ライフサイエンスコーパス: endopeptidase

1 ereas Lc-Lys-2 is a gamma-D-glutamyl-L-lysyl endopeptidase.

2 ide substrate indicated that IrCD1 is a true endopeptidase.

3 amoyl-L-alanine amidase and D-alanyl-glycine endopeptidase.

4 n in cjj81176_1105, a putative peptidoglycan endopeptidase.

5 f interaction between the substrate and BoNT endopeptidase.

6 tease 8, matrix metalloprotease 9, or prolyl endopeptidase.

7 eurotoxins is their light chain (LC), a Zn2+ endopeptidase.

8 Neprilysin is a zinc-dependent endopeptidase.

9 that shares limited homology with CaaX-type endopeptidases.

10 cally profiling the substrate specificity of endopeptidases.

11 mechanism of their inhibition of asparaginyl endopeptidases.

12 ve "activation cascades" with other KLKs and endopeptidases.

13 tiple amidases, lytic transglycosylases, and endopeptidases.

14 ust positive cooperativity not seen in other endopeptidases.

15 gned to the astacin family of zinc-dependent endopeptidases.

16 ved epitope of each of the Bd3459 and Bd0816 endopeptidases.

17 MPs) and cysteine cathepsins are families of endopeptidases.

18 ld for designing substrates for any group of endopeptidases.

19 The universally conserved kinase-associated endopeptidase 1 (Kae1) protein family has established ro

20 g matrix metalloproteases 8 and 9 and prolyl endopeptidase, a serine protease for which we identify a

21 ShyA is a D,d-endopeptidase able to cleave most peptide chain cross-li

22 es a homolog of the SagA cell wall-dependent endopeptidase, acquired distinct transposon insertions i

23 by the addition of lysostaphin, a bacterial endopeptidase active at neutral pH that can substitute f

24 NG1686 contains M23B endopeptidase active sites found in proteins that cleave

25 acid in both the DD-carboxypeptidase and DD-endopeptidase activities of a class C LMM-PBP.

26 different, both groups of NAPs activate the endopeptidase activities of their BoNTs without any need

27 he effect on both DD-carboxypeptidase and DD-endopeptidase activities was determined.

28 for both the dd-carboxypeptidase and the 4,3-endopeptidase activities were prepared by multistep synt

29 f the proteins (SpoIIP) has both amidase and endopeptidase activities, such that it removes the stem

30 G1686 possesses both dd-carboxypeptidase and endopeptidase activities.

31 have substantially higher isopeptidase than endopeptidase activities.

32 l enzyme having both dd-carboxypeptidase and endopeptidase activities.

33 PME was separated from the abundant cysteine endopeptidases activities using sequential hydrophobic i

34 onary inflammation through decreasing prolyl endopeptidase activity and AcPGP.

35 Complexation inhibits endopeptidase activity and cell wall decrosslinking in v

36 nicking of BoNT/E significantly enhances its endopeptidase activity and that at the physiological tem

37 s an M23 peptidase that exhibits D-Ala-D-Asp endopeptidase activity and that this activity is require

38 ERAP1 variants associated with reduced endopeptidase activity appear to be protective against A

39 Previously, we reported an endopeptidase activity based method (Endopep-MS) that de

40 II MCPs exhibit Ca(2+) dependence for their endopeptidase activity in vitro.

41 show that the eponymous asparagine-specific endopeptidase activity is electrostatically generated by

42 The endopeptidase activity is specific to hydrolysis of 4,3-

43 The toxicity is related to a poor zinc endopeptidase activity located in a 50-kDa domain known

44 Endopeptidase activity may be the main switch that gover

45 peptide substrates to measure the intrinsic endopeptidase activity of bead-captured BoNT.

46 that Bacillus subtilis cells require the DL-endopeptidase activity of CwlO or LytE for growth.

47 nique in that it can effectively distinguish endopeptidase activity of FAP from that of other related

48 We also detected the endopeptidase activity of orally administered BoNT/A1 co

49 s study, we report that NEP has the dominant endopeptidase activity toward Abeta in macrophages.

