ライフサイエンスコーパス: endophenotype

1 DD, an important aspect of its utility as an endophenotype.

2 d their first-degree relatives as a possible endophenotype.

3 ritable, supporting its value as a potential endophenotype.

4 ucture, allowing refinement of the suggested endophenotype.

5 my of this disease based on the genotype and endophenotype.

6 es in schizophrenia could be an age-specific endophenotype.

7 ational processing as a neural systems-level endophenotype.

8 nning and white matter hypoplasia within the endophenotype.

9 ulant addiction may depend on an impulsivity endophenotype.

10 ulation we sought to quantify this cognitive endophenotype.

11 irect genetic effects, and thus a more valid endophenotype.

12 verity, suggesting its value as an objective endophenotype.

13 fication of genes relevant for the DS neural endophenotype.

14 between common genetic variability and brain endophenotype.

15 e quantitative corticosteroid responsiveness endophenotype.

16 nd TREML2 with Alzheimer disease (AD) and AD endophenotypes.

17 ther neurodevelopmental and neuropsychiatric endophenotypes.

18 owth in key cell types may contribute to ASD endophenotypes.

19 hibition were also investigated as cognitive endophenotypes.

20 1,004 individuals were also assessed for the endophenotypes.

21 ggest that this underlies various depressive endophenotypes.

22 abnormalities, revealing potential psychosis endophenotypes.

23 tions that might also be candidate psychosis endophenotypes.

24 ional connections in relatives for potential endophenotypes.

25 ikely focus on the role of rare variants and endophenotypes.

26 eptor ErbB4 in schizophrenia and many of its endophenotypes.

27 and neuronal circuits that underlie disease endophenotypes.

28 n a validated candidate gene and an auditory endophenotypes.

29 py, revealing associations with four or more endophenotypes.

30 s knockout mice is associated with cognitive endophenotypes.

31 map quantitative intermediate phenotypes or endophenotypes.

32 e whether any of these traits represent true endophenotypes.

33 on or how they may be linked to specific RTT endophenotypes.

34 f DISC1 mutation on developmental/anatomical endophenotypes.

35 this heterogeneity is to focus on promising endophenotypes.

36 was sufficient to induce multiple SZ-related endophenotypes.

37 o the post-adolescent onset of schizophrenia endophenotypes.

38 r pathophysiology to circuit and behavioural endophenotypes.

39 ve (conventionally defined as >155 ms) as an endophenotype, a maximum LOD score of 3.6 was obtained i

40 Identifying symptom-based endophenotypes across diagnoses may aid gene-finding eff

41 risk for phenotypes (depression/anxiety) and endophenotypes (amygdala reactivity).

42 la reactivity, a transdiagnostic psychiatric endophenotype and an important stress hormone response t

43 , and both parents underwent a comprehensive endophenotype and clinical characterization.

44 Identification of this endophenotype and its cognitive correlates provides targ

45 lar mechanisms associated with this peculiar endophenotype and its relations to IR in the obese adole

46 ttle is known about the neurobiology of this endophenotype and no known in vivo molecular imaging stu

47 AnkG isoform imbalance is a novel molecular endophenotype and potential therapeutic target.

48 dentification of distinct PCC/natural season endophenotypes and a partial correlation between the TSS

49 Cav1.2 mechanism in neuropsychiatric-related endophenotypes and a potential future therapeutic target

50 (United States and Denmark), we constructed endophenotypes and assessed their relationship with mort

51 Our results indicate that both neural endophenotypes and genetic variation give rise to the va

52 , they suggest its involvement in DS-related endophenotypes and identify new potential therapeutic st

53 ygous p35 knockout mice model both cognitive endophenotypes and molecular changes reminiscent of schi

54 udies and extreme osteoarthritis phenotypes; endophenotypes and pain; and overlap of osteoarthritis w

55 Pennsylvania, we obtained strikingly similar endophenotypes and relationships to mortality.

56 ards dimensional approaches that incorporate endophenotypes and statistical classification methods.

