleolytic cleavage by No-Go decay (NGD).

82 Previously, endonucleolytic cleavage by ribonuclease RNase J1 in a 3

83 iphosphate to a monophosphate triggers rapid endonucleolytic cleavage by RNase E.

84 nerate a monophosphate group that stimulates endonucleolytic cleavage by RNase E.

85 Efficient endonucleolytic cleavage by RTH1 nuclease has been demon

86 a catalytic riboswitch that is activated for endonucleolytic cleavage by the coenzyme glucosamine-6-p

87 osome fragmentation, which was distinct from endonucleolytic cleavage commonly associated with apopto

88 ere that 3'-end processing in vitro involves endonucleolytic cleavage downstream from the mature term

89 me-mediated beta-elimination reaction, or by endonucleolytic cleavage downstream of the baseless suga

90 The hMRN endonucleolytic cleavage events are further stimulated b

91 generated from the 3'-extended precursors by endonucleolytic cleavage followed by exonucleolytic trim

92 of most eukaryotic mRNAs are produced by an endonucleolytic cleavage followed by synthesis of a poly

93 quires processing of their 3'UTRs through an endonucleolytic cleavage guided by the U7 snRNA, which i

94 ing of histone pre-mRNA requires a single 3' endonucleolytic cleavage guided by the U7 snRNP that bin

95 degradation in Escherichia coli begins with endonucleolytic cleavage has been challenged by the rece

96 ivity and a potential consensus sequence for endonucleolytic cleavage identified, the structures of t

97 ccharomyces cerevisiae promote site-specific endonucleolytic cleavage in 25S ribosomal RNA (rRNA) adj

98 sults highlight the underappreciated role of endonucleolytic cleavage in controlling mRNA fates in ma

99 Rlp7p may also be required for the endonucleolytic cleavage in internal transcribed spacer

100 In contrast, Nop4, a protein required for endonucleolytic cleavage in ITS1, binds the pre-rRNA nea

101 ort a systematic study of small RNA-mediated endonucleolytic cleavage in mouse through integrative an

102 activity of the exosome is not required for endonucleolytic cleavage in no-go decay.

103 histone genes undergo efficient and faithful endonucleolytic cleavage in nuclear extracts prepared fr

104 This endonucleolytic cleavage is believed to involve the cova

105 Our previous studies demonstrated that the endonucleolytic cleavage is catalyzed by the cleavage/po

106 The mechanism of endonucleolytic cleavage is not consistent with the mech

107 Similar disruption of endonucleolytic cleavage is observed, except for the pla

108 The common belief that endonucleolytic cleavage is the initial, rate-determinin

109 In particular, Ire1p endonucleolytic cleavage leaves 2', 3'-cyclic phosphates

110 which the primer has an unannealed 5'-tail, endonucleolytic cleavage near the annealing point releas

111 The process is characterized by an endonucleolytic cleavage near the stall sequence, but th

112 atalytic subunit (DNA-PKcs) that carries out endonucleolytic cleavage of 5' and 3' overhangs.

113 of blunt-ended duplex DNA substrates and the endonucleolytic cleavage of 5'-bifurcated nucleic acids

114 ine or histidine in lieu of Tyr-274 catalyze endonucleolytic cleavage of a 60 bp duplex DNA at the CC

115 ologous oligonucleotides that originate from endonucleolytic cleavage of cellular mRNA during the pro

116 ntation during apoptosis is characterized by endonucleolytic cleavage of chromosomal DNA into an olig

117 Such endonucleolytic cleavage of circular double-stranded DNA

118 The endonucleolytic cleavage of circular dsDNA is consistent

119 A conserved response to stress involves endonucleolytic cleavage of cytoplasmic transfer RNAs (t

120 MRN-mediated endonucleolytic cleavage of DNA at sites of protein addu

121 poptosis, as measured by standard assays for endonucleolytic cleavage of DNA.

122 us gene, strongly suggest that they arise by endonucleolytic cleavage of endogenous PG mRNA.

123 ects a preferred site of posttranscriptional endonucleolytic cleavage of genomic RNA.

124 tro, the same protein is responsible for the endonucleolytic cleavage of histone pre-mRNA and the sub

125 Following endonucleolytic cleavage of histone pre-mRNA, the downst

126 The enzyme catalyses endonucleolytic cleavage of Holliday junction-containing

127 Endonucleolytic cleavage of Holliday junctions is import

128 on, and it also induces a template-dependent endonucleolytic cleavage of host mRNAs.

129 TerL, following endonucleolytic cleavage of immature viral DNA concateme

130 ion factor, X-box-binding protein 1, through endonucleolytic cleavage of its messenger RNA (mRNA).

