ライフサイエンスコーパス: endothelium

1 et that patrols the intraluminal side of the endothelium.

2 by generating a senescent, pro-inflammatory endothelium.

3 e number of aberrant crypt foci in the colon endothelium.

4 tes leukocyte adhesion and rolling along the endothelium.

5 cells, showing no effect on the integrity of endothelium.

6 -Idd22 endothelium compared with NOD-derived endothelium.

7 ioventricular cushions and coronary vascular endothelium.

8 ce and protection of the renal microvascular endothelium.

9 tions of bladder cancer cells (BCs) with the endothelium.

10 ssive cancer cells and the properties of the endothelium.

11 which prevents uncontrolled layering of the endothelium.

12 bind to cell surfaces and protect the donor endothelium.

13 of OxPAPC-assisted recovery of inflamed lung endothelium.

14 ut acted differently, extensively killing MV endothelium.

15 is involved in E2-mediated protection of the endothelium.

16 oid of the KCa activity abundant in arterial endothelium.

17 lation system, leukocytes, and the activated endothelium.

18 ry and anti-atherogenic molecule in vascular endothelium.

19 ecifically expressed by venous and capillary endothelium.

20 zed arteries showed good regeneration of the endothelium.

21 ican fragment uniquely localized to vascular endothelium.

22 cells and highly induced on tumor-associated endothelium.

23 tes adhesion of T cells to inflamed vascular endothelium.

24 hat elicit monocyte recruitment to activated endothelium.

25 tes an inflammatory response in the adjacent endothelium.

26 +)LFA-1(+)) complementary to activated brain endothelium.

27 ling along the luminal side of the lymphatic endothelium.

28 r VLA-4), and leukocyte adhesion to vascular endothelium.

29 olved in adherence to the apical side of the endothelium.

30 lar cells, with negligible expression in the endothelium.

31 the atheroprotective role of miR-146a in the endothelium.

32 ne therapy might not effectively protect the endothelium.

33 ting a local protective role of Sphk1 in the endothelium.

34 ntracellular adhesion molecule 1 on inflamed endothelium.

35 periodontal disease acts as an insult to the endothelium.

36 o the long-term inflammatory response of the endothelium.

37 ation, and coagulation in lung microvascular endothelium.

38 pen the VEC junctions and migrate across the endothelium.

39 cancer cell transmigration across lymphatic endothelium.

40 monocyte firm adhesion to HLA I Ab-activated endothelium.

41 which localized adjacent and external to the endothelium.

42 ibute appreciably to regeneration of cardiac endothelium.

43 II-induced recruitment of leukocytes to the endothelium.

44 KATP channels are indeed present in vascular endothelium.

45 cell-derived intestinal epithelium and human endothelium.

46 in the vicinity of the abluminal side of the endothelium.

47 al pigment epithelium (RPE), or the vascular endothelium.

48 Cs and white blood cells, platelets, and the endothelium.

49 -NEMO, delivering the Nemo gene to the brain endothelium.

50 pha) to increase recruitment to the vascular endothelium.

51 creased monocyte recruitment to the vascular endothelium.

52 lised with endothelial markers on sinusoidal endothelium.

53 the presence of Weibel-Palade bodies in the endothelium.

54 on also decreases with age in human vascular endothelium.

55 olved in leukocyte transmigration across the endothelium.

56 n regions where pericyte somata adjoined the endothelium.

57 ntravasation of tumor cells across an intact endothelium.

58 population and may reflect activation of the endothelium.

59 ated with better functioning of the vascular endothelium.

60 enhanced expression of VE-cadherin in tumor endothelium, activating TIE-2 and tight junction pathway

61 Vascular endothelium activation and lymphocyte attraction, togeth

62 ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of alpha4 integrin re

63 ular model that measures alterations in sRBC/endothelium adhesion under postcapillary venular conditi

64 ssion of miR-497 approximately 195 in murine endothelium alleviates age-related reduction of type CD3

65 major regulator of angiogenesis, in retinal endothelium and abrogate angiogenesis in the mouse model

66 l barrier properties in the retinal vascular endothelium and activation of the EPAC-Rap1 pathway may

67 erin is highly expressed in pancreatic tumor endothelium and alters tumor vessel parameters through a

68 ry and pro-resolving effects on injured lung endothelium and alveolar epithelium, including enhancing

69 esulted in efficient transduction of corneal endothelium and an increase in aqueous concentration and

70 s CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis.

