ライフサイエンスコーパス: endoperoxide

1 ad no effect on the rate of formation of the endoperoxide.

2 ns, suggest that the nanotube oxide is a 1,4-endoperoxide.

3 mportant in influencing the stability of the endoperoxide.

4 intermediate (9) as found on the pathway to endoperoxide.

5 which is 13.9 kcal/mol less stable than the endoperoxide.

6 kaloids that contain a unique eight-membered endoperoxide.

7 g rates of MDA production from prostaglandin endoperoxide.

8 n to irreversibly yield a highly fluorescent endoperoxide.

9 chromophore encapsulated inside a macrocycle endoperoxide.

10 xides, bicyclic endoperoxides, and dioxolane-endoperoxides.

11 vation of PPARg by interactions with shunted endoperoxides.

12 enation of arachidonic acid to prostaglandin endoperoxides.

13 IsoTxs), are formed by rearrangement of IsoP endoperoxides.

14 nd reversible formation of the corresponding endoperoxides.

15 n by (1)O(2) generated various aldehydes and endoperoxides.

16 ve been synthesized and converted into their endoperoxides 1-O2 upon oxidation with singlet oxygen.

17 Provided by total synthesis, endoperoxides 18, 20, and 22 underwent intramolecular ox

18 N-hydroxyphthalimide (NHPI, 5 equiv) formed endoperoxide 2 in 76% yield at ambient temperature.

19 stabilized radicals on rings A and C to form endoperoxide 2.

20 Tricyclic endoperoxide 20 was converted to methyl and benzyl ether

21 urification and identification of ergosterol endoperoxide, a B-ring oxysterol.

22 beta-Carotene-5,8-endoperoxide, a specific marker for singlet oxygen oxida

23 graphy-mass spectrometry analysis to monitor endoperoxide activation by measurement of a stable rearr

24 Heating of the endoperoxides affords the parent anthracenes by release

25 The endoperoxide also undergoes hydrolytic opening followed

26 Therefore, we explored whether the IsoP endoperoxides also undergo rearrangement to form IsoLGs.

27 ion of arachidonic acid at C-11, followed by endoperoxide and cyclopentane ring formation, and then a

28 Taichunamides C and D contain endoperoxide and methylsulfonyl units, respectively.

29 with the histidyl imidazole ring to form an endoperoxide and then converted to the 2-oxo-histidine (

30 well-characterized antimalarials, including endoperoxides and 4-aminoquinolines, as well as compound

31 methodology expands the synthetic utility of endoperoxides and further underlines their potential as

32 unstable products, such as the prostaglandin endoperoxides and leukotriene A(4) epoxide of mammalian

33 monstrated that hybrid compounds, comprising endoperoxides and vinyl sulfones, were capable of high a

34 peroxides, serial cyclic peroxides, bicyclic endoperoxides, and dioxolane-endoperoxides.

35 In spite of the recent increase in endoperoxide antimalarials under development, it remains

36 d artemether, along with the fully synthetic endoperoxide antimalarials, are believed to mediate thei

37 PGH2-like endoperoxides are intermediates in this pathway.

38 We suggest that bicyclic endoperoxides are the major TBARS active compounds prese

39 )) without irradiation and identified a 6,13-endoperoxide as the sole regioisomer.

40 hysiological pH values, both ASG and the ASG endoperoxide (ASG-EP) do not themselves photosensitize t

41 atalyzed disproportionation of a hydroperoxy endoperoxide available by singlet oxygenation of cyclohe

42 Yet, the mechanisms of most endoperoxide biosyntheses are not well understood.

43 n several cases, the only well-characterized endoperoxide biosynthetic enzyme is prostaglandin H synt

44 roartemisinin, to determine the chemistry of endoperoxide bridge activation to reactive intermediates

45 Desoxyartemisinin lacks an endoperoxide bridge and is ineffective both as an inhibi

46 nd it is hypothesized that activation of the endoperoxide bridge by an iron(II) species, to form C-ce

47 death is a consequence of activation of the endoperoxide bridge to radical species, which triggers c

48 ophenoxy)dihydroartemisinin, which lacks the endoperoxide bridge, was 50- and 130-fold less active in

49 rescein and Cy3) through an Fe(II)-cleavable endoperoxide bridge, where Fe(II)-triggered peroxide cle

50 beta-Carotene endoperoxide, but not xanthophyll endoperoxide, rapidly

51 d through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES).