131 the fact that most miRNAs are generated from endonucleolytic cleavage of longer transcripts, this fin

132 Endonucleolytic cleavage of mRNA in the daa operon of Es

133 SiRNAs typically induce endonucleolytic cleavage of mRNA with near-perfect compl

134 with the C terminus of Rpb1 and catalyze the endonucleolytic cleavage of nascent snRNAs near their 3'

135 tion of the 3' end of histone mRNA occurs by endonucleolytic cleavage of pre-mRNA releasing the matur

136 x is a group of proteins responsible for the endonucleolytic cleavage of primary small nuclear RNA (s

137 ation for the influence of 5' termini on the endonucleolytic cleavage of primary transcripts, which a

138 roL The terminator fragment derived from the endonucleolytic cleavage of proL transcript is degraded

139 RNA group I intron catalyzes a site-specific endonucleolytic cleavage of RNA, DNA, and chimeric RNA/D

140 ucleotides (PAMmers) stimulate site-specific endonucleolytic cleavage of ssRNA targets, similar to PA

141 miRNAs and other small RNAs that direct endonucleolytic cleavage of target mRNAs produce diagnos

142 n are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly unders

143 lear RNA by PB2, which then usually leads to endonucleolytic cleavage of the capped primer 13 nucleot

144 f Escherichia coli adhesins, is regulated by endonucleolytic cleavage of the daaABCDPE primary transc

145 sibly via a helicase mechanism, and eventual endonucleolytic cleavage of the DNA.

146 be required for a degradation step following endonucleolytic cleavage of the excised lariat.

147 reactivates arrested polymerase by inducing endonucleolytic cleavage of the nascent transcript by th

148 is of the majority of snRNAs involves 3' end endonucleolytic cleavage of the nascent transcript from

149 ption by RNA polymerase II is preceded by an endonucleolytic cleavage of the nascent transcript.

150 ves an enzymatic cascade, initiating with an endonucleolytic cleavage of the pre-mRNA at an editing s

151 U-deletion editing involves endonucleolytic cleavage of the pre-mRNA at the editing

152 The 3' end of histone mRNA is formed by an endonucleolytic cleavage of the primary transcript after

153 did not require ATP, and was accompanied by endonucleolytic cleavage of the resulting 3' overhang.

154 NA strand; however, the structural basis for endonucleolytic cleavage of the RNA strand remains elusi

155 in both flies and mammals, each siRNA guides endonucleolytic cleavage of the target RNA at a single s

156 Thus, the RISC-component that mediates endonucleolytic cleavage of the target RNA remains to be

157 ino acid residues involved in recognition or endonucleolytic cleavage of these diverse substrates.

158 ethylation increases the angiogenin-mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading

159 erved stress response in eukaryotes involves endonucleolytic cleavage of transfer RNAs (tRNAs).

160 let-7 miRNA-induced and Argonaute-catalysed endonucleolytic cleavage on target mRNAs at various site

161 c silencing of complementary target mRNAs by endonucleolytic cleavage or translational repression.

162 The RNase P-mediated endonucleolytic cleavage plays a crucial role in the 3'

163 es typically show chromatin condensation and endonucleolytic cleavage prior to obvious membrane or or

164 -rps14 operons revealed other polyadenylated endonucleolytic cleavage products, indicating that poly(

165 Whether its restriction activity involves endonucleolytic cleavage remains unclear.

166 An internal deletion of endonucleolytic cleavage sites previously identified wit

167 g affinities, (f) the presence or absence of endonucleolytic cleavage sites, (g) control of intracell

168 two distinct steps; the first is a specific endonucleolytic cleavage step called "processing," and t

169 La cell nuclear extract strongly reduced the endonucleolytic cleavage step of the cleavage and polyad

170 on the assumption that the decay involves an endonucleolytic cleavage that functionally inactivates t

171 one pre-mRNAs are processed at the 3' end by endonucleolytic cleavage that is not followed by polyade

172 iotic DSBs in budding yeast are processed by endonucleolytic cleavage that releases Spo11 attached to

173 pre-tRNAs in conformations that allow the 3' endonucleolytic cleavage to occur.

