ライフサイエンスコーパス: endosomal

1 This interaction prevents endosomal accumulation and favours the proteasome-depend

2 S-CoV infection of cultured cells depends on endosomal acid pH-dependent proteases rather than on the

3 This paper explores the contributions of endosomal acidification and various proteases to coronav

4 Inhibiting phagocytosis and endosomal acidification in BMDCs or moDCs impaired the r

5 n mediated by L lactis G121 was dependent on endosomal acidification in dendritic cells (DCs).

6 this hypothesis, we found that inhibition of endosomal acidification only modestly decreased entry, a

7 nd requires both bacterial uptake by DCs and endosomal acidification.

8 Endosomal alkalinization was observed in hearts from rat

9 somes undergo fusion and fission events with endosomal and lysosomal compartments, a process called '

10 nserved tetraspanin protein enriched in late endosomal and lysosomal compartments.

11 ane protein-2 (LIMP-2/SCARB2) contributes to endosomal and lysosomal function.

12 (TRPML1) is a cation channel located within endosomal and lysosomal membranes.

13 We further demonstrate that the endosomal beta2-adrenergic receptor signal confers unifo

14 e further experimentally validated by hsc-70 endosomal binding experiments and endosomal microautopha

15 some-like mechanism of eHAV egress involving endosomal budding of HAV capsids into multivesicular bod

16 yndecan endocytosis and on syntenin-syndecan endosomal budding, upstream of ARF6 small GTPase and its

17 L1 proteolytic products are produced during endosomal capsid processing and L2/DNA complexes segrega

18 etromer and retriever complexes critical for endosomal cargo recycling.

19 vitro model of the BBB, we identify NHE9, an endosomal cation/proton exchanger, as a novel regulator

20 er, these findings uncover an FcRn-dependent endosomal cellular-sorting pathway that has great import

21 Here we report that Ent5, an endosomal clathrin adaptor in Saccharomyces cerevisiae,

22 solic PKC and nuclear ERK, which derive from endosomal CLR.

23 ABMA provokes Rab7-positive late endosomal compartment accumulation in mammalian cells wi

24 ighted by Toll-like receptor 9 (TLR9) in the endosomal compartment and cyclic GMP-AMP synthase (cGAS)

25 -derived vesicles (MDVs) are targeted to the endosomal compartment has remained unclear.

26 rmit regulated targeting of ClC-4 to various endosomal compartment systems via expression of differen

27 in may accompany the viral genome beyond the endosomal compartment.

28 r trypsin accumulation and loss of the early endosomal compartment.

29 cropinocytosis and membrane fusion in a late endosomal compartment.

30 nd phosphatidylserine (PS) on CCVs and early endosomal compartments and perturbs the activity of the

31 lized DNA nanostructures survive uptake into endosomal compartments and, in a mouse model, exhibit a

32 The disruption of endosomal compartments leads to elevated BMP signaling w

33 e activity and delivers the oligomers to the endosomal compartments of professional antigen presentin

34 Despite significant vacuolization of endosomal compartments similar to SPPL2a(-/-) B cells, C

35 n and dynamics at the plasma membrane and in endosomal compartments, (c) TCR signal transduction lead

36 d Nsg2 only partially co-localize with known endosomal compartments, and it was suggested that they m

37 aling machinery are associated with distinct endosomal compartments, but how endosomal traffic affect

38 nism of action of ABMA is restricted to host-endosomal compartments, it reduces cell infection by pat

39 cts locally at synaptic terminals to disrupt endosomal compartments, leading to aberrant wiring defec

40 nerve terminals to alter trafficking between endosomal compartments, leading to defects in synaptic s

41 systems of neurons, including enlargement of endosomal compartments, progressive accumulation of auto

42 D1d proteins were retained in early and late endosomal compartments, respectively, supporting an impa

43 omoted virus uptake and the acidification of endosomal compartments, resulting in an accelerated fusi

44 nipavirus fusion protein occurs in recycling endosomal compartments.

45 receptors localized at the cell surface and endosomal compartments.

46 omal compartments and a dramatic pH shift of endosomal compartments.

47 osphatidylinositol-4-phosphate mark distinct endosomal compartments.

48 ic receptor cargo between the early and late endosomal compartments.

49 activity and of RhoA-dependent transport of endosomal contents to the plasma membrane.