50 1 has a peptidoglycan D-isoglutamyl-L-lysine endopeptidase activity via a NlpC/P60 homology domain.

51 203, Glu204, Tyr656, and Asn704) promote FAP endopeptidase activity via distinct mechanisms of transi

52 PBP4 DD-endopeptidase activity was also affected, with substitut

53 ed modifiers (SUMO) for protein conjugation (endopeptidase activity) and removing conjugated SUMO fro

54 ked peptidoglycan (the substrate for the 4,3-endopeptidase activity) increase.

55 was accompanied with great reduction of NEP endopeptidase activity, which might be due to the dimini

56 eptidase- (amino- or carboxy-), amidase-, or endopeptidase activity.

57 to be essential for AIP production and AgrB endopeptidase activity.

58 nd possesses both dd-carboxypeptidase and dd-endopeptidase activity.

59 ion of Ala657 and the conserved residues for endopeptidase activity.

60 DPP-4 substrate binding residues support FAP endopeptidase activity.

61 ptidyl peptidase activity, but FAP alone has endopeptidase activity.

62 d aminopeptidase activity but no carboxy- or endopeptidase activity.

63 orresponds to DPP-4 Asp663, is important for endopeptidase activity; however, its specific role remai

64 s of inhibitors specific for the asparaginyl endopeptidases (AE) (legumains).

65 Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine

66 terminal acyclic TI, depends on asparaginyl endopeptidase (AEP) for maturation.

67 to determine the extent to which asparagine endopeptidase (AEP) influences human Ag and Ii processin

68 Here, we show that asparagine endopeptidase (AEP) is activated under acidic condition,

69 Asparagine endopeptidase (AEP) is an unusually specific endosomal a

70 ctodomain and can be performed by asparagine endopeptidase (AEP) or cathepsin family members.

71 delta-secretase, also known as asparagine endopeptidase (AEP) or legumain, is a lysosomal cysteine

72 illing of bacteria by AMs through asparagine endopeptidase (AEP), a key endosomal cysteine protease.

73 Here we show that asparagine endopeptidase (AEP), a lysosomal cysteine proteinase, is

74 Here we show that asparagine endopeptidase (AEP), a pH-controlled cysteine proteinase

75 Asparagine endopeptidase (AEP), also called legumain, is highly exp

76 identified unique expression of asparaginyl endopeptidase (AEP), intercellular adhesion molecule 1 (

77 Delta-secretase, a lysosomal asparagine endopeptidase (AEP), simultaneously cleaves both APP and

78 Asparaginyl endopeptidase (AEP), which is overexpressed predominantl

79 milar structural fold with other asparaginyl endopeptidases (AEP).

80 In seeds, PawS1 is matured by asparaginyl endopeptidases (AEPs) into the cyclic peptide SFTI-1 (su

81 ides a rationale for the mechanism of BoNT/E endopeptidase against its intracellular substrate, SNAP-

82 precursor of AIP, and the integral membrane endopeptidase AgrB.

83 The peptidoglycan endopeptidase, AmpH, was identified as being important f

84 and analyzed, under the same conditions, the endopeptidase and carboxypeptidase-like activities of th

85 acid or pH 6.0 medium activated asparaginyl endopeptidase and consequently produced the cleavage of

86 bitors of dipeptidyl peptidase-IV and prolyl endopeptidase and could potentially be used as dietary i

87 residues provide marked TSS energy for both endopeptidase and dipeptidyl peptidase substrates, and s

88 ECEL1 encodes a neuronal endopeptidase and is expressed in the brain and peripher

89 llular matrix collagen breakdown with prolyl endopeptidase and leukotriene A4 hydrolase serving as th

90 The highly conserved Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/E

91 fsANP are preferentially degraded by neutral endopeptidase and serine peptidases, respectively.

92 ith significant homology to mammalian prolyl endopeptidase and the bacterial peptidase oligopeptidase

93 serotype D (GHRH-LHN/D, where HN/D indicates endopeptidase and translocation domain type D).