57 This study supports use of relevant endophenotypes and the bootstrap total significance test

58 quence of the interplay between the relevant endophenotypes and their local, organ-based environment.

59 cript perturbations correlated with clinical endophenotypes and were enriched for genes associated wi

60 by the incorporation of intermediate traits (endophenotypes) and of environmental factors into geneti

61 regions linked and/or associated with these endophenotypes, and others previously associated to ADHD

62 loci for social responsiveness validates the endophenotype approach for the identification of genetic

63 tics research on SUDs and the utility of the endophenotype approach in enhancing our understanding of

64 Important examples of such endophenotypes are inflammation, fibrosis, and thrombosi

65 s-impulsive personality traits may represent endophenotypes associated with the risk of developing co

66 0(-)(5), respectively) illustrating how this endophenotype-based approach can be used to identify new

67 This endophenotype-based approach provides evidence for a gen

68 redicting genetic homogeneity by identifying endophenotypes becomes more important.

69 er, the stark similarity in phenotype and/or endophenotype between monkeys and patients suggested tha

70 Those who have the endophenotype but who are not ill nevertheless still suf

71 However, none of these endophenotypes can account for the near-permanent qualit

72 logies, we here investigated whether AD-like endophenotypes can be created in mice by expression of h

73 Elucidating such novel neural endophenotypes can facilitate new approaches to BP predi

74 opened up the possibility of identifying new endophenotypes characteristic of biological substrates u

75 genes to proteins and cellular functions to endophenotypes, cognitive impairments, symptoms, and dia

76 Linkage analyses of the 12 endophenotypes collectively identified one region meetin

77 bootstrap analyses confirmed that the 47 SNP-endophenotype combinations with the strongest evidence o

78 The wider use of quantitative endophenotypes, combined with unbiased methods for selec

79 disease-specific processes, is to construct endophenotypes comprising linear combinations of physiol

80 Thus, this endophenotype construct may represent an underlying phen

81 We also reproduced the endophenotype constructs, especially the dominant physic

82 Among the most widely discussed candidate endophenotypes, differences in cerebellar volume have be

83 gree relatives, suggesting that the proposed endophenotype does not generalize to functional brain ac

84 Breaking addiction down into contributing endophenotypes enables its study in a variety of model s

85 ugs, leading to the description of addiction endophenotypes, especially for cocaine addiction.

86 peptides concentrations could be a suitable endophenotype for a genome-wide association study (GWAS)

87 CSF or plasma APOE levels could be a useful endophenotype for AD and to identify genetic variants as

88 ting that APOE levels in CSF may be a useful endophenotype for AD.

89 provides validation of the use of EEG as an endophenotype for alcoholism.

90 ponse time has been proposed as an important endophenotype for attention deficit hyperactivity disord

91 enotype by using social responsiveness as an endophenotype for autism spectrum disorder.

92 brain networks as a potential neurocognitive endophenotype for bipolar disorder and provides evidence

93 To assess whether such impairments may be an endophenotype for bipolar disorder, the authors examined

94 as SZR and PBPR perhaps indicating a common endophenotype for both disorders.

95 -based imaging provides a novel quantitative endophenotype for genetic association studies directed t

96 f intra-ocular pressure (IOP), an underlying endophenotype for glaucoma.

97 ine-induced dopamine release may be a useful endophenotype for investigating the genetic basis of sch

98 We have identified a brain-based endophenotype for major depressive disorder (MDD) that i

99 It has been proposed as an endophenotype for OCD because it is heritable and more p

100 dysfunction may constitute a neurocognitive endophenotype for OCD, possibly reflecting limbic interf

101 brain circuitry thus emerges as a promising endophenotype for OCD.

102 ase and is unlikely to be a useful surrogate endophenotype for POAG.

103 pression of an identified disease gene as an endophenotype for quantitative linkage analysis may ther

104 tle reflex has been suggested as a candidate endophenotype for schizophrenia research, as it shows hi

105 mon radiographic finding and may be a useful endophenotype for small vessel diseases.

