ライフサイエンスコーパス: endoribonuclease

1 terspaced short palindromic repeats (CRISPR) endoribonuclease.

2 ation and help to identify new roles of this endoribonuclease.

3 dent on Ire1, an ER membrane-resident kinase/endoribonuclease.

4 NA component of mitochondrial RNA processing endoribonuclease.

5 iated with G3BP, a phosphorylation-dependent endoribonuclease.

6 resence of Mg(2+), RNase BN was primarily an endoribonuclease.

7 iated by a bifunctional transmembrane kinase/endoribonuclease.

8 U(L)41 gene of herpes simplex virus 1 is an endoribonuclease.

9 ial toxin that is an ssRNA- and ACA-specific endoribonuclease.

10 ical characterization of a novel coronavirus endoribonuclease.

11 n Escherichia coli is cleaved by RNase P, an endoribonuclease.

12 erged on a single-strand specific, regulated endoribonuclease.

13 que example of a protein-guided programmable endoribonuclease.

14 t shutoff protein (vhs), a virion-associated endoribonuclease.

15 fect of HBx protein on activity of the Dicer endoribonuclease.

16 is a highly conserved tRNA 3'-end processing endoribonuclease.

17 ltiple copies in both Csm complexes, acts as endoribonuclease.

18 cerevisiae model host, we tested eight known endoribonucleases.

19 cessing by a large family of CRISPR-specific endoribonucleases.

20 '-truncated viral RNAs are generated by host endoribonucleases.

21 tive because UA dinucleotides are cleaved by endoribonucleases.

22 d by RNase L and other metal-ion-independent endoribonucleases.

23 hed by a combination of exoribonucleases and endoribonucleases.

24 t into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserve

25 proteins with greatly reduced but detectable endoribonuclease activities.

26 IRE1alpha to activate its protein kinase and endoribonuclease activities.

27 s) protein of herpes simplex virus (HSV) has endoribonuclease activity and rapidly reduces protein sy

28 SV-2 infection in a manner that requires vhs endoribonuclease activity and that, befitting this abili

29 alysis of the mechanism shows that IRE1alpha endoribonuclease activity decreased PER1 mRNA in tumor c

30 Here, we test the requirement for vhs endoribonuclease activity in disruption of SG formation.

31 ivo, we investigated the requirement for vhs endoribonuclease activity in disruption of SG formation.

32 This enzyme is the main endoribonuclease activity in plant cells and localizes t

33 that the dDis3 N-terminus is sufficient for endoribonuclease activity in vitro and that proper N-ter

34 inant RB47 including the NCL did not display endoribonuclease activity in vitro, versions lacking the

35 yme 1alpha (IRE1alpha), while activating its endoribonuclease activity in vitro.

36 Concentrations of Mn(2+) needed for endoribonuclease activity induced significant conformati

37 Our studies demonstrate that endoribonuclease activity is required for vhs to disrupt

38 Together these data indicate that endoribonuclease activity must be maintained in order fo

39 depend on antisense RNA and might implicate endoribonuclease activity of CSP41a.

40 Intracellular CD24 inhibits the specific endoribonuclease activity of G3BP toward BART mRNA in st

41 additional transcripts, which shows that the endoribonuclease activity of GhoS has been broadened as

42 The endoribonuclease activity of IRE1 appears to be required

43 We show that the endoribonuclease activity of IRE1alpha is required to sp

44 ds MazF(Sa) to form a complex to inhibit the endoribonuclease activity of MazF(Sa).

45 o better define the relationship between the endoribonuclease activity of murine hepatitis virus (MHV

46 another coronavirus, demonstrating that the endoribonuclease activity of Nsp15 may be common to coro

47 t protein synthesis, whereas PemI blocks the endoribonuclease activity of PemK.

48 The endoribonuclease activity of the mouse hepatitis virus (

49 The endoribonuclease activity of the SARS-CoV Nsp15 (sNsp15)

50 clock PER1 mRNA as a novel substrate of the endoribonuclease activity of the UPR sensor IRE1alpha.