71 Wnt/Norrin signaling activity in the retinal endothelium and coordinate the timing of both vascular p

72 tion and invasion, promoting adhesion to the endothelium and disrupting its integrity, and improving

73 by dysregulated cross talk between pulmonary endothelium and epithelium in Mgp-null lungs.

74 he migration of tumor cells across the local endothelium and escape into vessel flow.

75 he synthesis of proadhesive VWF by the liver endothelium and favors platelet integrin-dependent throm

76 platelets predominantly bound to peri-injury endothelium and formed HIT antigenic complexes that were

77 e impact of conditional deletion of Bmal1 in endothelium and hematopoietic cells in murine models of

78 od from tissues is actively regulated by the endothelium and is essential for transport, inflammation

79 at arterial pressure equilibrates within the endothelium and is transmitted to the supporting basemen

80 h neutrophil migration through the lymphatic endothelium and luminal crawling.

81 grins is critical for lymphocyte adhesion to endothelium and migration throughout the body.

82 ontrast group was localized to the capillary endothelium and neuronal interstitium and, in two cases,

83 sly and this occurs at the interface between endothelium and pericytes in human pancreatic cancer.

84 n, the key adherens junction protein between endothelium and pericytes; and increases in the vessel d

85 We detected ELA expression in human vascular endothelium and plasma.

86 Visualizing the glomerular endothelium and podocyte-endothelium interface revealed

87 stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of

88 n induced loss of mural cell coverage on the endothelium and reduced endothelial barrier function, an

89 We found TRPV4 expression in the endothelium and retinal pigment epithelium (RPE) compone

90 extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowin

91 asis on the mechanisms of injury to the lung endothelium and the alveolar epithelium.

92 vation of the cytokine network, the vascular endothelium and the coagulation system, with the excepti

93 ion, the influence of tumor stiffness on the endothelium and the impact on metastasis is unknown.

94 that vitronectin rapidly accumulates on the endothelium and the platelet thrombus following injury.

95 meters for schizont adhesion to the vascular endothelium and to predict bond dynamics in the contact

96 pletion impaired cancer cell adhesion to the endothelium and transendothelial migration, resulting in

97 portance of such metabolic regulation in the endothelium and uncovered core metabolic pathways and me

98 nal surface characterized by Eph-B4-positive endothelium and underlying SMC and infiltrating cells su

99 n of markers indicative of the human corneal endothelium, and can be tissue-engineered onto thin corn

100 is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbalpha

101 ores the anti-inflammatory properties of the endothelium, and reconstitutes the activity of endotheli

102 otent stem cell-derived epithelium and human endothelium, and show nutrient absorption after transpla

103 is tissue did not originate from the corneal endothelium, and they maintained fibroblastic phenotype

104 endothelial cells (BLECs) derive from venous endothelium, are distinct from macrophages, and are sens

105 into proximal and distal tubules as well as endothelium, as highlighted by histology and by the spec

106 ene expression was localized to the vascular endothelium at baseline and did not affect total renal n

107 selectively bound to photochemically injured endothelium at sites where surface glycocalyx was reduce

108 role of stem cell-derived exosomes on mouse endothelium at the cellular level.

109 pressed on the cell surface of the allograft endothelium, autoantigens are usually cryptic.

110 ial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by severa

111 large-scale apertures, thereby breaching the endothelium barrier.

112 ition of the Wnt/beta-catenin pathway in CNS endothelium before disease onset exacerbates the clinica

113 ween the coagulation system and the vascular endothelium, brain tissue, inflammatory mechanisms, and

114 at P-selectin is not only expressed on tumor endothelium but also on glioblastoma cells.