94 ty to Type VI secretion system peptidoglycan endopeptidases and recognition by the Drosophila innate

95 fluorescent probe in vitro using a panel of endopeptidases and specific inhibitor.

96 /P60 domain (gamma-d-glutamyl-l-diamino acid endopeptidase) and is expected to play an important role

97 orescent domains separate on cleavage by the endopeptidase, and emission from the directly excited GF

98 hat other thiorphan/phosphoramidon-sensitive endopeptidases are at work.

99 ting that yet other NEP-like Abeta-degrading endopeptidases are contributing to Abeta catabolism.

100 These experiments revealed that endopeptidases are the major proteolytic activities secr

101 matrix metalloproteases 8 and -9 and prolyl endopeptidase, are also elevated in these samples.

102 ays, enzyme-linked immunosorbent assays, and endopeptidase assays and by mass spectrometry.

103 BoNT endopeptidase assays using short substrate homologues ha

104 diabetes, I2(PP2A) is cleaved by asparaginyl endopeptidase at Asn-175 into the N-terminal fragment (I

105 consisting of basic residues by well studied endopeptidases belonging to the subtilisin superfamily.

106 tability and high specificity for particular endopeptidases but have not been extensively studied for

107 AcPGP by more than 50% (P < 0.01) and prolyl endopeptidase by 46% (P = 0.02), without significant imp

108 KFL), a substrate of the endosomal/lysosomal endopeptidase cathepsin B, connected to oligo-(L)-lysine

109 encing analysis, we identified the lysosomal endopeptidase cathepsin Ba (ctsba) as the gene deficient

110 Unlike endopeptidases cathepsin B and L, T. gondii cathepsin Cs

111 n (ChiW) and a putative l-alanyl-d-glutamate endopeptidase (ChiX), and subsequent biochemical analyse

112 Endopeptidase cleavage at Lys(91) generates a cleaved gl

113 Specific endopeptidases cleave chromogranin A into biologically a

114 ocate intracellularly, where the light-chain endopeptidase cleaves the SNARE complex proteins, subver

115 rived from Streptococcus pyogenes (IdeS), an endopeptidase, cleaves human IgG into F(ab')2 and Fc fra

116 in anaphase when separase, a giant cysteine endopeptidase, cleaves the Scc1/Rad21 subunit of cohesin

117 was reported that GCPII can also serve as an endopeptidase cleaving amyloid beta (Abeta) peptides and

118 wo-component protease consists of a Ser-type endopeptidase ClpP, which relies on the ATP-dependent un

119 polypeptide (LMP) 2 (beta1i), multicatalytic endopeptidase complex-like-1 (beta2i), and LMP7 (beta5i)

120 ent of the paralytic disease botulism, is an endopeptidase composed of a catalytic domain (or light c

121 that deficiency of the VWF-cleaving ADAMTS13 endopeptidase contributes to the development of VEGF inh

122 We investigated whether neutral endopeptidase could inhibit angiogenesis in vivo utilizi

123 dual transglycosylases, transpeptidases, and endopeptidases could introduce new material into an exis

124 Further, we identified the metallo-endopeptidase CpaA, which has been shown previously to c

125 cell wall elongation requires two redundant endopeptidases, CwlO and LytE.

126 hat resist intestinal proteases by exogenous endopeptidases, decrease of intestinal permeability by b

127 The purified endopeptidase degraded gonococcal peptidoglycan in vitro

128 olism is dependent on degradation by neutral endopeptidase, dipeptidyl peptidase IV, and aminopeptida

129 in lytic activity conferred on the LambdaSa2 endopeptidase domain by either LysK or lysostaphin SH3b

130 ion within the zinc coordination site of the endopeptidase domain completely abolished SXN101742 inhi

131 d GH-releasing hormone (GHRH) domain and the endopeptidase domain of botulinum toxin serotype D (GHRH

132 ytic activity conferred on the streptococcal endopeptidase domain, and surprisingly these same fusion

133 rves as the substrate for its glycyl-glycine endopeptidase domain.