51 VapC-mt4 exhibited sequence-specific endoribonuclease activity on mRNA templates at ACGC and

52 Recombinant human LACTB2 displayed robust endoribonuclease activity on ssRNA with a preference for

53 We present evidence that ablation of vhs endoribonuclease activity results in defects in vhs-medi

54 (SARS-CoV) produced in Escherichia coli has endoribonuclease activity that preferentially cleaved 5'

55 indicating that YoeB by itself does not have endoribonuclease activity under the conditions used.

56 indicating that YafO by itself does not have endoribonuclease activity under the conditions used.

57 ddition to nitric oxide, stimulation of IRE1 endoribonuclease activity with the flavonol quercetin le

58 xosome has both 3' to 5' exoribonuclease and endoribonuclease activity, and the available evidence su

59 Mn(2+) at 2 to 10 mM was needed for optimal endoribonuclease activity, but Mg(2+) and several other

60 he dimer in solution and severely diminished endoribonuclease activity, indicating that the dimer is

61 as impaired in hexamer formation and had low endoribonuclease activity, suggesting that oligomerizati

62 the point mutation D215N, which ablates its endoribonuclease activity, to disrupt SG formation in bo

63 IRE1 also has an endoribonuclease activity, which initiates a non-convent

64 binding and directly activates the latter's endoribonuclease activity.

65 ters, IRE1 dephosphorylation, and decline in endoribonuclease activity.

66 gesting that oligomerization is required for endoribonuclease activity.

67 e active site, were significantly reduced in endoribonuclease activity.

68 SP41, a chloroplast RNA-binding protein with endoribonuclease activity.

69 transmembrane kinase Ire1, which induces its endoribonuclease activity.

70 loroplast to regulate the activation of RB47 endoribonuclease activity.

71 ly, that SG disassembly can be driven by vhs endoribonuclease activity.

72 nd Rrp44/Dis3, a subunit that also catalyzes endoribonuclease activity.

73 unconventional splicing mechanism using its endoribonuclease activity.

74 ied from chloroplasts in association with an endoribonuclease activity; however, protein sequencing f

75 tly process an rAP site in DNA and have weak endoribonuclease and 3'-exonuclease activities on r8oxoG

76 how RNase BN can act as both an exo- and an endoribonuclease and also demonstrate that its exoribonu

77 istic insight for the regulation of the Las1 endoribonuclease and identifies the tetrameric Grc3/Las1

78 icolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibioti

79 ytically inert but associates with Rrp44, an endoribonuclease and processive 3'-->5' exoribonuclease,

80 RNA cleavage by some endoribonucleases and self-cleaving ribozymes produces R

81 '-->3' phosphodiesterases, a purine-specific endoribonuclease, and a reverse transcriptase.

82 E1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation

83 em is a sequence- and single-strand-specific endoribonuclease, and many studies have led to the propo

84 YbeY, a previously unidentified endoribonuclease, and the exonuclease RNase R act togeth

85 nduced silencing complex (RISC), wherein the endoribonuclease Argonaute and single-stranded small int

86 lease L (RNase L) is a metal-ion-independent endoribonuclease associated with antiviral and antibacte

87 essing was independent of the broad-spectrum endoribonucleases associated with mRNA turnover and stil

88 CSP41 is a ubiquitous chloroplast endoribonuclease belonging to the short chain dehydrogen

89 Here, we show that Drosha, an endoribonuclease best known for its role in the biogenes

90 trated the involvement of the RNase III-like endoribonuclease, Bs-RNase III, in scRNA processing.