52 Squaraine rotaxane endoperoxides can be stored indefinitely at temperatures

53 Several of the new endoperoxide chemical entities consistently demonstrated

54 ntoxic doses of a chemical compound from the endoperoxide class that decomposes in water generating s

55 ghly conserved alkylation profile, with both endoperoxide classes targeting proteins in the glycolyti

56 ort the first synthesis of the more complex, endoperoxide-containing members of this family.

57 de moieties is well known, the production of endoperoxide-containing oxo-A2E may account, at least in

58 initially formed endoperoxide, otherwise the endoperoxide decomposes to regenerate starting material.

59 n or by thermal decomposition of naphthalene endoperoxide derivatives.

60 urement of a stable rearrangement product of endoperoxide-derived radicals, which was formed in sensi

61 glet oxygen that reacts with alkenes to form endoperoxides, diooxetanes, or hydroperoxides, which are

62 Here, we show that prostaglandin endoperoxide E(2) selectively inhibits activation-induce

63 In vitro studies showed that endoperoxide (EP) 3 and 4 receptors were responsible for

64 Artemisinin, a sesquiterpene lactone endoperoxide extracted from Artemisia annua L (family As

65 While this conformation allows endoperoxide formation between C-11 and C-9, it also imp

66 lectronic factors in the regioselectivity of endoperoxide formation of tetracene derivatives using (1

67 help to unravel the novel mechanism for this endoperoxide formation reaction.

68 ar non-haem iron enzyme that can catalyse an endoperoxide formation reaction.

69 ylalanine, the FtmOx1 catalysis diverts from endoperoxide formation to the more commonly observed hyd

70 whereas electron density is a determinant of endoperoxide formation, steric factors are most importan

71 ort the involvement of singlet oxygen in the endoperoxide formation.

72 nzyme that catalyzes the synthesis of cyclic endoperoxides from arachidonic acid to yield prostagland

73 ty of acenes but also protects the resulting endoperoxides from thermal decomposition.

74 The endoperoxide functional group is both the pharmacophore

75 ponsible for intracellular activation of the endoperoxide group and that this is the chemical basis o

76 to one another make it difficult to form the endoperoxide group from the 11-hydroperoxyl radical.

77 diate is able to add to C-9 to form the 9,11 endoperoxide group of PGG2.

78 Prostaglandin endoperoxide H synthase (COX-2) activity was detected at

79 Prostaglandin-endoperoxide H synthase (PGHS) (EC 1.14.99.1) expression

80 TPA increased prostaglandin endoperoxide H synthase (PGHS) activity and increased th

81 s with specific members of the prostaglandin-endoperoxide H synthase (PGHS) family.

82 en detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated

83 The largest difference was seen with PG endoperoxide H synthase (PGHS)-1.

84 Prostaglandin endoperoxide H synthase 2 (PGHS-2) catalyzes the rate-li

85 the amount of immunodetectable prostaglandin endoperoxide H synthase 2 (PGHS-2).

86 duces hyaluronan synthesis and prostaglandin-endoperoxide H synthase 2 in human orbital fibroblasts i

87 annel leads to inactivation of prostaglandin endoperoxide H synthase, the three serine residues in AO

88 clooxygenase (COX) activity of prostaglandin endoperoxide H synthase, which ultimately blocks the for

89 tive and mutant forms of ovine prostaglandin endoperoxide H synthase-1 (oPGHS-1) have suggested that

90 Prostaglandin endoperoxide H synthase-1 (PGHS-1) is expressed constitu

91 d associates functionally with prostaglandin-endoperoxide H synthase-1 (PGHS-1), the constitutive cyc

92 crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen comple

93 Increased expression of prostaglandin endoperoxide H synthase-2 (PGHS-2) has been implicated i

94 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also called cyclooxy

95 Prostaglandin endoperoxide H synthase-2 (PGHS-2), also known as cycloo

96 COX-2, formally known as prostaglandin endoperoxide H synthase-2 (PGHS-2), catalyzes the commit

97 diated through an induction of prostaglandin-endoperoxide H synthase-2 (PGHS-2), the inflammatory cyc

98 thasone but not by SC 58125, a prostaglandin endoperoxide H synthase-2 (PGHS-2)-selective inhibitor.