115 tely 195 cluster is high in CD31(hi)Emcn(hi) endothelium but gradually decreases during ageing.

116 onprostatic tumors may not be limited to the endothelium but may also include solid tumor tissue of n

117 e from Drosha-deficient and control vascular endothelium, but Drosha (cKO)-derived hematopoietic stem

118 ells, mast cells, fibroblasts, and lymphatic endothelium, but keratinocytes were the earliest targets

119 Stimulation of lymphatic endothelium by acetylcholine or a TRPV4 channel agonist

120 ctivation of the IgG receptor FcgammaRIIB in endothelium by hyposialylated IgG plays an important rol

121 and pathogens can pass directly through the endothelium by opening holes in endothelial cells, known

122 Activation of the endothelium by pro-inflammatory stimuli plays a key role

123 on of firm leukocyte adhesion to human brain endothelium by two different brain endothelial microRNAs

124 re we show that the permeability of vascular endothelium can be increased using an external magnetic

125 mbination with a low or high FcRn-expressing endothelium cell line to clearly define the FcRn involve

126 in weaker adherence of T cells to NOD-Idd22 endothelium compared with NOD-derived endothelium.

127 (2+) ([Ca(2+) ]i ), hyperpolarization of the endothelium coordinates vascular smooth muscle relaxatio

128 hest levels of LPA1, LPA2, LPA4, and LPA6 In endothelium-denuded thoracic aorta (TA) and abdominal ao

129 ferent physiologic or pharmacologic stimuli, endothelium-dependent (micro)vascular reactivity can be

130 ignificantly improved vascular reactivity to endothelium-dependent and -independent vasodilators as w

131 erol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dila

132 The primary outcome was change in endothelium-dependent brachial artery flow-mediated dila

133 Acetylcholine caused endothelium-dependent dilatation that was decreased in o

134 protective endothelial functions, including endothelium-dependent dilatation.

135 ear-activated Kir currents and inhibition of endothelium-dependent flow-induced vasodilatation (FIV)

136 2-CreNox2KO mice, along with preservation of endothelium-dependent relaxation during angiotensin II s

137 lose inspection reveals a specific effect on endothelium-dependent relaxation in mesenteric resistanc

138 Endothelium-dependent responses to acetylcholine in pres

139 riments from mice showed that L5 compromised endothelium-dependent vascular relaxation through a nitr

140 xposure of WKY rat aortas to IL-17F impaired endothelium-dependent vascular relaxation, whereas IL-17

141 ctional hyperaemia are reduced with age, and endothelium-dependent vasodilatation declines with age i

142 Endothelium-dependent vasodilatation was impaired in cor

143 ostatic conditions demonstrated a decline in endothelium-dependent vasodilatation, but restored the f

144 airment of coronary blood flow responses and endothelium-dependent vasodilatation.

145 active hyperemic index (RHI), which measures endothelium-dependent vasodilation and is a surrogate ma

146 cid (LPA) has been recognized recently as an endothelium-dependent vasodilator, but several lines of

147 release, at least partly contributes to the endothelium-dependent vasorelaxation induced by the KATP

148 downregulated endothelial Cav1 and impaired endothelium-dependent vasorelaxation that was rescued by

149 endothelial dysfunction measured by blunted endothelium-dependent vasorelaxation to acetylcholine, w

150 othelial ER stress, associated impairment of endothelium-dependent vasorelaxation, and preserves endo

151 es in the regulation of vasoconstriction and endothelium-dependent vasorelaxation.

152 R-204 expression, reduced Cav1, and impaired endothelium-dependent vasorelaxation.

153 In striking contrast to the endothelium-derived hyperpolarization (EDH) characterist

154 ATPase in humans, consistent with a role for endothelium-derived hyperpolarization in functional symp

155 present in arterial endothelium to generate endothelium-derived hyperpolarization.

156 n endothelial cells to produce nitric oxide, endothelium-derived hyperpolarizing factor, or prostagla

157 In particular, the production of endothelium-derived nitric oxide and activation of solub

158 Endothelial microparticles (EMPs) are endothelium-derived submicron vesicles that are released

159 induction of adhesion molecules in the graft endothelium due to increased GATA2 SUMOylation.