174 Endonucleolytic cleavage was 5' to the abasic site.

175 First, only few mRNAs that undergo low-level endonucleolytic cleavage were observed, suggesting that

176 hat are perfectly complementary by directing endonucleolytic cleavage where they anneal, thereby trig

177 revents both removal of the poly(A) tail and endonucleolytic cleavage within primary transcripts, but

178 , together with the effect of tail length on endonucleolytic cleavage within primary transcripts, sug

179 RecBCD action is required for stimulating endonucleolytic cleavage within the transpososome-protec

180 The second event (endonucleolytic cleavage) occurs after a variable delay

181 a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role

182 The 5' extremity of 12S rRNA is generated by endonucleolytic cleavage, and TbDSS-1 degrades resulting

183 e substrates before and after their exo- and endonucleolytic cleavage, as well as structures of uncle

184 ough a series of processing steps, including endonucleolytic cleavage, nuclear export and a strand se

185 ation followed by exonucleolytic decay, mRNA endonucleolytic cleavage, or translational inhibition.

186 d in standard enzymatic reactions (ligation, endonucleolytic cleavage, random labeling, PCR, and cycl

187 n elongation are recognized and targeted for endonucleolytic cleavage, referred to as 'no-go decay'.

188 onal diversity, while Gfh1 inhibits exo- and endonucleolytic cleavage, RNA synthesis, and pyrophospho

189 Mus81-Eme1 complex resolves DNA junctions by endonucleolytic cleavage.

190 bstrates for both exonucleolytic and 5' flap endonucleolytic cleavage.

191 ognizing the stalled ribosome and triggering endonucleolytic cleavage.

192 d pyrophosphorolysis, GreA enhances only the endonucleolytic cleavage.

193 fic and nonspecific polyadenylation and also endonucleolytic cleavage.

194 of this mutant was due to retardation of the endonucleolytic cleavage.

195 migration whereas RuvC resolves junctions by endonucleolytic cleavage.

196 ze c-myc mRNA in vitro by protecting it from endonucleolytic cleavage.

197 ed SoxR in protecting the soxS operator from endonucleolytic cleavage.

198 nsferrin receptor results in protection from endonucleolytic cleavage.

199 anslation at a premature nonsense codon, and endonucleolytic cleavage.

200 troy complementary transposon transcripts by endonucleolytic cleavage.

201 ut, in contrast to the BTR complex, do so by endonucleolytic cleavage.

202 The editing endonucleolytic cleavages being lost when the editing co

203 Mature miRNAs are produced by two sequential endonucleolytic cleavages facilitated by Drosha in the n

204 patterns in vivo suggesting Rrp44-dependent endonucleolytic cleavages in the 5'-ETS and ITS2 regions

205 tructures did not prevent degradation, rapid endonucleolytic cleavages most likely trigger RNA destru

206 We applied RAMP to examine how endonucleolytic cleavages of the mouse pre-rRNA transcri

207 The endonucleolytic cleavages produced by Orf20 generated a

208 t multiple sites is a prerequisite for three endonucleolytic cleavages that initiate small subunit bi

209 ) that binds to RNase E and inhibits RNase E endonucleolytic cleavages without altering cleavage site

210 icipates in initiating mRNA turnover through endonucleolytic cleavages.

211 y because all its action on 6S RNA is due to endonucleolytic cleavages.

212 rongly accumulated, without affecting normal endonucleolytic cleavages.

213 meiotic double-strand breaks (DSBs) requires endonucleolytic clipping of Rec12(Spo11)-oligonucleotide

214 osphorylation--IRE1alpha's RNase also causes endonucleolytic decay of many ER-localized mRNAs, includ

215 These results reveal the role of endonucleolytic DNA cleavage in restriction and yet poin

216 Endonucleolytic DNA fragmentation is the common end poin

217 itochondrial gene expression thus depends on endonucleolytic excision of tRNAs.

218 Pre-tRNAs thus require precise endonucleolytic excision.

219 erged from the common ancestor and then two "endonucleolytic" families branched out, separating "blun

220 by 3'-exonucleolytic degradation rather than endonucleolytic fragmentation by RNase E.

221 Here we investigate the endonucleolytic function of Ago2 and other nucleases by

222 We have examined the endonucleolytic function of Mre11 on defined, radiolabel

223 ements and possessed both exonucleolytic and endonucleolytic functions.

224 eased multiple- and single turnover rates of endonucleolytic hydrolysis at near physiological salt co

225 a conserved DNA repair pathway by making an endonucleolytic incision at the 3' side one nucleotide f

226 a conserved DNA repair pathway by making an endonucleolytic incision at the 3'-side 1 nt from a deam

227 cally stimulates both the exonucleolytic and endonucleolytic incision functions of EXO-1.

228 repair of deaminated DNA bases by making an endonucleolytic incision on the 3' side one nucleotide f

229 NA template and, remarkably, proceeded by an endonucleolytic mechanism.

230 ortant counterpoints in our understanding of endonucleolytic mechanisms and of damaged DNA recognitio

231 nsfers and canonical one-metal and two-metal endonucleolytic mechanisms are provided along with possi

232 , the balance between the exonucleolytic and endonucleolytic modes of hydrolysis shifted in favor of

233 oxidative, hydrolytic, and/or 2'-OH-mediated-endonucleolytic modes of scission.