134 erminal extension, cleaved off by a specific endopeptidase during maturation.

135 Ang II binding proteins, later identified as endopeptidases EC 3.4.24.15 and/or EC 3.4.24.16.

136 t proteolytic complex, is a highly conserved endopeptidase encoded by CLPP and forms an element of th

137 We showed that fibulin-4 binds procollagen C-endopeptidase enhancer 1 (Pcolce), which enhances proteo

138 ed in fibroblasts--collagen I, procollagen C endopeptidase enhancer 1, secreted protein acidic and ri

139 ignificant correlation between procollagen C-endopeptidase enhancer protein 2 (PCPE2) single nucleoti

140 The PHEX gene encodes a zinc endopeptidase expressed in osteoblasts and contributes t

141 oproteinases (MMPs) are a family of secreted endopeptidases expressed by neurons and glia.

142 e that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, ov

143 sA is a structurally distinct member of this endopeptidase family, consistent with its activity again

144 Asparaginyl endopeptidase from Alzheimer disease brain could cleave

145 Here, we evaluate the usage of a prolyl endopeptidase from Aspergillus niger (An-PEP) for HDX-MS

146 cipitation was applied to fractionate glycyl endopeptidase from the papaya latex of Red Lady and Khac

147 To counteract endopeptidases from the host or microbial competitors, T

148 nce, we deconvoluted such a network of major endopeptidases functioning in invertebrate intestinal pr

149 Glutamyl endopeptidase (GE) from Alcalase 2.4 L was purified usin

150 canase gene atlA but carried a peptidoglycan endopeptidase gene in place of atlA.

151 e binding pocket conserved in active metallo-endopeptidases has been adapted to control PG hydrolysis

152 MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role

153 MPs), a family of extracellular matrix (ECM) endopeptidases, have been implicated in the pathogenesis

154 A serine endopeptidase, hereby-named Destructin-1, was subsequent

155 atrix protein 1), Phex (phosphate-regulating endopeptidase homolog), and Bsp (bone sialoprotein).

156 for helical shape: three LytM peptidoglycan endopeptidase homologs (csd1-3) and a ccmA homolog.

157 enesis of Alzheimer disease, and asparaginyl endopeptidase-I2(PP2A)-protein phosphatase 2A-Tau hyperp

158 Here, we identify DipM, a putative LytM endopeptidase in Caulobacter crescentus, and show that i

159 cell shape and suggest that the role of this endopeptidase in forming coccoid morphology may be criti

160 eptidase inhibitor, which is cleaved by host endopeptidases in an accessible bait region.

161 In contrast, the major endopeptidases in the digestive fluid of the Venus flytr

162 endothelial cells demonstrated that neutral endopeptidase inhibition significantly enhanced fibrobla

163 trategies were tested: inhibition of neutral endopeptidase, inhibition of aldose reductase plus lipoi

164 ity when given in combination with a neutral endopeptidase inhibitor (enhances endogenous natriuretic

165 e array of distinct serpins with serine-type endopeptidase inhibitor activity.

166 tulinum neurotoxin A light chain (BoNT/A LC) endopeptidase inhibitor by screening the National Cancer

167 Gly-136, which was inhibited by the neutral endopeptidase inhibitor CGS24592 and heparin.

168 Through single coinjection of the neutral endopeptidase inhibitor phosphoramidon (PA), we were abl

169 ut microbiome encode a relative of the human endopeptidase inhibitor, alpha2-macroglobulin (alpha2M).