160 ogenic effects of catecholoestradiols in the endothelium during pregnancy.

161 s of platelet interaction with the activated endothelium encompass (1) platelet rolling via interacti

162 isturbed flow conditions including those the endothelium experiences in the carotid artery are respon

163 ough MyD88-dependent activation of the brain endothelium followed by COX1-mediated cerebral prostagla

164 human pluripotent stem cells into haemogenic endothelium followed by screening of 26 candidate haemat

165 were likely to proliferate and generate new endothelium following injury.

166 matrix, is characterized by the presence of endothelium-free channels in the myxoid matrix.

167 the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition a

168 ons, monocytes are readily captured onto the endothelium from free flow.

169 esizing enzyme cyclooxygenase-2 in the brain endothelium, generated with an inducible CreER(T2) under

170 The endothelium glycome may therefore be considered as a key

171 of control pathways regulating the vascular endothelium have illuminated how this single cell layer

172 zed endothelial population, termed hemogenic endothelium (HE), located in the ventral wall of the dor

173 f MO-MDSCs from blood via hepatic sinusoidal endothelium (HSEC) contributes to their enrichment withi

174 thrombocytopenia, and injury to the vascular endothelium, illustrating challenges yet to overcome for

175 nth), effectively reduced IH without causing endothelium impairment and vessel shrinkage.

176 hologies including intimal hyperplasia (IH), endothelium impairment, and vessel shrinkage.

177 In health, activated Tie2 maintains the endothelium in a quiescent state characterized by dynami

178 ein, is highly expressed on pancreatic tumor endothelium in a vascular endothelial growth factor (VEG

179 ls to crawl along the lumen of the lymphatic endothelium in an ICAM-1/MAC-1-dependent manner.

180 icate an underappreciated functional role of endothelium in maintaining systemic energy homeostasis.

181 or Ly6Clo monocyte transmigration across the endothelium in murine CRC tumors.

182 understand the sources that generate cardiac endothelium in new blood vessels after injury.

183 The role of the endothelium in protecting from chronic liver disease and

184 Although the role of the endothelium in regulating the passage of leukocytes and

185 the local production of nitric oxide by the endothelium in response to luminal shear stress, which i

186 lls at the periphery and to CD31(+) vascular endothelium in the core.

187 b regulated lumen formation of the capillary endothelium in the renal medulla.

188 Across phyla, HSCs arise from hemogenic endothelium in the ventral floor of the dorsal aorta con

189 a mechanism involving ERbeta to protect the endothelium in TNFalpha-induced inflammation.

190 activation and monocyte arrest on activated endothelium in vitro.

191 and downregulates Sirt1 in the vascular wall/endothelium in vivo and in endothelial cells in vitro.

192 c environment of the pulmonary microvascular endothelium in vivo.

193 late N-cadherin levels on the surface of the endothelium, in vitro This facilitates N-cadherin-depend

194 ly expressed genes related to differentiated endothelium including Ets1&2, Gata2, Cd31, Vwf, and Notc

195 e-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T

196 Furthermore, loss of Notch1 in adult endothelium increases hypercholesterolemia-induced ather

197 Kir2.1 has no effect on endothelium-independent and K(+) -induced vasodilatation

198 METHODS AND H2O2 induced endothelium-independent vasodilation in non-CAD adipose

199 hepatocyte, biliary epithelium and vascular endothelium injury during preservation and post-transpla

200 RATIONALE: In the endothelium, insulin stimulates endothelial NO synthase

201 leakage reduced, suggesting preserved renal endothelium integrity, as confirmed by higher capillary

202 facilitates N-cadherin-dependent cancer cell-endothelium interaction.

203 zing the glomerular endothelium and podocyte-endothelium interface revealed the presence of endotheli

204 mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory propert

205 SMCs, tubular epithelial cells, interstitial endothelium, interstitial inflammatory infiltrates, and

206 tiates hyperpolarization that conducts along endothelium into FAs.

