ライフサイエンスコーパス: endoreplication

1 DNA replication without cell division (i.e., endoreplication).

2 treplicative cell cycle arrest and increased endoreplication.

3 d is then redistributed during the course of endoreplication.

4 phasizing its role in linking cell shape and endoreplication.

5 ESE (SIM) gene, which encodes a repressor of endoreplication.

6 otic tissues, but has a lesser effect on DNA endoreplication.

7 ms that support the onset and progression of endoreplication.

8 prisingly, however, ORC1 is not required for endoreplication.

9 itotic, but undergo extensive growth and DNA endoreplication.

10 nduced tension anisotropy stimulates ectopic endoreplication.

11 sistent with their involvement in regulating endoreplication.

12 rapped, immature oocytes that have undergone endoreplication.

13 ndergoing mitotic DNA replication as well as endoreplication.

14 se in their ability to grow and to carry out endoreplication, a modified cell cycle in which DNA repl

15 epithelium through regulation of epithelial endoreplication, a modified cell cycle that entails geno

16 Endoreplication, also called endoreduplication, is a mod

17 Endoreplication, also known as endoreduplication, is a p

18 ve a defect in two types of DNA replication, endoreplication and chorion gene amplification.

19 However, E type cyclins seem essential for endoreplication and exit from quiescence.

20 A null mutation in dm results in attenuated endoreplication and growth arrest early in larval develo

21 We observe increased endoreplication and growth of larval tissues in these do

22 omal instability, indicating that inaccurate endoreplication and karyokinesis occur during MK polyplo

23 Thus, dMyc is required for endoreplication and larval growth.

24 We demonstrate that in the processes of endoreplication and photomorphogenesis, LIP1 acts downst

25 that, in addition to proliferation, germline endoreplication and ploidy are also affected by the loss

26 phoblast giant cells, which normally undergo endoreplication and reach elevated ploidies, showed a ma

27 f PNCs per cell increases with the rounds of endoreplication and that PNCs split into doublets during

28 Finally, endoreplication and the accompanying changes in epitheli

29 required for light-controlled inhibition of endoreplication and tolerance to salt stress in Arabidop

30 ion of BLT results in an additional round of endoreplication, and blt mutants uncouple DNA content fr

31 yploid cells can originate from cell fusion, endoreplication, and cytokinesis failure.

32 r is required for and sufficient to drive EC endoreplication, and Ras/Raf signalling upregulates E2f1

33 Our results indicate that larval growth and endoreplication are coupled processes that, although lin

34 dMyc driven growth and endoreplication are strongly attenuated when the endocyc

35 cystocytes do not undergo multiple rounds of endoreplication as the nurse cells do in a normal egg ch

36 der cells form by spatiotemporally regulated endoreplication, caused primarily by cytokinesis failure

37 ei form tumor-like structures from continued endoreplication, cell growth and retinal differentiation

38 In endoreplication, cells with replicated genomes bypass mi

39 Blockade of VEGFR-3 promoted endoreplication consistently.

40 tion in nurse cells at the end of the unique endoreplication cycle 5 and repressing transcription of

41 One, the switch from the endoreplication cycle to a gene-amplification phase, dur

42 polyploid through an experimentally induced endoreplication cycle.

43 plication to mitosis is absent in Drosophila endoreplication cycles (endocycles), during which discre

44 Overall our results suggest that transient endoreplication cycles generate a diverse population of

45 We show that the endoreplication defect resulted from a failure to downre

46 essed all the phenotypes associated with the endoreplication defect.

47 depletion of Enok also partially rescued the endoreplication defects in Elg1-depleted nurse cells.

48 ntrast to its dramatic effects on growth and endoreplication, dMyc is dispensable for the mitotic div

49 ton may provide a temporal cue ensuring that endoreplication does not begin until the cells have fini

50 e (CDK) inhibitors and is a key regulator of endoreplication during the development of trichomes (sho

51 Furthermore, endoreplication from G2 phase is independent of p53 cont

52 Endoreplication from G2 phase lacks all hallmarks of mit

53 enance proteins are apparently essential for endoreplication, implying that some aspects of initiatio

54 n factors that are not strictly required for endoreplication in Drosophila.

55 nd apoptotic rates of myoblasts, and display endoreplication in residual myotubes.

56 docycle in these cells; Tec29 must delay DNA endoreplication in the salivary placode cells until they

57 to suppress mitosis as part of the switch to endoreplication in trichomes.

58 An important example is endoreplication, in which endocycling cells alternate be

59 ts, DNA replication is severely impaired and endoreplication is fully suppressed.

60 Endoreplication is often associated with increased cell

61 t, the ability of dMyc to promote growth and endoreplication is only partly reduced when PI3K activit

62 In Drosophila larvae, epithelial endoreplication leads to progressive changes in dendrite

63 se of cell fusion or abnormal cell division (endoreplication, mitotic slippage, or cytokinesis failur

64 ome are reminiscent of "mitotic slippage" or endoreplication observed in some other eukaryotes.

65 Endoreplication occurs exclusively in EBs and newborn EC

66 In addition, we discuss briefly how endoreplication occurs in response to certain physiologi

67 is necessary to repress excess branching and endoreplication of Arabidopsis trichomes.

68 This defines a new mechanism by which endoreplication of DNA can be triggered and maintained i

69 the entry of cells into mitosis and leads to endoreplication of DNA from G2 phase.

70 nd proper execution of the nurse cell cycle (endoreplication of DNA) and the oocyte cell cycle (karyo

71 ring a developmentally regulated switch from endoreplication of the entire genome to amplification of

72 cision of chromosome breakage sequences, and endoreplication of the new macronuclear genome and event

73 nuclear-specific DNA occurs independently of endoreplication of the new macronuclear genome that take

74 n days 6 and 10 post ovulation initiated the endoreplication of the uterine surface epithelium to for

75 However, endoreplication of trophoblast giant cells and megakaryo

76 ed in which the oocyte nucleus has undergone endoreplication often resulting in the formation of 16 n

77 s, providing an explanation for the distinct endoreplication parameters compared with Drosophila.

78 Comparison with endoreplication pathways in Drosophila and mammals indic

79 Ttk overexpression stops endoreplication prematurely and alleviates the endocycle

80 es also often undergo an additional round of endoreplication resulting in enlarged nuclei with ploidy

81 ns of the cell cycle, termed collectively as endoreplication, resulting in polyploid cells that suppo

82 cating regions occasionally fail to complete endoreplication, resulting in underreplicated domains of

83 that while acting synergistically to promote endoreplication, SIM and SMR1 play different roles in af

84 vae is accompanied by defects in mitosis and endoreplication similar to that associated with nutritio

85 r, less branched and undergo fewer rounds of endoreplication than wild-type trichomes.

86 etameres that proceed through many cycles of endoreplication, the cells that constitute the Tr2 branc

87 nisms all use similar components to initiate endoreplication, the components are deployed differently

88 ibitor with a key function in the mitosis-to-endoreplication transition.

89 ct on mitosis prompted investigations of the endoreplication variant of the cell cycle.

90 NA synthesis, demonstrating that the lack of endoreplication was a cell-autonomous defect.

91 rotein that promotes a shift from mitosis to endoreplication was lower in abcb19 hypocotyls, and fluo

92 and dMyc (Diminutive) are key regulators of endoreplication, which is necessary but not sufficient t

93 Drosophila larval tissues undergo endoreplication without cell division, and the latest re

94 istence of Cdk2 activity in G2 cells induces endoreplication without mitosis.