91 IL-17-mediated signaling, requiring MCPIP1's endoribonuclease but not deubiquitinase domain.

92 brane and that toxin MqsR (a 5'-GCU-specific endoribonuclease) causes membrane damage in a GhoT-depen

93 w temperature, induction of an mRNA-specific endoribonuclease causing host cell growth arrest, and cu

94 DICER1 is an RNase III endoribonuclease central to miRNA biogenesis, and germli

95 ily are double-stranded RNA (dsRNA) specific endoribonucleases characterized by a signature motif in

96 Altogether, results reveal a site-specific endoribonuclease cleavage event that seems to depend on

97 quency and location of metal-ion-independent endoribonuclease cleavage sites within host and viral RN

98 Our results establish that Grc3 drives Las1 endoribonuclease cleavage to its targeted C2 site both i

99 Studies with cells lacking RNase L, the endoribonuclease component of the interferon-regulated 2

100 P) is an essential, evolutionarily conserved endoribonuclease composed of 10 different protein subuni

101 line mutations in DICER1, a gene encoding an endoribonuclease critical to the generation of small non

102 as aeruginosa, crRNA biogenesis requires the endoribonuclease Csy4, which binds and cleaves the repet

103 Here, we identify the endoribonuclease (Csy4) responsible for CRISPR transcrip

104 In addition to the endoribonuclease Dcr1, RNAi in S. pombe requires two int

105 ctions, the virion host shutoff (Vhs) (UL41) endoribonuclease degrades many cellular and viral mRNAs.

106 implex virus (HSV) virion host shutoff (Vhs) endoribonuclease degrades many host and viral mRNAs.

107 ase BN acted as either an exoribonuclease or endoribonuclease depending on the nature of the added di

108 We have previously demonstrated that the endoribonuclease DICER facilitates chromatin decondensat

109 The endoribonuclease Dicer is a key component of the human R

110 The endoribonuclease dicer is a major component of the miRNA

111 anscriptional silencing) complex, and 3) the endoribonuclease Dicer ortholog Dcr1.

112 are generated predominantly by the type III endoribonuclease Dicer-like 1 (DCL1) but do not require

113 The endoribonuclease, Dicer, is indispensable for generating

114 RNase BN, a member of the RNase Z family of endoribonucleases, differs from other family members in

115 arget in MM using a small-molecule IRE1alpha endoribonuclease domain inhibitor MKC-3946.

116 of XBP1 splicing by inhibition of IRE1alpha endoribonuclease domain is a potential therapeutic optio

117 on loop phosphorylation in activation of the endoribonuclease domain of Ire1.

118 Rrp44p also contains an endoribonuclease domain.

119 t containing the unique cytosolic kinase and endoribonuclease domains of human IRE1alpha (hIRE1alpha-

120 abundance due to efficient processing by the endoribonuclease DROSHA, which initiates miRNA biogenesi

121 Here we show that the endoribonuclease E (RNaseE) and RNA helicase B (RhlB) co

122 Escherichia coli endoribonuclease E has a major influence on gene express

123 The T(2) family of nonspecific endoribonucleases (EC ) is a widespread family of RNases

124 mRNA interferases are sequence-specific endoribonucleases encoded by the toxin-antitoxin systems

125 uch as MazF and ChpBK, are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) system

126 mRNA interferases are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) system

127 We found that deletion of the endoribonuclease-encoding Dicer1 specifically in Th17 ce

128 se that PemK and its homologues form a novel endoribonuclease family that interferes with mRNA functi

129 ployed TIER-seq (transiently inactivating an endoribonuclease followed by RNA-seq) to profile cleavag

130 Ribonuclease (RNase) P is a site-specific endoribonuclease found in all kingdoms of life.

131 RNA against degradation by copies of the Vhs endoribonuclease from infecting virions and greatly enha

132 ibonuclease Sa (RNase Sa), a small, guanylyl-endoribonuclease from Streptomyces aureofaciens, was com

133 Restrictocin and related fungal endoribonucleases from the alpha-sarcin family site-spec

134 These proteins may provide the endoribonuclease function in editing.

135 diction module" is a sequence-specific (ACA) endoribonuclease functional only for single-stranded RNA