207 1) that are sufficient to convert haemogenic endothelium into haematopoietic stem and progenitor cell

208 ownstream arterioles that conducts along the endothelium into proximal FAs.

209 nfiltration, tumor cell (TC) adhesion to the endothelium, intravasation, lung colonization, and posts

210 ntiate the concept that the continuity of SC endothelium is an important determinant of outflow resis

211 e engaged in different contexts in which the endothelium is challenged or dysfunctional.

212 The vascular endothelium is critical for induction of appropriate lin

213 The endothelium is critical in the tumour microenvironment:

214 The endothelium is exposed to various flow patterns such as

215 f cardiovascular disease (CVD), the vascular endothelium is the layer of initiation for the progressi

216 t of the diseased cells with a healthy donor endothelium is the only currently available treatment.

217 es support the concept that the perithrombus endothelium is the predominant site of HIT antigen assem

218 complementary signalling occurs in lymphatic endothelium is unknown.

219 rophils and activated neutrophils damage the endothelium, leading to vascular inflammation and necros

220 Both diffused through the endothelium, LUV-TRAIL being more efficient in killing t

221 P-selectin expression by the endothelium may enhance VTE by increasing the recruitmen

222 the mechanisms that control RBC adhesion to endothelium may lead to novel approaches to both prevent

223 tion along the endothelium or protecting the endothelium may provide a therapeutic opportunity to pre

224 Selective damage to endothelium midway between FAs and primary arterioles el

225 culture of a 3D breast tumour model and a 2D endothelium model for cross-talk and drug delivery studi

226 ll bodies and neurites as well as within the endothelium of blood vessels with an increase in the den

227 ly domain containing 2A (MFSD2A) through the endothelium of brain, retina, and placenta.

228 eriocular mesenchymal-like cells and corneal endothelium of early zebrafish embryos.

229 th a time course similar to that observed in endothelium of resistance arteries (i.e. rapid initial p

230 trabecular meshwork together with inner wall endothelium of Schlemm's canal (SC) provide the bulk of

231 2/CD98 was strongly expressed in neurons and endothelium of seizure-affected brains and less in react

232 of the spinal cord meninges, but not by the endothelium of the blood-spinal cord barrier.

233 and progenitor cells arise from the vascular endothelium of the dorsal aorta and subsequently switch

234 cells are generated first from the vascular endothelium of the dorsal aorta and then the fetal liver

235 irment of TGF-beta signaling in the vascular endothelium of the eye is sufficient to trigger CNV form

236 The endothelium of the Ncx1 (-/-) mutant DA lacked normal ex

237 microfluidic device designed to monitor the endothelium on two fronts: the real-time monitoring of t

238 that disrupting antigen formation along the endothelium or protecting the endothelium may provide a

239 the central and peripheral pIOL edge to the endothelium (P </= 0.005).

240 c and inflammatory disorders associated with endothelium perturbation, VWF release, and complement ac

241 The cardiac endothelium plays a crucial role in the development of a

242 This disruption in the function of the endothelium predisposes it toward formation of atheroscl

243 The vascular endothelium presents a major transport barrier to drug d

244 sts can transdifferentiate into new coronary endothelium raises a new and exciting approach to promot

245 ear stress due to blood flow on the vascular endothelium regulates blood vessel development, remodeli

246 Production of these metabolites by gut endothelium requires MFSD2A; endothelial progenitor cell

247 reprogramming models of induced neurons and endothelium, respectively.

