ライフサイエンスコーパス: endoreduplication

1 gulated during "all JAKs inhibitor"-mediated endoreduplication.

2 , resulting in either mitotic catastrophe or endoreduplication.

3 to the mitotic stage preceding the onset of endoreduplication.

4 age, impaired proliferation, and chromosomal endoreduplication.

5 e fraction of cells in G(2)/M and undergoing endoreduplication.

6 creased enzyme activity but had no effect on endoreduplication.

7 d, S phase wt cells also elicited a state of endoreduplication.

8 se, while preserving diploidy by suppressing endoreduplication.

9 ls, while preserving diploidy by suppressing endoreduplication.

10 This phenomenon is known as endoreduplication.

11 as well as defects in fertility and gut-cell endoreduplication.

12 3) are consistent with a function for SIM in endoreduplication.

13 on is involved in the cellular transition to endoreduplication.

14 as effectively blocked, so that there was no endoreduplication.

15 yclin B1/Cdc2 activity and the occurrence of endoreduplication.

16 evelopment imply that ZmWee1 plays a role in endoreduplication.

17 conditions that gave relatively synchronous endoreduplication.

18 xit from the mitotic cell cycle and onset of endoreduplication.

19 resulted in a higher tendency to undergo DNA endoreduplication.

20 of try, it synergistically enhanced trichome endoreduplication.

21 f chromosomal segregation, and underwent DNA endoreduplication.

22 tored cyclin E/Cdk2 regulation and prevented endoreduplication.

23 teristics, despite showing normal growth and endoreduplication.

24 synchronously from the mitotic cell cycle to endoreduplication.

25 f nutrient acquisition induce localized host endoreduplication.

26 icating that KRP5 is a positive regulator of endoreduplication.

27 g of the divergence is near-synchronous with endoreduplication.

28 nsible for mitotic exit and earlier onset of endoreduplication.

29 2, operating as a rate-determining factor of endoreduplication.

30 erved specifically in cells known to undergo endoreduplication.

31 persistent p21 expression and resistance to endoreduplication.

32 which promote cell proliferation and repress endoreduplication.

33 preventing improper cell cycle re-entry and endoreduplication.

34 s, a defect we associate with an increase in endoreduplication.

35 rvening mitotic division, a process known as endoreduplication.

36 ndosperm transition from mitotic division to endoreduplication.

37 geminin is part of the mechanism regulating endoreduplication.

38 noblastoma protein phosphorylation, limiting endoreduplication.

39 Targeting all JAKs also caused endoreduplication 48 and 72 hours after treatment.

40 Endoreduplication, a modified cell cycle that allows cel

41 Giant cells have undergone endoreduplication, a specialized cell cycle in which cel

42 tes: (i) a low percentage of cells undergoes endoreduplication, achieving higher than 4n ploidy, and

43 at STM inhibits cellular differentiation and endoreduplication, acting through CK and the CK-inducibl

44 lating the postmitotic checkpoint to prevent endoreduplication after an aberrant mitosis.

45 116 and U2OS), and both cell lines underwent endoreduplication after Nutlin-3a removal.

46 and CDC2 in Nutlin-3a-treated cells and for endoreduplication after Nutlin-3a removal.

47 on megakaryocytic colony growth and nuclear endoreduplication, alone or in the presence of thrombopo

48 mponents manipulated to promote induced host endoreduplication and (b) biotroph effectors that facili

49 w that MeJA activates critical regulators of endoreduplication and affects the expression of key dete

50 In contrast, RO3306 induced abortive endoreduplication and apoptosis in embryonic stem cells,

51 Endoreduplication and apoptosis in response to VX-680 ar

52 In contrast, endoreduplication and apoptosis occur in the p53 wild-ty

53 ein phosphorylation, followed by progressive endoreduplication and apoptosis.

54 cycle, the cell will likely enter a state of endoreduplication and become giant.

55 tive NCI-H1299 cells inhibits VX-680-induced endoreduplication and cell death.

56 nts, less is known about the coordination of endoreduplication and cell differentiation.

57 kernels when endosperm cells were undergoing endoreduplication and cell division.