136 d III CRISPR/Cas systems, the Cas6 family of endoribonucleases generates functional CRISPR-derived RN

137 The RNase E/G family of endoribonucleases has a central role in RNA degradation

138 Most endoribonucleases have been shown to act distributively;

139 to RNase L and other single-strand specific endoribonucleases, (ii) RNase L-dependent and RNase L-in

140 We demonstrate that the endoribonuclease III, DICER1, contributes to the establi

141 RNase E, an essential endoribonuclease in Escherichia coli, is involved in 9S

142 RNase Y is a recently identified endoribonuclease in Gram-positive bacteria, and an RNase

143 s intact 7SL RNA, with 7SLrem produced by an endoribonuclease in the absence of NC.

144 ssues suggest a novel role for the regulated endoribonuclease in the pathogenesis of prostate cancer.

145 Germline truncating mutations in DICER1, an endoribonuclease in the RNase III family that is essenti

146 ssociated with miR biogenesis, and Dicer, an endoribonuclease in the RNaseIII family associated with

147 says suggest that the toxin is an Mg-enabled endoribonuclease, inhibited by the antitoxin.

148 analogs are the first reported specific IRE1 endoribonuclease inhibitors.

149 The endoribonuclease initiates nonconventional splicing of H

150 The ER-resident transmembrane kinase-endoribonuclease inositol-requiring enzyme 1 (IRE1) is t

151 served ER-resident UPR regulator, the kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1), is

152 d by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme-1alpha (IRE1a

153 RNase MRP is a ribonucleoprotein endoribonuclease involved in eukaryotic pre-rRNA process

154 e (HPC1), encodes a single-stranded specific endoribonuclease involved in the antiviral actions of IF

155 itous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide ra

156 To identify host endoribonucleases involved in degradation of Tomato bush

157 The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing of the mRNA for

158 In S. pombe, the ER membrane-resident kinase/endoribonuclease Ire1 utilizes a mechanism of selective

159 ivates the bifunctional transmembrane kinase/endoribonuclease Ire1.

160 ls and eosinophils selectively activated the endoribonuclease IRE1alpha and spliced Xbp1 mRNA without

161 mic reticulum (ER) stress, the transmembrane endoribonuclease Ire1alpha performs mRNA cleavage reacti

162 olded protein response is the protein kinase/endoribonuclease IRE1alpha.

163 lasmic reticulum by the transmembrane kinase-endoribonuclease Ire1p.

164 s at the type I transmembrane protein kinase/endoribonuclease Ire1p.

165 acillus subtilis have demonstrated that this endoribonuclease is essential for the maturation of tRNA

166 The bacteriophage T4-encoded RegB endoribonuclease is produced during the early stage of p

167 navirus nonstructural protein 15 (nsp15), an endoribonuclease, is required for evasion of dsRNA senso

168 E1alpha), an ER transmembrane protein kinase/endoribonuclease, is required to maintain hepatic lipid

169 Cleavage occurs by an unidentified endoribonuclease, is translation dependent and involves

170 Results indicated that endoribonuclease J2 contributes significantly to the deg

171 ty of the translumenal endoplasmic reticulum endoribonuclease/kinase, IRE1 alpha, to impair the gener

172 The protein was further identified as an endoribonuclease L-PSP (Liver-Perchloric acid-soluble pr

173 Accordingly, overexpression of the Ngl2p endoribonuclease led to an increased accumulation of cle

174 The role of such endoribonucleases may have broad implication in cell phy

175 iptome degradation by the sequence-dependent endoribonuclease MazF, to a synthetic circuit can increa

176 In this article, we show that the endoribonuclease MCP-1-induced protein 1 (MCPIP1; also k

177 The monocyte endoribonuclease MCPIP1 negatively regulates inflammatio

178 , RNA interference-mediated knockdown of the endoribonuclease MRP did not result in a clear defect in

179 Analysis of DeltaermC mRNA processing in endoribonuclease mutant strains showed that this process

180 that postsynaptic knockdown of dicer-1, the endoribonuclease necessary for microRNA synthesis, leads

181 ns a novel uridylate-specific Mn2+-dependent endoribonuclease (NendoU).