50 in snx-1(0) and rme-8(ts) mutants increased endosomal coverage and intensity of HGRS-1-labeled micro

51 uld be abrogated by inhibiting the lysosomal-endosomal degradation pathway.

52 surface expression, in a mechanism involving endosomal degradation, in order to evade NK cell recogni

53 of cortactin as a positive regulator of late endosomal docking and exosome secretion.

54 nce microscopy (nanoscopy), investigation of endosomal dynamics in live cells remained difficult as t

55 ocess involving endocytic uptake followed by endosomal escape and cytosolic access.

56 revent autophagic degradation and to promote endosomal escape and nuclear trafficking.

57 ving several distinct steps; among these the endosomal escape appeared to be of particular importance

58 trating polymers that undergo acid-activated endosomal escape in living cells.Hydrogen bonding plays

59 ssay, we were able to quantitatively measure endosomal escape into the cytoplasm of live cells via re

60 itro by binding capsid proteins and blocking endosomal escape of virus.

61 s by binding to capsid proteins and blocking endosomal escape of virus.

62 ith a loading efficiency of 17% and enhanced endosomal escape promoted by the protonated imidazole mo

63 ylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi trigge

64 Here we investigated how endosomal F trafficking affects HeV assembly.

65 increased apoE4 aggregation and compromised endosomal function further exacerbate the inhibitory eff

66 cular characterization of CELL DEATH RELATED ENDOSOMAL FYVE/SYLF PROTEIN 1 (CFS1).

67 Endosomal GPCRs are a drug target that deserve further a

68 ruses in endocytic compartments resulting in endosomal hydrogen peroxide generation, which suppresses

69 This massive endosomal influx was accompanied by dramatic recruitment

70 l effects of ERBB2 signaling suppression and endosomal internalization of ERBB2, Therefore, reexpress

71 minal lysines caused APP redistribution from endosomal intraluminal vesicles (ILVs) to the endosomal

72 Furthermore, B. neotomae exhibited early endosomal (LAMP-1) and late endoplasmic reticulum (calre

73 ii aspartyl protease 3 (ASP3) resides in the endosomal-like compartment and is crucially associated t

74 PSEN2), recently shown to be enriched on the endosomal limiting membrane compared with PSEN1.

75 id nanovesicles released after fusion of the endosomal limiting membrane with the plasma membrane.

76 form individually from inward budding of the endosomal limiting membrane, plant ILVs form as networks

77 ndosomal intraluminal vesicles (ILVs) to the endosomal limiting membrane, with a subsequent decrease

78 Surprisingly, the regulatory early endosomal lipid phosphatidylinositol-3-phosphate (PtdIns

79 BAR domains of MoVps17 are essential for its endosomal localization and function.

80 o a subset of cells requires endocytosis and endosomal low pH.

81 The ensuing alkalization of the endosomal lumen increased translocation of TfRs to the h

82 chanisms, including specific branches of the endosomal-lysosomal and ubiquitin-proteasome systems, in

83 is activated by sensing ligands in specific endosomal-lysosomal compartments.

84 Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease:

85 Abnormalities of the endosomal-lysosomal network (ELN) are a signature featur

86 k type C (NPC) disease, where defects in the endosomal-lysosomal protein NPC1 or NPC2 cause intracell

87 yspersin as the linker between BORC and late endosomal/lysosomal adaptor and mitogen activated protei

88 associated microglia (DAM), which encodes an endosomal/lysosomal cathepsin inhibitor named Cystatin F

89 Isoform a3 was associated with the late endosomal/lysosomal compartment.

90 ons in lipid metabolism associated with late endosomal/lysosomal dysfunction may play a role in the p

91 , whose gene products are key players in the endosomal/lysosomal egress of low-density lipoprotein-de

92 lecular nanoparticle (NP) enabling excellent endosomal/lysosomal escape and efficient siRNA decomplex

93 gh level of cellular uptake and an excellent endosomal/lysosomal escape capability.