106 ort the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.

107 rected attention, and may represent a useful endophenotype for studying individual differences in att

108 m (EEG) oscillatory activity may be a useful endophenotype for studying the genetics of disorders cha

109 in these structures is considered a putative endophenotype for the disorder.

110 panic disorder, and therefore represents an endophenotype for these disorders.

111 nce of an underlying previously undiscovered endophenotype for this disorder.

112 ew objective index of the genetic utility of endophenotypes for any heritable illness.

113 and declarative (facial) memory as candidate endophenotypes for bipolar disorder.

114 lial risk of BP, and at low risk to identify endophenotypes for BP.

115 TION: Our study demonstrates the efficacy of endophenotypes for broadening our understanding of the g

116 ral signatures that can serve as informative endophenotypes for future genetic studies.

117 e biomarkers may also be effectively used as endophenotypes for genetic studies of AD.

118 ypically use simple activity-based assays as endophenotypes for more complex emotional states of the

119 approach has the potential to discover novel endophenotypes for neuropsychiatric disorders and to bet

120 relatives suggest these may be white matter endophenotypes for OCD.

121 nd state markers, thus highlighting possible endophenotypes for ongoing research.

122 t interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope

123 d before these measures can be considered as endophenotypes for psychiatric or neurological illnesses

124 , and introspection, are potential candidate endophenotypes for psychopathic traits.

125 ic domains, we identified a set of objective endophenotypes for recurrent major depression in a sampl

126 motor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric d

127 search for neurocognitive and neuroanatomic endophenotypes for schizophrenia in large unselected mul

128 analytic approach, one can discover and rank endophenotypes for schizophrenia, or any heritable disea

129 rtex grey matter volume reductions are valid endophenotypes for schizophrenia, specifically investiga

130 The results suggest that the cellular endophenotypes for SZ and BD may be determined by multip

131 Delta and fast alpha activity were unique endophenotypes for SZ and PBP probands, respectively.

132 er provides a means of identifying potential endophenotypes for this condition.

133 relatives may represent a brain structural 'endophenotype' for DS.

134 cated as a potential intermediate phenotype (endophenotype) for addictive disorders and comorbid exte

135 Impulsivity is an endophenotype found in many psychiatric disorders includ

136 A neurocognitive endophenotype has been proposed for stimulant dependence

137 e for susceptibility to four cardiac-related endophenotypes: higher resting heart rate (HR), the elec

138 We tested the endophenotype hypothesis by applying polygenic SNP score

139 first molecular genetic test of the classic endophenotype hypothesis, which states that alleles asso

140 , rather than representing a transdiagnostic endophenotype in ADHD and OCD, were associated with diso

141 be fruitful to use epigenetic tissue age as endophenotype in GWAS.

142 tives that could explain persistence of this endophenotype in the population.

143 Importantly, identification of an endophenotype in this kindred not only aided ascertainme

144 t marker in patients with COS, with a milder endophenotype in unaffected siblings associated with res

145 G (b-wave amplitude at Vmax) is a biological endophenotype in young offspring at high genetic risk (H

146 we tested for neuroanatomical and cognitive endophenotypes in a group of adults with ADHD, their una

147 e of PrP(C) to rescue or halt established AD endophenotypes in a therapeutic disease-modifying time w

148 pital fasciculus are putative neurocognitive endophenotypes in adult ADHD.

149 ular pathways and connect them to behavioral endophenotypes in cognitive disorders has proven to be a

150 itable neurophysiological and neurocognitive endophenotypes in data collected by the Consortium on th

151 h for discovering and empirically validating endophenotypes in extended pedigrees with very few affec

152 tigate the heritability of some of these key endophenotypes in extended pedigrees.

153 her use of white matter integrity markers as endophenotypes in genetic studies.