182 e and respiratory syndrome virus (PRRSV) RNA endoribonuclease nsp11 belongs to the XendoU superfamily

183 Coronaviruses encode an endoribonuclease, Nsp15, which has a poorly defined role

184 RNase E, a multifunctional endoribonuclease of Escherichia coli, attacks substrates

185 RNase E, an essential endoribonuclease of Escherichia coli, interacts through

186 d-RNA-activated protein kinase (PKR) and the endoribonuclease of the 2',5'-oligoadenylate synthetase-

187 A new study reveals that a calcium-activated endoribonuclease of the EndoU protein family promotes th

188 r RNase M5, the two known narrow-specificity endoribonucleases of Bacillus subtilis, was responsible

189 s both a distributive exoribonuclease and an endoribonuclease on model RNA substrates and to be inhib

190 se III superfamily of double-strand-specific endoribonucleases participate in diverse RNA maturation

191 The PRRSV nsp11 endoribonuclease plays a vital role in arterivirus repli

192 liberated from the complex, YoeB acts as an endoribonuclease, preferentially cleaving 3' of purine n

193 I to cleave double-stranded RNA (dsRNA) into endoribonuclease-prepared siRNA (esiRNA) that can target

194 is an ankyrin repeat domain-containing dual endoribonuclease-pseudokinase that is activated by unusu

195 We show that RDE-1 can instead recruit an endoribonuclease, RDE-8, to target RNA.

196 differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encodi

197 While IRE1 has been identified as the endoribonuclease required for cleavage of this mRNA, the

198 red in DNA repair, and Rnt1p (RNase III), an endoribonuclease required for RNA maturation.

199 mily of double-stranded RNA (dsRNA)-specific endoribonucleases required for RNA maturation and gene r

200 Here, we report that the essential Las1 endoribonuclease requires its binding partner, the polyn

201 Ribonuclease P (RNase P) is a Mg2+-dependent endoribonuclease responsible for the 5'-maturation of tr

202 activation of RNase Y, a recently identified endoribonuclease, revealed a role in processing and degr

203 omponent of the mitochondrial RNA processing endoribonuclease (RMRP) give rise to the autosomal reces

204 bacteria, RhlB associates with the essential endoribonuclease RNase E as part of the multi-enzyme RNA

205 o profile cleavage products of the essential endoribonuclease RNase E in Salmonella enterica.

206 The endoribonuclease RNase E is a key enzyme in RNA metaboli

207 The Escherichia coli endoribonuclease RNase E is central to the processing an

208 The endoribonuclease RNase E plays an important role in RNA

209 ternary complex of Hfq, sRNA and mRNA guides endoribonuclease RNase E to initiate turnover of both th

210 component of the degradosome complex is the endoribonuclease RNase E, a multidomain protein composed

211 rotein acts as an inhibitor of the essential endoribonuclease RNase E, and we demonstrated that ectop

212 nts of the C. crescentus degradosome are the endoribonuclease RNase E, the exoribonuclease polynucleo

213 The hydrolytic endoribonuclease RNase E, which is widely distributed in

214 teraction with the scaffolding domain of the endoribonuclease RNase E.

215 ly reversed by overexpression of the related endoribonuclease RNase G or by mutation of the gene enco

216 ) elicit cleavage of the targeted RNA by the endoribonuclease RNase H1, whereas siRNAs mediate cleava

217 recent findings that the narrow-specificity endoribonuclease RNase III and the 5' exonuclease RNase

218 The endoribonuclease RNase III cleaves double stranded RNAs,

219 age including the double-strand RNA-specific endoribonuclease RNase III.