94 o the cationic polymer segments enhanced the endosomal/lysosomal escape of NPs via the proton sponge

95 An increase in PV-endosomal/lysosomal fusion accompanied by augmented PV d

96 es treated with Wnt5a demonstrated increased endosomal/lysosomal fusions with parasite-containing vac

97 ) from the endoplasmic reticulum (ER) to the endosomal/lysosomal pathway by transiently binding DP(84

98 ng key genes involved in the endocytotic and endosomal/lysosomal pathways, and disruption of miR-153

99 ated YopB and YopD colocalized with the late endosomal/lysosomal protein LAMP1 and that the frequency

100 ids have been previously associated with the endosomal/lysosomal storage diseases Niemann-Pick and ne

101 Importantly, we found that late endosomal/lysosomal targeting and secretion of mHtt coul

102 ound that the protein is secreted via a late endosomal/lysosomal unconventional secretory pathway.

103 ion of MT1-MMP with membranes containing the endosomal markers Rab5 and Rab7 but increased localizati

104 Their partial co-localization with canonical endosomal markers thus reflects their rapid flux towards

105 The molecular mechanisms that regulate late endosomal maturation and function are not completely elu

106 Endosomal maturation and transport constitutes a complex

107 hemotin regulates endosomal maturation during phagocytosis by repressing t

108 fferential pH-dependent fold stability along endosomal maturation is an essential protein-inherent de

109 sence of HIV-1 and is a general regulator of endosomal maturation.

110 ein Beclin1 regulates activation of Rab5 and endosomal-mediated degradation of mitochondria, suggesti

111 that also activate mitochondrial autophagy, endosomal-mediated mitochondrial clearance is initiated

112 de sequences become available to disrupt the endosomal membrane and to assure highly efficient releas

113 that YopK limits the induction or sensing of endosomal membrane damage by components of the type III

114 between YopD and Galectin-3, an indicator of endosomal membrane damage.

115 This pathway functions to promote endosomal membrane influx in infected macrophages, and i

116 tes the large enzymes, LF and EF, across the endosomal membrane into the host cell's cytosol.

117 erol transport pathway regulated by the late endosomal membrane protein Niemann-Pick disease type C p

118 reased indicating its trafficking within the endosomal membrane system.

119 xin (SNX) proteins that normally function in endosomal membrane trafficking are a major class of incl

120 Endosomal membrane trafficking requires coordination bet

121 pore formation and translocation across the endosomal membrane.

122 Pase and phosphoinositide composition of the endosomal membrane.

123 rocessing of a larger pool of APP-CTF on the endosomal membrane.

124 x, iron enters the cytoplasm via DMT1 in the endosomal membrane.

125 he genome-containing core by perforating the endosomal membrane.

126 icient cells rescues retromer recruitment to endosomal membranes and GLUT1 surface recycling.

127 cause they should overcome the plasmatic and endosomal membranes for favoring exogenous Ag access to

128 onstrates that motor activity and binding to endosomal membranes mediated by GIPC and PI(4,5)P2 are c

129 The peptide conjugation enables targeting of endosomal membranes so that light-triggered cytosolic re

130 that SOCS2 binds to EphA2 in the context of endosomal membranes.

131 nistic evidence into how RidL is targeted to endosomal membranes.

132 by hsc-70 endosomal binding experiments and endosomal microautophagy assays.

133 ys, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chap

134 autophagy, chaperone-mediated autophagy, and endosomal microautophagy.

135 in bone marrow and spleen and analyzed their endosomal morphology, BCR expression, and signal transdu

136 Loss-of-function mutations in human endosomal Na(+)(K(+))/H(+) exchangers (NHEs) NHE6 and NH

137 The endosomal network maintains cellular homeostasis by sort

138 t redistributes degraded cargo back into the endosomal network.

139 tiology of human disorders linked to loss of endosomal NHE function.

140 w that transport activity of the orthologous endosomal NHE Nhx1 is important for multivesicular body

141 However, the molecular basis of how these endosomal NHEs control endocytic trafficking is unclear.

142 se and restricts TLR7 signaling, and that an endosomal NOX2 inhibitor decreases viral pathogenicity.

143 o et al. show that virus infection activates endosomal NOX2 oxidase and restricts TLR7 signaling, and

144 ndoplasmic reticulum, not co-localizing with endosomal or Golgi markers.