154 ory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clin

155 that plasma Abeta peptides levels are valid endophenotypes in GWASs and can be used to characterize

156 ut also provide tools for studying cognitive endophenotypes in mice.

157 our current knowledge of causal pathways and endophenotypes in MS is limited.

158 al models have demonstrated disease-relevant endophenotypes in prenatally stressed offspring and have

159 entary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their famil

160 ory processing are among the best documented endophenotypes in schizophrenia, possibly due to loss of

161 consortia: the Consortium on the Genetics of Endophenotypes in Schizophrenia, the Project among Afric

162 rs of FBDs, identification of biomarkers and endophenotypes in symptom severity and treatment respons

163 e utility of quantitative neurophysiological endophenotypes in the study of the genetics of brain fun

164 th the onset of IR, and describe a distinct "endophenotype" in obese adolescents characterized by a t

165 s of quantitative intermediate phenotypes or endophenotypes, in tandem with studies of unrelated indi

166 These findings suggest that structural endophenotypes, in the form of variations in gray matter

167 ously demonstrated the heritability of these endophenotypes; in the present study, genetic linkage wa

168 A risk endophenotype included greater activation of cortical at

169 A resilience endophenotype included greater activation of the dorsal

170 Top-ranked endophenotypes included the Beck Depression Inventory, b

171 rom the TwinsUK cohort, and glaucoma-related endophenotypes, including intraocular pressure (IOP), ve

172 al and biologic intermediate phenotypes (or 'endophenotypes') indexing anxiety-proneness offers an im

173 provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric

174 Here we report a cellular endophenotype involving increased stress response (HSP27

175 dysgenesis, which can be regarded as a MCOR endophenotype, is consistent with the view that deletion

176 Electrophysiological endophenotypes lie between risks and symptoms and have t

177 nd/or associated to ADHD, suggest that these endophenotypes lie on shared pathways.

178 eterogeneity of MDD by focusing on promising endophenotypes linked to specific pathophysiological abn

179 ) exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of t

180 gical features (i.e., brain oscillations) as endophenotypes, making it possible to identify susceptib

181 oncentrations were found to be the strongest endophenotype markers, with heritability estimates of 46

182 This abnormality may be a structural endophenotype marking risk for psychotic illness and it

183 Additional genetic studies of this endophenotype may help identify genetic variants or netw

184 The identification of intermediate or endophenotypes may accelerate this effort.

185 The identification of addiction endophenotypes may be useful in facilitating the rationa

186 h linking epigenetic variability with neural endophenotypes may broadly explain individual difference

187 tended family design, we used a quantitative endophenotype, measured in all individuals: number of al

188 t studies here, and suggest how neuroimaging endophenotypes might prove useful for the development of

189 totic disruption that displays schizophrenic endophenotypes modulated by prenatal factors and reversi

190 In this study, we construct endophenotype network models and explore their relation

191 Endophenotypes (neurobiological markers that cosegregate

192 In ALS endophenotypes, neuroimaging has also shown a diverse sp

193 al visual engagement as a neurodevelopmental endophenotype not only for autism, but also for populati

194 s a potential candidate for a neurocognitive endophenotype of ADHD.

195 vation identified may represent a functional endophenotype of autism, related to familial risk for th

196 Therefore, hyperexcitability is one early endophenotype of bipolar disorder, and our model of iPSC

197 ient prediction error signal, as a candidate endophenotype of bipolar disorder.

198 Impulsivity is a validated endophenotype of both bipolar disorder and suicidal beha

199 ogy of mood disorders and could represent an endophenotype of depression.

200 patients and siblings, and so constitutes an endophenotype of juvenile myoclonic epilepsy.

201 tic spine morphogenesis and plasticity is an endophenotype of many neurodevelopmental and neuropsychi

202 led axial length increase in the mutant (the endophenotype of myopia).

203 motor area hyperactivity is a neurocognitive endophenotype of OCD that is possibly related to ineffic

204 Deficient response inhibition is a promising endophenotype of OCD, although its functional neural cor

205 es of working memory may be a neurocognitive endophenotype of OCD.