99 Prostaglandin endoperoxide H synthases (PGHS)-1 and -2, also called cy

100 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2 convert arachid

101 Prostaglandin endoperoxide H synthases (PGHSs) 1 and 2, also known as

102 e cyclooxygenase activities of prostaglandin endoperoxide H synthases (PGHSs) 1 and 2.

103 Prostaglandin endoperoxide H synthases (PGHSs) catalyze the committed

104 clooxygenase (COX) activity of prostaglandin endoperoxide H synthases (PGHSs) converts arachidonic ac

105 Prostaglandin-endoperoxide H synthases (PGHSs) have a cyclooxygenase t

106 Prostaglandin endoperoxide H synthases (PGHSs), also called cyclooxyge

107 Prostaglandin endoperoxide H synthases (PGHSs)-1 and -2 (also called c

108 cyclooxygenase active site of prostaglandin endoperoxide H synthases (PGHSs)-1 and -2.

109 Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the

110 Prostaglandin endoperoxide H synthases 1 and 2, also known as cyclooxy

111 Prostaglandin endoperoxide H synthases are targets of nonspecific nons

112 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) are th

113 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) conver

114 the crystal structures of the prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and PGHS-2), f

115 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs) can oxygenate

116 Prostaglandin endoperoxide H synthases-1 and -2 (PGHSs) catalyze the c

117 The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; als

118 of O(2), and two electrons to prostaglandin endoperoxide H(2) (PGH(2)).

119 rmational changes in the human prostaglandin endoperoxide H(2) synthase enzyme (PGHS-2).

120 nvert arachidonic acid (AA) to prostaglandin endoperoxide H(2).

121 cal target of acetaminophen is prostaglandin endoperoxide H2 synthase (PGHS).

122 ore, the stereochemistry of Type IV bicyclic endoperoxides has been determined by conversion to penta

123 hensive study of methylated pyridone-derived endoperoxides has led to the development of water-solubl

124 Prostaglandin bicyclic endoperoxides have been detected from the autoxidation o

125 All four possible types (I-IV) of bicyclic endoperoxides have been found starting from different re

126 Although endoperoxides have been suggested as key reaction interm

127 n a freestanding water droplet to produce an endoperoxide in 54-72% yields.

128 ies in which singlet oxygen was generated by endoperoxide in the presence of A2E revealed that vitami

129 The use of artemisinin or other endoperoxides in combination with other drugs is a strat

130 es revealed the presence of (1)O(2)-specific endoperoxides in low-light-grown plants, indicating chro

131 ar addition of 1,3-dicarbonyl equivalents to endoperoxides in the presence of an organocatalyst yield

132 In HL-60 cells the endoperoxides induce caspase-dependent apoptotic cell de

133 Overall, these results indicate that endoperoxide-induced cell death is a consequence of acti

134 iring mitochondria play an essential role in endoperoxide-induced cytotoxicity (artesunate IC(50) val

135 l molecular imaging using squaraine rotaxane endoperoxides, interlocked fluorescent and chemiluminesc

136 No endoperoxide intermediate could be detected by low-tempe

137 HKs result from the rearrangement of a di-endoperoxide intermediate formed in the COX-2-dependent

138 everal of the by-products are formed from an endoperoxide intermediate via reactions that are well pr

139 We explored whether isoprostane endoperoxide intermediates also rearrange to levuglandin

140 (COX-1 and COX-2) followed by metabolism of endoperoxide intermediates by terminal PG synthases.

141 IsoP and NPs derive from endoperoxide intermediates that isomerize to D/E-ring fo

142 ormed by reduction and rearrangement of IsoP endoperoxide intermediates, respectively.

143 pounds and PGs is that IsoPs are formed from endoperoxide intermediates, the vast majority of which c

144 of prostaglandins, isoprostanes (isoPs), via endoperoxide intermediates, we postulated previously tha

145 f cyclization of dioxalanyl intermediates to endoperoxide intermediates.

146 ecomposition of the initially formed [4 + 2] endoperoxide into products through a radical chain mecha

147 The major pathway from the endoperoxide is O-O bond cleavage (22.0 kcal/mol barrier

148 The endoperoxide is only formed if ring A is unsaturated and

149 rgo photochemistry at a wavelength where the endoperoxide is transparent, allowing its isolation.