145 development in host cells deficient for late endosomal or lysosomal proteins revealed that the Nieman

146 aled increased co-localization of HIV-1 with endosomal or multi vesicular body (MVB) markers such as

147 Exosomes are viral-like particles from endosomal origin that can reprogram recipient cells.

148 otein kinase enzymes or endocytosis to block endosomal PACAP receptor extracellular signal-regulated

149 n trafficking and suggest a crucial role for endosomal PAR2 signaling in pathways of tissue repair an

150 The autophagic endosomal pathway facilitates low-pH-mediated maturation

151 Although this endosomal pathway is activated by stressors that also ac

152 This autophagic endosomal pathway is proposed as a new mechanism that fa

153 Abrogation of Rab5 function and the endosomal pathway results in the accumulation of stresse

154 the peptide and cargo enter the cell via an endosomal pathway where the pH changes from neutral to a

155 he sorting events directing them to distinct endosomal pathways control guidance decisions.

156 y interconnections between the autophagy and endosomal pathways dictating GLUT1 trafficking and extra

157 Endosomal PE binding led to functional changes in endoth

158 tudy highlights a possible role of recycling endosomal pH in regulating receptor-mediated signaling t

159 nt iron uptake in hBMVECs by fine-tuning the endosomal pH in response to paracrine signals and is the

160 Proteolytic cleavage and NPC1 binding at endosomal pH lead to conformational rearrangements of GP

161 pecifically designed a family of ratiometric endosomal pH probes for use in live-cell STED nanoscopy.

162 ders of magnitude slower than protonation at endosomal pH, suggesting that a transporter model is lik

163 as its release upon particle degradation at endosomal pH.

164 expressed GPC to mediate membrane fusion at endosomal pH.

165 ing endosomes in hBMVECs where it raises the endosomal pH.

166 ailure to form an activation-induced Rab7(+) endosomal/phagosomal compartment.

167 atively charged headgroups, such as the late endosomal phospholipid bis(monoacylglycero)phosphate.

168 We therefore conclude that the endosomal pool of PI3P, generated by the class III phosp

169 We show that unlike the endosomal pool, the activity and localization of mTORC2

170 predominantly with a distinct KSR1-positive endosomal population.

171 Non-endosomal processing enzymes add to the number of epitop

172 Although intracellular endosomal processing in dendritic cells and B cells has

173 antiviral effect was exerted at the level of endosomal processing of the incoming capsid and depended

174 riguing feature of HeV is the utilization of endosomal protease for activation of the viral fusion pr

175 wever, be bypassed by point mutations in the endosomal protein Vps13 or by overexpression of the mito

176 tion is dependent on expression of the early endosomal proteins Rab5, D52, and EEA1.

177 will require rethinking of how this class of endosomal proteins regulates trafficking of much longer-

178 now show that Nsg1 and Nsg2 are not resident endosomal proteins, but traffic rapidly from the cell su

179 was tested for the presence of autophagy and endosomal proteins, microtubule-associated protein 1 lig

180 ious components forming and controlling this endosomal proteolytic machinery.

181 he endosomal TLR transporter UNC93B1 and the endosomal proton transporter, solute carrier family 15,

182 ase caused by mutations in the gene encoding endosomal proton-chloride exchange transporter 5.

183 osomes with liposomes containing exocytic or endosomal Q-SNAREs and directly interacted with late end

184 oblem in understanding this dual function of endosomal Rab7/Ypt7, using a fully reconstituted system,

185 Dab2 also modulates endosomal Ras/MAPK (Erk1/2) activity by regulating the d

186 Accordingly, targeted inhibition of endosomal reactive oxygen species production abrogates i

187 We conclude that endosomal reactive oxygen species promote fundamental mo

188 ons may interfere with interactions with the endosomal receptor LAMP1 or interfere at another stage i

189 this regulatory network and dysregulation of endosomal receptor sorting.

190 Nsg1 has been implicated in regulating endosomal recycling and sorting of several important neu

191 BRI1 abundance is regulated by endosomal recycling and vacuolar targeting, but the role

192 However, the role of Neo1 in endosomal recycling is not well characterized.

193 Lowered IIS thus elevates endosomal recycling of GJs in neurons and other cell typ

194 Endosomal recycling of GJs was also stimulated in cultur

195 Endosomal recycling of transmembrane proteins requires s

196 nternalized epidermal growth factor, whereas endosomal recycling proceeds unperturbed.

197 actively suppresses autophagy and maintains endosomal recycling, thereby preventing endosomes and au

198 ctopic expression of RABEP2 had no effect on endosomal recycling.

199 mes, and interference approaches against the endosomal regulators Rab5 and Rab7.

200 ery called VIPER (virus-inspired polymer for endosomal release).