170 f the largest and most conserved families of endopeptidases involved in diverse cellular activities,

171 occus aureus lysostaphin and LytM, and to DD-endopeptidases involved in entry of bacteriophage to hos

172 ix metalloproteases (MMPs) are Zn-containing endopeptidases involved in the degradation of extracellu

173 show that the level of activated asparaginyl endopeptidase is significantly increased, and this enzym

174 that the cleavage of cross-links by the new endopeptidases is needed for surface growth of the saccu

175 Limited proteolysis, accomplished by endopeptidases, is a ubiquitous phenomenon underlying th

176 consists of five proteins, Kinase-Associated Endopeptidase (Kae1), a highly conserved protein present

177 e inactive pro-forms of KDEL-tailed cysteine endopeptidases (KDEL-CysEP) associated with programmed c

178 The BoNT/A LC endopeptidase kinetics at the optimally active temperatu

179 in this study as a SNAP-25 homologue for the endopeptidase kinetics study of BoNT/A LC.

180 as incubated with neprilysin (300 ng/ml), an endopeptidase known to hydrolyze Abeta1-40 and the expec

181 Nep1.SIGNIFICANCE STATEMENT Neprilysins are endopeptidases known to degrade a number of small peptid

182 Neprilysins are endopeptidases known to degrade a number of small peptid

183 n the active site of the acid-active gliadin endopeptidase KumaMax.

184 tivity of the redox-sensitive ATG4B cysteine endopeptidase, leading to enhanced LC3B delipidation and

185 An asparaginyl endopeptidase (legumain) also synergized with cathepsin

186 shown to be potent inhibitors of asparaginyl endopeptidases (legumains) from the bloodfluke, Schistos

187 Prolyl endopeptidase-like (PREPL) is a newly described member o

188 ase and Other Proteins of small Size (KEOPS)/Endopeptidase-like and Kinase associated to transcribed

189 to the peptidoglycan-targeting glycylglycine endopeptidase lysostaphin, compared to the wild type.

190 um toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conv

191 s developed for the quantitation of the zinc endopeptidase matrix metalloproteinase 9 (MMP-9) from mo

192 Our previous results showed that an endopeptidase, matrix metalloproteinase-3 (MMP3), was in

193 lic peptides, appears to involve asparaginyl endopeptidase-mediated processing from larger precursor

194 or the suppression process, as was a related endopeptidase, MepA.

195 tter the relationship between ICAM-5 and the endopeptidase metalloproteinase-9 (MMP-9), which mediate

196 oping Endopep-MS, a mass spectrometric-based endopeptidase method for the detection and differentiati

197 dipeptidyl peptidase-IV (DPP-IV) and neutral endopeptidase (NEP) 24.11 severely compromises its effec

198 establish the effect of oleacein on neutral endopeptidase (NEP) activity and other functions of huma

199 a half-life due to its resistance to neutral-endopeptidase (NEP) digestion.

200 our efforts to identify a selective neutral endopeptidase (NEP) inhibitor as a potential treatment f

201 Neutral endopeptidase (NEP) is expressed on normal prostate epit

202 xpression of the SP-degrading enzyme neutral endopeptidase (NEP) is increased, compared to control sk

203 The endopeptidase neprilysin (NEP) is a major amyloid-beta (

204 The endopeptidase neprilysin has been successfully used to r

205 d to decreased levels of the metallomembrane endopeptidase neprilysin, normal levels were maintained

206 through the expression and execution of two endopeptidases, neprilysin (NEP) and insulin-degrading e

207 We demonstrated recently that pneumococcal endopeptidase O (PepO) is a ubiquitously expressed, mult

208 entified a novel 72-kDa pneumococcal protein endopeptidase O (PepO), as a plasminogen- and fibronecti

209 e showed that legumain, the only asparaginyl endopeptidase of the mammalian genome, is highly express

210 in uniquely blocked many serine and cysteine endopeptidases of disparate architecture and substrate s

211 ss a single target bond and inhibit selected endopeptidases of particular specificity and class.

212 endogenous inhibitors of the zinc-dependent endopeptidases of the matrix metalloproteinase families.

213 -regulating gene, which is homologous to the endopeptidases of the X-chromosome (PHEX).