150 staglandin and thromboxane synthase-directed endoperoxide isomerization demonstrated that PGE, PGD, a

151 o probe for a role of P450s in prostaglandin endoperoxide metabolism, we studied the 12-hydroxyheptad

152 Because the cytotoxicity of endoperoxide moieties is well known, the production of e

153 ed dioxolane-isoprostanes) having a bicyclic endoperoxide moiety characteristic of the isoprostanes a

154 mega-chains in the V-shaped pockets, and the endoperoxide moiety interacts with S(gamma) of C110.

155 complex mixture of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic p

156 The synthesis of the sesquiterpene endoperoxide natural product 10,12-peroxycalamenene has

157 termediates distinct from previously studied endoperoxide natural products.

158 Neither an endoperoxide nor a dioxetane intermediate was detected b

159 hich a C-8 carbon radical displaces the 9,11-endoperoxide O-O bond to yield an 8,9-11,12-diepoxide th

160 )] produced thermally by (18)O-(18)O labeled endoperoxide of N,N'-di(2,3-hydroxypropyl)-1,4-naphthale

161 hydride transfer from the bound NADPH to the endoperoxide of PGH(2) without the participation of spec

162 proceeds with high yield without losing the endoperoxide of the artemisinin backbone.

163 or the decomposition of the initially formed endoperoxide, otherwise the endoperoxide decomposes to r

164 o the arachidonic acid-derived prostaglandin endoperoxide PGH(2).

165 the cyclooxygenase metabolite prostaglandin endoperoxide (PGH(2)).

166 alyzed the isomerization of the intermediate endoperoxides, PGH(2)-G and PGH(2)-EA, to the correspond

167 ights into how a cell processes the unstable endoperoxide PGH2 during the inactivation of a major met

168 nverts arachidonic acid to the prostaglandin endoperoxide PGH2, from which all other prostaglandins a

169 e catalyzing the conversion of prostaglandin endoperoxide (PGH2) into thromboxane A2 (TxA2) which pla

170 erium solvent effects, experiments utilizing endoperoxide, phosphorescence, and chemiluminescence que

171 The selective accumulation of beta-carotene endoperoxide points at the PSII reaction centers, rather

172 signaling by oxygenating arachidonic acid to endoperoxide precursors of prostaglandins and thromboxan

173 gn and synthesis of a series of biotinylated endoperoxide probe molecules for use in proteomic studie

174 nd a second oxygenation at C-15 to yield the endoperoxide product, prostaglandin G(2).

175 The bicyclic endoperoxide prostaglandin (PG) H2 undergoes nonenzymati

176 rearrangements of the cyclooxygenase-derived endoperoxide, prostaglandin H2, avidly binds to proteins

177 The cyclooxygenase-derived endoperoxide, prostaglandin H2, can undergo rearrangemen

178 At low pH, the endoperoxide protonates to create a hydroperoxide carboc

179 a-Carotene endoperoxide, but not xanthophyll endoperoxide, rapidly accumulated during high-light stre

180 The large difference in endoperoxide reactivity for the two SREP stereoisomers i

181 the PGD(2) 11-ketoreductase and PGH(2) 9,11-endoperoxide reductase activities of PGFS.

182 PGF(2)(alpha) from PGH(2) by the PGH(2) 9,11-endoperoxide reductase activity and 9alpha,11beta-PGF(2)

183 putative catalytic mechanism of PGH(2) 9,11-endoperoxide reductase of PGFS is proposed.

184 amine the catalytic mechanism of PGH(2) 9,11-endoperoxide reductase, a crystal structure of PGFS[NADP

185 neuroprostanes and enhanced DHA, but not AA, endoperoxide reduction in vivo and in vitro.

186 e of fragmentation following Fe(II)-mediated endoperoxide reduction is established.

187 roduces the corresponding squaraine rotaxane endoperoxides (SREPs) quantitatively.