201 osinic/polycytosinic acid (polyIC) and allow endosomal release, while DUPA targets PC cells.

202 Thus, endosomal retention of TLR9 via the interaction of IRAP

203 ermore, we observed strong colocalization of endosomal SDPN-1 with the F-actin biosensor Lifeact, and

204 cytosolic receptors, dependent on STING, and endosomal sensors, dependent on Unc93b1, can provoke inf

205 y within nerve terminals to disrupt synaptic endosomal signaling and induce neuropathology.

206 ficking, leading to expansion of a recycling endosomal signaling compartment containing Sorting Nexin

207 We investigated the contribution of endosomal signaling of the calcitonin receptor-like rece

208 gs demonstrate a novel mechanism of receptor endosomal signaling required for specific peripheral imm

209 a concomitant increase in beta2AR-dependent endosomal signaling.

210 likely to be the toxic species that disrupt endosomal signaling.

211 l Q-SNAREs and directly interacted with late endosomal SNARE complexes.

212 However, insertion of early endosomal SNARE proteins suffices to convert liposomes i

213 Remarkably, its pattern of associations with endosomal SNAREs is consistent with SedV(Sed5) playing r

214 The roles of HIP1 and the endosomal SNX1 and SNX27 were further characterized in m

215 S35, we demonstrate a specific role for this endosomal sorting complex in the trafficking of AMPA rec

216 go) are delivered to endosomes and sorted by endosomal sorting complex required for transport (ESCRT)

217 The endosomal sorting complex required for transport (ESCRT)

218 ion requires Tsg101, a component of cellular endosomal sorting complex required for transport (ESCRT)

219 ll factors is no more apparent than when the endosomal sorting complex required for transport (ESCRT)

220 Components of the endosomal sorting complex required for transport (ESCRT)

221 UIM), a sorting element usually found in the endosomal sorting complex required for transport (ESCRT)

222 ntegral membrane proteins is directed by the endosomal sorting complex required for transport (ESCRT)

223 by different cell types, a process requiring endosomal sorting complex required for transport (ESCRT)

224 The CFS1 protein interacts with the ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT I (ESCR

225 tidyl peptidase 4 (DPP4) along with multiple endosomal sorting complex required for transport III (ES

226 sis, mediated by both dynamin and the ESCRT (endosomal sorting complex required for transport) machin

227 used siRNA to suppress expression of ESCRT (endosomal sorting complex required for transport) protei

228 omain of Raf also coprecipitates with ESCRT (endosomal sorting complex required for transport)-associ

229 egulated tyrosine kinase substrate (Hrs), an endosomal sorting complexes required for transport (ESCO

230 Microdomains containing endosomal sorting complexes required for transport (ESCR

231 , we found that the membrane fission complex endosomal sorting complexes required for transport (ESCR

232 The endosomal sorting complexes required for transport (ESCR

233 role is the specific recruitment of critical endosomal sorting complexes required for transport (ESCR

234 Endosomal sorting complexes required for transport III (

235 VB) pathway using a dominant negative ESCRT (endosomal sorting complexes required for transport) comp

236 y stunt virus (TBSV) co-opts cellular ESCRT (endosomal sorting complexes required for transport) prot

237 Cell death, autophagy and endosomal sorting contribute to many physiological, deve

238 ntegral component of the ubiquitin-dependent endosomal sorting machinery and highlight the dual role

239 ignal at five cytodomain-located lysines for endosomal sorting of APP.

240 ecular targeting of proteins involved in the endosomal sorting of PC1 and PC2 could lead to new thera

241 has interacts with ubiquitin to regulate the endosomal sorting of receptors for lysosomal degradation

242 s revealed noncanonical roles for Galphas in endosomal sorting of receptors to lysosomes.

243 Retromer organizes the endosomal sorting pathway in conjunction with various so

244 serve to regulate the biogenesis of tubular endosomal sorting profiles.

245 They further suggest that disruption of APP endosomal sorting reduces its sequestration in ILVs and

246 ein complex that plays a specialized role in endosomal sorting, have been linked to Alzheimer's and P

247 s may represent a key signal controlling APP endosomal sorting.

248 5% with Tf, which is indicative of selective endosomal sorting.