214 ely 10(5) M(-1)s(-1)) variant of the E. coli endopeptidase OmpT that selectively hydrolyzes peptides

215 phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and by dentin

216 phosphate-regulating gene with homologies to endopeptidases on the X chromosome (Phex) cause X-linked

217 phosphate-regulating gene with homologies to endopeptidases on the X-chromosome (PHEX).

218 ks angiotensin converting enzyme and neutral endopeptidase, on these endpoints.

219 cute lymphoblastic leukemia antigen, neutral endopeptidase, or enkephalinase, can be used as a marker

220 y ex vivo treatment with O-sialoglycoprotein endopeptidase (OSGE) can reverse many aspects of the age

221 We show here that deleting the endopeptidase PBP 4 from strains lacking AmiC produces l

222 Another endopeptidase, PBP 7, fulfills a secondary role.

223 Prolyl endopeptidase (PEP) cleaves neuropeptides and is a drug

224 ivity of a number of enzymes, such as prolyl endopeptidase (PEP, EC 3.4.21.26), has been linked to th

225 s degradation is mediated by the cytoplasmic endopeptidase PepO, which is the first identified enzyma

226 Inactivating mutations of the endopeptidase PHEX or the SIBLING protein DMP1 result in

227 associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, dec

228 y ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of bio

229 Separase, an endopeptidase, plays a pivotal role in the separation of

230 We find that P. aeruginosa LasA endopeptidase potentiates lysis of S. aureus by vancomyc

231 were removed from partially purified glycyl endopeptidase (PPGE).

232 that of other related enzymes such as prolyl endopeptidase (PREP) and was validated using Fap-deficie

233 Prolyl endopeptidase (PREP) has been implicated in neuronal fun

234 Prolyl endopeptidase (Prep) is a member of the prolyl peptidase

235 A predicted target of miR-324-3p is prolyl endopeptidase (Prep), a serine peptidase involved in the

236 e distinct from the well-described CaaX-type endopeptidases RAS Converting Enzyme1 (RCE1) and zinc me

237 believed to catalyze DD-carboxypeptidase and endopeptidase reactions in vivo.

238 ondin motifs (ADAMTS) constitute a family of endopeptidases related to matrix metalloproteinases.

239 erefore, we hypothesize that SCO4 is a novel endopeptidase required for critical protein modification

240 cules with minimum interacting motifs showed endopeptidase resistance and better inhibitory activitie

241 s resemble lysozyme-like enzymes and metallo-endopeptidases, respectively.

242 on in regulating OCN and the identity of the endopeptidase responsible for pro-OCN cleavage in osteob

243 te that this new family of Ras/Rap1-specific endopeptidases (RRSPs) has potential to inactivate both

244 ndoprotease (EP-B2 from barley) and a prolyl endopeptidase (SC PEP from Sphingomonas capsulata), for

245 Endopeptidases sensitive to inhibition by thiorphan and

246 in diameter and contain DNA, adhesin P5, IgA endopeptidase, serine protease, and heme utilization pro

247 escentus, with a specific focus on LytM-like endopeptidases, soluble lytic transglycosylases and amid

248 ococcus maripaludis homologue of Rce1, whose endopeptidase specificity for farnesylated peptides mimi

249 oligopeptidase (PREP), with which it shares endopeptidase specificity.

250 SUMO domain, and the C-terminal tails direct endopeptidase specificity.

251 fication in Escherichia coli of three new DD-endopeptidases (Spr, YdhO and YebA) which are collective

252 For example, cysteine protease (SspB), endopeptidase (SspA), staphopain (ScpA), and aureolysin

253 Ala657 also stabilizes endopeptidase substrate binding and additionally dictate

254 peptidase related to autolytic glycylglycine endopeptidases such as Staphylococcus aureus lysostaphin

255 factor's primary action as an intracellular endopeptidase targeting mitogen-activated protein kinase

256 The threonine endopeptidase Taspase1 has a critical role in cancer cel

257 We show that AlbD is a novel type of endopeptidase that catalyzes the cleavage of albicidin a

258 romatography, and gp13 was found to be a d,d-endopeptidase that cleaved the peptide cross-link.

