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1 mportant neuroendocrine precursor processing endoprotease.
2 lamin A appears to be mediated by a specific endoprotease.
3 nsertion, are processed by a liver cytosolic endoprotease.
4 eutral pH, resulted in the activation of the endoprotease.
5 e and functions as a potent inhibitor of the endoprotease.
6 eting signals may also be substrates of this endoprotease.
7 Rcr3 encodes a secreted papain-like cysteine endoprotease.
8 hRCE1, encodes a 35-kDa membrane-associated endoprotease.
9 s are activated by specific cleavage with an endoprotease.
10 convertase family members or other unrelated endoproteases.
11 y the "prohormone convertase" (PC) family of endoproteases.
12 ed technology to study intracellular BoNT/LC endoproteases.
13 n of many pathogenic molecules has made this endoprotease a target for the development of potent and
16 ting of light chain (LC) with zinc-dependent endoprotease activity connected by one disulfide bond to
18 8 microm, respectively, confirming glutamine endoprotease activity in whole saliva and the influence
21 otulinum neurotoxin A (BoNT/A) has intrinsic endoprotease activity specific for SNAP-25, a key protei
22 educed levels of both the Rce1 mRNA and CAAX endoprotease activity, and the hearts manifested an accu
26 n with enzymes like Aspergillus niger propyl-endoprotease (AN-PEP), which can hydrolyse gluten, has b
27 tion strategy to three enzymatic systems, an endoprotease, an exoprotease, and a Ser/Thr phosphatase.
29 DegQ protein has the properties of a serine endoprotease and is processed by the removal of a 27-res
30 lly produced as proenzymes, are activated by endoproteases, and remove either C-terminal hydrophobic
33 xpression system, which indicates that novel endoproteases are responsible for generating these produ
34 tivation of numerous pathogens points to the endoprotease as a strategic target for therapeutics.
35 notably conserved and suggest that specific endoproteases as well as carboxypeptidase are involved i
38 family of seven structurally related serine endoproteases, at least one of which, furin, cleaves aft
39 ible to cleavage by extracellular furin-like endoproteases, but cleaved ATXalpha remains structurally
41 MP-13), gelatinases (MMP-2, MMP-9), cysteine endoproteases (cathepsin S and K), and interleukin-1beta
43 ur results not only show conservation of the endoprotease cleavage mechanism for mitochondrial import
44 s and induction of calcium transients, while endoproteases cleave PTHrP, resulting in fragments with
46 t detectors, ASE sensory neurons, used BLI-4 endoprotease-dependent cleavage to release the insulin-l
47 product, consisting of a glutamine-specific endoprotease (EP-B2 from barley) and a prolyl endopeptid
48 ne protease 2 is not only the major cysteine endoprotease expressed in Giardia, but is also central t
49 mport that requires an inducible cytoplasmic endoprotease for activation of cryptic mitochondrial tar
51 nalization, the efficiency of sorting of the endoprotease from the cell surface to early endosomes is
52 that biogenesis of Axl1p, an insulinase-like endoprotease from yeast, is dependent upon the cytosolic
54 The fragment is apparently generated by the endoprotease furin after the toxin has been endocytosed.
55 Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulatio
56 bited in the presence of an inhibitor of the endoprotease furin but was not affected by inhibitors of
58 st, the central role of the host cell serine endoprotease furin in the proteolytic activation of nume
61 inactive proenzyme that is activated by the endoprotease furin, which cleaves an RARLPR/D sequence t
63 ecific site is the recognition motif for the endoprotease, furin, which is located in the Golgi appar
64 otein sigma3 and contain protein mu1/mu1C as endoprotease-generated fragments mu1delta/delta and phi.
66 , greater than 90% of label was found in the endoprotease Glu-C digestion fragments which contain the
68 V; more recently, probes that target caspase endoproteases have been developed and are undergoing ear
69 einases (MMPs), a family of Zn(2+)-dependent endoproteases, have been shown to act as fine regulators
70 main is homologous to a bacterial heat shock endoprotease (HtrA), a protein indispensable to the surv
71 sphorylated or unphosphorylated forms of the endoprotease in AtT-20 cells demonstrates that the integ
73 ptide acts as a substrate for the prelamin A endoprotease in vitro, with cleavage of the synthetic pe
75 C1 (SPC3) are the major precursor processing endoproteases in a wide variety of neural and endocrine
78 participates with the concurrently produced endoproteases in procuring nutrients; an equivalent func
80 Exg1 (major exoglucanase), or loss of Kex2 (endoprotease involved in Exg1 processing), rescued growt
81 a suis 1330 is a member of a novel family of endoproteases involved in the maturation of proteins des
82 to whole saliva revealed that the glutamine endoprotease is derived from dental plaque and likely mi
83 ed membrane-associated isoprenylated protein endoprotease is important in the processing of isoprenyl
85 ture secretory granules, suggesting that the endoprotease is retrieved from the clathrin-coated ISGs.