58 y a role in arresting mitosis during the DNA endoreduplication and cell expansion phase of seed devel

59 ion occurred without cell division involving endoreduplication and cell growth, thereby circumventing

60 an unexpected yet specific role of SEC24A in endoreduplication and cell size patterning in the Arabid

61 could bind chromatin to coordinately control endoreduplication and chromatin structure and allow the

62 e G2 phase of the cell cycle, accompanied by endoreduplication and consequently polyploidization.

63 Shared mechanisms to promote host endoreduplication and development of nutrient exchange/f

64 of cell proliferation and the transition to endoreduplication and differentiation during organ forma

65 lar regulatory pathways to drive S. meliloti endoreduplication and differentiation during symbiosis.

66 ell division by regulating the transition to endoreduplication and differentiation.

67 tivation, and the strong association between endoreduplication and impaired proliferation, may place

68 due to inhibition of Aurora kinases included endoreduplication and inhibition of histone H3 phosphory

69 ybridisation (CGH) showed mutually exclusive endoreduplication and loss of heterozygosity events in c

70 telet production and function by stimulating endoreduplication and megakaryocyte formation from marro

71 We now report that endoreduplication and mitotic failure occur during telom

72 ependent manner by stimulating megakaryocyte endoreduplication and new megakaryocyte formation from m

73 ype and that diploidisation is the result of endoreduplication and not cell fusion.

74 1) modulates a number of processes including endoreduplication and plant disease resistance, but the

75 oly-(ethylene glycol), induces megakaryocyte endoreduplication and proliferation in vitro and in vivo

76 Loss-of-function alleles show reduced endoreduplication and reduced expansion in trichomes and

77 tokinesis failure, causing several rounds of endoreduplication and resulting in multinucleated cells.

78 me amplification, abnormal spindle assembly, endoreduplication and significant chromosome instability

79 times complete only the first two rounds of endoreduplication and stall at 8C.

80 xpand during early development, undergo more endoreduplication and that have a striking nuclear morph

81 plex co-ordination of cell division, growth, endoreduplication and the acquisition of differentiated

82 nt of p53 wild-type cancer cells can promote endoreduplication and the generation of therapy-resistan

83 ther cells are susceptible to Nutlin-induced endoreduplication and therapy resistance could help dire

84 by specifically affecting cell enlargement, endoreduplication and/or cell division.

85 posable elements (TEs), is maintained during endoreduplication, and drops precipitously within the ge

86 l and phosphorylation state concomitant with endoreduplication, and it is phosphorylated in vitro by

87 vent a DNA damage signal at chromosome ends, endoreduplication, and senescence.

88 ppresses development of an abnormal state of endoreduplication arising after S phase DNA damage.

89 acute chromosomal aberrations and underwent endoreduplication at a high rate.

90 f inner cell mass (ICM) and causes premature endoreduplication at eight cells, rather than 32 cells.

91 y at high concentrations but cause bacterial endoreduplication at sublethal concentrations.

92 Here, we show that variation in endoreduplication between Arabidopsis thaliana accession

93 ts revealed that p57 was required to trigger endoreduplication by inhibiting CDK1, while p21 suppress

94 the developmental transition from mitosis to endoreduplication by modulating anaphase-promoting compl

95 ay function as a repressor of mitosis in the endoreduplication cell cycle.

96 Both the mitotic and endoreduplication cell cycles were stimulated.

97 breast cancer cell lines and results in the endoreduplication (cellular DNA content >4N) of MCF-7 an

98 nism by which this occurs is via postmitotic endoreduplication checkpoint and mitotic catastrophe.

99 Successful progression of the endoreduplication cycle in Arabidopsis requires a plant

100 he switch from the mitotic cell cycle to the endoreduplication cycle, which accompanies cell expansio

101 ping roles during the mitotic cell cycle and endoreduplication cycle.

102 Medicago truncatula is driven by successive endoreduplication cycles and transcriptional reprogrammi

103 the tendency of Rb-negative cells to undergo endoreduplication cycles when p21 is expressed may have

104 amplify its chromosomal DNA content through endoreduplication cycles.