259 Taspase1 was identified as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL)

260 Bace1 is an endopeptidase that cleaves the amyloid precursor protein

261 from Vibrio vulnificus to be a site-specific endopeptidase that cleaves within the Switch 1 region of

262 Calpain is a cytosolic cysteine endopeptidase that has been implicated in a number of di

263 They identify a novel endopeptidase that is necessary to generate the helical

264 ur results clearly identify AlbD as a unique endopeptidase that is the first member of a new subfamil

265 rix metalloproteinase (MMP)-9 expression, an endopeptidase that participates in diverse pathologic pr

266 that matrix metalloproteinase-9 (MMP-9), an endopeptidase that regulates the pericellular environmen

267 involved in this pathway is AgrB, a membrane endopeptidase that removes the AgrD carboxy-tail.

268 Separase is an endopeptidase that separates sister chromatids by cleavi

269 Botulinum neurotoxins (BoNTs) are zinc endopeptidases that block release of the neurotransmitte

270 d/or biochemically characterized are metallo-endopeptidases that cleave cross-links in the peptidogly

271 f Haemophilus influenzae are highly specific endopeptidases that cleave the hinge region of human IgA

272 etome of P. destructans, and identify serine endopeptidases that have the clear potential to facilita

273 proteinases (MMPs) comprise a family of zinc endopeptidases that play major roles in the physiology a

274 Matrix metalloproteinases (MMPs) are zinc endopeptidases that play roles in numerous pathophysiolo

275 Matrix metalloproteases (MMPs) are endopeptidases that regulate diverse biological processe

276 ive to proteases (cathepsin B and asparagine endopeptidase) that are over-expressed by resistant leuk

277 red for kidney membranes or purified neutral endopeptidase to abolish ANP-dependent activation of NPR

278 ces before or after the scissile bond showed endopeptidase to be superior to dipeptidase activity for

279 ach can be successfully used for any type of endopeptidase to deliver high activity and selectivity i

280 in/SUMO-specific proteases (SENPs) act as an endopeptidase to process the pre-SUMO or as an isopeptid

281 Exposure of prolyl endopeptidases to bile acids made them more susceptible

282 This was confirmed by analyzing endopeptidase-treated pilin by mass spectrometry.

283 d peptidoglycan, whereas LytM, a pentaglycyl-endopeptidase, triggers polypeptide release from the bac

284 describe the first crystal structures of the endopeptidase-type gammaGH (zgammaGH) from zebrafish and

285 The isolation of endopeptidase variants that can discriminate between sub

286 No other known cytosolic aminopeptidase or endopeptidase was found to digest these polyQ peptides.

287 Protamex, an endopeptidase was used to digest oat bran protein isolat

288 ld-type neutrophils with O-sialoglycoprotein endopeptidase was used to reduce the PSGL-1 density to t

289 vels of the enzyme that degrades SP, neutral endopeptidase, were increased.

290 roadly speaking, SENP1 is the most efficient endopeptidase, whereas SENP2 and -5-7 have substantially

291 Ps belong to the zinc- and calcium-dependent endopeptidases which are involved in the proteolytic deg

292 Incubation with neutral endopeptidase, which degrades bombesin, or bombesin rece

293 inhibitors inhibit ACE activity and neutral endopeptidase, which degrades natriuretic peptides.

294 on between RpfB and a putative mycobacterial endopeptidase, which we named Rpf-interacting protein A

295 d metalloproteinases are members of the zinc endopeptidases, which cleave components of the extracell

296 try involves the predator's peptidoglycan DD-endopeptidases, which decrosslink cell walls and prevent

297 Calpain is a family of calcium-dependent endopeptidases, which plays an important role in ECM rem

298 Glycyl endopeptidase with high purification fold (PF) and yield

299 ion of Tau, and the knockdown of asparaginyl endopeptidase with siRNA abolished this pathway in SH-SY

300 Matrix metalloproteinases (MMPs) are zinc-endopeptidases with multifactorial actions in central ne