86 hat glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivit
87 iquitously expressed, TGN/endosomal membrane endoprotease, is present in the regulated pathway of neu
89 pid vacuolar degradation of the resident TGN endoprotease Kex2p and aberrantly secreted approximately
90 ected members of a family of subtilisin-like endoproteases known as the prohormone convertases (PCs).
91 racterized KEX2 gene, which encodes a serine endoprotease localized to the late Golgi compartment.
93 he amino acid sequence of HSV-1 TK is known, endoprotease Lys-C, V8 protease, trypsin, or chymotrypsi
97 rities of protease IV to the lysine-specific endoprotease of Achromobacter lyticus suggested three po
101 or amino peptidases to follow the action of endoproteases on peptide substrates that are blocked at
102 comprising a primary receptor and a separate endoprotease operates as a portal for activation of SARS
103 the proteins were N-terminally truncated by endoproteases or exopeptidases, and many were further mo
104 bitor leupeptin, suggesting that one or more endoproteases other than furin have a detectable but lim
105 mogranin A is a substrate for the endogenous endoproteases PC1 and furin in vivo, and that such proce
106 sing by the mammalian subtilisin-like serine endoproteases PC1 and PC2 (prohormone convertases 1 and
108 tic activity, termed prenyl protein-specific endoprotease (PPEP) activity, has been solubilized in CH
109 age depended on PC5 (a subtilisin/kexin like endoprotease present in endothelial cells), we transfect
110 dressed the question of whether furin is the endoprotease primarily responsible for processing the hu
111 bolishes NF-kappaB transcription by inducing endoprotease processing of the N-terminus of p65, a proc
116 expression of the major precursor processing endoproteases, prohormone convertases PC1 and PC2 in Cpe
117 ast three amino acids are cleaved off by the endoprotease, RAS-converting enzyme 1 (RCE1), and the pr
118 methyltransferase ICMT or the prenylprotein endoprotease RCE1 in vitro, but they did inhibit ZMPSTE2
119 In this work, we demonstrate that the CAAX endoprotease Rce1 is required for lamin B1 endoproteolys
121 cids of farnesylated K-Ras with the specific endoprotease Rce1p abolished its binding to microtubules
122 on resulted in mislocalization of furin, the endoprotease responsible for cleavage of insulin and hep
123 ch, prohormone convertase 1/3 (PC1/3) is the endoprotease responsible for the conversion of proghreli
126 vage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence
128 gamma-Secretase is a membrane-associated endoprotease that catalyzes the final step in the proces
129 f reaction products showed that Fv-cmp is an endoprotease that cleaves a peptide bond on the C-termin
130 in secondary granules, was identified as an endoprotease that degrades LLO, and blocking neutrophil
133 sent potent inhibitors of furin, a mammalian endoprotease that plays an important role in metabolism,
137 n addition, we have identified two candidate endoproteases that are expressed in the testes and that
138 ix metalloproteinases (MMPs) are a family of endoproteases that break down extracellular matrix and w
139 g protease, is a member of a novel family of endoproteases that includes a tail-specific protease fro
141 a family of at least seven calcium-dependent endoproteases that process a wide variety of precursor p
143 amily of subtilisin-like, eukaryotic, serine endoproteases that process substrates important in the d
144 e search for the proprotein convertases, the endoproteases that work along with carboxypeptidases and
147 ognized by a family of subtilisin/kexin-like endoproteases, we postulated that members of the subtili
148 oxin (BoNT) types A and B are Zn2+-requiring endoproteases which potently block neurotransmitter rele
149 of metalloproteinases (amino-, carboxy-, and endoproteases), which were blocked in infected cells wit
150 ino acids and has homology to bacterial HtrA endoprotease, which acts as a chaperone at low temperatu
152 coding a protein homologous to fungal serine endoproteases, which localize to the Golgi apparatus.
153 xpression is controlled by furin-like serine endoproteases, which selectively process transmembrane m
154 convertase family of enzymes includes seven endoproteases with significant redundancy in their cleav
155 , RhoG mislocalization by the prenylcysteine endoprotease YopT was demonstrated by two independent as
156 ear lamina protein (LMNA) and its processing endoprotease (ZMPSTE24), a kinase (AKT2), and a protein
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