ライフサイエンスコーパス: endothelin A receptor

1 and osteoblastic metastases in vivo via the endothelin A receptor.

2 eases PKC activity via binding to endogenous endothelin(A) receptors.

3 Therefore, we assessed the effect of endothelin-A receptor antagonism in the response of pulm

4 Treatment with an orally active endothelin A receptor antagonist dramatically decreased

5 ety of zibotentan (ZD4054), an oral specific endothelin A receptor antagonist, has been investigated

6 Atrasentan, a selective endothelin A receptor antagonist, has been shown to redu

7 BQ123, an endothelin A receptor antagonist, prevented thrombin's i

8 209,670, and the less potent, but selective, endothelin-A receptor antagonist BMS-182,874 in radiocon

9 -phenyl-4H-1-benzopyran-4-one (LY294002) and endothelin-A receptor antagonist cyclo(L-Leu-D-Trp-D-Asp

10 with a highly selective, well-characterized endothelin-A receptor antagonist partly protected GFR, a

11 The endothelin-A receptor antagonist, BQ-123, could attenuat

12 Half of the rings were pretreated with the endothelin-A receptor antagonist, BQ123 (10(-5) M or 10(

13 Interest has grown in using Endothelin A receptor antagonists as adjuvant or combina

14 gations involving alpha-emitting radium-223, endothelin-A receptor antagonists atrasentan and ziboten

15 ishment of osteoblastic bone metastases, and endothelin A receptor blockade represents effective trea

16 Acute endothelin A receptor blockade with FR-139317 resulted i

17 Endothelin-A receptor blockade is an effective means of

18 In summary, endothelin-A receptor blockade with a highly selective,

19 riction, which was reversed partially by the endothelin A receptor blocker BQ123 and completely by fa

20 experiments, endothelin 1 (which stimulates endothelin A receptors) caused comparable contraction of

21 dothelin signaling via the activation of the endothelin-A receptor (EDNRA) by endothelin-1 may play a

22 helin-1 (Edn1)-induced signaling through the endothelin-A receptor (Ednra) is crucial for cranial NCC

23 Endothelin-A receptor (Ednra) signaling in crest cells i

24 cranial NCCs, some of which are regulated by endothelin-A receptor (Ednra) signaling.

25 tions mediated by two receptor subtypes, the endothelin A receptor (ET(A)R) and the endothelin B rece

26 amined the effect of atrasentan, a selective endothelin A receptor (ET(A)R) antagonist, on albuminuri

27 uring ischaemia through direct activation of endothelin A receptors (ET(A)Rs).

28 othelins stimulate leptin production via the endothelin-A receptor (ET(A)), as judged by a potency ra

29 can produce ET-1, undergo ET-1-dependent and endothelin-A receptor (ET(A))-dependent activation, and

30 Activation of endothelin-A receptor (ET(A)R) by endothelin-1 (ET-1) dr

31 o three groups: placebo (RVD+PTRAS), chronic endothelin-A receptor (ET-A) blockade (RVD+PTRAS+ET-A),

32 ly identical to the defects seen in ET-1 and endothelin A receptor (ETA)-deficient embryos.

33 g-term treatment strategy with the selective endothelin-A receptor (ETA) antagonist, ambrisentan, des

34 angiotensin II type 1A receptor (AT1AR) and endothelin A receptor (ETAR), activation of ETARs result

35 Mechanistically, endothelin A receptor (ETAR)-positive macrophages are hi

36 on of its cognate G protein-coupled receptor endothelin A receptor (ETAR).

37 In EOC, the endothelin-1 (ET-1, EDN1)-endothelin A receptor (ETAR, EDNRA) signaling axis regul

38 Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its

39 eviously showed that activation of the human endothelin A receptor (HETAR) by endothelin-1 (Et-1) sel

40 ion of similar magnitude (P </= 0.05) of the endothelin A receptor in the lung tissue.

41 Selectively inhibiting the endothelin A receptors in dogs with CHF produced hemodyn

42 ults are consistent with the hypothesis that endothelin-A receptors mediate endothelin-induced change

43 sed in rejecting allotransplanted lungs, (3) endothelin-A receptors mediate the proliferative respons

44 No change in expression of endothelin A receptor was observed 7 days after inductio

45 This effect, mediated by the endothelin-A receptor, was associated with a shift in ML