188 en to the imidazole ring to form an unstable endoperoxide, subsequent rearrangement of the endoperoxi

189 We show that endoperoxides such as OZ439, a stable synthetic molecule

190 ion of manganese-reconstituted prostaglandin endoperoxide synthase (Mn-PGHS) with 15-hydroperoxyeicos

191 gh utilization of constitutive prostaglandin endoperoxide synthase (PGHS) -1 and induced PGHS-2, resp

192 matory agents (NSAIDs) bind to prostaglandin endoperoxide synthase (PGHS) and induce a conformational

193 Prostaglandin endoperoxide synthase (PGHS) is a heme protein that cata

194 rostaglandin H(2) synthesis by prostaglandin endoperoxide synthase (PGHS) requires the heme-dependent

195 Prostaglandin endoperoxide synthase (PGHS)-2, the inducible isoform of

196 dependent upon the induced expression of PG endoperoxide synthase (PGHS)-2.

197 itric oxide synthase (NOS) and prostaglandin endoperoxide synthase (PGHS).

198 s time-dependent inhibitors of prostaglandin endoperoxide synthase (PGHS).

199 ngs, we observed that whereas a selective PG endoperoxide synthase (Ptgs) 1 inhibitor SC-560 failed t

200 PGs are derived from arachidonic acid by PG-endoperoxide synthase (PTGS)-1 and PTGS2.

201 BACKGROUND & AIMS: Prostaglandin-endoperoxide synthase (Ptgs)2 is an enzyme involved in p

202 mage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxygenase [COX] 1

203 rate was also not available to prostaglandin endoperoxide synthase 1 in the immediate phase of prosta

204 tions, but only a single gene, prostaglandin-endoperoxide synthase 1/cyclooxgenase 1 (PTGS1/COX1; P =

205 ce suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxyg

206 .02) with a genetic variant in prostaglandin-endoperoxide synthase 2 (PTGS2) (rs12042763).

207 an expression of PLA(2)G4A and prostaglandin endoperoxide synthase 2 (PTGS2) in wild-type mice.

208 Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulatory enzy

209 utively express high levels of prostaglandin-endoperoxide synthase 2 (Ptgs2, also known as Cox-2) alt

210 AF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 (PTGS2, cyclooxygenase 2), sugge

211 1 in the induction of the gene coding for PG-endoperoxide synthase 2 and in the induction of CREB pho

212 ivation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of arachidonic ac

213 n levels of MIC1 and levels of prostaglandin-endoperoxide synthase 2 expression (PTGS2 or cyclooxygen

214 (TLR signaling-deficient) and prostaglandin-endoperoxide synthase 2(-/-) (Ptgs2(-/-)) mice exhibited

215 A549 cells showed that PTGS2 (prostaglandin-endoperoxide synthase 2) was one of the highly induced g

216 wn as COX2), the gene encoding prostaglandin-endoperoxide synthase 2, allowing activated RAS/P-MAPK-s

217 ly, celecoxib, an inhibitor of prostaglandin-endoperoxide synthase 2, reduced polyp numbers in Apc(Mi

218 The gene expressions of prostaglandin-endoperoxide synthase 2, tissue inhibitor of metalloprot

219 hibition of protein kinase A superinduced PG-endoperoxide synthase 2.

220 docrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent

221 g the levels of NO synthase or prostaglandin endoperoxide synthase or by inhibiting the release of ar

222 tis to inhibit cyclooxygenase (prostaglandin-endoperoxide synthase), thereby decreasing production of

223 mmon target for these drugs is prostaglandin endoperoxide synthase, also referred to as cyclooxygenas

224 staglandin G/H synthase (PGHS; prostaglandin endoperoxide synthase, cyclooxygenase) by proinflammator

225 ase (COX), also referred to as prostaglandin endoperoxide synthase, is the rate-limiting enzyme for t

226 ion in regulating ET-1-induced prostaglandin endoperoxide synthase, prostaglandin G/H synthase (PGHS)

227 f the constitutively expressed prostaglandin endoperoxide synthase, Ptgs1 (Cox-1), a nuclear receptor

228 nes, is a minor product of the prostaglandin endoperoxide synthase-1 (PG G/H S-1) expressed in human

229 this drug, we expressed human prostaglandin endoperoxide synthase-1 (PGHS-1) and PGHS-2 and purified

230 crystal structure of the ovine prostaglandin endoperoxide synthase-1 (PGHS-1)/S- flurbiprofen complex

231 it arachidonate oxygenation by prostaglandin endoperoxide synthase-1 and -2 (PGHS-1 and -2, respectiv