206 tal plasticity and learning as a provisional endophenotype of PD would facilitate investigation of th

207 into an established and clinically relevant endophenotype of prodromal HD.

208 hypothesis that network randomization is an endophenotype of schizophrenia and therefore evident als

209 4 polymorphisms also affect another proposed endophenotype of schizophrenia, namely sensory gating as

210 sured by prepulse inhibition--an established endophenotype of schizophrenia.

211 ficits of prepulse inhibition, a widely used endophenotype of schizophrenia.

212 bility to genetically improve the behavioral endophenotype of Syngap1 mice decreased slowly over post

213 ing cognitive processes and may represent an endophenotype of the disease.

214 ulsive disorder (OCD) research and may be an endophenotype of the disorder.

215 erative diseases, suggesting these may be an endophenotype of the disorders.

216 Impulsivity is an endophenotype of vulnerability for compulsive behaviors.

217 s that impulsivity may be a transnosological endophenotype of vulnerability to compulsivity.

218 en implicated in many behavioral domains and endophenotypes of autism, including abnormal neural sign

219 The lack of distinct endophenotypes of bipolar mania and schizophrenia has co

220 Three putative endophenotypes of depression were found to have partiall

221 mine the neural correlates of three emerging endophenotypes of depression: neuroticism, blunted rewar

222 teins implicated in epilepsy and autism, two endophenotypes of FXS.

223 Although neural endophenotypes of heightened or extreme antisocial behav

224 etween resting state EEG current density and endophenotypes of interest.

225 nsitive behaviors and is required to mediate endophenotypes of mania and depression in rodents.

226 in excitatory synapses can cause behavioral endophenotypes of mental illness.

227 abnormal behaviors that are often considered endophenotypes of schizophrenia and autism spectrum diso

228 models of synaptic dysfunction demonstrated endophenotypes of schizophrenia as well as bioenergetic

229 nhibitor MS-275 both cognitive and molecular endophenotypes of schizophrenia can be rescued in p35 he

230 These mice are a valuable tool for studying endophenotypes of schizophrenia, but highlight that sing

231 y contributes to genetic modulation of known endophenotypes of schizophrenia-like higher-level cognit

232 and molecular alterations and the cognitive endophenotypes of schizophrenia.

233 otential in mice and rats, respectively, two endophenotypes of schizophrenia.

234 Bipolar I disorder is highly heritable, but endophenotypes of the disorder mediating genetic risk ar

235 s and weight loss, two of the most prominent endophenotypes of the HD-like disease in mice.

236 adult-born hippocampal neurons with specific endophenotypes of these disorders.

237 een human DLG4 gene variation and key neural endophenotypes of Williams' syndrome and perhaps cortico

238 ves, suggesting that this is a systems-level endophenotype or marker of familial risk.

239 eptor systems that may be implicated in this endophenotype or the phenotypic expression of trauma-rel

240 into more homogeneous subgroups based on the endophenotype [panel of biomarkers]) with the aim to ref

241 We identified in rodents an innate endophenotype predicting individual risk for alcohol-rel

242 ency could represent a stress susceptibility endophenotype predisposing to the development of trauma-

243 The most dominant endophenotype primarily reflected the physical activity

244 Applying endophenotype ranking value analysis to a high-dimension

245 Here, we describe the endophenotype ranking value, a new objective index of th

246 case the shifting research landscape towards endophenotype refinement in clinical and preclinical set

247 Measuring cognitive endophenotypes related to both the disorder and mechanis

248 mice lacking CRTC1 associate neurobehavioral endophenotypes related to mood disorders.

249 tergic neurons promotes the manifestation of endophenotypes related to psychiatric disorders includin

250 The analyses identified two heritable endophenotypes related to Tourette syndrome that cross t

251 or magnitude and replicability of behavioral endophenotypes relevant to autism and Phelan-McDermid sy

252 ate homeostasis, thought to underlie several endophenotypes relevant to schizophrenia.