234 anding question on the exonucleolytic versus endonucleolytic nature of 16S rRNA maturation.

235 these decay products are the consequence of endonucleolytic or 5'-to-3' exonucleolytic activity is u

236 ation in Escherichia coli employs a one-step endonucleolytic pathway that does not involve any of the

237 The endonucleolytic petD cleavage products can be polyadenyl

238 3 pre-rRNA base-pairing interactions mediate endonucleolytic pre-rRNA cleavages.

239 oly(A) tail removal by RNase E is in fact an endonucleolytic process that is regulated by the phospho

240 monophosphorylated as a result of sequential endonucleolytic processing by Drosha and Dicer from long

241 cts, the downstream product of atpB pre-mRNA endonucleolytic processing cannot be detected, even tran

242 3'-ends of primary transcripts, the sites of endonucleolytic processing in the 3' untranslated and in

243 that MrsC, directly or indirectly, controls endonucleolytic processing of mRNAs that may be independ

244 s to be extended toward the ICL, followed by endonucleolytic processing of the crosslink, lesion bypa

245 ied two polycistronic tRNA transcripts whose endonucleolytic processing was solely dependent on RNase

246 -protein-primed DNA synthesis and subsequent endonucleolytic processing.

247 A termini can be sampled for suitability for endonucleolytic processing.

248 . solfataricus CMR cleaves RNA targets in an endonucleolytic reaction at UA dinucleotides.

249 main structure, and the protein splicing and endonucleolytic reactions are catalyzed by residues in d

250 ow that Zn2+ can serve as a cofactor for the endonucleolytic reactions catalyzed by either the full-l

251 version mediated by Piv and transposition or endonucleolytic reactions catalyzed by enzymes of the re

252 Exonucleolytic and fork-gap-endonucleolytic reactions were also stimulated by the pr

253 t has two size classes, suggesting different endonucleolytic regulatory mechanisms.

254 RNase P is generally responsible for endonucleolytic removal of a leader sequence of precurso

255 pre-tRNAs, Lhp1p is required for the normal endonucleolytic removal of the 3' trailer sequence.

256 tRNA units within each operon following the endonucleolytic removal of the distal Rho-independent tr

257 er, RNase E is primarily responsible for the endonucleolytic removal of the entire Rho-independent tr

258 es two reactions in vivo: 1) the binding and endonucleolytic removal of the terminal dinucleotides of

259 ceeds in three steps: 3'-end processing, the endonucleolytic removal of the two terminal nucleotides

260 Endonucleolytic ribozymes constitute a class of non-codi

261 obably triggered by its ability to induce an endonucleolytic RNA cleavage, was separable from its tra

262 s a principal intermediate in factor-induced endonucleolytic RNA cleavage.

263 The hairpin ribozyme is a small endonucleolytic RNA motif with potential for targeted RN

264 rom exonucleolytic digestion but facilitates endonucleolytic scission by MRX with a dependence on ATP

265 uimolar production of rRNAs, it requires the endonucleolytic separation of pre-rRNAs to initiate rRNA

266 Minimally, the action of RISC requires the endonucleolytic slicer activity of Argonaute2 (Ago2) dir

267 Here we demonstrate that endonucleolytic slicing of a transcript by the cytosolic

268 d by the ping-pong cycle, which couples Piwi endonucleolytic slicing of target RNAs to biogenesis of

269 to cleave bifurcated, or branched DNA, in an endonucleolytic, structure-specific manner.

270 the U(L)89 open reading frame may encode an endonucleolytic subunit of the putative HCMV terminase.

271 Gre-factors, which stimulate an endogenous, endonucleolytic transcript cleavage activity of the RNA

272 ion elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA

273 of a small catalytic RNA that catalyses the endonucleolytic transesterification of RNA in a highly s

274 of a small catalytic RNA which catalyses the endonucleolytic transesterification of RNA in a highly s

275 3'-phosphoglycolate or 3'-hydroxyl terminus, endonucleolytic trimming of 2-4 nucleotides from the 3'-

276 not D165N Artemis suggests that the lack of endonucleolytic trimming of DNA ends is the principal ca

277 To examine whether endonucleolytic trimming of terminally blocked DSBs by A

278 unt-ended DNA, and promotes slow and limited endonucleolytic trimming of the 5'-terminal strand, resu

279 e Z, and establishing its biological role in endonucleolytic tRNA 3' end processing.

280 ts, which were designed to probe pathways of endonucleolytic versus exonucleolytic decay, were measur