105 nvestigated how the epigenome changes during endoreduplication cycles.

106 Our results suggest that endoreduplication-dependent epigenetic changes contribut

107 The lower level of endoreduplication did not affect cell size and only slig

108 Endoreduplication disrupts the alternation of DNA synthe

109 Mitotic exit and onset of endoreduplication do not correlate with an up-regulation

110 cts to promote cell division and/or suppress endoreduplication during leaf development.

111 Genome endoreduplication during mammalian development is a rare

112 h cells end their mitotic division and start endoreduplication earlier.

113 o, bacteroid differentiation is driven by an endoreduplication event that is induced by host nodule-s

114 eckpoint function are more likely to undergo endoreduplication followed by eventual apoptosis.

115 To study the genetic regulation of endoreduplication, four inbreds were crossed to B73 and

116 Endoreduplication gave rise to stable tetraploid clones

117 described quantitative trait gene underlying endoreduplication in Arabidopsis.

118 ons rendered E7 unable to induce S phase and endoreduplication in differentiated keratinocytes and re

119 y dictate cell cycle arrest; but suppressing endoreduplication in endocycling cells, an effect that c

120 ometry was used to assess the variability of endoreduplication in endosperms of maize inbred lines.

121 genes is associated with a higher degree of endoreduplication in enlarged C(4) bundle sheath cells.

122 CT116 p21(+/+) cells paralleled the onset of endoreduplication in HCT116 p21(-/-) cells.

123 n proliferating tissues and also compromises endoreduplication in larval salivary glands.

124 FZR2 is sufficient to drive ectopic or extra endoreduplication in leaves, roots, and flowers, leading

125 During the transition from mitosis to endoreduplication in maize endosperm, CycZme1 transcript

126 We conclude that cellular programming during endoreduplication in megakaryocytes is associated with r

127 assembly of prereplication complexes and for endoreduplication in megakaryotes and giant trophoblast

128 We previously documented endoreduplication in mouse cells with persistent telomer

129 quantitative analysis of DNA replication and endoreduplication in nuclei from pulse-labeled developin

130 ediately after Nutlin-3a removal could drive endoreduplication in otherwise resistant 4N cells.

131 Furthermore, we show that MTI-induced endoreduplication in p53-deficient HIp21 cells was due t

132 ion of the cell cycle and for suppression of endoreduplication in pupal wing cells.

133 on increases chromocenter decondensation and endoreduplication in the Arabidopsis trithorax-related p

134 al and mesophyll cell number, a reduction in endoreduplication in the epidermis, and an increase in e

135 r, smaller cell volume, and reduced level of endoreduplication in the mutant endosperm.

136 pendent quiescent center differentiation and endoreduplication in the primary root tip.

137 es during the transition from replication to endoreduplication in the Rcho-1 rat choriocarcinoma cell

138 ies was associated with abnormal mitosis and endoreduplication in the recovering cells and was correl

139 To investigate this process, we reduced endoreduplication in transgenic maize endosperm by ectop

140 ication in the epidermis, and an increase in endoreduplication in trichomes.

141 n of the ectoplacental cone and chorion, and endoreduplication in trophoblast giant cells.

142 Thus, endoreduplication in TS cells is triggered by p57 inhibi

143 gression in both cell lines, with associated endoreduplication in U2OS cells.

144 required for both mitosis and prevention of endoreduplication in wing cells.

145 g cells, and loss of KRP5 function decreases endoreduplication, indicating that KRP5 is a positive re

146 Localized host endoreduplication induced by adapted plant biotrophs pro

147 The G2-M arrest and endoreduplication induced by JAK inhibitors were reduced

148 ill be consolidated into a single strain by "endoreduplication intercross." Chemically synthesized ge