253 These endophenotypes represent traits that are less complex an

254 elatives of patients, indicating they may be endophenotypes representing increased genetic risk for O

255 d area of the brain recapitulates behavioral endophenotypes seen in humans diagnosed with autism (anh

256 ty yet impaired spatial learning and memory, endophenotypes similar to those of NMDA receptor knock-d

257 e to other psychiatric disorders to identify endophenotype-specific responses relevant to neurobiolog

258 The endophenotype status of these abnormalities is supported

259 tify DMNs and to test their biomarker and/or endophenotype status.

260 Endophenotype studies of obsessive-compulsive disorder (

261 or to increased variance of such underlying endophenotypes (such as body weight).

262 the effects of genetic variation on relevant endophenotypes, such as hippocampal volume loss.

263 ing heritable components of the disorder, or endophenotypes, such as language or social cognition, pr

264 n a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared n

265 se data support the idea that PPI is a valid endophenotype that can be used to explore the genetic ar

266 Thus, gene expression is an endophenotype that can lead to the discovery of the unde

267 Attentional bias to threat is a key endophenotype that contributes to the chronicity of trau

268 his mechanism represent a microcircuit-level endophenotype that could link diverse genetic and develo

269 ce that reduced spindle activity in SZ is an endophenotype that impairs sleep-dependent memory consol

270 that overactive performance monitoring is an endophenotype that indicates vulnerability for OCD.

271 or the first time provides a window into the endophenotype that may result from a subset of the genes

272 ished serotonergic tone in the OFC may be an endophenotype that predisposes to behavioral inflexibili

273 atter, WM growth may also be an age-specific endophenotype that shows compensatory normalization with

274 suggest that they most likely represent true endophenotypes that could aid in the identification of g

275 ion deficits in these nodes may be useful as endophenotypes that extend beyond the affected individua

276 replicated and widely regarded as candidate endophenotypes that may facilitate understanding of schi

277 uroeconomics can provide promising candidate endophenotypes that might help clarify the basis of high

278 than clinical observation such as monitoring endophenotypes that result from associated risk factors.

279 ISC1) confers a genetic risk at the level of endophenotypes that underlies many major mental disorder

280 One such 'endophenotype,' the distribution of vasopressin 1a recep

281 nfluence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic sy

282 f mammalian behaviour, from neuropsychiatric endophenotypes to circadian rhythms.

283 at integrate transcriptomic, epigenetic, and endophenotype traits with systems biology to annotate ge

284 Endophenotypes, traits genetically correlated with an il

285 ophrenia-1 (DISC1), a factor that influences endophenotypes underlying schizophrenia and several othe

286 ates that selection of ASD subjects based on endophenotypes unraveled biologically relevant pathway d

287 omposite and clinical phenotypes measure the endophenotype using treatment effect area under the rece

288 d association analyses to neuropsychological endophenotypes using microsatellite and single nucleotid

289 ls with ASD, and, critically, whether neural endophenotypes vary as a function of aggregate genetic r

290 Heritability estimates for both endophenotypes were high and statistically significant (

291 Associations with endophenotypes were observed for 46 genes of potential f

292 identified heritable, schizophrenia-related endophenotypes were observed, and several genes of poten

293 , selected schizophrenic-like phenotypes and endophenotypes were rescued by chronic haloperidol treat

294 n siblings are likely to be an age-dependent endophenotype, which normalize by the typical age of ons

295 ulation the composite phenotype measured the endophenotype with an AUC of 0.74, significantly exceedi

296 Thus AMD most likely represents an endophenotype with differing underlying pathogenesis in

297 The composite phenotype measured the endophenotype with higher accuracy, higher stability acr

298 iate biological phenotypes in the context of endophenotypes within distinct behavioural domains.

299 dities will enable us to define neurological endophenotypes within the autism spectrum.

300 the dominant physical activity and pulmonary endophenotype, within demographic subpopulations of thes