232 on increases the expression of prostaglandin endoperoxide synthase-2 (PGHS-2) in ovine fetal brain re

233 Site-directed mutants of prostaglandin-endoperoxide synthase-2 (PGHS-2) with changes in the per

234 The prostaglandin endoperoxide synthase-2 (PGS-2) gene encodes an isoform

235 of prostaglandin E(2) and the prostaglandin-endoperoxide synthase-2 (PTGS2, or COX-2) increase in ac

236 hown that forced expression of prostaglandin endoperoxide synthase-2 [also called cyclooxygenase (COX

237 inocytes from four new donors showed that PG-endoperoxide synthase-2 was dramatically induced by cis-

238 genase-2 (COX-2, also known as prostaglandin endoperoxide synthase-2) signaling cascade plays an esse

239 l-like receptor 4, cryropyrin, prostaglandin-endoperoxide synthase-2, and heparinase genes.

240 mRNA and protein expression of prostaglandin endoperoxide synthase/cyclooxygenase-2 (COX-2), the key

241 2)) and its processing enzyme, prostaglandin-endoperoxide-synthase-2/ cyclooxygenase-2 (PTGS2/COX-2),

242 Prostaglandin endoperoxide synthases (PTGS), commonly referred to as c

243 of constitutive and inducible prostaglandin endoperoxide synthases by serving as a substrate for the

244 ary mode of action in mammals (prostaglandin-endoperoxide synthases) but modulated genes associated w

245 clooxygenase (COX) activity of prostaglandin endoperoxide synthases.

246 Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antima

247 hraquinones in the presence of oxygen yields endoperoxides that can be reduced to produce 1-hydroxyme

248 The resulting endoperoxide then undergoes additional transformations,

249 ndoperoxide, subsequent rearrangement of the endoperoxide to a dioxirane, and decomposition of the di

250 any role in the reductive activation of the endoperoxide to cytotoxic carbon-centered radicals.

251 ing the rearrangement of an initially formed endoperoxide to give A and B from reaction of 1 with sin

252 s an isomerization of prostaglandin H(2), an endoperoxide, to prostacyclin.

253 ated the selective cytotoxic activity of the endoperoxides toward leukemia cell lines (HL-60 and Jurk

254 The cytotoxic activity of these endoperoxides toward rapidly dividing human carcinoma ce

255 agonist and a thromboxane A(2)/prostaglandin endoperoxide (TP) receptor antagonist, while 3',5'-diiod

256 ivation of the thromboxane-A2 /prostaglandin-endoperoxide (TP) receptor.

257 vely characterized thromboxane/prostaglandin endoperoxide (TP) receptors, from human platelets and ra

258 ICL-1 utilizes a bioinspired endoperoxide trigger to release d-aminoluciferin for sel

259 inhibitor release and quantitatively measure endoperoxide turnover in parasitized red blood cells.

260 Oxabicycloheptane analogs of prostaglandin endoperoxide, U-44069 and U-46619, induced spectral chan

261 cture as the SREP-int stereoisomer, with the endoperoxide unit directed inside the macrocycle cavity.

262 e less stable SREP-ext stereoisomer with the endoperoxide unit directed outside the macrocycle.

263 beta-Carotene endoperoxide was found to have a relatively fast turnove

264 The bicyclic endoperoxide was rearranged to a diepoxide with CoTPP.

265 s, arising from rearrangements of anthracene endoperoxides were isolated and characterized.

266 ompounds alpha-linolenic acid and ergosterol endoperoxide, which were active against Cryptococcus neo

267 le via a [4 + 2] cycloaddition to form a 2,5-endoperoxide, which, upon warming, decomposes to a hydro

268 cid (AA) and 2-arachidonylglycerol (2-AG) to endoperoxides, which are subsequently transformed to pro

269 enation of arachidonic acid to prostaglandin endoperoxides, which are the common intermediates in the

270 ise diradical pathway to form cyclohexadiene endoperoxide with an activation barrier of 6.5 kcal/mol

271 E209 is a superior next generation endoperoxide with combined pharmacokinetic and pharmacod

272 Artemisinin is a sesquiterpene endoperoxide with potent antimalarial properties, produc

273 The bicyclic endoperoxides with the two alkyl chains syn on the cyclo

274 water droplet interface and gave the highest endoperoxide yields.