249 ciated protein 1 (UBAP1), a component of the endosomal-sorting complex required for transport I (ESCR

250 Here we identified the endosomal-sorting-complex-required-for-transport (ESCRT)

251 of the fatty acid transporter CD36 from its endosomal storage compartment to the sarcolemma as the p

252 racellular signals by mobilizing Notch1 from endosomal stores.

253 In endothelial cells, endosomal surplus of superoxide causes pro-inflammatory

254 ng, and support the potential utility of the endosomal system as a druggable target for signaling.

255 Neurons have adapted their endosomal system to meet their unique and complex needs.

256 lt in massive membrane vacuolation along the endosomal system, but the cell-specific functions of PIK

257 ene in assembly or maintenance of the apical endosomal system.

258 ic targeting of this pathogenic process with endosomal-targeted reactive oxygen species inhibitors ha

259 iniCORVET complex as an unconventional early endosomal tether in Drosophila.

260 pontaneous disease, but was dependent on the endosomal TLR transporter UNC93B1 and the endosomal prot

261 anistically explain the previously described endosomal TLR-mediated resistance to L. major infection.

262 his uptake, mediated through CD21, triggered endosomal TLR7 and led to the secretion of interferon (I

263 Here we show that genetic inhibition of endosomal TLRs has the opposite effect on accumulation o

264 Recognition of self nucleic acids by endosomal TLRs in B cells and pDCs is thought to be an i

265 Signaling via endosomal TLRs was required for autophagy because macrop

266 one required for appropriate localization of endosomal TLRs, but the mechanisms are unknown.

267 Endosomal Toll-like receptors (TLRs) have been shown to

268 Rather, it is critical for activating endosomal toll-like receptors and antiviral humoral immu

269 ith distinct endosomal compartments, but how endosomal traffic affects T cell signaling remains ill-d

270 nderscore the importance of finely regulated endosomal traffic in TCR signal transduction and T cell

271 In SPPL2a(-/-) B cells, such an NTF impairs endosomal trafficking and BCR signal transduction.

272 e risk-variant APOL1 alleles interferes with endosomal trafficking and blocks autophagic flux, which

273 Maintaining anterograde endosomal trafficking during pancreatitis maintains VAMP

274 While clues have existed that endosomal trafficking is associated with Alzheimer's dis

275 ependent chemotactic responses often involve endosomal trafficking of signaling proteins; coincidentl

276 Genetic manipulations to increase endosomal trafficking of synaptic growth receptors from

277 Yeast strains defective in endosomal trafficking or organelle acidification but not

278 virion-assigned step, such as cell binding, endosomal trafficking or pore formation.

279 ssary for EV formation, implicating the host endosomal trafficking pathway in orthopoxvirus infection

280 n impairment of conserved core intracellular endosomal trafficking processes.

281 ciations of schizophrenia SNPs with AD+P are endosomal trafficking, autophagy and calcium channel sig

282 DISLL motif is phosphorylated and regulates endosomal trafficking, in primary neurons.

283 The role of cortactin, a regulator of late endosomal trafficking, in the biogenesis and secretion o

284 ynaptic growth arise from defective synaptic endosomal trafficking, leading to expansion of a recycli

285 Bacteria alter the normal endosomal trafficking, prevent the maturation of phagoso

286 aling receptors, are critically regulated by endosomal trafficking, suggesting that endosomes might p

287 (Vps34), which is an essential regulator of endosomal trafficking.

288 umulates in the nucleus after activation and endosomal transport to a perinuclear position.

289 Endolysosomal acidification and the endosomal transporter protein UNC93B1 was required for p

290 specifically controls TLR3- and TLR4-induced endosomal TRIF (TIR domain-containing adapter-inducing i

291 protein complex involved in the formation of endosomal tubular structures that mediates the sorting o

292 hat loss of Parkin function led to decreased endosomal tubulation and membrane association of vesicle

293 Consistent with a role for ER-mediated endosomal tubule fission in lysosome function, similar l

294 thy and suggest that coupling of ER-mediated endosomal tubule fission to lysosome function links diff

295 s and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved an

296 protein IST1 at ER-endosome contacts drives endosomal tubule fission.

297 ates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the Annexin A2/a

298 um in diameter) Munc13-4(+)/Rab7(+)/Rab11(+) endosomal vacuoles.

299 the subject be an animal or an intracellular endosomal vesicle, the two primary modes of biological l

300 mbrane, mitochondria, and a subpopulation of endosomal vesicles.