248 tudy, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla prote

249 ANCA-activated neutrophils interact with the endothelium, resulting in necrotizing vasculitis.

250 ated clearance of activated platelets by the endothelium results in an anti-inflammatory, anticoagula

251 The endothelium serves as a protective semipermeable barrier

252 The endothelium serves as a size-selective barrier and tight

253 into liposomes, designed to target inflamed endothelium, shows reduced atherosclerosis and CC format

254 Endothelium-specific ablation of Hdac3 in mice led to bl

255 Endothelium-specific CCN1 deletion in mice using a cre/l

256 Here we report that vascular endothelium-specific deletion of mouse Drosha (Drosha (c

257 AZ are essential for vascular development as endothelium-specific deletion of YAP/TAZ leads to impair

258 Endothelium-specific knockdown of HIF-1alpha impairs the

259 Endothelium-specific transgenic and global knockin mice

260 ic cytokines and gradually degrade endosteal endothelium, stromal cells, and osteoblastic cells, wher

261 Next, we observed the endothelium structure lost its integrity in the co-cultu

262 1) and a global hypermethylation in vascular endothelium subjected to disturbed flow.

263 eries where disturbed blood flow renders the endothelium susceptible to inflammation.

264 The endothelium-targeted gene therapy improved the integrity

265 molecular sensor of physical exercise in the endothelium that triggers endothelial communication to m

266 physical withdrawal of mural cells from the endothelium that was accompanied by an inhibition of end

267 Here, we address Piezo1 in adult endothelium, the major control site in physical activity

268 um falciparum (iRBCs) adhere to the vascular endothelium through adhesive protrusions called "knobs"

269 sel periphery are able to disrupt the vessel endothelium through cell division and detach into circul

270 es and the end-point characterization of the endothelium through immunostaining.

271 nvasion ability, and their adhesion to human endothelium through inhibiting integrin alphavbeta6, MMP

272 which activate the innate immune system and endothelium to an inflammatory, proadhesive state that p

273 (+) TNBC tumor cells and targeting the tumor endothelium to block tumor neovascularization.

274 n isothiocyanate-conjugated isolectin-B4 for endothelium to demarcate vascular structures and quantif

275 -activated K(+) channels present in arterial endothelium to generate endothelium-derived hyperpolariz

276 ds (FA) are transported across the capillary endothelium to parenchymal tissues.

277 Rhythmic twitch contractions stimulate FA endothelium to release nitric oxide in response to eleva

278 mucosa but also restored the ability of the endothelium to resolve intestinal inflammation, compared

279 e recruitment of blood leukocytes across the endothelium to sites of tissue infection is central to i

280 d rolling interactions on E-selectin-bearing endothelium under flow conditions in vitro as well as in

281 ollowed by (2) firm platelet adhesion to the endothelium via interaction of platelet alphaIIbbeta3 wi

282 nterrogate the proteome of pancreatic cancer endothelium via phage display and identify hornerin as a

283 First, we demonstrated the endothelium was functional, whereas the tumour model exh

284 DT endothelium was Prox1-positive, CD31-positive and LYVE-1

285 for inactivation of Hey2 specifically in the endothelium was used to study the biological consequence

286 ular Ca(2+) signalling dynamics in lymphatic endothelium, we excised collecting lymphatic vessels fro

287 rs in DF-EC interaction and if DF effects on endothelium were dependent of its internalization.

288 cking FcgammaRIIB globally or selectively in endothelium were protected from insulin resistance as a

289 D and smaller distance between pIOL edge and endothelium were risk factors for EC loss.

290 , red blood cell extravasation, and plumping endothelium were the main histopathologic features.

291 anistically, CatG is immobilized on arterial endothelium where it activates leukocytes to firmly adhe

292 dium promoted the differentiation toward the endothelium, whereas epithelial medium promoted the diff

293 hypercoagulable state and activation of the endothelium, which is associated with mortality.

294 of salt sensitivity may be a function of the endothelium, which is integrally involved in the vascula

295 ioblasts, but less efficiently to haemogenic endothelium, which only produced primitive haematopoieti

296 head muscles (HMs) and hypobranchial artery endothelium, which we demonstrate are co-specified with

297 Furthermore, we integrated the microfluidic endothelium with a computer-controlled mechanical stretc

298 rthermore, we detected an altered glomerular endothelium with disrupted sub-endothelial integrity.

299 Selectively damaging the endothelium with light-dye treatment midway between a FA

300 Preserving endosteal endothelium with the small molecule deferoxamine or a ge