220 f OAS, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RN

221 The endoribonuclease RNase L is a key mediator of IFN induct

222 hat senses double-stranded RNA and activates endoribonuclease RNase L to cleave viral and cellular RN

223 racellular RNA decay by the pseudokinase and endoribonuclease RNase L.

224 of intracellular RNA by the kinase homology endoribonuclease RNase L.

225 ther, this work suggests a role for the host endoribonuclease RNase MRP in viral RNA degradation and

226 Our results demonstrate that the endoribonuclease RNase MRP specifically cleaves the CLB2

227 P RNA is the RNA subunit of a ubiquitous endoribonuclease RNase P that consists of one RNA subuni

228 The Escherichia coli endoribonucleases RNase E (Rne) and RNase G (Rng) have s

229 of time-lapse microscopy and a human kinesin endoribonucleases RNase III-prepared short interfering R

230 and Rpp25 are two key subunits of the human endoribonucleases RNase P and MRP.

231 omain of IRE1alpha, inhibits both kinase and endoribonuclease (RNase) activities of the stress sensor

232 homo-oligomerization of its cytosolic kinase/endoribonuclease (RNase) domains to activate mRNA splici

233 nd conformational changes to the cytoplasmic endoribonuclease (RNase) domains, which render them func

234 We found that the ER transmembrane kinase/endoribonuclease (RNase) IRE1alpha is a key component of

235 ansducer IRE1alpha is a transmembrane kinase endoribonuclease (RNase) that cleaves mRNA substrates to

236 inositol requiring enzyme 1alpha (IRE1alpha) endoribonuclease (RNase), a key mediator of the UPR, cle

237 ivates IRE1alpha, an ER transmembrane kinase-endoribonuclease (RNase).

238 , 3' maturation of tRNAs is catalyzed by the endoribonuclease, RNase BN/RNase Z, which cleaves after

239 Many sRNAs recruit the endoribonuclease, RNase E, to facilitate processing of m

240 ere we show that activation of the antiviral endoribonuclease, RNase L, by 2',5'-linked oligoadenylat

241 protein components are shared with a related endoribonuclease, RNase P.

242 as1 cross talk draws unexpected parallels to endoribonucleases RNaseL and Ire1, and establishes Grc3/

243 In metazoans, cleavage by the endoribonuclease SMG6 is often the first degradative eve

244 best-characterized activity of vhs is as an endoribonuclease specific for mRNA in vivo, we investiga

245 an antitoxin from a type V system (GhoS, an endoribonuclease specific for the mRNA of the toxin GhoT

246 tRNA in many organisms is carried out by an endoribonuclease termed RNase Z or 3'-tRNase, which clea

247 during maturation of tRNA is catalyzed by an endoribonuclease, termed RNase Z.

248 HSV) virion host shutoff (Vhs) protein is an endoribonuclease that accelerates decay of many host and

249 es IRE1alpha, an ER transmembrane kinase and endoribonuclease that activates the transcription factor

250 s been shown to be a sequence-specific (ACA) endoribonuclease that cleaves cellular mRNAs and effecti

251 entified Pyrococcus furiosus Cas6 as a novel endoribonuclease that cleaves CRISPR RNAs within the rep

252 strate that ChpBK is a new sequence-specific endoribonuclease that cleaves mRNAs both in vivo and in

253 dies reveal that PemK is a sequence-specific endoribonuclease that cleaves mRNAs to inhibit protein s

254 Ribonuclease P (RNase P) is a ubiquitous endoribonuclease that cleaves precursor tRNAs to generat

255 Staphylococcus aureus is a sequence-specific endoribonuclease that cleaves the majority of the mRNAs

256 RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-s

257 Las1 is a recently discovered endoribonuclease that collaborates with Grc3-Rat1-Rai1 t

258 ondrial RNA processing (MRP) is an essential endoribonuclease that consists of one RNA component and

259 the virion host shutoff protein (VHS) is an endoribonuclease that degrades mRNA.