149 Endoreduplication is a process by which cells successive

150 Endoreduplication is also reduced in dark-grown sim hypo

151 Endoreduplication is different between inbred lines by 1

152 Endoreduplication is found in animals and is widespread

153 When induced host endoreduplication is limited, biotroph growth and/or dev

154 Endoreduplication is the process where a cell replicates

155 Although the role of endoreduplication is unclear, it is thought to provide a

156 Although endoreduplication is widespread in eukaryotes, we know v

157 Endoreplication, also called endoreduplication, is a modified cell cycle in which DNA

158 Endoreplication, also known as endoreduplication, is a phyogenetically widespread modif

159 to its described activity as a repressor of endoreduplication, KAK may play a role in vascular devel

160 GL1 overexpression also reduced endoreduplication levels in both the epidermis and trich

161 Parental and progeny endoreduplication levels were compared and heritabilitie

162 The resistance to endoreduplication observed in some cell lines was associ

163 urther experimentation revealed induced host endoreduplication occurred exclusively at the infection

164 imilar arrest distributions [corrected], DNA endoreduplication occurred in pRb-negative but not in pR

165 work, we show that some, but not all, of the endoreduplication of Arabidopsis (Arabidopsis thaliana)

166 thout cytokinesis and subsequently underwent endoreduplication of DNA despite activation of a p53-dep

167 in progeny of ASI2 germ line knockouts, but endoreduplication of the macronuclear genome is arrested

168 profound cellular differentiation, including endoreduplication of the ome.

169 revealing that inactivation of CDK1 triggers endoreduplication only in cells programmed to differenti

170 to oxygen deprivation and could form through endoreduplication or cell fusion, generating regular-siz

171 the p21Waf1/Cip1 activated G2 block undergo endoreduplication, passing through another S-phase befor

172 tory activity that peaks coincident with the endoreduplication phase of endosperm development.

173 test the feasibility of introgressing a high endoreduplication phenotype into a midwestern dent inbre

174 ingly, mutant root hairs complete the normal endoreduplication programme, increasing their nuclear pl

175 ted synthesis of the defective enzyme to the endoreduplication rather than the mitotic phase of endos

176 lei of sim trichomes have a reduced level of endoreduplication relative to WT trichome nuclei.

177 enlarged polyploid beta cells as a result of endoreduplication replacing proliferation.

178 Conversely, endoreduplication represses small cell identity.

179 but did not prevent G1/S transition so that endoreduplication resulted.

180 t, by increasing gene copy number, localized endoreduplication serves as a mechanism to meet the enha

181 scued clones prevented without also inducing endoreduplication, suggesting that these two key roles f

182 gene expression with high and low levels of endoreduplication, suggesting that this process may not

183 characterized by mitotic cell proliferation, endoreduplication, the accumulation of storage compounds

184 To determine how p21 prevents MTI-induced endoreduplication, the G1/S and G2/M checkpoint pathways

185 hat CDKA;1 is epistatic to RBR1 and controls endoreduplication through an RBR1-dependent pathway.

186 nstrated that the induction of p21 inhibited endoreduplication through direct cyclin E/Cdk2 regulatio

187 However, some cell lines underwent endoreduplication to relatively high extents after Nutli

188 m with either of two other mutants affecting endoreduplication, triptychon (try) and glabra3 (gl3) ar

189 size and leaf ploidy levels, suggesting that endoreduplication underpins leaf thickness in tomato.

190 Induced endoreduplication was abrogated in myb3r4 mutants, and G

191 arrest of the mitotic cycle at the onset of endoreduplication was associated with a failure to assem

192 Three measurements of endoreduplication were calculated from these data and an

193 en midwestern dent types, and high levels of endoreduplication were observed in popcorns.

194 TS cells revealed that CDK2 is required for endoreduplication when CDK1 is inhibited.

195 mitosis, on the one hand, and prevention of endoreduplication when cells are arrested in G2, on the

196 s in a substantial increase in the degree of endoreduplication, whereas inducible expression of p21(W

197 es during the cell-cycle but also suppresses endoreduplication, which is associated with polyploidy a

198 with a >/=4N DNA content, a process known as endoreduplication, which results in polyploidy.

199 tion, a period that encompasses the onset of endoreduplication, while the Zeama;KRP;2 protein decline

200 a mays) endosperm undergo multiple cycles of endoreduplication, with some attaining DNA contents as h