ライフサイエンスコーパス: endothelin-3

1 bond of big endothelin-3 producing bioactive endothelin-3.

2 potent bioactive peptide, by cleavage of big endothelin-3, a larger intermediate precursor.

3 protein is a zinc endopeptidase that yields endothelin-3, a potent bioactive peptide, by cleavage of

4 roblast growth factor, stem cell factor, and endothelin-3, along with exposure to UVB can transform n

5 Endothelin-3 also does not increase the number of enteri

6 -crest-derived cell cultures was promoted by endothelin-3 and inhibited by BQ 788.

7 Endothelin-1 and endothelin-3 are principally produced by vascular endoth

8 ptor, endothelin receptor-B, and its ligand, endothelin-3, are required for the development of both m

9 er of neuronal development, was inhibited by endothelin-3, but promoted by BQ 788.

10 , expressed in K562 and HEK293 cells, had no endothelin-3-converting activity, in contrast to the com

11 frican heritage than in Caucasians also have endothelin-3-converting enzyme activity and that the rec

12 y of zinc endopeptidases and functions as an endothelin-3-converting enzyme.

13 neural crest cells is reduced in the gut of endothelin 3-deficient embryos.

14 explants of the terminal bowel of E12 ls/ls (endothelin-3-deficient) mice, but could be induced to do

15 d the mutant cells never responded to Mgf or endothelin 3, did not express Dct, and never showed pigm

16 endothelin B receptor (Ednrb(s-l); refs 1,2) endothelin 3 (Edn3(ls): refs 1,3) the tyrosine kinase re

17 Endothelin 3 (Edn3) encodes a ligand important to develo

18 in white mutants a transcriptional defect in endothelin 3 (edn3), encoding a peptide factor that prom

19 d by molecules such as the signaling protein endothelin 3 (EDN3), its receptor (the endothelin recept

20 ceptor (EDNRB) and its physiological ligand, endothelin 3 (EDN3).

21 endothelin receptor-B (Ednrb) and its ligand endothelin-3 (Edn3) affect the development of two neural

22 We suggest that endothelin-3/endothelin B normally prevents the prematur

23 To analyze the effects of endothelin-3/endothelin B on the differentiation of ente

24 Loss of Endothelin-3/Endothelin receptor B (EDNRB) signaling lea

25 spectively, by the endogenous neuropeptides, endothelin-3 (ET-3) and atrial natriuretic peptide (ANP)

26 In addition, endothelin-3 (ET-3) and N-succinyl-[Glu9, Ala11, 15]-ET-

27 rol mutant protein, specifically cleaved big endothelin-3 (ET-3) at Trp(21)-Ile(22), yielding ET-3, a

28 eptides which render endothelin-1 (ET-1) and endothelin-3 (ET-3) relatively unreactive and resistant

29 Endothelin-1 (ET-1) and endothelin-3 (ET-3) were injected via a double-injection

30 and distribution of endothelin-1 (ET-1) and endothelin-3 (ET-3) were studied in the retinas of diabe

31 sly shown that the endogenous neuropeptides, endothelin-3 (ET-3), and atrial natriuretic peptide (ANP

32 otein-coupled growth factor receptor ligand, endothelin-3 (ET-3), regulate astrocyte proliferation at

33 oenvironment is critical in this process and endothelin-3 (ET3) is known to have an essential role.

34 Endothelin-3 failed to stimulate the incorporation of [3

35 Our findings indicate that SOX10 and endothelin 3 have a crucial role in the maintenance of m

36 regulator SOX10 and the signalling molecule endothelin 3 have important roles in the development of

37 ient) mice, but could be induced to do so by endothelin-3 if a source of neural precursors was presen

38 Endothelin-3 inhibited neuronal development, an effect t

39 We also demonstrate that endothelin 3 inhibits reversibly the commitment and diff

40 crest-derived cells were exposed in vitro to endothelin-3, IRL 1620 (an endothelin B agonist), and/or

41 The dependence of ENS progenitors on endothelin 3 is more pronounced at the migratory front o

42 , provided that the melanocyte growth factor endothelin-3 is present, a small number of MITF/beta-Gal

43 In combination with stem cell factor and endothelin 3, LIF induced formation of disorganized stru

44 is associated with relatively high levels of endothelin 3 mRNA.

45 Addition of the Kit ligand Mgf or endothelin 3 or a combination of these factors all rapid

46 erminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B.

47 up to 3-fold) by three known glial mitogens, endothelin-3, platelet-derived growth factor, or phorbol

48 C-ANP also strongly inhibited the endothelin-3-, platelet-derived growth factor-, and phor

49 tially cleaves a Trp(21)-Ile(22) bond of big endothelin-3 producing bioactive endothelin-3.

50 The magnitude of contractions caused by endothelin 3 was reduced further when infection was pres

51 mpetitive inhibition of 125I-endothelin 1 by endothelin 3 was significant for a two-site binding mode

52 of crest-derived cells, and did so even when endothelin-3 was absent and BQ 788 was present.

53 In contrast, contractions caused by endothelin 3 were reduced in bronchi from rejecting allo

54 Endothelin 3 (which stimulates endothelin A and B recept