260 sing (MRP) is an essential ribonucleoprotein endoribonuclease that functions in the degradation of sp

261 ibonuclease E (RNase E) is a multifunctional endoribonuclease that has been evolutionarily conserved

262 Restrictocin is a site-specific endoribonuclease that inactivates ribosomes by cleaving

263 MazFSa is a sequence-specific endoribonuclease that inhibits the growth of S. aureus a

264 RNase G (rng) is an E. coli endoribonuclease that is homologous to the catalytic dom

265 cherichia coli encodes RNase E, an essential endoribonuclease that is involved in both mRNA decay and

266 RNase E of Escherichia coli is an essential endoribonuclease that is involved in many aspects of RNA

267 her, this study discovered that LACTB2 is an endoribonuclease that is involved in the turnover of mit

268 Herpes simplex virus 1 (HSV-1) encodes an endoribonuclease that is responsible for the shutoff of

269 These data indicate that KREPB1 is an endoribonuclease that is specific for RNA editing deleti

270 RNase L is an endoribonuclease that mediates diverse antiproliferative

271 ase inositol-requiring protein-1 (IRE-1), an endoribonuclease that mediates unconventional splicing,

272 Furthermore, RNase P, an endoribonuclease that normally generates the mature 5'-e

273 ulation is affected by RNase E, an essential endoribonuclease that not only turns over RNA but also p

274 RNase E is an essential endoribonuclease that plays a central role in the proces

275 sp15 (nonstructural protein 15), a hexameric endoribonuclease that preferentially cleaves 3' of uridi

276 n-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine

277 C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removi

278 RNase L is a uniquely regulated endoribonuclease that requires 5'-triphosphorylated, 2',

279 U(L)41 gene of herpes simplex virus 1 is an endoribonuclease that selectively degrades mRNAs during

280 Remarkably, these VapCs are all endoribonucleases that cleave RNAs essential for decodin

281 re than half of these encode VapC PIN domain endoribonucleases that inhibit cell growth by unknown me

282 mutant at 45 degrees C, making YbeY the only endoribonuclease to be implicated in the critically impo

283 Thus, MazF functions as a toxic endoribonuclease to interfere with the function of cellu

284 tomics and purified MqsR, we determined that endoribonuclease toxin MqsR degrades YgiS mRNA, which en

285 multifunctional DNA/RNA-binding protein, and endoribonuclease UK114 (UK).

286 of the alpha-sarcin family of site-specific endoribonucleases, uses electrostatic interactions to bi

287 ere, a group I ribozyme, which can act as an endoribonuclease, was partnered with the R3C ribozyme, w

288 ein (CSP)41a, a highly conserved chloroplast endoribonuclease, was reduced >90% by the expression of

289 By using a sequence-specific endoribonuclease, we show that the rare arginine codons,

290 nd purified to homogeneity acts as bona fide endoribonuclease when tested on in vitro transcribed IEX

291 MazF(Sa) is a novel sequence-specific endoribonuclease which cleaves mRNA to inhibit protein s

292 vening spacers through the function of Cas6e endoribonuclease, which cleaves at specific positions of

293 ss is sensed by Ire1, a transmembrane kinase/endoribonuclease, which initiates the non-conventional s

294 d that the antiviral effector 2-5A-dependent endoribonuclease, which is not an ISG in humans, is high

295 presence in B. subtilis of another specific endoribonuclease, which may be ribosome associated.

296 We demonstrate that HigB is an endoribonuclease whose enzymatic activity is dependent o

297 It was previously characterized as an endoribonuclease with preference for single-stranded (ss

298 on-structural protein 15 is a Mn2+-dependent endoribonuclease with specificity for cleavage at uridyl

299 RNase Z(L) (dRNaseZ) belongs to a family of endoribonucleases with a major role in tRNA 3'-end proce

300 ver requires knowledge of cleavages by major endoribonucleases within a living cell.